AEGIS: Agent oriented organisations

Today's enterprises are faced with highly dynamic, sometimes even hostile environments. This paper dicovers that the two most prominent organizational strategies addressing these challenges, namely that of widespread decentralization and of business process orientation, are inherently conflicting. We argue that cooperative knowledge processing technology can contribute to dissolve this conflict. For this purpose, we introduce the reader into the field of Distributed Artificial Intelligence. On that basis we then develop the concept of Agent oriEnted orGanISations (AEGIS), in order to support the flexible modeling and management of business processes in decentralized organizational settings. Applying to methods of Distributed Planning a set of process modeling and process interaction operators is defined. These operators also permit to automatically create and customize computerized configurations of business processes. The concepts are presented in the context of an application in private banking, namely that of a Credit Advisory System

Speedy Transactions in Multicore In-Memory Databases

Silo is a new in-memory database that achieves excellent performance and scalability on modern multicore machines. Silo was designed from the ground up to use system memory and caches efficiently. For instance, it avoids all centralized contention points, including that of centralized transaction ID assignment. Silo's key contribution is a commit protocol based on optimistic concurrency control that provides serializability while avoiding all shared-memory writes for records that were only read. Though this might seem to complicate the enforcement of a serial order, correct logging and recovery is provided by linking periodically-updated epochs with the commit protocol. Silo provides the same guarantees as any serializable database without unnecessary scalability bottlenecks or much additional latency. Silo achieves almost 700,000 transactions per second on a standard TPC-C workload mix on a 32-core machine, as well as near-linear scalability. Considered per core, this is several times higher than previously reported results.Engineering and Applied Science

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

Background: Rhabdoid tumors are highly aggressive malignancies affecting infants and very young children. In many instances these tumors are resistant to conventional type chemotherapy necessitating alternative approaches. Methods: Proliferation assays (MTT), apoptosis (propidium iodide/annexin V) and cell cycle analysis (DAPI), RNA expression microarrays and western blots were used to identify synergism of the HDAC (histone deacetylase) inhibitor SAHA with fenretinide, tamoxifen and doxorubicin in rhabdoidtumor cell lines. Results: HDAC1 and HDAC2 are overexpressed in primary rhabdoid tumors and rhabdoid tumor cell lines. Targeting HDACs in rhabdoid tumors induces cell cycle arrest and apoptosis. On the other hand HDAC inhibition induces deregulated gene programs (MYCC-, RB program and the stem cell program) in rhabdoid tumors. These programs are in general associated with cell cycle progression. Targeting these activated pro-proliferative genes by combined approaches of HDAC-inhibitors plus fenretinide, which inhibits cyclinD1, exhibit strong synergistic effects on induction of apoptosis. Furthermore, HDAC inhibition sensitizes rhabdoid tumor cell lines to cell death induced by chemotherapy. Conclusion: Our data demonstrate that HDAC inhibitor treatment in combination with fenretinide or conventional chemotherapy is a promising tool for the treatment of chemoresistant rhabdoid tumors.<br

Neutrinos below 100 TeV from the southern sky employing refined veto techniques to IceCube data

Many Galactic sources of gamma rays, such as supernova remnants, are expected to produce neutrinos with a typical energy cutoff well below 100 TeV. For the IceCube Neutrino Observatory located at the South Pole, the southern sky, containing the inner part of the Galactic plane and the Galactic Center, is a particularly challenging region at these energies, because of the large background of atmospheric muons. In this paper, we present recent advancements in data selection strategies for track-like muon neutrino events with energies below 100 TeV from the southern sky. The strategies utilize the outer detector regions as veto and features of the signal pattern to reduce the background of atmospheric muons to a level which, for the first time, allows IceCube searching for point-like sources of neutrinos in the southern sky at energies between 100 GeV and several TeV in the muon neutrino charged current channel. No significant clustering of neutrinos above background expectation was observed in four years of data recorded with the completed IceCube detector. Upper limits on the neutrino flux for a number of spectral hypotheses are reported for a list of astrophysical objects in the southern hemisphere.Comment: 19 pages, 17 figures, 2 table

International Workshops of PAAMS 2013, Salamanca, Spain, May 22-24, 2013. Proceedings

