Nefrolitiasi da iperparatiroidismo primitivo: uso del Cinacalcet in pazienti non trattabili con terapia chirurgica

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Cocaina E Insufficienza Renale Acuta

Il consumo di cocaina ha raggiunto proporzioni epidemiche. le complicanze renali correlate al suo abuso sono sempre più frequentemente evidenziate. descriviamo 4 casi clinici di insufficienza renale acuta da overdose di cocaina da noi riscontrati negli ultimi 18 mesi. la insufficienza renale era in tutti i casi correlata a rabdomiolisi, che è il meccanismo patogenetico più comune. a causa del "late referral" alla nostra struttura, non è stata effettuata una pronta ed efficace terapia medica ed è stato necessario in tutti i casi istituire trattamento emodialitico prima della riprese funzionale dell'organo

Valutazione metabolica e gestione medica della nefrolitiasi: Quale futuro?

Abstract non disponibil

Evaluation of a quality system developed for pharmacy teaching laboratories

Background: The implementation of a quality system improves the educational quality of activities undertaken in a laboratory. Aim: To evaluate the perception of undergraduate pharmacy students and laboratory demonstrators on the quality system implemented in the laboratories of the Department of Pharmacy at the University of Malta. Method: A self-administered questionnaire was developed, psychometrically evaluated and distributed to second, third and fourth year undergraduate pharmacy students and laboratory demonstrators (N=110). Results: Out of a total of 94 questionnaires collected, 91 participants agreed that the implemented quality system is important to carry out procedures correctly and safely in the laboratory and is a helpful educational tool for students to appreciate quality processes in pharmacy (n=84). Ninety two participants agreed that standard operating procedures are an essential aspect of a quality system and are important educational tools for laboratory work (n=73). Conclusion: The implemented laboratory quality system is a valuable educational tool for pharmacy students.peer-reviewe

Vi è un'alternativa alla paratiroidectomia nei pazienti con calcolosi renale da iperparatiroidismo primitivo? Tre casi clinici

Abstract non disponibil

Un anno di letteratura nefrologica sulla nefrolitiasi

Abstract non disponibil

Predictors of orbital convergence in primates: A test of the snake detection hypothesis of primate evolution

Traditional explanations for the evolution of high orbital convergence and stereoscopic vision in primates have focused on how stereopsis might have aided early primates in foraging or locomoting in an arboreal environment. It has recently been suggested that predation risk by constricting snakes was the selective force that favored the evolution of orbital convergence in early primates, and that later exposure to venomous snakes favored further degrees of convergence in anthropoid primates. Our study tests this snake detection hypothesis (SDH) by examining whether orbital convergence among extant primates is indeed associated with the shared evolutionary history with snakes or the risk that snakes pose for a given species. We predicted that orbital convergence would be higher in species that: 1) have a longer history of sympatry with venomous snakes, 2) are likely to encounter snakes more frequently, 3) are less able to detect or deter snakes due to group size effects, and 4) are more likely to be preyed upon by snakes. Results based on phylogenetically independent contrasts do not support the SDH. Orbital convergence shows no relationship to the shared history with venomous snakes, likelihood of encountering snakes, or group size. Moreover, those species less likely to be targeted as prey by snakes show significantly higher values of orbital convergence. Although an improved ability to detect camouflaged snakes, along with other cryptic stimuli, is likely a consequence of increased orbital convergence, this was unlikely to have been the primary selective force favoring the evolution of stereoscopic vision in primates

Evaluación de las características hidroquímicas de antiguos cauces del Río Dulce en Villa Nueva, provincia de Santiago del Estero

