Governance And Its Impact On Textile Companies

From an economic perspective, the flaws and weaknesses of the government seem to be more evident because of situations such as vagueness of the boundaries between governments and public policies that make it harder work in an attempt to regulate activities of companies to generate small effective numbers and productive trade relations. To know the situation in the textile sector a diagnostic was carried out in 17 companies in production, technological development areas and university services, with an exploratory and quantitative study, and transeccional design. Afterwards were given a qualitative perspective with action research design when applying interviews with government representatives, and advisory councils, chambers of commerce to establish their participation in finding solutions in relations to the problems observed: distrust of the business sector programs offered by the government, minimal participation in training and innovation forums in Consultation Councils and in the decision-making process which prevent the sector increase its development

Development and validation of a tool to measure collaborative practice between community pharmacists and physicians from the perspective of community pharmacists: the professional collaborative practice tool.

BACKGROUND: Collaborative practice between community pharmacists and physicians is becoming increasingly common. Although tools and models to explore collaborative practice between both health care professionals have been developed, very few have been validated for their use in clinical practice. The objective of this study was to develop and validate a tool for measuring collaborative practice between community pharmacists and physicians from the perspective of community pharmacists. METHODS: The DeVellis method was used to develop and validate the Professional Collaborative Practice Tool. A pool of 40 items with Likert frequency scales was generated based on previous literature and expert opinion. This study was undertaken in Spain. A sample of community pharmacists providing medication reviews with follow-up and a random sample of pharmacists providing usual care were invited to participate. Exploratory and confirmatory factor analysis was used to assess the tool's reliability and content validity. RESULTS: Three hundred thirty-six pharmacists were invited with an overall response rate of 84.8%. The initial 40 items selected were reduced to 14 items. Exploratory Factor Analysis provided a 3-factor solution explaining 62% of the variance. Confirmatory Factor Analysis confirmed the three factors "Activation for collaborative professional practice," the "Integration in collaborative professional practice," and the "Professional acceptance in collaborative professional practice." The tool demonstrated an adequate fit (X2/df = 1.657, GFI = 0.889 and RMSEA = 0.069) and good internal consistency (Cronbach's alpha = 0.924). CONCLUSIONS: The Professional Collaborative Practice Tool has shown good internal reliability and criterion validity. The tool could be used to measure the perceived level of collaborative practice between community pharmacists and physicians and monitor changes over time. Its applicability and transferability to other settings should be evaluated

Minimal Modification To The Tri-bimaximal Neutrino Mixing

Current experimental data on neutrino oscillations are consistent with the tri-bimaximal mixing. If future experimental data will determine a non-zero $V_{e3}$ and/or find CP violations in neutrino oscillations, there is the need to modify the mixing pattern. We find that a simple neutrino mass matrix, resulting from $A_4$ family symmetry breaking with residual $Z_3$ and $Z_2$ discrete symmetries respectively for the Higgs sectors generating the charged lepton and neutrino mass matrices, can satisfy the required modifications. The neutrino mass matrix is minimally modified with just one additional complex parameter compared with the one producing the tri-bimaximal mixing. In this case, the CP violating Jarlskog factor $J$ has a simple form ($|J|=|V_{e1}V_{e3}|/2\sqrt{3}$ for real neutrino mass matrix), and also $V_{\mu i} = 1/\sqrt{3}$. We also discuss how this mixing matrix can be tested experimentally.Comment: Latex 11 pages with no figures. References adde

Dynamic modeling of the effect of water management on polymer electrolyte fuel cells performance

Water management in Polymer Electrolyte Fuel Cell (PEFC) is a key factor in fuel cell performance, and it is an important contributor to the proton exchange membrane durability. Water droplet accumulation in the channel causes non-uniform distribution of gas pressure and spatial inhomogeneity of the local current density in potentiostatic mode. These spatial and temporal fluctuations in the operating conditions imply unequal use of the membrane surface and the catalyst layer, producing uneven degradation and aging of the Membrane Electrode Assembly (MEA). In order to study the dynamic and spatial performance of the fuel cell, a three-level model has been developed. The model is composed of a two-phase, where steam and liquid water drops movement are considered in the channel model; liquid water and gas diffusion are considered in Gas Diffusion Layers (GDLs) model; and finally, the electrochemical reactions are represented in the electrochemical model. The complete model provides a wider understanding of the effect of water on PEFCs and allows to analyze the local current density and the water distribution in response to experimental set-up parameters such as anode and cathode gas flows, total current or channel geometries. The model has been validated using neutron images and segmented cells technique to evaluate the spatial distribution of liquid water and current density in the cell. The developed model and the simulation procedure proposed in this paper allow obtaining long-term dynamic simulations with low computational effort

