Hemodynamic and inotropic effects of endothelin-1 in vivo

Endothelin-1 (ET-1) is known to have strong vasoactive properties. Contradictory results have been reported with regard to its inotropic effects. This study examined the dose-dependent (500, 1000, 2500, 5000 and 10,000 ng ET-1/kg vs. NaCl controls) hemodynamic and inotropic effects of ET-1 in 53 open-chest rats during and after a 7-min infusion. Besides measurements in the intact circulation the myocardial function was examined by isovolumic registrations independent of peripheral vascular effects. A transient ET-1 induced (500, 1000, 2500, 5000 ng ET-1/kg) decrease of the left ventricular systolic pressure (LVSP) and the mean aortic pressure (AoPmean) was followed by a dose-related rise of these pressures (LVSP: -1%, -1%, +8%, +16% vs. preinfusion values; AoPmean: -11%, +9%, +39%, +52%). Heart rate (HR) was not influenced by ET-1. Due to the dose-dependent decrease of the stroke volume (SV) the cardiac output (CO) was reduced (CO: -8%, -23%, -40%, -50%). After an initial vasodilatation ET-1 elevates the total peripheral resistance (TPR: -1%, +49%, +139%, +215%) dose-dependently. 10,000 ng ET-1/kg was a lethal dose resulting in cardiac failure within minutes (low output). Since the maximum of the isovolumic LVSP (peak LVSP) and the corresponding dP/dtmax (peak dP/dtmax) were unchanged under ET-1, the isovolumic measurements do not indicate a positive inotropic effect of ET-1 in vivo in contrast to published results of in vitro experiments. It may be possible that a direct positive inotropic effect of ET-1 observed in in vitro studies is counterbalanced in vivo by an indirect negative inotropic effect due to the coronary-constrictive effect of ET-1

Probing the centre of the large circumstellar disc in M17

We investigated the nature of the hitherto unresolved elliptical infrared emission in the centre of the ~20000 AU disc silhouette in M 17. We combined high-resolution JHKsL'M' band imaging carried out with NAOS/CONICA at the VLT with [Fe II] narrow band imaging using SOFI at the NTT. The analysis is supported by Spitzer/GLIMPSE archival data and by already published SINFONI/VLT Integral Field Spectroscopy data. For the first time, we resolve the elongated central infrared emission into a point-source and a jet-like feature that extends to the northeast in the opposite direction of the recently discovered collimated H2 jet. They are both orientated almost perpendicular to the disc plane. In addition, our images reveal a curved southwestern emission nebula whose morphology resembles that of the previously detected northeastern one. Both nebulae are located at a distance of 1500 AU from the disc centre. We describe the infrared point-source in terms of a protostar that is embedded in circumstellar material producing a visual extinction of 60 <= Av <= 82. The observed Ks band magnitude is equivalent to a stellar mass range of 2.8 Msun <= Mstar <= 8 Msun adopting conversions for a main-sequence star. Altogether, we suggest that the large M 17 accretion disc is forming an intermediate to high-mass protostar. Part of the accreted material is expelled through a symmetric bipolar jet/outflow.Comment: 6 pages, 3 figures, accepted by MNRAS (16 May 2008

Multi-Modal Pre-Training for Automated Speech Recognition

Traditionally, research in automated speech recognition has focused on local-first encoding of audio representations to predict the spoken phonemes in an utterance. Unfortunately, approaches relying on such hyper-local information tend to be vulnerable to both local-level corruption (such as audio-frame drops, or loud noises) and global-level noise (such as environmental noise, or background noise) that has not been seen during training. In this work, we introduce a novel approach which leverages a self-supervised learning technique based on masked language modeling to compute a global, multi-modal encoding of the environment in which the utterance occurs. We then use a new deep-fusion framework to integrate this global context into a traditional ASR method, and demonstrate that the resulting method can outperform baseline methods by up to 7% on Librispeech; gains on internal datasets range from 6% (on larger models) to 45% (on smaller models).Comment: Presented at ICASSP 202

Depositional Environments and Sequence Stratigraphy of a Breathitt Group Exposure, U.S. 25E, Flat Lick, Kentucky

The Pennsylvanian fluvial deltaic Breathitt Group is exposed along U.S. 25E near Flat Lick, Ky. This exposure is ideal for field trips because of the quality of the exposure, its accessibility, the range of facies present, and its potential for demonstrating principles of outcrop-based sequence-stratigraphic interpretation. Eight facies are present and represent deposition in fluvial, delta-plain, and delta-front environments. Several facies contain an abundance of trace fossils, and a wide range of sedimentary structures are also present. Flooding surfaces are well developed in the delta front and delta plain and are characterized by abrupt contacts with distal, deeper-water deltaic environments overlying proximal, shallower-water deltaic environments. Major flooding surfaces display evidence of condensation, including firmgrounds and enrichment of authigenic minerals such as siderite. At this exposure, most parasequence sets display progradational stacking and are interpreted as highstand systems tracts. Two sequence boundaries are present that may represent two different scales of sequences. The upper sequence boundary is more obvious and is characterized by a prominent erosional surface and is overlain by multistory fluvial channels. The lower and more subtle sequence boundary is interpreted as an interfluve surface marked by a bleached paleosol

