ALMA and NACO observations towards the young exoring transit system J1407 (V1400 Cen)

Our aim was to directly detect the thermal emission of the putative exoring system responsible for the complex deep transits observed in the light curve for the young Sco-Cen star 1SWASP J140747.93-394542.6 (V1400 Cen, hereafter J1407), confirming it as the occulter seen in May 2007, and to determine its orbital parameters with respect to the star. We used the Atacama Large Millimeter/submillimeter Array (ALMA) to observe the field centred on J1407 in the 340 GHz (Band 7) continuum in order to determine the flux and astrometric location of the ring system relative to the star. We used the VLT/NACO camera to observe the J1407 system in March 2019 and to search for the central planetary mass object at thermal infrared wavelengths. We detect no point source at the expected location of J1407, and derive an upper limit $3\sigma$ level of $57.6~\mu\rm{Jy}$. There is a point source detected at an angular separation consistent with the expected location for a free-floating ring system that occulted J1407 in May 2007, with a flux of $89~\mu\rm{Jy}$ consistent with optically thin dust surrounding a massive substellar companion. At 3.8 microns with the NACO camera, we detect the star J1407 but no other additional point sources within 1.3 arcseconds of the star, with a lower bound on the sensitivity of $6M_{Jup}$ at the location of the ALMA source, and down to $4M_{Jup}$ in the sky background limit. The ALMA upper limit at the location of J1407 implies that a hypothesised bound ring system is composed of dust smaller than $1\rm{~mm}$ in size, implying a young ring structure. The detected ALMA source has multiple interpretations, including: (i) it is an unbound substellar object surrounded by warm dust in Sco-Cen with an upper mass limit of $6M_{Jup}$, or (ii) it is a background galaxy.Comment: Accepted for publication in A&A (6 pages, 5 figures). Reduced data and reduction scripts on GitHub at https://github.com/mkenworthy/j1407_alma_detectio

Dark Matter in Dwarf Spheroidals I: Models

This paper introduces a new two-parameter family of dwarf spheroidal (dSph) galaxy models. The density distribution has a Plummer profile and falls like the inverse fourth power of distance in projection, in agreement with the star-count data. The first free parameter controls the velocity anisotropy, the second controls the dark matter content. The dark matter distribution can be varied from one extreme of mass-follows-light through a near-isothermal halo with flat rotation curve to the other extreme of an extended dark halo with harmonic core. This family of models is explored analytically in some detail -- the distribution functions, the intrinsic moments and the projected moments are all calculated. For the nearby Galactic dSphs, samples of hundreds of discrete radial velocities are becoming available. A technique is developed to extract the anisotropy and dark matter content from such data sets by maximising the likelihood function of the sample of radial velocities. This is constructed from the distribution function and corrected for observational errors and the effects of binaries. Tests on simulated data sets show that samples of 1000 discrete radial velocities are ample to break the degeneracy between mass and anisotropy in the nearby dSphs. Interesting constraints can already be placed on the distribution of the dark matter with samples of 160 radial velocities (the size of the present-day data set for Draco).Comment: 16 pages, version in press at MNRA

Blue straggler stars in dwarf spheroidal galaxies

Blue straggler star (BSS) candidates have been observed in all old dwarf spheroidal galaxies (dSphs), however whether or not they are authentic BSSs or young stars has been a point of debate. To both address this issue and obtain a better understanding of the formation of BSSs in different environments we have analysed a sample of BSS candidates in two nearby Galactic dSphs, Draco and Ursa Minor. We have determined their radial and luminosity distributions from wide field multicolour imaging data extending beyond the tidal radii of both galaxies. BSS candidates are uniformly distributed through the host galaxy, whereas a young population is expected to show a more clumpy distribution. Furthermore, the observed radial distribution of BSSs, normalized to both red giant branch (RGB) and horizontal branch (HB) stars, is almost flat, with a slight decrease towards the centre. Such a distribution is at odds with the predictions for a young stellar population, which should be more concentrated. Instead, it is consistent with model predictions for BSS formation by mass transfer in binaries (MT-BSSs). Such results, although not decisive, suggest that these candidates are indeed BSSs and that MT-BSSs form in the same way in Draco and Ursa Minor as in globular clusters. This favours the conclusion that Draco and Ursa Minor are truly 'fossil' galaxies, where star formation ceased completely more than 8 billion years ago.Comment: 16 pages, 10 figures, MNRAS, in pres

Extremely metal-poor stars in classical dwarf spheroidal galaxies: Fornax, Sculptor and Sextans

