A SEPT1-based scaffold is required for Golgi integrity and function

Compartmentalization of membrane transport and signaling processes is of pivotal importance to eukaryotic cell function. While plasma membrane compartmentalization and dynamics are well known to depend on the scaffolding function of septin GTPases, the roles of septins at intracellular membranes have remained largely elusive. Here, we show that the structural and functional integrity of the Golgi depends on its association with a septin 1 (SEPT1)-based scaffold, which promotes local microtubule nucleation and positioning of the Golgi. SEPT1 function depends on the Golgi matrix protein GM130 (also known as GOLGA2) and on centrosomal proteins, including CEP170 and components of γ-tubulin ring complex (γ-Turc), to facilitate the perinuclear concentration of Golgi membranes. Accordingly, SEPT1 depletion triggers a massive fragmentation of the Golgi ribbon, thereby compromising anterograde membrane traffic at the level of the Golgi

Data filtering in the readout of the CMS Electromagnetic Calorimeter

For an efficient data taking, the Electromagnetic Calorimeter (ECAL) data of the CMS experiment must be limited to 10\% of the full event size (1MB). Other requirements limit the average data size to 2kB per data acquisition link. These conditions imply a reduction factor of close to twenty on the data collected. The data filtering in the readout of the ECAL detector is discussed. Test beam data are used to study the digital filtering applied in the readout channels and a full detector simulation allows to estimate the energy thresholds to achieve the desired data suppression factor

Архітектурна спадщина Закарпаття під натиском новобуду

Multilocus sequence types (STs) were determined for 232 and 737 Campylobacter jejuni/coli isolates from Dutch travellers and domestically acquired cases, respectively. Putative risk factors for travel-related campylobacteriosis, and for domestically acquired campylobacteriosis caused by exotic STs (putatively carried by returning travellers), were investigated. Travelling to Asia, Africa, Latin America and the Caribbean, and Southern Europe significantly increased the risk of acquiring campylobacteriosis compared to travelling within Western Europe. Besides eating chicken, using antacids, and having chronic enteropathies, we identified eating vegetable salad outside Europe, drinking bottled water in high-risk destinations, and handling/eating undercooked pork as possible risk factors for travel-related campylobacteriosis. Factors associated with domestically acquired campylobacteriosis caused by exotic STs involved predominantly person-to-person contacts around popular holiday periods. We concluded that putative determinants of travel-related campylobacteriosis differ from those of domestically acquired infections and that returning travellers may carry several exotic strains that might subsequently spread to domestic populations even through limited person-to-person transmission

Les Houches 2015: Physics at TeV colliders - new physics working group report

We present the activities of the 'New Physics' working group for the 'Physics at TeV Colliders' workshop (Les Houches, France, 1-19 June, 2015). Our report includes new physics studies connected with the Higgs boson and its properties, direct search strategies, reinterpretation of the LHC results in the building of viable models and new computational tool developments. Important signatures for searches for natural new physics at the LHC and new assessments of the interplay between direct dark matter searches and the LHC are also considered.Comment: Proceedings of the New Physics Working Group of the 2015 Les Houches Workshop, Physics at TeV Colliders, Les Houches 1-19 June 2015. 197 page

Mesoscale productivity fronts and local fishing opportunities in the European Seas

This study evaluates the relationship between both commercial and scientific spatial fisheries data and a new satellite-based estimate of potential fish production (Ocean Productivity available to Fish, OPFish) in the European Seas. To construct OPFish, we used productivity frontal features derived from chlorophyll-a horizontal gradients, which characterize 10%–20% of the global phytoplankton production that effectively fuels higher trophic levels. OPFish is relatively consistent with the spatial distribution of both pelagic and demersal fish landings and catches per unit of effort (LPUEs and CPUEs, respectively). An index of harvest relative to ocean productivity (HP index) is calculated by dividing these LPUEs or CPUEs with OPFish. The HP index reflects the intensity of fishing by gear type with regard to local fish production. Low HP levels indicate lower LPUEs or CPUEs than expected from oceanic production, suggesting over-exploitation, while high HP levels imply more sustainable fishing. HP allows comparing the production-dependent suitability of local fishing intensities. Our results from bottom trawl data highlight that over-exploitation of demersal species from the shelves is twice as high in the Mediterranean Sea than in the North-East Atlantic. The estimate of HP index by dominant pelagic and demersal gears suggests that midwater and bottom otter trawls are associated with the lowest and highest overfishing, respectively. The contrasts of fishing intensity at local scales captured by the HP index suggest that accounting for the local potential fish production can promote fisheries sustainability in the context of ecosystem-based fisheries management as required by international marine policies

EX Lupi in quiescence

EX Lup is the prototype of EXors, a subclass of low-mass pre-main sequence stars whose episodic eruptions are attributed to temporarily increased accretion. In quiescence the optical and near-infrared properties of EX Lup cannot be distinguished from those of normal T Tau stars. Here we investigate whether it is the circumstellar disk structure which makes EX Lup an atypical Class II object. During outburst the disk might undergo structural changes. Our characterization of the quiescent disk is intended to serve as a reference to study the physical changes related to one of EX Lupi's strongest known eruptions in 2008 Jan-Sep. We searched the literature for photometric and spectroscopic observations including ground-based, IRAS, ISO and Spitzer data. After constructing the optical-infrared spectral energy distribution (SED), we compared it with the typical SEDs of other young stellar objects and modeled it using the Monte Carlo radiative transfer code RADMC. A mineralogical decomposition of the 10 micron silicate emission feature and also the description of the optical and near-infrared spectra were performed. The SED is in general similar to that of a typical T Tauri star, though above 7 micron EX Lup emits higher flux. The quiescent phase data suggest low level variability in the optical-mid-infrared domain. Integrating the optical and infrared fluxes we derived a bolometric luminosity of 0.7 L_Sun. The 10 micron silicate profile could be fitted by a mixture consisting of amorphous silicates, no crystalline silicates were found. A modestly flaring disk model with a total mass of 0.025 M_Sun and an outer radius of 150 AU was able to reproduce the observed SED. The derived inner radius of 0.2 AU is larger than the sublimation radius, and this inner gap sets EX Lup aside from typical T Tauri stars.Comment: Accepted for publication in Astronomy and Astrophysics, 10 pages, 6 figure