A Diffractive Study of Parametric Process in Nonlinear Photonic Crystals

We report a general description of quasi-phase-matched parametric process in nonlinear photonic crystals (NLPC) by extending the conventional X-ray diffraction theory in solids. Under the virtual wave approximation, phase-matching resonance is equivalent to the diffraction of the scattered virtual wave. Hence a modified NLPC Ewald construction can be built up, which illustrates the nature of the accident for the diffraction of the virtual wave in NLPC and further reveals the complete set of diffractions of the virtual wave for both of the air-dielectric and dielectric-dielectric contacts. We show the two basic linear sequences, the anti-stacking and para-stacking linear sequences, in one-dimension (1D) NLPC and present a general rule for multiple phase-matching resonances in 1D NLPC. The parameters affecting the NLPC structure factor are investigated, which indicate that not only the Ewald construction but also the relative NLPC atom size together determine whether a diffraction of the virtual wave can occur in 2D NLPC. The results also show that 1D NLPC is a better choice than 2D NLPC for a single parametric process

Blood, sweat and tears: a review of non-invasive DNA sampling

The use of DNA data is ubiquitous across animalsciences. DNA may be obtained from an organism for a myriad of reasonsincluding identification and distinction between cryptic species, sex identification, comparisons of different morphocryptic genotypes or assessments of relatedness between organisms prior to a behavioural study. DNA should be obtained while minimizing the impact on the fitness, behaviour or welfare of the subject being tested, as this can bias experimental results and cause long-lasting effects on wild animals. Furthermore, minimizing impact on experimental animals is a key Refinement principle within the '3Rs' framework which aims to ensure that animal welfare during experimentation is optimised. The term 'non-invasive DNA sampling' has been defined to indicate collection methods that do not require capture or cause disturbance to the animal, including any effects on behaviour or fitness. In practice this is not always the case, as the term 'non-invasive' is commonly used in the literature to describe studies where animals are restrained or subjected to aversive procedures. We reviewed the non-invasive DNA sampling literature for the past six years (380 papers published in 2013-2018) and uncovered the existence of a significant gap between the current use of this terminology (i.e. 'non-invasive DNA sampling') and its original definition. We show that 58% of the reviewed papers did not comply with the original definition. We discussthe main experimental and ethical issuessurrounding the potential confusion or misuse of the phrase 'non-invasive DNA sampling' in the current literature and provide potential solutions. In addition, we introduce the terms 'non-disruptive' and 'minimally disruptive' DNA sampling, to indicate methods that eliminate or minimise impacts not on the physical integrity/structure of the animal, but on its behaviour, fitness and welfare, which in the literature reviewed corresponds to the situation for which an accurate term is clearly missing. Furthermore, we outline when these methods are appropriate to use

"There is no brute world, only an elaborated world": Merleau-Ponty on the intersubjective constitution of the world

In his later works, Merleau-Ponty proposes the notion of 'the flesh' (la chair) as a new 'element', as he put it, in his ontological monism designed to overcome the legacy of Cartesian dualism with its bifurcation of all things into matter or spirit. Most Merleau-Ponty commentators recognise that Merleau-Ponty's notion of 'flesh' is inspired by Edmund Husserl's conceptions of 'lived body' (Leib) and 'vivacity' or 'liveliness' (Leiblichkeit). But it is not always recognised that, for Merleau-Ponty, the constitution of the world of perception, the problem of embodiment or incarnation, is at the very same time one with the problem of the experience of others in what Husserl called Einfühlung or Fremderfahung and indeed one with the problem of the constitution of the commonly shared world 'for all'. As Merleau-Ponty put it in his late essay 'The Philosopher and His Shadow' in Signs, 'the problem of Einfühlung, like that of my incarnation, opens on the meditation of sensible being, or, if you prefer, it betakes itself there'. In other words, the problem of the apprehension of the other is part of the overall apprehension of the transcendent world. In this paper I want to meditate on the relations between embodiment, experience of others, and experience of the world in Merleau-Ponty's philosophy. I will take particular note, as in the title of this presentation, of the claim made by Merleau-Ponty in The Visible and the Invisible that 'there is no brute world, only an elaborated world' (il n'y a pas de monde brut, il n'y a qu'un monde élaboré). Author has checked copyrightAD 22/01/201

Intellectual disability in patients with MODY due to hepatocyte nuclear factor 1B (HNF1B) molecular defects

International audienc

The colour and stereo surface imaging system (CaSSIS) for the ExoMars Trace Gas Orbiter

The Colour and Stereo Surface Imaging System (CaSSIS) is the main imaging system onboard the European Space Agency’s ExoMars Trace Gas Orbiter (TGO) which was launched on 14 March 2016. CaSSIS is intended to acquire moderately high resolution (4.6 m/pixel) targeted images of Mars at a rate of 10–20 images per day from a roughly circular orbit 400 km above the surface. Each image can be acquired in up to four colours and stereo capability is foreseen by the use of a novel rotation mechanism. A typical product from one image acquisition will be a 9.5 km×∼45 km swath in full colour and stereo in one over-flight of the target thereby reducing atmospheric influences inherent in stereo and colour products from previous high resolution imagers. This paper describes the instrument including several novel technical solutions required to achieve the scientific requirements