We present the results of a dedicated search for extremely metal-poor stars in the Fornax, Sculptor and Sextans dSphs. Five stars were selected from two earlier VLT/Giraffe and HET/HRS surveys and subsequently followed up at high spectroscopic resolution with VLT/UVES. All of them turned out to have [Fe/H] <= -3 and three stars are below [Fe/H] -3.5. This constitutes the first evidence that the classical dSphs Fornax and Sextans join Sculptor in containing extremely metal-poor stars and suggests that all of the classical dSphs contain extremely metal-poor stars. One giant in Sculptor at [Fe/H]=-3.96 +- 0.10 is the most metal-poor star ever observed in an external galaxy. We carried out a detailed analysis of the chemical abundances of the alpha, iron peak, and the heavy elements, and we performed a comparison with the Milky Way halo and the ultra faint dwarf stellar populations. Carbon, barium and strontium show distinct features characterized by the early stages of galaxy formation and can constrain the origin of their nucleosynthesis.Comment: In A&A. This version corrects a few typographical errors in the coordinates of some of our stars (Table 1

First Pharmacokinetic Data of Tenofovir Alafenamide Fumarate and Tenofovir With Dolutegravir or Boosted Protease Inhibitors in African Children: A Substudy of the CHAPAS-4 Trial

BACKGROUND: We evaluated the pharmacokinetics of tenofovir alafenamide fumarate (TAF) and tenofovir in a subset of African children enrolled in the CHAPAS-4 trial. METHODS: Children aged 3-15 years with human immunodeficiency virus infection failing first-line antiretroviral therapy were randomized to emtricitabine/TAF versus standard-of-care nucleoside reverse transcriptase inhibitor combination, plus dolutegravir, atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir. Daily emtricitabine/TAF was dosed according to World Health Organization (WHO)-recommended weight bands: 120/15 mg in children weighing 14 to <25 kg and 200/25 mg in those weighing ≥25 kg. At steady state, 8-9 blood samples were taken to construct pharmacokinetic curves. Geometric mean (GM) area under the concentration-time curve (AUC) and the maximum concentration (Cmax) were calculated for TAF and tenofovir and compared to reference exposures in adults. RESULTS: Pharmacokinetic results from 104 children taking TAF were analyzed. GM (coefficient of variation [CV%]) TAF AUClast when combined with dolutegravir (n = 18), darunavir/ritonavir (n = 34), or lopinavir/ritonavir (n = 20) were 284.5 (79), 232.0 (61), and 210.2 (98) ng*hour/mL, respectively, and were comparable to adult reference values. When combined with atazanavir/ritonavir (n = 32), TAF AUClast increased to 511.4 (68) ng*hour/mL. For each combination, tenofovir GM (CV%) AUCtau and Cmax remained below reference values in adults taking 25 mg TAF with a boosted protease inhibitors. CONCLUSIONS: In children, TAF combined with boosted PIs or dolutegravir and dosed according to WHO-recommended weight bands provides TAF and tenofovir concentrations previously demonstrated to be well tolerated and effective in adults. These data provide the first evidence for use of these combinations in African children. CLINICAL TRIALS REGISTRATION: ISRCTN22964075

Blue straggler stars in dwarf spheroidal galaxies II: Sculptor and Fornax

The existence of blue straggler stars (BSSs) in dwarf spheroidal galaxies (dSphs) is still an open question. In fact, many BSS candidates have been observed in the Local Group dSphs, but it is unclear whether they are real BSSs or young stars. Shedding light on the nature of these BSS candidates is crucial, in order to understand the star formation history of dSphs. In this paper, we consider BSS candidates in Sculptor and Fornax. In Fornax there are strong hints that the BSS population is contaminated by young stars, whereas in Sculptor there is no clear evidence of recent star formation. We derive the radial and luminosity distribution of BSS candidates from wide field imaging data extending beyond the nominal tidal radius of these galaxies. The observations are compared with the radial distribution of BSSs expected from dynamical simulations. In Sculptor the radial distribution of BSS candidates is consistent with that of red horizontal branch (RHB) stars and is in agreement with theoretical expectations for BSSs generated via mass transfer in binaries. On the contrary, in Fornax the radial distribution of BSS candidates is more concentrated than that of all the considered stellar populations. This result supports the hypothesis that most of BSS candidates in Fornax are young stars and is consistent with previous studies.Comment: 14 pages, 10 figures, accepted for publication in MNRA

