856 research outputs found
A comunicação da Embrapa Trigo em um dia de campo de inverno 2013.
Editores técnicos: Joseani Mesquita Antunes, Ana Lídia Variani Bonato, Márcia Barrocas Moreira Pimentel
Reconstruction of the two-dimensional gravitational potential of galaxy clusters from X-ray and Sunyaev-Zel'dovich measurements
The mass of galaxy clusters is not a direct observable, nonetheless it is
commonly used to probe cosmological models. Based on the combination of all
main cluster observables, that is, the X-ray emission, the thermal
Sunyaev-Zel'dovich (SZ) signal, the velocity dispersion of the cluster
galaxies, and gravitational lensing, the gravitational potential of galaxy
clusters can be jointly reconstructed. We derive the two main ingredients
required for this joint reconstruction: the potentials individually
reconstructed from the observables and their covariance matrices, which act as
a weight in the joint reconstruction. We show here the method to derive these
quantities. The result of the joint reconstruction applied to a real cluster
will be discussed in a forthcoming paper. We apply the Richardson-Lucy
deprojection algorithm to data on a two-dimensional (2D) grid. We first test
the 2D deprojection algorithm on a -profile. Assuming hydrostatic
equilibrium, we further reconstruct the gravitational potential of a simulated
galaxy cluster based on synthetic SZ and X-ray data. We then reconstruct the
projected gravitational potential of the massive and dynamically active cluster
Abell 2142, based on the X-ray observations collected with XMM-Newton and the
SZ observations from the Planck satellite. Finally, we compute the covariance
matrix of the projected reconstructed potential of the cluster Abell 2142 based
on the X-ray measurements collected with XMM-Newton. The gravitational
potentials of the simulated cluster recovered from synthetic X-ray and SZ data
are consistent, even though the potential reconstructed from X-rays shows
larger deviations from the true potential. Regarding Abell 2142, the projected
gravitational cluster potentials recovered from SZ and X-ray data reproduce
well the projected potential inferred from gravitational-lensing observations.
(abridged)Comment: accepted for publication in the journal A&
Blubber Transciptome Response to Acute Stress Axis Activation Involves Transient Charges in Adipogenesis and Lipolysis in Fast-Adapted Marine Mammal
Stress can compromise an animal\u27s ability to conserve metabolic stores and participate in energy-demanding activities that are critical for fitness. Understanding how wild animals, especially those already experiencing physiological extremes (e.g. fasting), regulate stress responses is critical for evaluating the impacts of anthropogenic disturbance on physiology and fitness, key challenges for conservation. However, studies of stress in wildlife are often limited to baseline endocrine measurements and few have investigated stress effects in fasting-adapted species. We examined downstream molecular consequences of hypothalamic-pituitary-adrenal (HPA) axis activation by exogenous adrenocorticotropic hormone (ACTH) in blubber of northern elephant seals due to the ease of blubber sampling and its key role in metabolic regulation in marine mammals. We report the first phocid blubber transcriptome produced by RNAseq, containing over 140,000 annotated transcripts, including metabolic and adipocytokine genes of interest. The acute response of blubber to stress axis activation, measured 2 hours after ACTH administration, involved highly specific, transient (lasting \u3c24 \u3ehours) induction of gene networks that promote lipolysis and adipogenesis in mammalian adipocytes. Differentially expressed genes included key adipogenesis factors which can be used as blubber-specific markers of acute stress in marine mammals of concern for which sampling of other tissues is not possible
An Affordable Upper-Limb Exoskeleton Concept for Rehabilitation Applications
