Modeling, Analysis and Testing of a Novel Spoke-Type Interior Permanent Magnet Motor with Improved Flux Weakening Capability

Spoke-type interior permanent magnet (IPM) machines are an attractive topology for high performance electric motors, especially designed for vehicle traction applications. In this paper, a special design for a spoke-type IPM motor is presented to enhance motor flux-weakening capability in the operation over a wide speed range. The proposed design consists of a simple and robust mechanical device that includes radially-displaceable rotor yokes, connected to the shaft by means of springs. At high speed, the centrifugal force prevails over the elastic one due to springs, causing the mobile yokes to displace radially and to establish a partial magnetic short circuit between permanent magnets. This increases permanent magnet leakage flux and consequently reduces the air-gap field. As a result, a mechanical flux weakening effect is achieved at high speed, which helps significantly reduce the demagnetizing d-axis current to be injected by the inverter, along with the related copper losses and demagnetization issues. The proposed design is investigated in the paper using an analytical model whose parameters are computed by finite-element analysis (FEA). The effectiveness of the solution being set forth is successfully proven by some testing on a laboratory prototype. Experimental results are compared to analytical predictions showing a satisfactory accordance

Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues

Advances in single-cell antibody cloning methods have led to the identification of a variety of broadly neutralizing anti–HIV-1 antibodies. We developed a computational tool (Antibody Database) to help identify critical residues on the HIV-1 envelope protein whose natural variation affects antibody activity. Our simplifying assumption was that, for a given antibody, a significant portion of the dispersion of neutralization activity across a panel of HIV-1 strains is due to the amino acid identity or glycosylation state at a small number of specific sites, each acting independently. A model of an antibody’s neutralization IC_(50) was developed in which each site contributes a term to the logarithm of the modeled IC_(50). The analysis program attempts to determine the set of rules that minimizes the sum of the residuals between observed and modeled IC_(50) values. The predictive quality of the identified rules may be assessed in part by whether there is support for rules within individual viral clades. As a test case, we analyzed antibody 8ANC195, an anti-glycoprotein gp120 antibody of unknown specificity. The model for this antibody indicated that several glycosylation sites were critical for neutralization. We evaluated this prediction by measuring neutralization potencies of 8ANC195 against HIV-1 in vitro and in an antibody therapy experiment in humanized mice. These experiments confirmed that 8ANC195 represents a distinct class of glycan-dependent anti–HIV-1 antibody and validated the utility of computational analysis of neutralization panel data

On the Influence of Pulse Shapes on Ionization Probability

We investigate analytical expressions for the upper and lower bounds for the ionization probability through ultra-intense shortly pulsed laser radiation. We take several different pulse shapes into account, including in particular those with a smooth adiabatic turn-on and turn-off. For all situations for which our bounds are applicable we do not find any evidence for bound-state stabilization.Comment: 21 pages LateX, 10 figure

The Short-term Car Flow Planning Model in Rail Freight Company – Case Study

AbstractWith the promotion of the environmentally friendly transportation modes (the European Commission supports the freight transport operations in the rail sector), an increase in the diversification of the demand is observed. While most rail freight companies tend to apply fixed schedules, this approach is not effective turns out to be ineffective due to the need to meet the customer's specific requirements.The purpose of this paper is to present a case study of empty wagon flow planning over a medium term horizon and to discuss the opportunities of improvement of this plans by discrete optimization. In order to increase the utilization and availability of wagons, the planning procedure with a rolling horizon has to be implemented. Unfortunately, since the plan has to be updated ca. every 4hours, this planning approach needs effective optimization tools. Our hybrid two-stage approach is designed to be implemented in such business environment. This formulation allows us to solve real life instances even for a 7-day time horizon

On the absence of bound-state stabilization through short ultra-intense fields

We address the question of whether atomic bound states begin to stabilize in the short ultra-intense field limit. We provide a general theory of ionization probability and investigate its gauge invariance. For a wide range of potentials we find an upper and lower bound by non-perturbative methods, which clearly exclude the possibility that the ultra intense field might have a stabilizing effect on the atom. For short pulses we find almost complete ionization as the field strength increases.Comment: 34 pages Late

Ionization Probabilities through ultra-intense Fields in the extreme Limit

We continue our investigation concerning the question of whether atomic bound states begin to stabilize in the ultra-intense field limit. The pulses considered are essentially arbitrary, but we distinguish between three situations. First the total classical momentum transfer is non-vanishing, second not both the total classical momentum transfer and the total classical displacement are vanishing together with the requirement that the potential has a finite number of bound states and third both the total classical momentum transfer and the total classical displacement are vanishing. For the first two cases we rigorously prove, that the ionization probability tends to one when the amplitude of the pulse tends to infinity and the pulse shape remains fixed. In the third case the limit is strictly smaller than one. This case is also related to the high frequency limit considered by Gavrila et al.Comment: 16 pages LateX, 2 figure