Polycyclic aromatic hydrocarbon selected galaxies

Polycyclic aromatic hydrocarbon (PAH) emission has been found in both starbursts and modestly starforming galaxies, but the relation between starforming activity and PAH luminosity is still a matter of debate. The different correlation degrees could be caused by the variety of optical and far-infrared sample selection criteria. In order to obtain a census of the typical properties of PAH emitting galaxies, we here study moderately distant galaxies which have been selected by their PAH emission. Combining the ISOCAM Parallel Survey at 6.7 micron with 2MASS we have colour-selected a sample of 120 candidates for strong PAH emission. We obtained optical and mid-infrared spectra of 75 and 19 sources, respectively, and analysed IRAS-ADDSCANs and available Spitzer 3.6-160 micron photometry. The Spitzer spectra exhibit clear PAH features and corroborate that our photometric selection criteria trace the PAH emission of galaxies fairly well. The optical spectra show emission lines, at median redshift z~0.1, as well as Hdelta and CaII absorption, indicating ongoing starformation as well as post-starbursts. The mid- and far-infrared spectral energy distributions (SEDs) provide evidence for a broad range of far-infrared (FIR) luminosities, but in general the dust is colder than for starburst galaxies like M82. For most galaxies the monocromatic luminosity peaks at about equal height at optical, 6.7 micron (PAH) and FIR wavelengths. In about 15% of the sources the FIR luminosity exceeds the optical and PAH energy output by about a factor 5-10 despite the cool dust temperature; in these galaxies a large dust mass of 10^8 - 10^9 M_sun is inferred.Comment: 14 pages, 11 figures, accepted for publication in Astronomy and Astrophysic

First Pharmacokinetic Data of Tenofovir Alafenamide Fumarate and Tenofovir With Dolutegravir or Boosted Protease Inhibitors in African Children: A Substudy of the CHAPAS-4 Trial.

BACKGROUND: We evaluated the pharmacokinetics of tenofovir alafenamide fumarate (TAF) and tenofovir in a subset of African children enrolled in the CHAPAS-4 trial. METHODS: Children aged 3-15 years with human immunodeficiency virus infection failing first-line antiretroviral therapy were randomized to emtricitabine/TAF versus standard-of-care nucleoside reverse transcriptase inhibitor combination, plus dolutegravir, atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir. Daily emtricitabine/TAF was dosed according to World Health Organization (WHO)-recommended weight bands: 120/15 mg in children weighing 14 to <25 kg and 200/25 mg in those weighing ≥25 kg. At steady state, 8-9 blood samples were taken to construct pharmacokinetic curves. Geometric mean (GM) area under the concentration-time curve (AUC) and the maximum concentration (Cmax) were calculated for TAF and tenofovir and compared to reference exposures in adults. RESULTS: Pharmacokinetic results from 104 children taking TAF were analyzed. GM (coefficient of variation [CV%]) TAF AUClast when combined with dolutegravir (n = 18), darunavir/ritonavir (n = 34), or lopinavir/ritonavir (n = 20) were 284.5 (79), 232.0 (61), and 210.2 (98) ng*hour/mL, respectively, and were comparable to adult reference values. When combined with atazanavir/ritonavir (n = 32), TAF AUClast increased to 511.4 (68) ng*hour/mL. For each combination, tenofovir GM (CV%) AUCtau and Cmax remained below reference values in adults taking 25 mg TAF with a boosted protease inhibitors. CONCLUSIONS: In children, TAF combined with boosted PIs or dolutegravir and dosed according to WHO-recommended weight bands provides TAF and tenofovir concentrations previously demonstrated to be well tolerated and effective in adults. These data provide the first evidence for use of these combinations in African children. CLINICAL TRIALS REGISTRATION: ISRCTN22964075

Start up and emergency stop of the electric drive under condition of EU fundamental safety requirements

This short document describes start up and emergency stop problems of the electric drive with squirrel cage motors under condition of UE fundamental safety requirements. Very important part of projecting process is control integrity. The risk assessments we have looked at so far have dealt with mechanical control measures, which are often required to interact with the machine's control system, either by preventing all dangerous machine movement or by stopping a specific operation. Every machine must be fitted with a control to bring it to a complete stop safety and the energy supply to the machine's actuators (mainly induction motors) must be removed once the stop has been achieved. The safety circuits of simple, stand-alone machines generally use relatively basic safety-related controls, designed with high-integrity hard-wired components, but principles for simple and more complicated systems are the same