Biozonation and biostratigraphic limits of the Tarbur formation around Shiraz (SW of Iran)

Mehr als 3000m der karbonatischen Tarbur Formation wurden in der Umgebung der Stadt Schiras durch sieben stratigraphische Profile untersucht. Zur Alters bestimmung mittels Foraminiferen der Tarbur Formation wurden davon 900 Dünnschliffe bearbeitet. Die Biozonen dieser stratigraphischen Profile basieren auf den ermittelten Indexforaminiferen. An Hand der ermittelten typischen Biozonen wurde das Alter der Tarbur-Fomation dem Campan-Unterem Paläozän zugeordnet. Es wurden vier Hauptmikrofazies, die Wackstone, Packstone, Grainstone und Boundstone beinhalten, festgestellt. Auf Grund der untersuchten Biostratigraphie ist festzustellen, dass die Obergrenzen der Lithostratigraphie und der Biostratigraphie der Tarbur-Formation nicht übereinstimmen. Over 3000 meters of the Tarbur carbonate rocks Formation in seven stratigraphic sections have been studied. 900 thin sections have provided. The biozones have established and well known foraminifers are identified in these stratigraphic sections. Index Biozone reflects Campanian-Lower Paleocene age for the Tarbur Formation. Four index microfacies are distinguished which are, wackestone, Packstone, grainstone and boundstone. Based on biostratigraphic study, upper limit lithostratigraphic of the Tarbur Formation is not comparable with upper biostratigraphic boundary

Integrating a suicide prevention program into the primary health care network: A field trial study in Iran

Objective. To describe and evaluate the feasibility of integrating a suicide prevention program with Primary Health Care services and evaluate if such system can improve screening and identification of depressive disorder, reduce number of suicide attempters, and lower rate of suicide completion. Methodology. This was a quasi-experimental trial in which one community was exposed to the intervention versus the control community with no such exposure. The study sites were two counties in Western Iran. The intervention protocol called for primary care and suicide prevention collaboration at different levels of care. The outcome variables were the number of suicides committed, the number of documented suicide attempts, and the number of identified depressed cases. Results. We identified a higher prevalence of depressive disorders in the intervention site versus the control site (� 2 = 14.8, P < 0.001). We also found a reduction in the rate of suicide completion in the intervention region compared to the control, but a higher prevalence of suicide attempts in both the intervention and the control sites. Conclusion. Integrating a suicide prevention program with the Primary Health Care network enhanced depression and suicide surveillance capacity and subsequently reduced the number of suicides, especially in rural areas. © 2015 Seyed Kazem Malakouti et al

Integrating a suicide prevention program into the primary health care network: A field trial study in Iran

Objective. To describe and evaluate the feasibility of integrating a suicide prevention program with Primary Health Care services and evaluate if such system can improve screening and identification of depressive disorder, reduce number of suicide attempters, and lower rate of suicide completion. Methodology. This was a quasi-experimental trial in which one community was exposed to the intervention versus the control community with no such exposure. The study sites were two counties in Western Iran. The intervention protocol called for primary care and suicide prevention collaboration at different levels of care. The outcome variables were the number of suicides committed, the number of documented suicide attempts, and the number of identified depressed cases. Results. We identified a higher prevalence of depressive disorders in the intervention site versus the control site (χ2=14.8, P<0.001). We also found a reduction in the rate of suicide completion in the intervention region compared to the control, but a higher prevalence of suicide attempts in both the intervention and the control sites. Conclusion. Integrating a suicide prevention program with the Primary Health Care network enhanced depression and suicide surveillance capacity and subsequently reduced the number of suicides, especially in rural areas

Game theory framework for MAC parameter optimization in energy-delay constrained sensor networks

Optimizing energy consumption and end-to-end (e2e) packet delay in energy-constrained, delay-sensitive wireless sensor networks is a conflicting multiobjective optimization problem. We investigate the problem from a game theory perspective, where the two optimization objectives are considered as game players. The cost model of each player is mapped through a generalized optimization framework onto protocol-specific MAC parameters. From the optimization framework, a game is first defined by the Nash bargaining solution (NBS) to assure energy consumption and e2e delay balancing. Secondy, the Kalai-Smorodinsky bargaining solution (KSBS) is used to find an equal proportion of gain between players. Both methods offer a bargaining solution to the duty-cycle MAC protocol under different axioms. As a result, given the two performance requirements (i.e., the maximum latency tolerated by the application and the initial energy budget of nodes), the proposed framework allows to set tunable system parameters to reach a fair equilibrium point that dually minimizes the system latency and energy consumption. For illustration, this formulation is applied to six state-of-the-art wireless sensor network (WSN) MAC protocols: B-MAC, X-MAC, RI-MAC, SMAC, DMAC, and LMAC. The article shows the effectiveness and scalability of such a framework in optimizing protocol parameters that achieve a fair energy-delay performance trade-off under the application requirements

