Solar Stereoscopy with STEREO/EUVI A and B spacecraft from small (6 deg) to large (170 deg) spacecraft separation angles

We performed for the first time stereoscopic triangulation of coronal loops in active regions over the entire range of spacecraft separation angles ($\alpha_{sep}\approx 6^\circ, 43^\circ, 89^\circ, 127^\circ$, and $170^\circ$). The accuracy of stereoscopic correlation depends mostly on the viewing angle with respect to the solar surface for each spacecraft, which affects the stereoscopic correspondence identification of loops in image pairs. From a simple theoretical model we predict an optimum range of $\alpha_{sep} \approx 22^\circ-125^\circ$, which is also experimentally confirmed. The best accuracy is generally obtained when an active region passes the central meridian (viewed from Earth), which yields a symmetric view for both STEREO spacecraft and causes minimum horizontal foreshortening. For the extended angular range of $\alpha_{sep}\approx 6^\circ-127^{\circ}$ we find a mean 3D misalignment angle of $\mu_{PF} \approx 21^\circ-39^\circ$ of stereoscopically triangulated loops with magnetic potential field models, and $\mu_{FFF} \approx 15^\circ-21^\circ$ for a force-free field model, which is partly caused by stereoscopic uncertainties $\mu_{SE} \approx 9^\circ$. We predict optimum conditions for solar stereoscopy during the time intervals of 2012--2014, 2016--2017, and 2021--2023.Comment: Solar Physics, (in press), 22 pages, 9 figure

A Nonlinear Force-Free Magnetic Field Approximation Suitable for Fast Forward-Fitting to Coronal Loops. I. Theory

We derive an analytical approximation of nonlinear force-free magnetic field solutions (NLFFF) that can efficiently be used for fast forward-fitting to solar magnetic data, constrained either by observed line-of-sight magnetograms and stereoscopically triangulated coronal loops, or by 3D vector-magnetograph data. The derived NLFFF solutions provide the magnetic field components $B_x({\bf x})$, $B_y({\bf x})$, $B_z({\bf x})$, the force-free parameter $\alpha({\bf x})$, the electric current density ${\bf j}({\bf x})$, and are accurate to second-order (of the nonlinear force-free $\alpha$-parameter). The explicit expressions of a force-free field can easily be applied to modeling or forward-fitting of many coronal phenomena.Comment: Solar Physics (in press), 26 pages, 11 figure

A Nonlinear Force-Free Magnetic Field Approximation Suitable for Fast Forward-Fitting to Coronal Loops. II. Numeric Code and Tests

Based on a second-order approximation of nonlinear force-free magnetic field solutions in terms of uniformly twisted field lines derived in Paper I, we develop here a numeric code that is capable to forward-fit such analytical solutions to arbitrary magnetogram (or vector magnetograph) data combined with (stereoscopically triangulated) coronal loop 3D coordinates. We test the code here by forward-fitting to six potential field and six nonpotential field cases simulated with our analytical model, as well as by forward-fitting to an exactly force-free solution of the Low and Lou (1990) model. The forward-fitting tests demonstrate: (i) a satisfactory convergence behavior (with typical misalignment angles of $\mu \approx 1^\circ-10^\circ$), (ii) relatively fast computation times (from seconds to a few minutes), and (iii) the high fidelity of retrieved force-free $\alpha$-parameters ($\alpha_{\rm fit}/\alpha_{\rm model} \approx 0.9-1.0$ for simulations and $\alpha_{\rm fit}/\alpha_{\rm model} \approx 0.7\pm0.3$ for the Low and Lou model). The salient feature of this numeric code is the relatively fast computation of a quasi-forcefree magnetic field, which closely matches the geometry of coronal loops in active regions, and complements the existing {\sl nonlinear force-free field (NLFFF)} codes based on photospheric magnetograms without coronal constraints.Comment: Solar PHysics, (in press), 25 pages, 11 figure

Cartan's spiral staircase in physics and, in particular, in the gauge theory of dislocations

In 1922, Cartan introduced in differential geometry, besides the Riemannian curvature, the new concept of torsion. He visualized a homogeneous and isotropic distribution of torsion in three dimensions (3d) by the "helical staircase", which he constructed by starting from a 3d Euclidean space and by defining a new connection via helical motions. We describe this geometric procedure in detail and define the corresponding connection and the torsion. The interdisciplinary nature of this subject is already evident from Cartan's discussion, since he argued - but never proved - that the helical staircase should correspond to a continuum with constant pressure and constant internal torque. We discuss where in physics the helical staircase is realized: (i) In the continuum mechanics of Cosserat media, (ii) in (fairly speculative) 3d theories of gravity, namely a) in 3d Einstein-Cartan gravity - this is Cartan's case of constant pressure and constant intrinsic torque - and b) in 3d Poincare gauge theory with the Mielke-Baekler Lagrangian, and, eventually, (iii) in the gauge field theory of dislocations of Lazar et al., as we prove for the first time by arranging a suitable distribution of screw dislocations. Our main emphasis is on the discussion of dislocation field theory.Comment: 31 pages, 8 figure

European practice patterns and barriers to smoking cessation after a cancer diagnosis in the setting of curative versus palliative cancer treatment

Background: Smoking cessation after a cancer diagnosis is associated with improved overall survival. Few studies have reported oncologists' cessation practice patterns, but differences between the curative and palliative settings have not been described. We aimed to study the oncologist's perceptions on patients' tobacco use, current practices and barriers to providing smoking cessation support, while distinguishing between treatment with curative (C) and palliative (P) intent.Methods: In 2019, an online 34-item survey was sent to approximately 6235 oncologists from 16 European countries. Responses were descriptively reported and compared by treatment setting.Results: Responses from 544 oncologists were included. Oncologists appeared to favour addressing tobacco in the curative setting more than in the palliative setting. Oncologists believe that continued smoking impacts treatment outcomes (C: 94%, P: 74%) and that cessation support should be standard cancer care (C: 95%, P: 63%). Most routinely assess tobacco use (C: 93%, P: 78%) and advise patients to stop using tobacco (C: 88%, P: 54%), but only 24% (P) -39% (C) routinely discuss medication options, and only 18% (P)-31% (C) provide cessation support. Hesitation to remove a pleasurable habit (C: 13%, P: 43%) and disbelieve on smoking affecting outcomes (C: 3%, P: 14%) were disparate barriers between the curative and palliative settings (p Conclusion: Oncologists appear to favour addressing tobacco use more in the curative setting; however, they discuss medication options and/or provide cessation support in a minority of cases. All patients who report current smoking should have access to evidence-based smoking cessation support, also patients treated with palliative intent given their increasing survival. </div

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

Age at first birth in women is genetically associated with increased risk of schizophrenia

Prof. Paunio on PGC:n jäsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe