Estimation of Dulling Rate and Bit Tooth Wear Using Drilling Parameters and Rock Abrasiveness

NoOptimisation of the drilling operations is becoming increasingly important as it can significantly reduce the oil well development cost. One of the major objectives in oil well drilling is to increase the penetration rate by selecting the optimum drilling bit based on offset wells data, and adjust the drilling factors to keep the bit in good condition during the operation. At the same time, it is important to predict the bit wear and the time to pull out the bit out of hole to prevent fishing jobs. Numerous models have been suggested in the literature for predicting the time to pull the bit out to surface rather than predict or estimate the bit wear rate. Majority of the available models are largely empirical and can be applied for limited conditions, and do not include all the drilling parameters such as the formation abrasiveness and bit hydraulic. In this paper, a new approach is presented to improve the drill bit wear estimation that consists of a combination of both Bourgoyne and Young (BY) drilling rate model and theory of empirical relation for the effects of rotary speed (RPM), and weight on bit (WOB) on drilling arte (ROP) and rate of tooth wear. In addition to the drilling parameters, the formation abrasiveness and the effect of the jet impact force of the mud have also been accounted to estimate the bit wear. The proposed model enables estimation of the rock abrasiveness, and that lead to calculate the dynamic dulling rate of the bit while drilling that used in more accurate to assess the bit tooth wear compared with the mechanical specific energy (MSE). Then the estimated dulling rate at the depth of pulling out is used to determine the dull grade of the bit. The technique is validated in five wells located in two different oil fields in Libya. All studied wells in this showed a good agreement between the actual bit tooth wear and the estimated bit tooth wear

Conversion From Tacrolimus to Belatacept to Prevent the Progression of Chronic Kidney Disease in Pancreas Transplantation: Case Report of Two Patients

Belatacept is a novel immunosuppressive agent that may be used as an alternative to calcineurin inhibitors (CNI) in immunosuppression (IS) regimens. We report two cases of pancreas transplant that were switched from tacrolimus (TAC) to belatacept. Case 1: 38‐year‐old female with pancreas transplant alone maintained on TAC‐based IS regimen whose serum creatinine (SCr) slowly deteriorated from 0.6 mg/dL at baseline to 2.2 mg/dL, 16 months posttransplant. A native kidney biopsy performed showed CNI toxicity. The patient was started on belatacept and TAC was eliminated. Case 2: 49‐year‐old female with simultaneous pancreas–kidney transplant, maintained on TAC‐based regimen where the SCr worsened over an initial 3‐month period from a baseline of 1.0 to 3.0 mg/dL. Belatacept was started and TAC was lowered. Due to persistent graft dysfunction and kidney transplant biopsy still showing changes consistent with CNI toxicity, the TAC was then discontinued. At >1 year postbelatacept and off TAC follow‐up, kidney function as measured by SCr remains stable at 1.0 ± 0.2 mg/dL in both recipients. Neither patient developed rejection following the switch, and pancreas allograft function remains stable in both recipients

3D computational fluid dynamics study of a drying process in a can making industry

YesIn the drying process of a can making industry, the drying efficiency of a thermal drying oven can be improved by adjusting the volumetric air flow rate of the blower. To maximize drying efficiency, an optimal flow rate is needed. Consequently, a three-dimensional computational fluid dynamics (CFD) is used to provide simulation according to the response of air velocity, air temperature and evaporated solvent concentration with respect to changes in volumetric air flow rate in the drying oven. An experimental study has been carried out to determine the evaporation rate of the solvent. To validate the models, the process data obtained from the CFD is compared with that obtained from actual data. In the accurate models, the simulation results demonstrate that the decrease in volumetric air flow rate provides no major discrepancy of the air velocity patterns in all dimensions and decreases the maximum temperature in the oven. Consequently, this decrease in volumetric air flow rate rapidly increases the evaporated solvent concentration in the beginning and then gradually decreases over the length of the oven. In addition, further reduction of the flow rate gives lower heat loss of the oven up to 83.67%.The authors would like to thank The Thailand Research Fund (TRF) under The Royal Golden Jubilee Ph.D. Program (PHD/0158/2550), The Institutional Research Grant (The Thailand Research Fund) (IRG 5780014) and Chulalongkorn University (Contract No. RES_57_411_21_076) for financial support to this work

Identification of New Drug Candidates Against \u3cem\u3eBorrelia burgdorferi\u3c/em\u3e Using High-Throughput Screening

Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of symptoms, such as muscle and joint pain, psychosocial and cognitive difficulties, and generalized fatigue. This condition is referred to as posttreatment Lyme disease syndrome. While there is no evidence for the presence of viable infectious organisms in individuals with posttreatment Lyme disease syndrome, some researchers found surviving Borrelia burgdorferi population in rodents and primates even after antibiotic treatment. Although such observations need more ratification, there is unmet need for developing the therapeutic agents that focus on removing the persisting bacterial form of B. burgdorferi in rodent and nonhuman primates. For this purpose, high-throughput screening was done using BacTiter-Glo assay for four compound libraries to identify candidates that stop the growth of B. burgdorferi in vitro. The four chemical libraries containing 4,366 compounds (80% Food and Drug Administration [FDA] approved) that were screened are Library of Pharmacologically Active Compounds (LOPAC1280), the National Institutes of Health Clinical Collection, the Microsource Spectrum, and the Biomol FDA. We subsequently identified 150 unique compounds, which inhibited .90% of B. burgdorferi growth at a concentration of ,25 µM. These 150 unique compounds comprise many safe antibiotics, chemical compounds, and also small molecules from plant sources. Of the 150 unique compounds, 101 compounds are FDA approved. We selected the top 20 FDA-approved molecules based on safety and potency and studied their minimum inhibitory concentration and minimum bactericidal concentration. The promising safe FDA-approved candidates that show low minimum inhibitory concentration and minimum bactericidal concentration values can be chosen as lead molecules for further advanced studies