This book constitutes the refereed proceedings of the Workshops which complemented the 11th International Conference on Practical Applications of Agents and Multi-Agent Systems, PAAMS 2013, held in Salamanca, Spain, in May 2013. This volume presents the papers that have been accepted for the workshops: Workshop on Agent-based Approaches for the Transportation Modeling and Optimization, Workshop on Agent-Based Solutions for Manufacturing and Supply Chain, Workshop on User-Centric Technologies and Applications, Workshop on Conflict Resolution in Decision Making, Workshop on Multi-Agent System Based Learning Environments, Workshop on Multi-agent based Applications for Sustainable Energy Systems, Workshop on Agents and multi-agent Systems for AAL and e-Healt

Search for Astrophysical Neutrinos from 1FLE Blazars with IceCube

The majority of astrophysical neutrinos have undetermined origins. The IceCube Neutrino Observatory has observed astrophysical neutrinos but has not yet identified their sources. Blazars are promising source candidates, but previous searches for neutrino emission from populations of blazars detected in ≳GeV gamma rays have not observed any significant neutrino excess. Recent findings in multimessenger astronomy indicate that high-energy photons, coproduced with high-energy neutrinos, are likely to be absorbed and reemitted at lower energies. Thus, lower-energy photons may be better indicators of TeV–PeV neutrino production. This paper presents the first time-integrated stacking search for astrophysical neutrino emission from MeV-detected blazars in the first Fermi Large Area Telescope low energy (1FLE) catalog using ten years of IceCube muon–neutrino data. The results of this analysis are found to be consistent with a background-only hypothesis. Assuming an E$^{-2}$ neutrino spectrum and proportionality between the blazars MeV gamma-ray fluxes and TeV–PeV neutrino flux, the upper limit on the 1FLE blazar energy-scaled neutrino flux is determined to be 1.64 × 10^-12} TeV cm$^{-2}$ s$^{-1}$ at 90% confidence level. This upper limit is approximately 1% of IceCube\u27s diffuse muon–neutrino flux measurement

Searching for High-energy Neutrino Emission from Galaxy Clusters with IceCube

Galaxy clusters have the potential to accelerate cosmic rays (CRs) to ultrahigh energies via accretion shocks or embedded CR acceleration sites. The CRs with energies below the Hillas condition will be confined within the cluster and eventually interact with the intracluster medium gas to produce secondary neutrinos and gamma rays. Using 9.5 yr of muon neutrino track events from the IceCube Neutrino Observatory, we report the results of a stacking analysis of 1094 galaxy clusters with masses ≳10$^{14}$ M⊙ and redshifts between 0.01 and ∼1 detected by the Planck mission via the Sunyaev–Zel’dovich effect. We find no evidence for significant neutrino emission and report upper limits on the cumulative unresolved neutrino flux from massive galaxy clusters after accounting for the completeness of the catalog up to a redshift of 2, assuming three different weighting scenarios for the stacking and three different power-law spectra. Weighting the sources according to mass and distance, we set upper limits at a 90% confidence level that constrain the flux of neutrinos from massive galaxy clusters (≳10$^{14}$ M⊙) to be no more than 4.6% of the diffuse IceCube observations at 100 TeV, assuming an unbroken E−$^{2.5}$ power-law spectrum

Searching for eV-scale sterile neutrinos with eight years of atmospheric neutrinos at the IceCube Neutrino Telescope

We report in detail on searches for eV-scale sterile neutrinos, in the context of a 3+1 model, using eight years of data from the IceCube Neutrino Telescope. By analyzing the reconstructed energies and zenith angles of 305,735 atmospheric νμ and ¯νμ events we construct confidence intervals in two analysis spaces: sin2(2θ$_{24}$) vs Δm2¦41 under the conservative assumption θ$_{34}$=0; and sin$^{2}$ (2θ$_{24}$) vs sin$^{2}$ (2θ$_{34}$) given sufficiently large Δm2¦41 that fast oscillation features are unresolvable. Detailed discussions of the event selection, systematic uncertainties, and fitting procedures are presented. No strong evidence for sterile neutrinos is found, and the best-fit likelihood is consistent with the no sterile neutrino hypothesis with a p value of 8% in the first analysis space and 19% in the second