Benefits of a dermocosmetic formulation with vitamins B3 and a B6 derivative combined with zinc-PCA for mild inflammatory acne and acne-prone skin

Acne is a chronic inflammatory disorder of the pilosebaceous follicles that affects 80% of the population. As topical agents for acneic skin treatment are often irritants, dermocosmetics, may improve therapy. Thus, we developed cosmetic formulations with nicotinamide (vitamin B3), pyridoxine tris-hexyldecanoate (a vitamin B6 derivative) and zinc- pyrrolidone carboxylic acid (PCA) in association, and evaluated their clinical efficacy, skin compatibility, and sensory properties. The formulation (vehicle) added with vitamin B3, the vitamin B6 derivative and zinc-PCA in combination was applied twice daily for six weeks on the forehead, malar and chin skin regions of sixteen subjects. Before (pre-treatment) and after treatment, these regions were evaluated using biophysical and skin imaging techniques. Inflammatory acne lesions were reduced by 60% after application of the complete formulation. Porphyrine reduction was shown in the majority of volunteers. The results shown an improvement of inflammatory acne lesions based on porphyrine reduction, lesion counts, skin compatibility and comedogenicity testing. The skin barrier function was not impaired by the experimental formulation, which demonstrates its efficacy in acne treatment without undesirable effects. The combination of Zn-PCA and vitamins B3 and B6 vehiculated in an adequate topical formulation can be considered as a safe and effective alternative treatment for mild inflammatory acneic skin

Efeitos do estresse térmico na atividade da ruminação e na degradabilidade ruminal in situ em vacas leiteiras.

No presente estudo objetivou-se avaliar os efeitos do estresse térmico (ET) sobre: i) tempo e o padrão diário de ruminação e ii) degradabilidade ruminal in situ em vacas da raça Girolando não lactantes. Nove vacas, pesando 556,2 ± 97,1 kg, foram alojadas em uma câmara climática (índice de temperatura e umidade - ITU médio = 83,1) ou em um freestall (ITU médio = 66,5), distribuídas aleatoriamente em delineamento de crossover. As vacas foram alimentadas em nível de mantença com silagem de milho ad libitum e 1 kg de concentrado. Para medir a ruminação foram utilizados sensores presos ao pescoço dos animais. A degradabilidade ruminal in situ foi avaliada por incubação de amostras de concentrado, silagem e dieta no rúmen de uma vaca fistulada por 6, 24, 48 e 96 h. O tempo de ruminação (TR) foi afetado pelo ET (P<0,001) e pela hora do dia (P<0,001). O padrão de ruminação para vacas controle e em ET teve o primeiro pico aproximadamente às 04:00h e a magnitude desse pico no ET foi 22,9% menor que nos animais do controle. O segundo pico de TR ocorreu à noite (~ 20:00h), quando o TR no ET foi 27,8% menor. Observou-se a redução na degradabilidade da matéria seca (DMD) do concentrado (85,1% vs 77,8%, controle e ET, respectivamente; P<0,05) e também na fração de degradação lenta do concentrado (93,9% vs 85,1%, respectivamente; P<0,05). A DMD da dieta reduziu de 73% para 70% para os animais expostos ao ET. Os resultados indicam que o ET afetou negativamente o tempo de ruminação e a degradabilidade ruminal in situ em vacas Girolando

Stability and sensory assessment of emulsions containing propolis extract and/or tocopheryl acetate

The prevention of skin aging has been one of the main aims of cosmetic products. Propolis and tocopheryl acetate can be promising substances because of their antioxidant properties. In this study, propolis extract was obtained and associated with tocopheryl acetate in a cream formulation, which then underwent stability and sensory assessment. The formulation containing propolis extract and tocopheryl acetate proved to be stable in the preliminary stability study, demonstrating gradual darkening and slight pH decrease when subjected to 60ºC for 28 days, but showing stability on rheological study. In the sensory analysis, the formulation containing these two components was preferred by the product testers over the base cream and creams containing propolis extract or tocopheryl acetate alone. In conclusion, given the stability of the formulation and the preference of the product testers for this formulation, this association proved promising for use in cosmetic formulations.A prevenção do envelhecimento cutâneo tem sido um dos principais focos dos produtos dermocosméticos. A própolis contém substâncias com atividade antioxidante, bem como o acetato de tocoferila é conhecido por apresentar esta atividade. Porém, a própolis apresenta odor muito característico e intenso, que pode interferir no sensorial do produto. Assim, no presente trabalho, obteve-se o extrato de própolis, que foi associado ao acetato de tocoferila em uma formulação de uso tópico, que foi avaliada quanto à estabilidade e às características sensoriais. Conduziu-se um estudo de estabilidade, no qual as formulações contendo ambos os compostos apresentaram escurecimento gradual e ligeira queda no pH após 28 dias sob 60 °C, tendo sido estável no estudo reológico. Na análise sensorial, realizada com 28 provadores, a formulação contendo extrato de própolis em associação com acetato de tocoferila foi a preferida, quando comparada com o creme base e o creme contendo somente extrato de própolis ou acetato de tocoferila. Em conclusão, devido à preferência dos provadores e ao estudo de estabilidade, a associação de extrato de própolis e de acetato de tocoferila mostrou ser promissora para uso em produtos dermocosméticos

Agricultura conservacionista na produção familiar de mandioca e milho no Juruá, Estado do Acre: efeitos da adoção nos resultados de safras de 2006 a 2014.

