3,506 research outputs found
Generative discriminative models for multivariate inference and statistical mapping in medical imaging
This paper presents a general framework for obtaining interpretable
multivariate discriminative models that allow efficient statistical inference
for neuroimage analysis. The framework, termed generative discriminative
machine (GDM), augments discriminative models with a generative regularization
term. We demonstrate that the proposed formulation can be optimized in closed
form and in dual space, allowing efficient computation for high dimensional
neuroimaging datasets. Furthermore, we provide an analytic estimation of the
null distribution of the model parameters, which enables efficient statistical
inference and p-value computation without the need for permutation testing. We
compared the proposed method with both purely generative and discriminative
learning methods in two large structural magnetic resonance imaging (sMRI)
datasets of Alzheimer's disease (AD) (n=415) and Schizophrenia (n=853). Using
the AD dataset, we demonstrated the ability of GDM to robustly handle
confounding variations. Using Schizophrenia dataset, we demonstrated the
ability of GDM to handle multi-site studies. Taken together, the results
underline the potential of the proposed approach for neuroimaging analyses.Comment: To appear in MICCAI 2018 proceeding
Astronomical Site Selection for Turkey Using GIS Techniques
A site selection of potential observatory locations in Turkey have been
carried out by using Multi-Criteria Decision Analysis (MCDA) coupled with
Geographical Information Systems (GIS) and satellite imagery which in turn
reduced cost and time and increased the accuracy of the final outcome. The
layers of cloud cover, digital elevation model, artificial lights, precipitable
water vapor, aerosol optical thickness and wind speed were studied in the GIS
system. In conclusion of MCDA, the most suitable regions were found to be
located in a strip crossing from southwest to northeast including also a
diverted region in southeast of Turkey. These regions are thus our prime
candidate locations for future on-site testing. In addition to this major
outcome, this study has also been applied to locations of major observatories
sites. Since no goal is set for \textit{the best}, the results of this study is
limited with a list of positions. Therefore, the list has to be further
confirmed with on-site tests. A national funding has been awarded to produce a
prototype of an on-site test unit (to measure both astronomical and
meteorological parameters) which might be used in this list of locations.Comment: 17 pages, 10 figures, accepted by Experimental Astronom
PDB127 GLP1 and Insulin Glargine Treatment Patterns Among Type 2 Diabetes Patients in Major EU Markets
Coplanar Asymmetric Angles and Symmetric Energy Sharing Triple Differential Cross Sections for 200 EV Electron-Impact Ionization of Ar (3p)
We have measured triple differential cross sections (TDCSs) for electron-impact ionization of the 3p shell of Ar at 200 eV incident electron energy. The experiments have been performed in coplanar asymmetric energy sharing geometry. The experimental results are compared with the theoretical models of three body distorted wave (3DW) and distorted wave Born approximation (DWBA)
Cytotoxic effect of eudesmanolides isolated from flowers of Tanacetum vulgare ssp. siculum
A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects
Towards Intelligent Lower Limb Prostheses with Activity Recognition
User’s volitional control of lower limb prostheses is still challenging task despite technological advancements. There is still a need for amputees to impose their will upon the prosthesis to drive in an accurate and interactive fashion. This study represents a brief review on control strategies using different sensor modalities for the purpose of phases/events detection and activity recognition. The preliminary work that is associated with middle-level control shows a simple and reliable method for event detection in real-time using a single inertial measurement unit. The outcome shows promising results
The effect of racemic gossypol and AT-101 on angiogenic profile of OVCAR-3 cells: a preliminary molecular framework for gossypol enantiomers
To compare the effect of racemic gossypol with its (–)/(–) enantiomer (AT-101) on expression profiles of angiogenic molecules by mRNA levels in human ovarian cancer cell line OVCAR-3. Methods: Cell viability assay (2,3-bis (2-methoxy-4-nitro-5- sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide) was used to detect cytotoxicity of gossypol enantiomers. DNA fragmentation by an enzyme-linked immunosorbent (ELISA) assay was used to evaluate the rate of apoptosis. The mRNA expression levels of angiogenic molecules were investigated by Human Angiogenesis RT2 ProfilerTM PCR Array (SuperArray, Frederick, MD). Results: Both racemic form and AT-101 resulted in a significant cytotoxicity and induced apoptosis. This effect was observed in a dose- and time dependent manner. However, AT-101 was much more potent. In addition, the treatment of 10 μM of racemic gossypol alone and 3 μM of AT-101 alone resulted in significant down-regulation (≥ 3 fold) in mRNA levels of some pivotal angiogenic molecules in OVCAR-3, but altered gene profiles were different by the treatment of each enantiomer. Conclusion: The efficacy of two gossypol enantiomers in OVCAR-3 cells showed distinction. AT-101 was much more potent than racemic gossypol, not only by means of cell death and apoptosis, but also by modulation of angiogenic molecules released from OVCAR-3 cells. Further studies with endothelial cells should be done to verify the anti-angiogenic effect of gossypol enantiomers in cancer treatment
Competing Ultrafast Energy Relaxation Pathways in Photoexcited Graphene
For most optoelectronic applications of graphene a thorough understanding of
the processes that govern energy relaxation of photoexcited carriers is
essential. The ultrafast energy relaxation in graphene occurs through two
competing pathways: carrier-carrier scattering -- creating an elevated carrier
temperature -- and optical phonon emission. At present, it is not clear what
determines the dominating relaxation pathway. Here we reach a unifying picture
of the ultrafast energy relaxation by investigating the terahertz
photoconductivity, while varying the Fermi energy, photon energy, and fluence
over a wide range. We find that sufficiently low fluence ( 4
J/cm) in conjunction with sufficiently high Fermi energy (
0.1 eV) gives rise to energy relaxation that is dominated by carrier-carrier
scattering, which leads to efficient carrier heating. Upon increasing the
fluence or decreasing the Fermi energy, the carrier heating efficiency
decreases, presumably due to energy relaxation that becomes increasingly
dominated by phonon emission. Carrier heating through carrier-carrier
scattering accounts for the negative photoconductivity for doped graphene
observed at terahertz frequencies. We present a simple model that reproduces
the data for a wide range of Fermi levels and excitation energies, and allows
us to qualitatively assess how the branching ratio between the two distinct
relaxation pathways depends on excitation fluence and Fermi energy.Comment: Nano Letters 201
Just Another Day on Twitter: A Complete 24 Hours of Twitter Data
At the end of October 2022, Elon Musk concluded his acquisition of Twitter.
In the weeks and months before that, several questions were publicly discussed
that were not only of interest to the platform's future buyers, but also of
high relevance to the Computational Social Science research community. For
example, how many active users does the platform have? What percentage of
accounts on the site are bots? And, what are the dominating topics and
sub-topical spheres on the platform? In a globally coordinated effort of 80
scholars to shed light on these questions, and to offer a dataset that will
equip other researchers to do the same, we have collected all 375 million
tweets published within a 24-hour time period starting on September 21, 2022.
To the best of our knowledge, this is the first complete 24-hour Twitter
dataset that is available for the research community. With it, the present work
aims to accomplish two goals. First, we seek to answer the aforementioned
questions and provide descriptive metrics about Twitter that can serve as
references for other researchers. Second, we create a baseline dataset for
future research that can be used to study the potential impact of the
platform's ownership change
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