A nonlocal, covariant generalisation of the NJL model

We solve a nonlocal generalisation of the NJL model in the Hartree approximation. This model has a separable interaction, as suggested by instanton models of the QCD vacuum. The choice of form factor in this interaction is motivated by the confining nature of the vacuum. A conserved axial current is constructed in the chiral limit of the model and the pion properties are shown to satisfy the Gell-Mann--Oakes--Renner relation. For reasonable values of the parameters the model exhibits quark confinement.Comment: 13 pages (RevTeX), MC/TH 94/1

Analysis of the vertexes ΞQ∗ΞQ′V\Xi_Q^*\Xi'_Q V, ΣQ∗ΣQV\Sigma_Q^*\Sigma_Q V and radiative decays ΞQ∗→ΞQ′γ\Xi_Q^*\to \Xi'_Q \gamma, ΣQ∗→ΣQγ\Sigma_Q^*\to \Sigma_Q \gamma

In this article, we study the vertexes $\Xi_Q^*\Xi'_Q V$ and $\Sigma_Q^* \Sigma_Q V$ with the light-cone QCD sum rules, then assume the vector meson dominance of the intermediate $\phi(1020)$, $\rho(770)$ and $\omega(782)$, and calculate the radiative decays $\Xi_Q^*\to \Xi'_Q \gamma$ and $\Sigma_Q^*\to \Sigma_Q \gamma$.Comment: 28 pages, 4 tables, revised versio

Condensate cosmology -- dark energy from dark matter

Imagine a scenario in which the dark energy forms via the condensation of dark matter at some low redshift. The Compton wavelength therefore changes from small to very large at the transition, unlike quintessence or metamorphosis. We study CMB, large scale structure, supernova and radio galaxy constraints on condensation by performing a 4 parameter likelihood analysis over the Hubble constant and the three parameters associated with Q, the condensate field: Omega_Q, w_f and z_t (energy density and equation of state today, and redshift of transition). Condensation roughly interpolates between Lambda CDM (for large z_t) and sCDM (low z_t) and provides a slightly better fit to the data than Lambda CDM. We confirm that there is no degeneracy in the CMB between H and z_t and discuss the implications of late-time transitions for the Lyman-alpha forest. Finally we discuss the nonlinear phase of both condensation and metamorphosis, which is much more interesting than in standard quintessence models.Comment: 13 pages, 13 colour figures. Final version with discussion of TE cross-correlation spectra for condensation and metamorphosis in light of the WMAP result

First-principles study of the structural energetics of PdTi and PtTi

The structural energetics of PdTi and PtTi have been studied using first-principles density-functional theory with pseudopotentials and a plane-wave basis. We predict that in both materials, the experimentally reported orthorhombic $B19$ phase will undergo a low-temperature phase transition to a monoclinic $B19'$ ground state. Within a soft-mode framework, we relate the $B19$ structure to the cubic $B2$ structure, observed at high temperature, and the $B19'$ structure to $B19$ via phonon modes strongly coupled to strain. In contrast to NiTi, the $B19$ structure is extremely close to hcp. We draw on the analogy to the bcc-hcp transition to suggest likely transition mechanisms in the present case.Comment: 8 pages 5 figure

Characterization of function of the GlgA2 glycogen/starch synthase in Cyanobacterium sp. Clg1 highlights convergent evolution of glycogen metabolism into starch granule aggregation

At variance with the starch-accumulating plants and most of the glycogen-accumulating cyanobacteria, Cyanobacterium sp. CLg1 synthesizes both glycogen and starch. We now report the selection of a starchless mutant of this cyanobacterium that retains wild-type amounts of glycogen. Unlike other mutants of this type found in plants and cyanobacteria, this mutant proved to be selectively defective for one of the two types of glycogen/starch synthase: GlgA2. This enzyme is phylogenetically related to the previously reported SSIII/SSIV starch synthase that is thought to be involved in starch granule seeding in plants. This suggests that, in addition to the selective polysaccharide debranching demonstrated to be responsible for starch rather than glycogen synthesis, the nature and properties of the elongation enzyme define a novel determinant of starch versus glycogen accumulation. We show that the phylogenies of GlgA2 and of 16S ribosomal RNA display significant congruence. This suggests that this enzyme evolved together with cyanobacteria when they diversified over 2 billion years ago. However, cyanobacteria can be ruled out as direct progenitors of the SSIII/SSIV ancestral gene found in Archaeplastida. Hence, both cyanobacteria and plants recruited similar enzymes independently to perform analogous tasks, further emphasizing the importance of convergent evolution in the appearance of starch from a preexisting glycogen metabolism network.Peer Reviewe

Granulocyte concentrates: Prolonged functional capacity during storage in the presence of phenotypic changes

Background Granulocyte transfusion has been proposed as a bridging therapy for patients with prolonged p

