2,046 research outputs found
Study of ARPES data and d-wave superconductivity using electronic models in two dimensions
We review the results of an extensive investigation of photoemission spectral
weight using electronic models for the high-Tc superconductors. Here we show
that some recently reported unusual features of the cuprates namely the
presence of (i) flat bands, (ii) small quasiparticle bandwidths, and (iii)
antiferromagnetically induced weight, have all a natural explanation within the
context of holes moving in the presence of robust antiferromagnetic
correlations. Introducing interactions among the hole carriers, a model is
constructed which has superconductivity, an optimal
doping of (caused by the presence of a large density of states at
the top of the valence band), and a critical temperature .Comment: 11 pages Z-compressed postscript, to appear in the Proceedings to the
Stanford Conference on Spectroscopies in Novel superconductor
The hidden face of wine polyphenol polymerization highlighted by high resolution mass spectrometry
Polyphenols, including tannins and red anthocyanin pigments, are responsible for the color, taste, and beneficial health properties of plant-derived foods and beverages, especially in red wines. Known compounds represent only the emerged part of the "wine polyphenol iceberg". It is believed that the immersed part results from complex cascades of reactions involving grape polyphenols and yeast metabolites. We used a nontargeted strategy based on high-resolution mass spectrometry and Kendrick mass defect plots to explore this hypothesis. Reactions of acetaldehyde, epicatechin, and malvidin-3-O-glucoside, representing yeast metabolites, tannins, and anthocyanins, respectively, were selected for a proof-of-concept experiment. A series of compounds including expected and so-farunknown structures were detected. Random polymerization involving both the original substrates and intermediate products resulting from cascade reactions was demonstrated
Forging Fluorine-Containing Quaternary Stereocenters by a Light-Driven Organocatalytic Aldol Desymmetrization Process
Reported herein is a light-triggered organocatalytic strategy for the desymmetrization of achiral 2-fluoro-substi- tuted cyclopentane-1,3-diketones. The chemistry is based on an intermolecular aldol reaction of photochemically generated hydroxy-o-quinodimethanes and simultaneously forges two adjacent fully substituted carbon stereocenters, with one bearing a stereogenic carbon–fluorine unit. The method uses readily available substrates, a simple chiral organocatalyst, and mild reaction conditions to afford an array of highly function- alized chiral 2-fluoro-3-hydroxycyclopentanones
Hole Doping Evolution of the Quasiparticle Band in Models of Strongly Correlated Electrons for the High-T_c Cuprates
Quantum Monte Carlo (QMC) and Maximum Entropy (ME) techniques are used to
study the spectral function of the one band Hubbard model
in strong coupling including a next-nearest-neighbor electronic hopping with
amplitude . These values of parameters are chosen to improve the
comparison of the Hubbard model with angle-resolved photoemission (ARPES) data
for . A narrow quasiparticle (q.p.) band is observed in the
QMC analysis at the temperature of the simulation , both at and away
from half-filling. Such a narrow band produces a large accumulation of weight
in the density of states at the top of the valence band. As the electronic
density decreases further away from half-filling, the chemical
potential travels through this energy window with a large number of states, and
by it has crossed it entirely. The region near momentum
and in the spectral function is more sensitive to doping
than momenta along the diagonal from to . The evolution with
hole density of the quasiparticle dispersion contains some of the features
observed in recent ARPES data in the underdoped regime. For sufficiently large
hole densities the ``flat'' bands at cross the Fermi energy, a
prediction that could be tested with ARPES techniques applied to overdoped
cuprates. The population of the q.p. band introduces a {\it hidden} density in
the system which produces interesting consequences when the quasiparticles are
assumed to interact through antiferromagnetic fluctuations and studied with the
BCS gap equation formalism. In particular, a region of extended s-wave is found
to compete with d-wave in the overdoped regime, i.e. when the chemical
potential has almost entirely crossed the q.p.Comment: 14 pages, Revtex, with 13 embedded ps figures, submitted to Phys.
Rev. B., minor modifications in the text and in figures 1b, 2b, 3b, 4b, and
6
Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain
<p>Abstract</p> <p>Background</p> <p>We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX).</p> <p>Results</p> <p>We examined <it>in vivo </it>LPA-induced LPA production using a biological titration assay with B103 cells expressing LPA<sub>1 </sub>receptors. Intrathecal administration of LPC caused time-related production of LPA in the spinal dorsal horn and dorsal roots, but not in the dorsal root ganglion, spinal nerve or sciatic nerve. LPC-induced LPA production was markedly diminished in ATX heterozygotes, and was abolished in mice that were deficient in LPA<sub>3</sub>, but not LPA<sub>1 </sub>or LPA<sub>2 </sub>receptors. Similar time-related and LPA<sub>3 </sub>receptor-mediated production of LPA was observed following intrathecal administration of LPA. In an <it>in vitro </it>study using spinal cord slices, LPA-induced LPA production was also mediated by ATX and the LPA<sub>3 </sub>receptor. Intrathecal administration of LPA, in contrast, induced neuropathic pain, which was abolished in mice deficient in LPA<sub>1 </sub>or LPA<sub>3 </sub>receptors.</p> <p>Conclusion</p> <p>These findings suggest that feed-forward LPA production is involved in LPA-induced neuropathic pain.</p
Bi-layer splitting in overdoped high cuprates
Recent angle-resolved photoemission data for overdoped Bi2212 are explained.
Of the peak-dip-hump structure, the peak corresponds the component
of a hole condensate which appears at . The fluctuating part of this same
condensate produces the hump. The bilayer splitting is large enough to produce
a bonding hole and an electron antibonding quasiparticle Fermi surface. Smaller
bilayer splittings observed in some experiments reflect the interaction of the
peak structure with quasiparticle states near, but not at, the Fermi surface.Comment: 4 pages with 2 figures - published versio
AT-101 ( R -(−)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model
Prostate cancer remains a leading cause of cancer death in American men. Androgen deprivation therapy (ADT) is the most common treatment for advanced prostate cancer patients; however, ADT fails in nearly all cases resulting in castration resistant or androgen-insensitive (AI) disease. In many cases, this progression results from dysregulation of the pro-survival Bcl-2 family proteins. Inhibition of pro-survival Bcl-2 family proteins, therefore, may be an effective strategy to delay the onset of AI disease. Gossypol, a small molecule inhibitor of pro-survival Bcl-2 family proteins, has been demonstrated to inhibit AI prostate cancer growth. The apoptotic effect of gossypol, however, has been demonstrated to be attenuated by the presence of androgen in a prostate cancer xenograft mouse model (Vertebral Cancer of Prostate [VCaP]) treated with AT-101 ( R -(−)-gossypol acetic acid). This study was undertaken to better understand the in vitro effects of androgen receptor (AR) on AT-101-induced apoptosis. VCaP cells treated with AT-101 demonstrated an increase in apoptosis and downregulation of Bcl-2 pro-survival proteins. Upon AR activation in combination with AT-101 treatment, apoptosis is reduced, cell survival increases, and caspase activation is attenuated. Akt and X inhibitor of apoptosis (XIAP) are downregulated in the presence of AT-101, and AR stimulation rescues protein expression. Combination treatment of bicalutamide and AT-101 increases apoptosis by reducing the expression of these pro-survival proteins. These data suggest that combination therapy of AT-101 and ADT may further delay the onset of AI disease, resulting in prolonged progression-free survival of prostate cancer patients. J. Cell. Biochem. 110: 1187–1194, 2010. Published 2010 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77515/1/22633_ftp.pd
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