In recent decades, many researchers have focused on the design and development of exoskeletons. Several strategies have been proposed to develop increasingly more efficient and biomimetic mechanisms. However, existing exoskeletons tend to be expensive and only available for a few people. This paper introduces a new gravity-balanced upper-limb exoskeleton suited for rehabilitation applications and designed with the main objective of reducing the cost of the components and materials. Regarding mechanics, the proposed design significantly reduces the motor torque requirements, because a high cost is usually associated with high-torque actuation. Regarding the electronics, we aim to exploit the microprocessor peripherals to obtain parallel and real-time execution of communication and control tasks without relying on expensive RTOSs. Regarding sensing, we avoid the use of expensive force sensors. Advanced control and rehabilitation features are implemented, and an intuitive user interface is developed. To experimentally validate the functionality of the proposed exoskeleton, a rehabilitation exercise in the form of a pick-and-place task is considered. Experimentally, peak torques are reduced by 89% for the shoulder and by 84% for the elbow
A weak lensing analysis of the PLCK G100.2-30.4 cluster
We present a mass estimate of the Planck-discovered cluster PLCK G100.2-30.4,
derived from a weak lensing analysis of deep SUBARU griz images. We perform a
careful selection of the background galaxies using the multi-band imaging data,
and undertake the weak lensing analysis on the deep (1hr) r-band image. The
shape measurement is based on the KSB algorithm; we adopt the PSFex software to
model the Point Spread Function (PSF) across the field and correct for this in
the shape measurement. The weak lensing analysis is validated through extensive
image simulations. We compare the resulting weak lensing mass profile and total
mass estimate to those obtained from our re-analysis of XMM-Newton
observations, derived under the hypothesis of hydrostatic equilibrium. The
total integrated mass profiles are in remarkably good agreement, agreeing
within 1 across their common radial range. A mass is derived for the cluster from our weak lensing
analysis. Comparing this value to that obtained from our reanalysis of
XMM-Newton data, we obtain a bias factor of (1-b) = 0.8 0.1. This is
compatible within 1 with the value of (1-b) obtained by Planck
Collaboration XXIV from their calibration of the bias factor using
newly-available weak lensing reconstructed masses.Comment: 11 pages, 12 figures, accepted for publication on Astronomy &
Astrophysics; updates in affiliation
Paving the way for the JWST: witnessing globular cluster formation at z>3
We report on five compact, extremely young (<10Myr) and blue (\beta_UV<-2.5,
F_\lambda =\lambda^\beta) objects observed with VLT/MUSE at redshift 3.1169,
3.235, in addition to three objects at z=6.145. These sources are magnified by
the Hubble Frontier Field galaxy clusters MACS~J0416 and AS1063. Their
de-lensed half light radii (Re) are between 16 to 140pc, the stellar masses are
~1-20 X 10^6 Msun, the magnitudes are m_uv=28.8 - 31.4 (-17<Muv<-15) and
specific star formation rates can be as large as ~800Gyr^-1. Multiple images of
these systems are widely separated in the sky (up to 50'') and individually
magnified by factors 3-40. Remarkably, the inferred physical properties of two
objects are similar to those expected in some globular cluster formation
scenarios, representing the best candidate proto-globular clusters (proto-GC)
discovered so far. Rest-frame optical high dispersion spectroscopy of one of
them at z=3.1169 yields a velocity dispersion \sigma_v~20km/s, implying a
dynamical mass dominated by the stellar mass. Another object at z=6.145, with
de-lensed Muv ~ -15.3 (m_uv ~ 31.4), shows a stellar mass and a star-formation
rate surface density consistent with the values expected from popular GC
formation scenarios. An additional star-forming region at z=6.145, with
de-lensed m_uv ~ 32, a stellar mass of 0.5 X 10^6 Msun and a star formation
rate of 0.06 Msun/yr is also identified. These objects currently represent the
faintest spectroscopically confirmed star-forming systems at z>3, elusive even
in the deepest blank fields. We discuss how proto-GCs might contribute to the
ionization budget of the universe and augment Lya visibility during
reionization. This work underlines the crucial role of JWST in characterizing
the rest-frame optical and near-infrared properties of such low-luminosity
high-z objects.Comment: 19 pages, 9 figures, 2 tables. MNRAS, version accepted by the refere
The Frontier Fields Lens Modeling Comparison Project
Gravitational lensing by clusters of galaxies offers a powerful probe of
their structure and mass distribution. Deriving a lens magnification map for a
galaxy cluster is a classic inversion problem and many methods have been
developed over the past two decades to solve it. Several research groups have
developed techniques independently to map the predominantly dark matter
distribution in cluster lenses. While these methods have all provided
