Immobilization of recombinant human endostatin to different supports: potential applications in biomedicine

Comunicaciones a congreso

A multiple dating-method approach applied to the Sanabria Lake moraine complex (NW Iberian Peninsula, SW Europe)

New evidence in the NW region of the Iberian Peninsula (c. 42º N 6 ºW) of a glacial advance coeval with the global Last Glacial Maximum (LGM) of the Marine Isotope Stage 2 has been identified through a dataset of exposure ages based on 23 10Be concentration measurements carried out on boulder samples taken from a set of latero-frontal moraines. Results span the interval 19.2e15.4 10Be ka, matching the last deglaciation period when Iberia experienced the coldest and driest conditions of the last 25 ka, and are consistent with Lateglacial chronologies established in other mountain regions from SW Europe. The extent of the LGM stade identified in this work is similar to the local maximum ice extent stade recorded and dated as prior to 33 ka using radiocarbon and optically stimulated luminescence. This work showcases how multiple-dating approaches and detailed geomorphological mapping are required to reconstruct realistic palaeoglacier evolution models

Ordovician (Floian-lower Darriwilian) conodont biofacies of the San Juan Formation in the Cerro Viejo of Huaco, Argentine Precordillera

The conodont biofacies from the San Juan Formation at the Cerro Viejo of Huaco, Central Precordillera of Argentina, are analyzed for the identification of faunal dynamics and sea-level changes. The Prioniodus elegans and Oepikodus evae zones, Floian in age (Lower Ordovician), are identified in the lower San Juan Formation at the inner part of the Huaco anticline. In the western flank of the anticline the succession of the carbonate stratigraphic unit extends from the Floian/Dapingian boundary (Lower-Middle Ordovician) up to the lower Darriwilian (Middle Ordovician) Lenodus variabilis Zone. For the interpretation of conodont biofacies through the Los Gatos creek section, 5044 conodonts from rock samples of the Floian to the lower Darriwilian are studied. Conodont abundance and generic diversity graphs, and cluster analysis, reveal the following biofacies. The Juanognathus-Bergstroemognathus, Protopanderodus-Reutterodus-Drepanodus, Protopanderodus-Oepikodus, Juanognathus-Semiacontiodus and Rossodus-Periodon-Protopanderodus biofacies are determined, which indicate various deposits stacking from inner to middle and outer carbonate ramp environments of the San Juan Formation. The associated analysis of biofacies and lithology allow for the recognition of two transgressive events in the San Juan Formation at the Los Gatos creek section, which could be related to transgressive systems tracts (TST) that occurred during the Lower and Middle Ordovician. The recovered conodonts have a CAI that varies from 2 to 2.5, indicating a burial paleotemperature between 60 and 155 °C. Furthermore, the variation of CAI in conodonts of the same sample, the presence of conodonts with corroded surface lamella, recrystallization and crystal overgrowths, and the presence of stylolites in limestone beds of the San Juan Formation indicate the circulation of hydrothermal fluids.Fil: Mango, Matías Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Albanesi, Guillermo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; Argentin