Radial Velocity Studies of Close Binary Stars.IV

Radial-velocity measurements and sine-curve fits to the orbital velocity variations are presented for the fourth set of ten close binary systems: 44 Boo, FI Boo, V2150 Cyg, V899 Her, EX Leo, VZ Lib, SW Lyn, V2377 Oph, Anon Psc (GSC 8-324), HT Vir. All systems are double-lined spectroscopic binaries with only two of them not being contact systems (SW Lyn and GSC 8-324) and with five (FI Boo, V2150 Cyg, V899 Her, EX Leo, V2377 Oph) being the recent photometric discoveries of the Hipparcos satellite project. Five of the binaries are triple-lined systems (44 Boo, V899 Her, VZ Lib, SW Lyn, HT Vir). Three (or possibly four) companions in the triple-lined systems show radial-velocity changes during the span of our observations suggesting that these are in fact quadruple systems. Several of the studied systems are prime candidates for combined light and radial-velocity synthesis solutions.Comment: aastex5.0, 5 figures in PS; submitted to Astron.

Ectomycorrhizal influence on the dynamics of sesquiterpene release by Tricholoma vaccinum

Tricholoma vaccinum is an ectomycorrhizal basidiomycete with high host specificity. The slow-growing fungus is able to produce twenty sesquiterpenes, including α-barbatene, sativene, isocaryophyllene, α-cuprenene, β-cedrene, ß-copaene, 4-epi-α-acoradiene, and chamigrene in axenic culture. For the three major compounds, Δ(6)-protoilludene, β-barbatene, and an unidentified oxygenated sesquiterpene (m/z 218.18), changed production during co-cultivation with the ectomycorrhizal partner tree, Picea abies, could be shown with distinct dynamics. During the mycorrhizal growth of T. vaccinum–P. abies, Δ(6)-protoilludene and the oxygenated sesquiterpene appeared at similar times, which warranted further studies of potential biosynthesis genes. In silico analyses identified a putative protoilludene synthesis gene, pie1, as being up-regulated in the mycorrhizal stage, in addition to the previously identified, co-regulated geosmin synthase, ges1. We therefore hypothesize that the sesquiterpene synthase pie1 has an important role during mycorrhization, through Δ(6)-protoilludene and/or its accompanied oxygenated sesquiterpene production

Appropriateness of oral anticoagulants for long-term treatment of atrial fibrillation in older people: results of an evidence-based review and international consensus validation process (OAC-FORTA 2016)

Background: Age appropriateness of anticoagulants for stroke prevention in atrial fibrillation is uncertain. Objective: To review oral anticoagulants for the treatment of atrial fibrillation in older (age >65 years) people and to classify appropriate and inappropriate drugs based on efficacy, safety and tolerability using the Fit-fOR-The-Aged (FORTA) classification. Methods: We performed a structured comprehensive review of controlled clinical trials and summaries of individual product characteristics to assess study and total patient numbers, quality of major outcome data and data of geriatric relevance. The resulting evidence was discussed in a round table with an interdisciplinary panel of ten European experts. Decisions on age appropriateness were made using a Delphi process. Results: For the eight drugs included, 380 citations were identified. The primary outcome results were reported in 32 clinical trials with explicit and relevant data on older people. Though over 24,000 patients aged >75/80 years were studied for warfarin, data on geriatric syndromes were rare (two studies reporting on frailty/falls/mental status) and missing for all other compounds. Apixaban was rated FORTA-A (highly beneficial). Other non-vitamin K antagonist oral anticoagulants (including low/high-intensity dabigatran and high-intensity edoxaban) and warfarin were assigned to FORTA-B (beneficial). Phenprocoumon, acenocoumarol and fluindione were rated FORTA-C (questionable), mainly reflecting the absence of data. Conclusions: All non-vitamin K antagonist oral anticoagulants and warfarin were classified as beneficial or very beneficial in older persons (FORTA-A or -B), underlining the overall positive assessment of the risk/benefit ratio for these drugs. For other vitamin-K antagonists regionally used in Europe, the lack of evidence should challenge current practice

Real-time Monitoring of High-speed Spindle Operations Using Infrared Data Transmission

AbstractHigh-performance cutting is carried out with high cutting and feed speeds. Particularly, the use of heavy cutting tools (e.g. in planing machines), it is important to monitor the clamping and balance condition of the mounted tool, as well as the process forces. Therefore, a real-time monitoring system for high-speed operations based on the IrDA protocol was developed. It could be shown that infrared data transmission systems allow shorter reaction times compared to conventional wireless LAN applications. The presented monitoring system provides a reaction time of 7.14 ms at a bandwidth of 42.5 kHz and a data rate of 4.1 MBit/s