Visualising the crossover between 3D and 2D topological defects in nematic liquid crystals

The topological properties of disclinations are quite different for liquid crystals in two dimensions (2D) or three dimensions (3D). In 2D, there are distinct types of disclinations with topological charges or winding numbers of any half-integer or integer. By contrast, in 3D, all half-integer disclinations are topologically equivalent to each other, and integer disclinations are not defects at all. In this study, we use numerical simulations to explore the crossover between 3D and 2D. We show that certain disclination lines between patterned surfaces can exist when the director field is free to rotate in 3D, but not when the director field is forced into the 2D plane (by an electric field applied to a liquid crystal with negative dielectric anisotropy). As a result, these disclinations are expelled from the liquid crystal.</p

UAV-assisted communication in remote disaster areas using imitation learning

Abstract The damage to cellular towers during natural and man-made disasters can disturb the communication services for cellular users. One solution to the problem is using unmanned aerial vehicles to augment the desired communication network. The paper demonstrates the design of a UAV-Assisted Imitation Learning (UnVAIL) communication system that relays the cellular users’ information to a neighbor base station. Since the user equipment (UEs) are equipped with buffers with limited capacity to hold packets, UnVAIL alternates between different UEs to reduce the chance of buffer overflow, positions itself optimally close to the selected UE to reduce service time, and uncovers a network pathway by acting as a relay node. UnVAIL utilizes Imitation Learning (IL) as a data-driven behavioral cloning approach to accomplish an optimal scheduling solution. Results demonstrate that UnVAIL performs similar to a human expert knowledge-based planning in communication timeliness, position accuracy, and energy consumption with an accuracy of 97.52% when evaluated on a developed simulator to train the UAV

Two-pore channels regulate Tat endolysosome escape and Tat-mediated HIV-1 LTR transactivation.

HIV-1 Tat is essential for HIV-1 replication and appears to play an important role in the pathogenesis of HIV-associated neurological complications. Secreted from infected or transfected cells, Tat has the extraordinary ability to cross the plasma membrane. In the brain, Tat can be taken up by CNS cells via receptor-mediated endocytosis. Following endocytosis and its internalization into endolysosomes, Tat must be released in order for it to activate the HIV-1 LTR promoter and facilitate HIV-1 viral replication in the nucleus. However, the underlying mechanisms whereby Tat escapes endolysosomes remain unclear. Because Tat disrupts intracellular calcium homeostasis, we investigated the involvement of calcium in Tat endolysosome escape and subsequent LTR transactivation. We demonstrated that chelating endolysosome calcium with high-affinity rhodamine-dextran or chelating cytosolic calcium with BAPTA-AM attenuated Tat endolysosome escape and LTR transactivation. Significantly, we demonstrated that pharmacologically blocking and knocking down the endolysosome-resident two-pore channels (TPCs) attenuated Tat endolysosome escape and LTR transactivation. This calcium-mediated effect appears to be selective for TPCs because knocking down TRPML1 calcium channels was without effect. Our findings suggest that calcium released from TPCs is involved in Tat endolysosome escape and subsequent LTR transactivation. TPCs might represent a novel therapeutic target against HIV-1 infection and HIV-associated neurological complications

Two-pore channels regulate Tat endolysosome escape and Tat-mediated HIV-1 LTR transactivation.

HIV-1 Tat is essential for HIV-1 replication and appears to play an important role in the pathogenesis of HIV-associated neurological complications. Secreted from infected or transfected cells, Tat has the extraordinary ability to cross the plasma membrane. In the brain, Tat can be taken up by CNS cells via receptor-mediated endocytosis. Following endocytosis and its internalization into endolysosomes, Tat must be released in order for it to activate the HIV-1 LTR promoter and facilitate HIV-1 viral replication in the nucleus. However, the underlying mechanisms whereby Tat escapes endolysosomes remain unclear. Because Tat disrupts intracellular calcium homeostasis, we investigated the involvement of calcium in Tat endolysosome escape and subsequent LTR transactivation. We demonstrated that chelating endolysosome calcium with high-affinity rhodamine-dextran or chelating cytosolic calcium with BAPTA-AM attenuated Tat endolysosome escape and LTR transactivation. Significantly, we demonstrated that pharmacologically blocking and knocking down the endolysosome-resident two-pore channels (TPCs) attenuated Tat endolysosome escape and LTR transactivation. This calcium-mediated effect appears to be selective for TPCs because knocking down TRPML1 calcium channels was without effect. Our findings suggest that calcium released from TPCs is involved in Tat endolysosome escape and subsequent LTR transactivation. TPCs might represent a novel therapeutic target against HIV-1 infection and HIV-associated neurological complications