Tecnologías del hidrógeno

El interés por las tecnologías del hidrógeno ha crecido en los últimos años, principalmente porque una economía basada en el hidrógeno puede dar respuesta a los grandes desafíos de la economía global del futuro: seguridad energética y cambio climático. Aprovechando este impulso, cada vez son más los países que están implementando un número creciente de políticas en favor del hidrógeno. Prueba de ello es la Estrategia Europea del Hidrógeno que establece al hidrógeno como un elemento esencial en| la descarbonización total del actual sistema energético para alcanzar el compromiso de la UE con la neutralidad de carbono en 2050. No obstante, el desarrollo exitoso de las tecnologías del hidrógeno requiere que todos los actores, incluidos los sectores público y privado, aumenten sus esfuerzos para acelerar su despliegue y hacer que su implantación a gran escala resulte competitiva. Los grupos de investigación que forman parte del área de trabajo de tecnologías del hidrógeno, dentro de la Plataforma Temática Interdisciplinar PTI Mobility 2030 del CSIC, trabajan en este sentido, desarrollando su labor en áreas tan diversas como la generación, el almacenamiento, la distribución y los usos del hidrógeno. The interest in hydrogen technologies has grown in recent years, mainly because an economy based on hydrogen can help to solve important challenges related to the global economy of the future: energy security and climate change. Taking advantage of this momentum, more and more countries are implementing a growing number of policies related to hydrogen. Indeed, the European Hydrogen Strategy establishes hydrogen as essential drivers for the total decarbonization of the current energy system in order to achieve the Ells commitment related to carbon neutrality by 2050. However, the successful development of the hydrogen technologies requires the collaboration of the public and private sectors to accelerate its deployment and make more competitive its implementation at large-scale. The research groups that take part of the line of work dedicated to hydrogen technologies, within the CSIC Interdisciplinary Thematic Platform PTI Mobility 2030, work in this regard, developing their investigations in several important areas related to the hydrogen technologies such as hydrogen generation, storage, distribution and uses

Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1

Altres ajuts: JM-P and NI-U are supported by the Spanish Secretariat of State of Research, Development and Innovation through grant SAF2016-80033-R. MG is supported by a Marie Curie Career Integration Grant (CIG) from the European Commission and by the Pla estratègic de recerca i innovació en salut (PERIS), from the Catalan government.Antigen presenting cells from the cervical mucosa are thought to amplify incoming HIV-1 and spread infection systemically without being productively infected. Yet, the molecular mechanism at the cervical mucosa underlying this viral transmission pathway remains unknown. Here we identified a subset of HLA-DR+ CD14+ CD11c+ cervical DCs at the lamina propria of the ectocervix and the endocervix that expressed the type-I interferon inducible lectin Siglec-1 (CD169), which promoted viral uptake. In the cervical biopsy of a viremic HIV-1+ patient, Siglec-1+ cells harbored HIV-1-containing compartments, demonstrating that in vivo, these cells trap viruses. Ex vivo, a type-I interferon antiviral environment enhanced viral capture and trans-infection via Siglec-1. Nonetheless, HIV-1 transfer via cervical DCs was effectively prevented with antibodies against Siglec-1. Our findings contribute to decipher how cervical DCs may boost HIV-1 replication and promote systemic viral spread from the cervical mucosa, and highlight the importance of including inhibitors against Siglec-1 in microbicidal strategies

Spin dynamics in the single-ion magnet [Er(W5O18)2]9−

In this work we present a detailed NMR and \u3bc+SR investigation of the spin dynamics in the new hydrated sodium salt containing the single-ion magnet [Er(W5O18)2]9-. The H1NMR absorption spectra at various applied magnetic fields present a line broadening on decreasing temperature which indicates a progressive spin freezing of the single-molecule magnetic moments. The onset of quasistatic local magnetic fields, due to spin freezing, is observed also in the muon relaxation curves at low temperature. Both techniques yield a local field distribution of the order of 0.1-0.2 T, which appears to be of dipolar origin. On decreasing the temperature, a gradual loss of the H1NMR signal intensity is observed, a phenomenon known as wipe-out effect. The effect is analyzed quantitatively on the basis of a simple model which relies on the enhancement of the NMR spin-spin, T2-1, relaxation rate due to the slowing down of the magnetic fluctuations. Measurements of spin-lattice relaxation rate T1-1 for H1NMR and of the muon longitudinal relaxation rate \u3bb show an increase as the temperature is lowered. However, while for the NMR case the signal is lost before reaching the very slow fluctuation region, the muon spin-lattice relaxation \u3bb can be followed until very low temperatures and the characteristic maximum, reached when the electronic spin fluctuation frequency becomes of the order of the muon Larmor frequency, can be observed. At high temperatures, the data can be well reproduced with a simple model based on a single correlation time \u3c4=\u3c40exp(\u394/T) for the magnetic fluctuations. However, to fit the relaxation data for both NMR and \u3bc+SR over the whole temperature and magnetic field range, one has to use a more detailed model that takes into account spin-phonon transitions among the Er3+ magnetic sublevels. A good agreement for both proton NMR and \u3bc+SR relaxation is obtained, which confirms the validity of the energy level scheme previously calculated from an effective crystal field Hamiltonian