remarkably high precision mass maps, particularly with exquisite imaging data
from the Hubble Space Telescope (HST), the reconstructions themselves have
never been directly compared. In this paper, we report the results of comparing
various independent lens modeling techniques employed by individual research
groups in the community. Here we present for the first time a detailed and
robust comparison of methodologies for fidelity, accuracy and precision. For
this collaborative exercise, the lens modeling community was provided simulated
cluster images -- of two clusters Ares and Hera -- that mimic the depth and
resolution of the ongoing HST Frontier Fields. The results of the submitted
reconstructions with the un-blinded true mass profile of these two clusters are
presented here. Parametric, free-form and hybrid techniques have been deployed
by the participating groups and we detail the strengths and trade-offs in
accuracy and systematics that arise for each methodology. We note in conclusion
that lensing reconstruction methods produce reliable mass distributions that
enable the use of clusters as extremely valuable astrophysical laboratories and
cosmological probes.Comment: 38 pages, 25 figures, submitted to MNRAS, version with full
resolution images can be found at
http://pico.bo.astro.it/~massimo/papers/FFsims.pd
Towards the Inhibition of Protein–Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives
Signal transducer and activator of transcription 3 (STAT3) is a validated anticancer target due to the relationship between its constitutive activation and malignant tumors. Through a virtual screening approach on the STAT3-SH2 domain, 5,6-dimethyl-1H,3H-2,1,3-benzothiadiazole-2,2-dioxide (1) was identified as a potential STAT3 inhibitor. Some benzothiadiazole derivatives were synthesized by employing a versatile methodology, and they were tested by an AlphaScreen-based assay. Among them, benzosulfamide 1 showed a significant activity with an IC50 = 15.8 \ub1 0.6 \ub5M as a direct STAT3 inhibitor. Notably, we discovered that compound 1 was also able to interact with cysteine residues located around the SH2 domain. By applying mass spectrometry, liquid chromatography, NMR, and UV spectroscopy, an in-depth investigation was carried out, shedding light on its intriguing and unexpected mechanism of interaction
Towards the Inhibition of Protein–Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives
Signal transducer and activator of transcription 3 (STAT3) is a validated anticancer target due to the relationship between its constitutive activation and malignant tumors. Through a virtual screening approach on the STAT3-SH2 domain, 5,6-dimethyl-1H,3H-2,1,3-benzothiadiazole-2,2-dioxide (1) was identified as a potential STAT3 inhibitor. Some benzothiadiazole derivatives were synthesized by employing a versatile methodology, and they were tested by an AlphaScreen-based assay. Among them, benzosulfamide 1 showed a significant activity with an IC50 = 15.8 ± 0.6 µM as a direct STAT3 inhibitor. Notably, we discovered that compound 1 was also able to interact with cysteine residues located around the SH2 domain. By applying mass spectrometry, liquid chromatography, NMR, and UV spectroscopy, an in-depth investigation was carried out, shedding light on its intriguing and unexpected mechanism of interaction
Evidence of Spiro-OMeTAD De-doping by tert-Butylpyridine Additive in Hole-Transporting Layers for Perovskite Solar Cells
The development of solid-state hole-transporting materials (HTMs) dates back to the first reports on solid-state dye-sensitized solar cells in 1998, which provided solar cell efficiencies around 1%. The need for these components has then steadily grown with the advent in 2009 of perovskite-based photovoltaics, which cannot sustain any liquid electrolyte. Spiro-OMeTAD molecules have been for many years the material of choice for this application. When doped with LiTFSI salts and tert-butylpyridine, the resulting mixture can efficiently extract photogenerated holes in the perovskite absorber and transport them to the collecting electrode. This benchmark for hole transport in third-generation hybrid photovoltaics suffers from intrinsic limitations, which have been studied widely over the years. A detailed molecular-level understanding of the processes involved in Spiro-OMeTAD-based HTM degradation is a key requirement for the future development of new stable and efficient substitutes for this task
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