As formas e as etapas atuais do uso do solo no Juruá, uma das regionais de desenvolvimento do Estado do Acre, não diferem do resto da Amazônia Brasileira. Envolvem o sistema de derruba e queima da floresta, tanto primária quanto secundária, o uso geral do solo em monocultivo e/ou em sucessão por períodos de até 5 anos com culturas exigentes em fertilidade do solo (arroz, feijão e milho nos dois primeiros anos) e depois com mandioca, menos exigente e tolerante à acidez do solo. Os resultados dos cultivos de mandioca e milho, apresentados neste comunicado técnico, são produtos de uma pesquisa conduzida em condições de campo, adotando-se princípios da agricultura conservacionista.bitstream/item/116756/1/25424.pd

Acesso a Tratamento Endovascular para Acidente Vascular Cerebral Isquémico em Portugal

Introduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular treatment in mainland Portugal and its administrative districts. Material and methods: A retrospective national multicentric cohort study was conducted, including all ischemic stroke patients treated with endovascular treatment in mainland Portugal over two years (July 2015 to June 2017). All endovascular treatment centers contributed to an anonymized database. Demographic, stroke-related and procedure-related variables were collected. Crude endovascular treatment rates were calculated per 100 000 inhabitants for mainland Portugal, and each district and endovascular treatment standardized ratios (indirect age-sex standardization) were also calculated. Patient time metrics were computed as the median time between stroke onset, first-door, and puncture. Results: A total of 1625 endovascular treatment procedures were registered. The endovascular treatment rate was 8.27/100 000 inhabitants/year. We found regional heterogeneity in endovascular treatment rates (1.58 to 16.53/100 000/year), with higher rates in districts closer to endovascular treatment centers. When analyzed by district, the median time from stroke onset to puncture ranged from 212 to 432 minutes, reflecting regional heterogeneity. Discussion: Overall endovascular treatment rates and procedural times in Portugal are comparable to other international registries. We found geographic heterogeneity, with lower endovascular treatment rates and longer onset-to-puncture time in southern and inner regions. Conclusion: The overall national rate of EVT in the first two years after the organization of EVT-capable centers is one of the highest among European countries, however, significant regional disparities were documented. Moreover, stroke-onset-to-first-door times and in-hospital procedural times in the EVT centers were comparable to those reported in the randomized controlled trials performed in high-volume tertiary hospitals.info:eu-repo/semantics/publishedVersio

Heritability of physical activity traits in Brazilian families: the Baependi Heart Study

<p>Abstract</p> <p>Background</p> <p>It is commonly recognized that physical activity has familial aggregation; however, the genetic influences on physical activity phenotypes are not well characterized. This study aimed to (1) estimate the heritability of physical activity traits in Brazilian families; and (2) investigate whether genetic and environmental variance components contribute differently to the expression of these phenotypes in males and females.</p> <p>Methods</p> <p>The sample that constitutes the Baependi Heart Study is comprised of 1,693 individuals in 95 Brazilian families. The phenotypes were self-reported in a questionnaire based on the WHO-MONICA instrument. Variance component approaches, implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package, were applied to estimate the heritability and to evaluate the heterogeneity of variance components by gender on the studied phenotypes.</p> <p>Results</p> <p>The heritability estimates were intermediate (35%) for weekly physical activity among non-sedentary subjects (weekly PA_NS), and low (9-14%) for sedentarism, weekly physical activity (weekly PA), and level of daily physical activity (daily PA). Significant evidence for heterogeneity in variance components by gender was observed for the sedentarism and weekly PA phenotypes. No significant gender differences in genetic or environmental variance components were observed for the weekly PA_NS trait. The daily PA phenotype was predominantly influenced by environmental factors, with larger effects in males than in females.</p> <p>Conclusions</p> <p>Heritability estimates for physical activity phenotypes in this sample of the Brazilian population were significant in both males and females, and varied from low to intermediate magnitude. Significant evidence for heterogeneity in variance components by gender was observed. These data add to the knowledge of the physical activity traits in the Brazilian study population, and are concordant with the notion of significant biological determination in active behavior.</p

Dark Energy Survey Year 3 results: Curved-sky weak lensing mass map reconstruction

We present reconstructed convergence maps, mass maps, from the Dark Energy Survey (DES) third year (Y3) weak gravitational lensing data set. The mass maps are weighted projections of the density field (primarily dark matter) in the foreground of the observed galaxies. We use four reconstruction methods, each is a maximum a posteriori estimate with a different model for the prior probability of the map: Kaiser-Squires, null B-mode prior, Gaussian prior, and a sparsity prior. All methods are implemented on the celestial sphere to accommodate the large sky coverage of the DES Y3 data. We compare the methods using realistic \u39bCDM simulations with mock data that are closely matched to the DES Y3 data. We quantify the performance of the methods at the map level and then apply the reconstruction methods to the DES Y3 data, performing tests for systematic error effects. The maps are compared with optical foreground cosmic-web structures and are used to evaluate the lensing signal from cosmic-void profiles. The recovered dark matter map covers the largest sky fraction of any galaxy weak lensing map to date

Cosmological constraints from multiple probes in the dark energy survey

International audienceThe combination of multiple observational probes has long been advocated as a powerful technique to constrain cosmological parameters, in particular dark energy. The Dark Energy Survey has measured 207 spectroscopically confirmed type Ia supernova light curves, the baryon acoustic oscillation feature, weak gravitational lensing, and galaxy clustering. Here we present combined results from these probes, deriving constraints on the equation of state, w, of dark energy and its energy density in the Universe. Independently of other experiments, such as those that measure the cosmic microwave background, the probes from this single photometric survey rule out a Universe with no dark energy, finding w=-0.80-0.11+0.09. The geometry is shown to be consistent with a spatially flat Universe, and we obtain a constraint on the baryon density of Ωb=0.069-0.012+0.009 that is independent of early Universe measurements. These results demonstrate the potential power of large multiprobe photometric surveys and pave the way for order of magnitude advances in our constraints on properties of dark energy and cosmology over the next decade