Histone Acetylation in the Nucleus Accumbens Shell Modulates Ethanol-Induced Locomotor Activity in DBA/2J Mice

A growing body of literature suggests that epigenetic mechanisms, including histone acetylation, may play key roles in drug abuse and the development of addiction. Experiments in the present study were designed to investigate the role of histone acetylation in ethanol-induced locomotor sensitization

CO<inf>2</inf> absorption using diethanolamine-water solutions in a rotating spiral contactor

Results for mass transfer in a rotating spiral device are presented here for absorption of carbon dioxide from nitrogen carrier gas using mixtures of diethanolamine (DEA) and water. The ability of the device to examine the full range of flow rate ratio for the two phases while controlling the relative thicknesses of the phase layers is applied to surveying absorption performance over a wide range of DEA concentration at 312 K and 1.8 bara. Comparisons are made for a fixed 86 μm liquid layer thickness, which is shown to fix also the fraction of the liquid accessible by diffusion, while maintaining 90% removal of CO2 from a gas stream of 10% (mole) CO2 in nitrogen. The increasing liquid viscosity with DEA fraction is countered by reducing the liquid flow rate to maintain constant liquid layer thickness and diffusion depth. The allowed gas throughput, while meeting 90% removal, increases with DEA concentration until the increasing viscosity gives sufficient reduction in liquid flow rate to offset the increasing CO2 capacity of the liquid. The maximum gas flow rate has a broad peak centred at a DEA mole fraction of about 0.072 (31% by mass). Utilisation of the amine is increased as DEA concentration increases, apparently as a result of the longer residence time, suggesting an effect of chemical time scales on the order of seconds. For a fixed concentration, full utilisation of the amine is achieved by decreasing the liquid flow rate, which reduces layer thickness and increases diffusion time. The work highlights the use of the rotating spiral for rapid and accurate testing to determine optimum liquid composition of absorbent formulations

Short-range correlations in low-lying nuclear excited states

The electromagnetic transitions to various low-lying excited states of 16O, 48Ca and 208Pb are calculated within a model which considers the short-range correlations. In general the effects of the correlations are small and do not explain the required quenching to describe the data.Comment: 6 pages, 2 postscript figures, 1 tabl

Muon capture on nuclei with N > Z, random phase approximation, and in-medium renormalization of the axial-vector coupling constant

We use the random phase approximation to describe the muon capture rate on ${}^{44}$Ca,${}^{48}$Ca, ${}^{56}$Fe, ${}^{90}$Zr, and ${}^{208}$Pb. With ${}^{40}$Ca as a test case, we show that the Continuum Random Phase Approximation (CRPA) and the standard RPA give essentially equivalent descriptions of the muon capture process. Using the standard RPA with the free nucleon weak form factors we reproduce the experimental total capture rates on these nuclei quite well. Confirming our previous CRPA result for the $N = Z$ nuclei, we find that the calculated rates would be significantly lower than the data if the in-medium quenching of the axial-vector coupling constant were employed.Comment: submitted to Phys. Rev.

Assessment of the Effects of 6 Standard Rodent Diets on Binge-Like and Voluntary Ethanol Consumption in Male C57BL/6J Mice

In recent years much attention has been given to the lack of reproducibility in biomedical research, particularly in pre-clinical animal studies. This is a problem that also plagues the alcohol research field, particularly in consistent consumption in animal models of alcohol use disorders. One often overlooked factor that could affect reproducibility is the maintenance diet used in pre-clinical studies

Tropical Herbivorous Phasmids, but Not Litter Snails, Alter Decomposition Rates By Modifying Litter Bacteria

Consumers can alter decomposition rates through both feces and selective feeding in many ecosystems, but these combined effects have seldom been examined in tropical ecosystems. Members of the detrital food web (litter-feeders or microbivores) should presumably have greater effects on decomposition than herbivores, members of the green food web. Using litterbag experiments within a field enclosure experiment, we determined the relative effects of common litter snails (Megalomastoma croceum) and herbivorous walking sticks (Lamponius portoricensis) on litter composition, decomposition rates, and microbes in a Puerto Rican rainforest, and whether consumer effects were altered by canopy cover presence. Although canopy presence did not alter consumers’ effects, focal organisms had unexpected influences on decomposition. Decomposition was not altered by litter snails, but herbivorous walking sticks reduced leaf decomposition by about 50% through reductions in high quality litter abundance and, consequently, lower bacterial richness and abundance. This relatively unexplored but potentially important link between tropical herbivores, detritus, and litter microbes in this forest demonstrates the need to consider autotrophic influences when examining rainforest ecosystem processes

Corticotropin Releasing Factor Signaling in the Central Amygdala is Recruited during Binge-Like Ethanol Consumption in C57BL/6J Mice

