19 research outputs found
Prompt K_short production in pp collisions at sqrt(s)=0.9 TeV
The production of K_short mesons in pp collisions at a centre-of-mass energy
of 0.9 TeV is studied with the LHCb detector at the Large Hadron Collider. The
luminosity of the analysed sample is determined using a novel technique,
involving measurements of the beam currents, sizes and positions, and is found
to be 6.8 +/- 1.0 microbarn^-1. The differential prompt K_short production
cross-section is measured as a function of the K_short transverse momentum and
rapidity in the region 0 < pT < 1.6 GeV/c and 2.5 < y < 4.0. The data are found
to be in reasonable agreement with previous measurements and generator
expectations.Comment: 6+18 pages, 6 figures, updated author lis
Study of a region on yeast chromosome XIII that complements pet G199 mutants (COX7) and carries a new non-essential gene
The mutants of Saccharomyces cerevisiae assigned to complementation group G199 are deficient in mitochondrial respiration and lack a functional cytochrome oxidase complex. Recombinant plasmids capable of restoring respiration were cloned by transformation of mutants of this group with a yeast genomic library. Sequencing indicated that a 2.1-kb subclone encompasses the very end (last 11 amino acids) of the PET111 gene, the COX7 gene and a new gene (YMR255W) of unknown function that potentially codes for a polypeptide of 188 amino acids (about 21.5 kDa) without significant homology to any known protein. We have shown that the respiratory defect corresponding to group G199 is complemented by plasmids carrying only the COX7 gene. The gene YMR255W was inactivated by one-step gene replacement and the disrupted strain was viable and unaffected in its ability to grow in a variety of different test media such as minimal or complete media using eight distinct carbon sources at three pH values and temperatures. Inactivation of this gene also did not affect mating or sporulatio
Measurement of sigma (pp -> bbX) at âs=7 TeV in the forward region
Decays of b hadrons into final states containing a D-0 meson and a muon are used to measure the bb; production cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC. In the pseudorapidity interval 2 < eta < 6 and integrated over all transverse momenta we find that the average cross-section to produce b-flavoured or b-flavoured hadrons is (75.3 +/- 5.4 +/- 13.0) mu b
Central nervous system paracoccidioidomycosis. Report of a case successfully treated with Itraconazol Paracoccidioidomicose do sistema nervoso central. Apresentação de um caso tratado com ĂȘxito com itraconazole
Paracoccidioidomycosis (PCM) is a primary pulmonary infection that often disseminates to other organs and systems. Involvement of the central nervous system (CNS) is rare and due to the fact that both clinical alertness and establishment of the diagnosis are delayed, the disease progresses causing serious problems. We report here a case of neuroparacoccidioidomycosis (NPCM), observed in a 55 year-old male, who consulted due to neurological symptoms (left hemiparesis, paresthesias, right palpebral ptosis, headache, vomiting and tonic clonic seizures) of a month duration. Upon physical examination, an ulcerated granulomatous lesion was observed in the abdomen. To confirm the diagnosis a stereotactic biopsy was taken; additionally, mycological tests from the ulcerated lesion and a bronchoalveolar lavage were performed. In the latter specimens, P. brasiliensis yeast cells were visualized and later on, the brain biopsy revealed the presence of the fungus. Treatment with itraconazole (ITZ) was initiated but clinical improvement was unremarkable; due to the fact that the patient was taking sodium valproate for seizure control, drug interactions were suspected and confirmed by absence of ITZ plasma levels. The latter medication was changed to clonazepam and after several weeks, clinical improvement began to be noticed and was accompanied by diminishing P. brasiliensis antigen and antibody titers. In the PCM endemic areas, CNS involvement should be considered more often and the efficacy of itraconazole therapy should also be taken into consideration.<br>A paracoccidioidomicose (PCM) Ă© infecção pulmonar primĂĄria que algumas vezes pode se disseminar a outros ĂłrgĂŁos e sistemas. O envolvimento do sistema nervoso central (SNC) Ă© raro e devido ao fato que a alerta clĂnica e o estabelecimento do diagnĂłstico sĂŁo tardios, a doença progride e o paciente piora. AquĂ apresentamos caso de neuroparacoccidioidomicose (NPCM) observada em homem de 55 anos de idade que referia sintomas neurolĂłgicos (hemiparalisia esquerda, parestesias, ptose pĂĄlpebral direita, dor de cabeça, vĂŽmito e convulsĂ”es) de um mes de duração. Ao exame fĂsico, foi achada lesĂŁo ulcerada e granulomatosa no abdĂŽmen. Como o diagnĂłstico era duvidoso, foi indicada biopsia estereotĂĄxica; alĂ©m disso provas micolĂłgicas a partir da lesĂŁo ulcerada e um lavado broncoalveolar foram realizados. Nas Ășltimas amostras P. brasiliensis foi observado e depois a biopsia do cĂ©rebro revelou a presença do fungo. O tratamento com itraconazol foi iniciado mas a melhoria clĂnica nĂŁo foi detectĂĄvel; devido ao fato que o paciente estava tomando valproato de sĂłdio para o controle das convulsĂŽes, foi suspeita interação entre os dois medicamentos, que foi confirmada pela ausĂȘncia do nĂvel plasmĂĄtico do antimicĂłtico. Este Ășltimo medicamento foi trocado por clonazepam e depois de algumas semanas a melhoria clĂnica foi percebida e acompanhada pela diminuição dos tĂtulos de antĂgenos e anticorpos do P. brasiliensis. Em ĂĄreas endĂȘmicas, o envolvimento do SNC deve ser considerado em doentes com PCM e a eficĂĄcia do itraconazole deve ser considerada
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African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans
Background: Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. Methods: We tested for association with haplotypes at the most replicated and significant childhood-onset asthma locus at 17q12-q21 and asthma in European American and African American children. Following this, we used whole-genome sequencing data from 1060 African American and 100 European American individuals to identify novel variants on a high-risk African Americanâspecific haplotype. We characterized these variants in silico using gene expression and ATAC-seq data from airway epithelial cells, functional annotations from ENCODE, and promoter capture (pc)Hi-C maps in airway epithelial cells. Candidate causal variants were then assessed for correlation with asthma-associated phenotypes in African American children and adults. Results: Our studies revealed nine novel African-specific common variants, enriched on a high-risk asthma haplotype, which regulated the expression of GSDMA in airway epithelial cells and were associated with features of severe asthma. Using ENCODE annotations, ATAC-seq, and pcHi-C, we narrowed the associations to two candidate causal variants that are associated with features of T2 low severe asthma. Conclusions: Previously unknown genetic variation at the 17q12-21 childhood-onset asthma locus contributes to asthma severity in individuals with African ancestries. We suggest that many other population-specific variants that have not been discovered in GWAS contribute to the genetic risk for asthma and other common diseases. © 2022, The Author(s).Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]