El acceso al agua segura, en pequeñas localidades como Villa Nueva, es un problema de vieja data. El Área de estudio está situada en el sector SO de la provincia de Santiago del Estero, y geomorfológicamente se ubica en el tramo medio de la Llanura Aluvial del Río Dulce. Se caracteriza por una sucesión de antiguos cauces colmatados y entrelazados. El trabajo de investigación se orientó hacia la caracterización hidroquímica del acuífero libre, y su utilización como soporte de almacenamiento y de recarga en forma natural o artificial, para el abastecimiento de agua destinada al consumo humano. Mediante perforaciones se realizaron estudios granulométricos de los sedimentos que permitieron obtener una aproximación acerca de la permeabilidad. Los análisis físico-químicos de las muestras de agua obtenidas, no superan los límites tolerables de las aguas seguras, excepto una de ellas, que supera la concentración de sulfatos.Access to safe water, in small towns like Villa Nueva, is a long-standing problem. The research area is located in the SW sector of the province of Santiago del Estero, and geomorphologically is located in the middle stretch of the Dulce River Floodplain. It is characterized by a succession of former channels silted and intertwined. The research work was oriented towards free aquifer hydrochemical characterization, and their use as storage media and recharge in natural or artificial, for the supply of water for human consumption. Through perforations were made sediments grain size determination studies, we have obtained an approximation concerning permeability. The physico-chemical analysis of water samples obtained do not exceed tolerable limits of safe water, except one, which exceeds the concentration of sulfates.Universidad Nacional de La Plat

Local Treatment of Triple-Negative Breast Cancer: Is Mastectomy Superior to Breast-Conserving Surgery?

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that lacks the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). TNBC accounts for about 15% of breast cancers and has a poorer prognosis as compared with other subtypes of breast cancer. The more rapid onset of this cancer and its aggressiveness have often convinced breast surgeons that mastectomy could provide better oncological results. However, there is no relevant clinical trial that has assessed differences between breast-conserving surgery (BCS) and mastectomy (M) in these patients. This population-based study aimed to investigate the distinct outcomes between conservative treatment and M in a case series of 289 patients with TNBC treated over a 9-year period. This monocentric study retrospectively evaluated patients with TNBC who underwent upfront surgery at Fondazione Policlinico Agostino Gemelli IRCCS, in Rome, between 1 January 2013 and 31 December 2021. First, the patients were divided in two groups according to the surgical treatment received: BCS vs. M. Then, the patients were stratified into four risk subclasses based on combined T and N pathological staging (T1N0, T1N+, T2-4N0 and T2-4N+). The primary endpoint of the study was to evaluate locoregional disease-free survival (LR-DFS), distant disease-free survival (DDFS) and overall survival (OS) in the different subclasses. We analyzed 289 patients that underwent either breast-conserving surgery (247/289, 85.5%) or mastectomy (42/289, 14.5%). After a median follow-up of 43.2 months (49.7, 22.2–74.3), 28 patients (9.6%) developed a locoregional recurrence, 27 patients (9.0%) showed systemic recurrence and 19 patients (6.5%) died. No significant differences due to type of surgical treatment were observed in the different risk subclasses in terms of locoregional disease-free survival, distant disease-free survival and overall survival. With the limits of a retrospective, single-center study, our data seem to indicate similar efficacy in terms of locoregional control, distant metastasis and overall survival with the use of upfront breast-conserving surgery as compared with radical surgery in the treatment of TNBC. Therefore, TNBC should not be considered to be a contraindication for breast conservation

A Web-based spatial decision supporting system for land management and soil conservation

Abstract. Today it is evident that there are many contrasting demands on our landscape (e.g. food security, more sustainable agriculture, higher income in rural areas, etc.) as well as many land degradation problems. It has been proved that providing operational answers to these demands and problems is extremely difficult. Here we aim to demonstrate that a spatial decision support system based on geospatial cyberinfrastructure (GCI) can address all of the above, so producing a smart system for supporting decision making for agriculture, forestry, and urban planning with respect to the landscape. In this paper, we discuss methods and results of a special kind of GCI architecture, one that is highly focused on land management and soil conservation. The system allows us to obtain dynamic, multidisciplinary, multiscale, and multifunctional answers to agriculture, forestry, and urban planning issues through the Web. The system has been applied to and tested in an area of about 20 000 ha in the south of Italy, within the framework of a European LIFE+ project (SOILCONSWEB). The paper reports – as a case study – results from two different applications dealing with agriculture (olive growth tool) and environmental protection (soil capability to protect groundwater). Developed with the help of end users, the system is starting to be adopted by local communities. The system indirectly explores a change of paradigm for soil and landscape scientists. Indeed, the potential benefit is shown of overcoming current disciplinary fragmentation over landscape issues by offering – through a smart Web-based system – truly integrated geospatial knowledge that may be directly and freely used by any end user (www.landconsultingweb.eu). This may help bridge the last very important divide between scientists working on the landscape and end users