A well-established body of work indicates a crucial role for corticotropin releasing factor (CRF) in neurobiological responses associated with excessive dependence-like ethanol drinking in ethanol vapor exposed rodents. Recent evidence demonstrates a role for CRF in the modulation of binge-like ethanol consumption by non-dependent mice, a behavior which can precede ethanol dependence. The CRF circuitry that is engaged by binge-like ethanol exposure, however, is unknown. Using converging approaches, we provide evidence that, similar to ethanol vapor-induced increases in ethanol intake, CRF signaling in the central nucleus of the amygdala (CeA) is engaged during binge-like ethanol consumption by C57BL/6J mice. Specifically, we found that binge-like consumption of an ethanol solution (20% ethanol v/v) was attenuated by pretreatment with the CRF1R antagonists antalarmin, (4-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino-1-butanol (LWH-63), and NBI-27914 at doses (30 mg/kg, i.p.) that did not alter non-binge-like ethanol consumption. Binge-like ethanol consumption resulted in significant increases of CRF immunoreactivity in the CeA immediately following ethanol drinking and 18-24 h following ethanol removal and also blocked the ability of CRF to enhance GABAergic transmission in the CeA 18-24 h following ethanol removal. Pretreatment with bilateral injections of antalarmin (1 μg/ 0.5 μl per side) into the CeA, but not the adjacent basolateral amygdala (BLA), significantly attenuated binge-like ethanol consumption. These findings suggest that CRF signaling in the CeA is recruited during excessive ethanol intake, prior to the development of dependence. We hypothesize that plastic changes in CRF signaling develop with repeated binge-like drinking episodes, contributing to the transition to dependence

Repeated Cycles of Binge-Like Ethanol Drinking in Male C57BL/6J Mice Augments Subsequent Voluntary Ethanol Intake But Not Other Dependence-Like Phenotypes

Recently, procedures have been developed to model specific facets of human alcohol abuse disorders, including those that model excessive binge-like drinking (i.e., “drinking in the dark”, or DID procedures) and excessive dependence-like drinking (i.e., intermittent ethanol vapor exposure). Similar neuropeptide systems modulate excessive ethanol drinking stemming from both procedures, raising the possibility that both paradigms are actually modeling the same phenotypes and triggering the same central neuroplasticity. Therefore, the goal of the present project was to study the effects of a history of binge-like ethanol drinking, using DID procedures, on phenotypes that have previously been described with procedures to model dependence-like drinking

Haptic pop-out of movable stimuli

When, in visual and haptic search, a target is easily found among distractors, this is called a pop-out effect. The target feature is then believed to be salient, and the search is performed in a parallel way. We investigated this effect with movable stimuli in a haptic search task. The task was to find a movable ball among anchored distractors or the other way round. Results show that reaction times were independent of the number of distractors if the movable ball was the target but increased with the number of items if the anchored ball was the target. Analysis of hand movements revealed a parallel search strategy, shorter movement paths, a higher average movement speed, and a narrower direction distribution with the movable target, as compared with a more detailed search for an anchored target. Taken together, these results show that a movable object pops out between anchored objects and this indicates that movability is a salient object feature. Vibratory signals resulting from the movable ball were found to be a reasonable explanation regarding the sensation responsible for the pop-out of movability

Ratings of age of acquisition of 299 words across 25 languages: Is there a cross-linguistic order of words?

We present a new set of subjective age-of-acquisition (AoA) ratings for 299 words (158 nouns, 141 verbs) in 25 languages from five language families (Afro-Asiatic: Semitic languages; Altaic: one Turkic language: Indo-European: Baltic, Celtic, Germanic, Hellenic, Slavic, and Romance languages; Niger-Congo: one Bantu language; Uralic: Finnic and Ugric languages). Adult native speakers reported the age at which they had learned each word. We present a comparison of the AoA ratings across all languages by contrasting them in pairs. This comparison shows a consistency in the orders of ratings across the 25 languages. The data were then analyzed (1) to ascertain how the demographic characteristics of the participants influenced AoA estimations and (2) to assess differences caused by the exact form of the target question (when did you learn vs. when do children learn this word); (3) to compare the ratings obtained in our study to those of previous studies; and (4) to assess the validity of our study by comparison with quasi-objective AoA norms derived from the MacArthur–Bates Communicative Development Inventories (MB-CDI). All 299 words were judged as being acquired early (mostly before the age of 6 years). AoA ratings were associated with the raters’ social or language status, but not with the raters’ age or education. Parents reported words as being learned earlier, and bilinguals reported learning them later. Estimations of the age at which children learn the words revealed significantly lower ratings of AoA. Finally, comparisons with previous AoA and MB-CDI norms support the validity of the present estimations. Our AoA ratings are available for research or other purposes