A Study of the Production of Neutrons for Boron Neutron Capture Therapy using a Proton Accelerator

Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy particularly well-suited to treating aggressive tumours that exhibit a high degree of infiltration of the surrounding healthy tissue. Such tumours, for example of the brain and lung, provide some of the most challenging problems in oncology. The first element of the therapy is boron-10 which is preferentially introduced into the cancerous cells using a carrier compound. Boron-10 has a very high capture cross-section with the other element of the therapy, thermal neutrons, resulting in the production of a lithium nucleus and an alpha particle which destroy the cell they are created in. However, a large flux of neutrons is required and until recently the only source used was a nuclear reactor. In Birmingham, studies of an existing BNCT facility using a 2.8 MeV proton beam and a solid lithium target have found a way to increase the beam power to a sufficient level to allow clinical trials, while maintaining the target solid. In this paper, we will introduce BNCT, describe the work in Birmingham and compare with other accelerator-driven BNCT projects around the World

The returns to microenterprise support among the ultrapoor: A field experiment in postwar Uganda

This is the final version of the article. Available from American Economic Association via the DOI in this record.We show that extremely poor, war-affected women in northern Uganda have high returns to a package of $150 cash, five days of business skills training, and ongoing supervision. Sixteen months after grants, participants doubled their microenterprise ownership and incomes, mainly from petty trading. We also show these ultrapoor have too little social capital, but that group bonds, informal insurance, and cooperative activities could be induced and had positive returns. When the control group received cash and training 20 months later, we varied supervision, which represented half of the program costs. A year later, supervision increased business survival but not consumption. (JEL I38, J16, J23, J24, L26, O15, Z13

Volunteering in the care of people with severe mental illness: a systematic review

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Effects of ocean acidification on invertebrate settlement at volcanic CO<inf>2</inf> vents

We present the first study of the effects of ocean acidification on settlement of benthic invertebrates and microfauna. Artificial collectors were placed for 1 month along pH gradients at CO2 vents off Ischia (Tyrrhenian Sea, Italy). Seventy-nine taxa were identified from six main taxonomic groups (foraminiferans, nematodes, polychaetes, molluscs, crustaceans and chaetognaths). Calcareous foraminiferans, serpulid polychaetes, gastropods and bivalves showed highly significant reductions in recruitment to the collectors as pCO2 rose from normal (336-341 ppm, pH 8.09-8.15) to high levels (886-5,148 ppm) causing acidified conditions near the vents (pH 7.08-7.79). Only the syllid polychaete Syllis prolifera had higher abundances at the most acidified station, although a wide range of polychaetes and small crustaceans was able to settle and survive under these conditions. A few taxa (Amphiglena mediterranea, Leptochelia dubia, Caprella acanthifera) were particularly abundant at stations acidified by intermediate amounts of CO2 (pH 7. 41-7.99). These results show that increased levels of CO2 can profoundly affect the settlement of a wide range of benthic organisms. © 2010 Springer-Verlag

Decision for reconstructive interventions of the upper limb in individuals with tetraplegia: the effect of treatment characteristics

Objective: To determine the effect of treatment characteristics on the\ud decision for reconstructive interventions for the upper extremities (UE) in\ud subjects with tetraplegia. - \ud Setting: Seven specialized spinal cord injury centres in the Netherlands. - \ud Method: Treatment characteristics for UE reconstructive interventions were\ud determined. Conjoint analysis (CA) was used to determine the contribution\ud and the relative importance of the treatment characteristics on the decision\ud for therapy. Therefore, a number of different treatment scenarios using these\ud characteristics were established. Different pairs of scenarios were presented\ud to subjects who were asked to choose the preferred scenario of each set. - \ud Results: forty nine subjects with tetraplegia with a stable C5, C6 or C7\ud lesion were selected. All treatment characteristics significantly influenced\ud the choice for treatment. Relative importance of treatment characteristics\ud were: intervention type (surgery or surgery with FES implant) 13%, number\ud of operations 15%, in patient rehabilitation period 22%, ambulant\ud rehabilitation period 9%, complication rate 15%, improvement of elbow\ud function 10%, improvement of hand function 15%. In deciding for therapy\ud 40% of the subjects focused on one characteristic. - \ud Conclusion: CA is applicable in Spinal Cord Injury medicine to study the\ud effect of health outcomes and non-health outcomes on the decision for\ud treatment. Non-health outcomes which relate to the intensity of treatment\ud are equally important or even more important than functional outcome in the\ud decision for reconstructive UE surgery in subjects with tetraplegia

The role of mentorship in protege performance

The role of mentorship on protege performance is a matter of importance to academic, business, and governmental organizations. While the benefits of mentorship for proteges, mentors and their organizations are apparent, the extent to which proteges mimic their mentors' career choices and acquire their mentorship skills is unclear. Here, we investigate one aspect of mentor emulation by studying mentorship fecundity---the number of proteges a mentor trains---with data from the Mathematics Genealogy Project, which tracks the mentorship record of thousands of mathematicians over several centuries. We demonstrate that fecundity among academic mathematicians is correlated with other measures of academic success. We also find that the average fecundity of mentors remains stable over 60 years of recorded mentorship. We further uncover three significant correlations in mentorship fecundity. First, mentors with small mentorship fecundity train proteges that go on to have a 37% larger than expected mentorship fecundity. Second, in the first third of their career, mentors with large fecundity train proteges that go on to have a 29% larger than expected fecundity. Finally, in the last third of their career, mentors with large fecundity train proteges that go on to have a 31% smaller than expected fecundity.Comment: 23 pages double-spaced, 4 figure