Huygens HASI servo accelerometer: a review and lessons learned

The Servo accelerometer constituted a vital part of the Huygens Atmospheric Structure Instrument (HASI): flown aboard the Huygens probe, it operated successfully during the probe's entry, descent, and landing on Titan, on 14th January 2005. This paper reviews the Servo accelerometer, starting from its development/assembly in the mid-1990s, to monitoring its technical performance through its seven-year long in-flight (or cruise) journey, and finally its performance in measuring acceleration (or deceleration) upon encountering Titan's atmosphere. The aim of this article is to review the design, ground tests, in-flight tests and operational performance of the Huygens Servo accelerometer. Techniques used for data analysis and lessons learned that may be useful for accelerometry payloads on future planetary missions are also addressed. The main finding of this review is that the conventional approach of having multiple channels to cover a very broad measurement range: from 10-6 g to the order of 10 g (where g = Earth's surface gravity, 9.8 m/s2), with on-board software deciding which of the channels to telemeter depending on the magnitude of the measured acceleration, works well. However, improvements in understanding the potential effects of the sensor drifts and ageing on the measurements can be achieved in future missions by monitoring the 'scale factor' – a measure of such sensors' sensitivity, along with the already implemented monitoring of the sensor's offset during the in-flight phase

Particle-Antiparticle Mixing, epsilon_K, Delta Gamma_q, A_SL^q, A_CP(B_d -> psi K_S), A_CP(B_s -> psi phi) and B -> X_{s,d} gamma in the Littlest Higgs Model with T-Parity

We calculate a number of observables related to particle-antiparticle mixing in the Littlest Higgs model with T-parity (LHT). The resulting effective Hamiltonian for Delta F=2 transitions agrees with the one of Hubisz et al., but our phenomenological analysis goes far beyond the one of these authors. In particular, we point out that the presence of mirror fermions with new flavour and CP-violating interactions allows to remove the possible Standard Model (SM) discrepancy between the CP asymmetry S_{psi K_S} and large values of |V_ub| and to obtain for the mass difference Delta M_s < (Delta M_s)_SM as suggested by the recent result by the CDF collaboration. We also identify a scenario in which simultaneously significant enhancements of the CP asymmetries S_{phi psi} and A_SL^q relative to the SM are possible, while satisfying all existing constraints, in particular from the B -> X_s gamma decay and A_CP(B -> X_s gamma) that are presented in the LHT model here for the first time. In another scenario the second, non-SM, value for the angle gamma=-(109+-6) from tree level decays, although unlikely, can be made consistent with all existing data with the help of mirror fermions. We present a number of correlations between the observables in question and study the implications of our results for the mass spectrum and the weak mixing matrix of mirror fermions. In the most interesting scenarios, the latter one turns out to have a hierarchical structure that differs significantly from the CKM one.Comment: 51 pages, 20 figures, 1 table. Extended discussion of the phases in the new mixing matrix V_Hd, some references added or updated, conclusions unchanged. Final version published in JHE

Liquid crystals and their defects

These lecture notes discuss classical models of liquid crystals, and the different ways in which defects are described according to the different models.Comment: CIME lecture course, Cetraro, 201

Identification of clonal hematopoiesis mutations in solid tumor patients undergoing unpaired next-generation sequencing assays

Purpose: In this era of precision-based medicine, for optimal patient care, results reported from commercial next-generation sequencing (NGS) assays should adequately reflect the burden of somatic mutations in the tumor being sequenced. Here, we sought to determine the prevalence of clonal hematopoiesis leading to possible misattribution of tumor mutation calls on unpaired Foundation Medicine NGS assays. Experimental Design: This was a retrospective cohort study of individuals undergoing NGS of solid tumors from two large cancer centers. We identified and quantified mutations in genes known to be frequently altered in clonal hematopoiesis (DNMT3A, TET2, ASXL1, TP53, ATM, CHEK2, SF3B1, CBL, JAK2) that were returned to physicians on clinical Foundation Medicine reports. For a subset of patients, we explored the frequency of true clonal hematopoiesis by comparing mutations on Foundation Medicine reports with matched blood sequencing. Results: Mutations in genes that are frequently altered in clonal hematopoiesis were identified in 65% (1,139/1,757) of patients undergoing NGS. When excluding TP53, which is often mutated in solid tumors, these events were still seen in 35% (619/1,757) of patients. Utilizing paired blood specimens, we were able to confirm that 8% (18/226) of mutations reported in these genes were true clonal hematopoiesis events. The majority of DNMT3A mutations (64%, 7/11) and minority of TP53 mutations (4%, 2/50) were clonal hematopoiesis. Conclusions: Clonal hematopoiesis mutations are commonly reported on unpaired NGS testing. It is important to recognize clonal hematopoiesis as a possible cause of misattribution of mutation origin when applying NGS findings to a patient's care