Cost-Utility Analysis of a Medication Review with Follow-Up Service for Older Adults with Polypharmacy in Community Pharmacies in Spain: The conSIGUE Program

© 2015, Springer International Publishing Switzerland. Background: The concept of pharmaceutical care is operationalized through pharmaceutical professional services, which are patient-oriented to optimize their pharmacotherapy and to improve clinical outcomes. Objective: The objective of this study was to estimate the incremental cost-effectiveness ratio (ICER) of a medication review with follow-up (MRF) service for older adults with polypharmacy in Spanish community pharmacies against the alternative of having their medication dispensed normally. Methods: The study was designed as a cluster randomized controlled trial, and was carried out over a time horizon of 6 months. The target population was older adults with polypharmacy, defined as individuals taking five or more medicines per day. The study was conducted in 178 community pharmacies in Spain. Cost-utility analysis adopted a health service perspective. Costs were in euros at 2014 prices and the effectiveness of the intervention was estimated as quality-adjusted life-years (QALYs). In order to analyze the uncertainty of ICER results, we performed a non-parametric bootstrapping with 5000 replications. Results: A total of 1403 older adults, aged between 65 and 94 years, were enrolled in the study: 688 in the intervention group (IG) and 715 in the control group (CG). By the end of the follow-up, both groups had reduced the mean number of prescribed medications they took, although this reduction was greater in the IG (0.28 ± 1.25 drugs; p < 0.001) than in the CG (0.07 ± 0.95 drugs; p = 0.063). Older adults in the IG saw their quality of life improved by 0.0528 ± 0.20 (p < 0.001). In contrast, the CG experienced a slight reduction in their quality of life: 0.0022 ± 0.24 (p = 0.815). The mean total cost was €977.57 ± 1455.88 for the IG and €1173.44 ± 3671.65 for the CG. In order to estimate the ICER, we used the costs adjusted for baseline medications and QALYs adjusted for baseline utility score, resulting in a mean incremental total cost of −€250.51 ± 148.61 (95 % CI −541.79 to 40.76) and a mean incremental QALY of 0.0156 ± 0.004 (95 % CI 0.008–0.023). Regarding the results from the cost-utility analysis, the MRF service emerged as the dominant strategy. Conclusion: The MRF service is an effective intervention for optimizing prescribed medication and improving quality of life in older adults with polypharmacy in community pharmacies. The results from the cost-utility analysis suggest that the MRF service is cost effective

Automatic Selection of Molecular Descriptors using Random Forest: Application to Drug Discovery

The optimal selection of chemical features (molecular descriptors) is an essential pre-processing step for the efficient application of computational intelligence techniques in virtual screening for identification of bioactive molecules in drug discovery. The selection of molecular descriptors has key influence in the accuracy of affinity prediction. In order to improve this prediction, we examined a Random Forest (RF)-based approach to automatically select molecular descriptors of training data for ligands of kinases, nuclear hormone receptors, and other enzymes. The reduction of features to use during prediction dramatically reduces the computing time over existing approaches and consequently permits the exploration of much larger sets of experimental data. To test the validity of the method, we compared the results of our approach with the ones obtained using manual feature selection in our previous study (Perez-Sanchez et al., 2014). The main novelty of this work in the field of drug discovery is the use of RF in two different ways: feature ranking and dimensionality reduction, and classification using the automatically selected feature subset. Our RF-based method out-performs classification results provided by Support Vector Machine (SVM) and Neural Networks (NN) approaches

Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors

Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms with cardiovascular risk factors and target organ damage (heart, vessels and kidney) in 411 subjects. Our results show that being carrier of the T allele in VAV2 rs602990 polymorphism is associated with an increased risk of obesity, reduced levels of ankle-brachial index and diastolic blood pressure and reduced retinal artery caliber. In addition, being carrier of T allele is associated with increased risk of target organ damage in males. On the other hand, being carrier of the T allele in VAV3 rs7528153 polymorphism is associated with a decreased susceptibility of developing a pathologic state composed by the presence of hypertension, diabetes, obesity or cardiovascular damage, and with an increased risk of developing altered basal glycaemia. This is the first report showing an association between VAV2 and VAV3 polymorphisms with cardiovascular risk factors and target organ damage