Identifying clinical clusters with distinct trajectories in first-episode psychosis through an unsupervised machine learning technique

The extreme variability in symptom presentation reveals that individuals diagnosed with a first-episode psychosis (FEP) may encompass different sub-populations with potentially different illness courses and, hence, different treatment needs. Previous studies have shown that sociodemographic and family environment factors are associated with more unfavorable symptom trajectories. The aim of this study was to examine the dimensional structure of symptoms and to identify individuals’ trajectories at early stage of illness and potential risk factors associated with poor outcomes at follow-up in non-affective FEP. One hundred and forty-four non-affective FEP patients were assessed at baseline and at 2-year follow-up. A Principal component analysis has been conducted to identify dimensions, then an unsupervised machine learning technique (fuzzy clustering) was performed to identify clinical subgroups of patients. Six symptom factors were extracted (positive, negative, depressive, anxiety, disorganization and somatic/cognitive). Three distinct clinical clusters were determined at baseline: mild; negative and moderate; and positive and severe symptoms, and five at follow-up: minimal; mild; moderate; negative and depressive; and severe symptoms. Receiving a low-dose antipsychotic, having a more severe depressive symptomatology and a positive family history for psychiatric disorders were risk factors for poor recovery, whilst having a high cognitive reserve and better premorbid adjustment may confer a better prognosis. The current study provided a better understanding of the heterogeneous profile of FEP. Early identification of patients who could likely present poor outcomes may be an initial step for the development of targeted interventions to improve illness trajectories and preserve psychosocial functioning

Cognitive clusters in first-episode psychosis

Impairments in a broad range of cognitive domains have been consistently reported in some individuals with first-episode psychosis (FEP). Cognitive deficits can be observed during the prodromal stage. However, the course of cognitive deficits is still unclear. The aim of this study was to identify cognitive subgroups over time and to compare their sociodemographic, clinical and functional profiles. A total of 114 patients with Schizophrenia Spectrum Disorders were included in the present study. We assessed subjects through psychiatric scales and eight neuropsychological tests at baseline and at two-year follow-up visit. We performed the Partition Around Medoids algorithm with all cognitive variables. Furthermore, we performed a logistic regression to identify the predictors related to the different cognitive clusters at follow-up. Two distinct subgroups were found: the first cluster characterized by cognitive impairment and a second cluster had relatively intact cognition in comparison with norms. Up to 54.7% of patients with cognitive deficits at baseline tended to improve during the first two years of treatment. Patients with intact cognition at follow-up had a higher socioeconomic status, later age of onset, lower negative symptoms and a higher cognitive reserve (CR) at baseline. CR and age of onset were the baseline variables that predicted cognitive impairment. This research allows us to obtain a better understanding of the heterogeneous profile of psychotic disorders. Identifying the characteristics of patients who will present a cognitive impairment could improve early detection and intervention. These results suggest that enhancing CR could contribute to improving the course of the illness. © 2021 Elsevier B.V

Measurement of the residual energy of muons in the Gran Sasso underground Laboratories

The MACRO detector was located in the Hall B of the Gran Sasso underground Laboratories under an average rock overburden of 3700 hg/cm^2. A transition radiation detector composed of three identical modules, covering a total horizontal area of 36 m^2, was installed inside the empty upper part of the detector in order to measure the residual energy of muons. This paper presents the measurement of the residual energy of single and double muons crossing the apparatus. Our data show that double muons are more energetic than single ones. This measurement is performed over a standard rock depth range from 3000 to 6500 hg/cm^2.Comment: 28 pages, 9 figure