Flushed with the flood: the raimbow trout Oncorhynchus mykiss in the Shatt Al-Arab River, Basrah, Iraq

Heavy storms continually persisted throughout the Iranian highlands and Iraq during the last few months. The consequences of the storms were recorded in several cities in Iraq; however, the toughest effects appeared to be in central and northern governorates, primarily regions through which the Tigris River runs, and those areas adjacent to Iran. The flood water, with high speed current seems to destroy and displaced several aquaculture facilities in Iran that propagate several fish species including the rainbow trout Oncorhynchus mykiss. This study reports on the presence of specimens of rainbow trout seem to be probably washed away by the flood and ended in the river of Shatt al-Arab, Basrah, south of Iraq. With the harsh environment of Shatt al-Arab River, i.e., unfavourable high salinity and temperature, the question will remain whether the rainbow trout will survive and establish a populations

Numerical modelling and sensitivity analysis of natural draft cooling towers

YesCooling towers are a relatively inexpensive and consistent method of ejecting heat from several industries such as thermal power plants, refineries, and food processing. In this research, an earlier model from literature was to be validated across three different case studies. Unlike previous models, this model considers the height of the fill as the discretised domain, which produces results that give it in a distribution form along the height of the tower. As there are limitations with the software used (gPROMS) where differential equations with respect to independent variables in the numerator and denominator cannot be solved, a derivative of the saturation vapour pressure with respect to the temperature of the air was presented. Results shown were in agreement with the literature and a parametric sensitivity analysis of the cooling tower design and operating parameters were undertaken. In this work the height of fill, mass flowrates of water and air were studied with respect to sensitivity analysis. Results had shown large variations in the outlet temperatures of the water and air if the mass flows of water and air were significantly reduced. However, upon high values of either variable had shown only small gains in the rejection of heat from the water stream. With respect to the height of the fill, at larger heights of the fill, the outlet water temperature had reduced significantly. From a cost perspective, it was found that a change in the water flowrate had incurred the largest cost penalty with a 1% increase in flowrate had increased the average operating cost by 1.2%. In comparison, a change in air flowrate where a 1% increase in flowrate had yielded an average of 0.4% increase in operating cost

Modeling Viscosity and Density of Ethanol-Diesel-Biodiesel Ternary Blends for Sustainable Environment

Rapid depletion in fossil fuels, inflation in petroleum prices, and rising energy demand have forced towards alternative transport fuels. Among these alternative fuels, diesel-ethanol and diesel-biodiesel blends gain the most attention due to their quality characteristics and environmentally friendly nature. The viscosity and density of these biodiesel blends are slightly higher than diesel, which is a significant barrier to the commercialization of biodiesel. In this study, the density and viscosity of 30 different ternary biodiesel blends was investigated at 15 °С and 40 °С, respectively. Different density and viscosity models were developed and tested on biodiesel blends soured from different feedstock’s including palm, coconut, soybean, mustard, and calophyllum oils. The prognostic ability and precisions of these developed models was assessed statistically using Absolute Percentage Error (APE) and Mean Absolute Percentage Error (MAPE). The MAPE of 0.045% and 0.085% for density model and 1.85%, 1.41%, 3.48% and 2.27%, 1.85%, 3.50% for viscosity models were obtained on % volume and % mass basis. These developed correlations are useful for ternary biodiesel blends where alcohols are the part of biodiesel blends. The modeled values of densities and viscosities of ternary blends were significantly comparable with the measured densities and viscosities, which are feasible to avoid the harm of vehicles’ operability

Deceased donor organ procurement injuries in the United States

AIM: To determine the incidence of surgical injury during deceased donor organ procurements. METHODS: Organ damage was classified into three tiers, from 1-3, with the latter rendering the organ non-transplantable. For 12 consecutive months starting in January of 2014, 36 of 58 organ procurement organization's (OPO)'s prospectively submitted quality data regarding organ damage (as reported by the transplanting surgeon and confirmed by the OPO medical director) seen on the procured organ. RESULTS: These 36 OPOs recovered 5401 of the nations's 8504 deceased donors for calendar year 2014. A total of 19043 organs procured were prospectively analyzed. Of this total, 59 organs sustained damage making them non-transplantable (0 intestines; 4 pancreata; 5 lungs; 6 livers; 43 kidneys). The class 3 damage was spread over 22 (of 36) reporting OPO's. CONCLUSION: While damage to the procured organ is rare with organ loss being approximately 0.3% of procured organs, loss of potential transplantable organs does occur during procurement

Current Status and Potential of Tire Pyrolysis Oil Production as an Alternative Fuel in Developing Countries

Current status and potential of tire pyrolysis oil production as an alternative fuel in developing countrie