Multi-wavelength study of the gravitational lens system RXS J1131-1231: III. Long slit spectroscopy: micro-lensing probes the QSO structure

(ABRIDGED) Aims: We discuss and characterize micro-lensing among the 3 brightest lensed images (A-B-C) of the gravitational lens system RXS J1131-1231 (a quadruply imaged AGN) by means of long slit optical and NIR spectroscopy. Qualitative constraints on the size of different emission regions are derived. Methods: We decompose the spectra into their individual emission components using a multi-component fitting approach. A complementary decomposition of the spectra enables us to isolate the macro-lensed fraction of the spectra independently of any spectral modelling. Results: -1. The data support micro-lensing de-amplification of images A and C. Not only is the continuum emission microlensed in those images but also a fraction of the Broad Line emitting Region (BLR).-2. Micro-lensing of a very broad component of MgII emission line suggests that the corresponding emission occurs in a region more compact than the other components of the emission line. -3. We find evidence that a large fraction of the FeII emission arises in the outer parts of the BLR. We also find very compact emitting region in the ranges 3080-3540 A and 4630-4800 A that is likely associated with FeII. -4. The OIII narrow emission line regions are partly spatially resolved. This enables us to put a lower limit of 110h^{-1} pc on their intrinsic size. -5. Analysis of MgII absorption found in the spectra indicates that the absorbing medium is intrinsic to the quasar, has a covering factor of 20%, and is constituted of small clouds homogeneously distributed in front of the continuum and BLRs. -6. Two neighbour galaxies are detected at redshifts z=0.10 and z=0.289. These galaxies are possible members of galaxy groups reported at those redshifts.Comment: Accepted by Astronomy and Astrophysics. Small modifications to match the final versio

Multiwavelength Observations of Pulsar Wind Nebulae

The extended nebulae formed as pulsar winds expand into their surroundings provide information about the composition of the winds, the injection history from the host pulsar, and the material into which the nebulae are expanding. Observations from across the electromagnetic spectrum provide constraints on the evolution of the nebulae, the density and composition of the surrounding ejecta, the geometry of the central engines, and the long-term fate of the energetic particles produced in these systems. Such observations reveal the presence of jets and wind termination shocks, time-varying compact emission structures, shocked supernova ejecta, and newly formed dust. Here I provide a broad overview of the structure of pulsar wind nebulae, with specific examples from observations extending from the radio band to very-high-energy gamma-rays that demonstrate our ability to constrain the history and ultimate fate of the energy released in the spin-down of young pulsars.Comment: 20 pages, 11 figures. Invited review to appear in Proc. of the inaugural ICREA Workshop on "The High-Energy Emission from Pulsars and their Systems" (2010), eds. N. Rea and D. Torres, (Springer Astrophysics and Space Science series

Spacetime Instanton Corrections in 4D String Vacua - The Seesaw Mechanism for D-Brane Models

We systematically investigate instanton corrections from wrapped Euclidean D-branes to the matter field superpotential of various classes of N=1 supersymmetric D-brane models in four dimensions. Both gauge invariance and the counting of fermionic zero modes provide strong constraints on the allowed non-perturbative superpotential couplings. We outline how the complete instanton computation boils down to the computation of open string disc diagrams for boundary changing operators multiplied by a one-loop vacuum diagram. For concreteness we focus on E2-instanton effects in Type IIA vacua with intersecting D6-branes, however the same structure emerges for Type IIB and heterotic vacua. The instantons wrapping rigid cycles can potentially destabilise the vacuum or generate perturbatively absent matter couplings such as proton decay operators, mu-parameter or right-handed neutrino Majorana mass terms. The latter allow the realization of the seesaw mechanism for MSSM-like intersecting D-brane models.Comment: 40 pages, 3 tables, 7 figures; v2: typos corrected, references added; v3: minor sign adjustments, some comments added; v4: published versio

Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection

Interstitial pneumonia linked with reactivation of latent human cytomegalovirus due to iatrogenic immunosuppression can be a serious complication of bone marrow transplantation therapy of aplastic anaemia and acute leukaemia1. Cellular immunity plays a critical role in the immune surveillance of inapparent cytomegalovirus infections in man and the mouse1−7. The molecular basis of latency, however, and the interaction between latently or recurrently infected cells and the immune system of the host are poorfy understood. We have detected a so far unknown antigen in the mouse model. This antigen is found in infected cells in association with the expression of the herpesvirus 'immediate early' genes and is recognized by cytolytic T lymphocytes (CTL)8. We now demonstrate that an unexpectedly high proportion of the CTL precursors generated in vivo during acute murine cytomegalovirus infection are specific for cells that selectively synthesize immediate early proteins, indicating an immunodominant role of viral non-structural proteins