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

An HIV vaccine capable of eliciting durable neutralizing antibody responses continues to be an important unmet need. Multivalent nanoparticles displaying a high density of envelope trimers may be promising immunogen forms to elicit strong and durable humoral responses to HIV, but critical particle design criteria remain to be fully defined. To this end, we developed strategies to covalently anchor a stabilized gp140 trimer, BG505 MD39, on the surfaces of synthetic liposomes to study the effects of trimer density and vesicle stability on vaccine-elicited humoral responses in mice. CryoEM imaging revealed homogeneously distributed and oriented MD39 on the surface of liposomes irrespective of particle size, lipid composition, and conjugation strategy. Immunization with covalent MD39-coupled liposomes led to increased germinal center and antigen-specific T follicular helper cell responses and significantly higher avidity serum MD39-specific IgG responses compared to immunization with soluble MD39 trimers. A priming immunization with liposomal-MD39 was important for elicitation of high avidity antibody responses, regardless of whether booster immunizations were administered with either soluble or particulate trimers. The stability of trimer anchoring to liposomes was critical for these effects, as germinal center and output antibody responses were further increased by liposome compositions incorporating sphingomyelin that exhibited high in vitro stability in the presence of serum. Together these data highlight key liposome design features for optimizing humoral immunity to lipid nanoparticle immunogens.National Institute of Allergy and Infectious Diseases (U.S.) (Award UM1AI100663)National Institutes of Health (U.S.) (Award P01-AI104715)National Institutes of Health (U.S.) (Award P01-AI048240)National Cancer Institute (U.S.) (Grant P30-CA14051

A review of power electronics equipment for all-electric ship MVDC power systems

Medium Voltage DC (MVDC) distribution Power Systems for all-electric ships (AES) can be regarded as functionally composed of three subsystems, namely the power sources, the load centers and the distribution network. Extensive use of power electronics is required for connecting power sources and load centers to the MVDC bus and for protecting the MVDC power system through properly placed DC circuit breakers. In this paper, an overview is given of the power electronics equipment found in the literature and on the market that could be suitable for use in future AES MVDC power systems. Some industrial experiences regarding DC generator systems, energy storage apparatus and solid-state DC circuit breaker prototypes are reported in the paper as examples of state-of-the-art realizations. Different DC/DC converters, which can be employed as solid-state transformers, are also discussed and a structure obtained by combining them is proposed

Design and simulation of a vehicle-To-grid system

Batteries of electric vehicles have to be charged by power electronic converters connected to the electric grid. If these power converters are bidirectional they can be exploited to act in support to the grid operation, thus realizing the so called vehicle-To-grid (V2G) systems. At the University of Trieste an experimental V2G apparatus is under construction. Its control system has been developed and the first simulation tests has been performed. The paper describes the V2G experimental apparatus with its control system and reports the results of the preliminary simulation tests

Auxiliares didácticos en la enseñanza de la endodoncia pre-clínica

 The pre-clinic training previous to the clinic teaching of the Endodontic is recognized and accepted by the majority of the Universities and Schools of Odontology in the world. For its development it is essential to have enough space, time and instruments. This brings about a real problem when the amount of students is big A group of dispositives used as didactic auxiliaries is described, specially for X-ray takings, in the subject of Endodontic "B" of the Odontology Faculty of the National University of Córdoba (Argentina). These include the traditional manikin, which permits the taking of only X-ray by shot and a dispositive that allows the taking of 4 to 8 X-ray at the same time. These dispositives have sorne advantages like: l) obtaining X-ray of good definition and Jittle distortion, 2) save time, 3) make the gratest use of the radiographic exposition with the smallest possible damage of the devices. The number of shots can be reduced to a fourth or eighthEl adiestramiento pre-clínico previo a la enseñanza clínica de la endodoncia, está reconocido y aceptado por la mayoría de las Facultades y Escuelas de Odontología del mundo. Su desarrollo exige disponer de espacio, tiempo y aparatología suficiente, lo que crea un verdadero problema cuando la población estudiantil es numerosa. Se describen una serie de dispositivos utilizados como auxiliares didácticos, especialmente para las tomas radiográficas, en la Cátedra de Endodoncia "B" de la Facultad de Odontología de la Universidad Nacional de Córdoba (Argentina), que van desde el clásico maniquí que permite la toma de una sola radiografía por disparo y de un dispositivo que hace posible la toma de 4 a 8 radiografías simultáneamente. Los mismos permiten ventajas tales como: 1) obtener placa de buena definición y escasa distorsión, 2) economizar tiempo, 3) aprovechar al máximo las exposiciones radiográficas con el mínimo desgaste de la aparatología, ya que el número de disparos puede reducirse a una cuarta u octava parte