Agricultural intensification, priming for persistence and the emergence of Nipah virus: a lethal bat-borne zoonosis

Emerging zoonoses threaten global health, yet the processes by which they emerge are complex and poorly understood. Nipah virus (NiV) is an important threat owing to its broad host and geographical range, high case fatality, potential for human-to-human transmission and lack of effective prevention or therapies. Here, we investigate the origin of the first identified outbreak of NiV encephalitis in Malaysia and Singapore. We analyse data on livestock production from the index site (a commercial pig farm in Malaysia) prior to and during the outbreak, on Malaysian agricultural production, and from surveys of NiV's wildlife reservoir (flying foxes). Our analyses suggest that repeated introduction of NiV from wildlife changed infection dynamics in pigs. Initial viral introduction produced an explosive epizootic that drove itself to extinction but primed the population for enzootic persistence upon reintroduction of the virus. The resultant within-farm persistence permitted regional spread and increased the number of human infections. This study refutes an earlier hypothesis that anomalous El Niño Southern Oscillation-related climatic conditions drove emergence and suggests that priming for persistence drove the emergence of a novel zoonotic pathogen. Thus, we provide empirical evidence for a causative mechanism previously proposed as a precursor to widespread infection with H5N1 avian influenza and other emerging pathogens

Load-deformation analysis on a slope at Gunung Pulai water treatment plant, Sultan Ibrahim reservoir

The Sultan Ibrahim Reservoir located at Gunung Pulai catchment area was previously managed by the Singapore's Public Utilities Board before the Board handed over the reservoir to Johor State Government under current management of the Syarikat Air Johor. At the present time, the Syarikat Air Johor is operating a Gunung Pulai Water Treatment Plant consisted of two main plants, i.e. Water Sedimentation Plant and Water Filtration Plant for treating raw water from the reservoir before supplying to the consumers. However, the integrity of water treatment plant's structure should be checked due to several cracks were observed, and moreover the structure was built over more than 90 years. The formation of the cracks in the Gunung Pulai Water Treatment Plant may be induced by movement of the sloping area to the south-east of Water Sedimentation Plant. The calculated Factor of Safety (FOS) via sensitivity analysis for cross sections of original slope indicates any decrease in friction angle and/or cohesion strength or increase in horizontal seismic load will further cause instability on slope. Also, the results of Load-Deformation analysis on cross sections of original slope show significant vertical displacement and horizontal displacement on the bottom and both sides of sedimentation tanks, respectively. The results indicate applied structural and water loads significantly affect deformation at both vertical and horizontal directions which could have contributed to FOS < 1 in slope stability analysis

Recurrent Zoonotic Transmission of Nipah Virus into Humans, Bangladesh, 2001–2007

More than half of identified cases result from person-to-person transmission

Risk Factors for Nipah Virus Encephalitis in Bangladesh1

Patients in Goalando were likely infected by direct contact with fruit bats or their secretions, rather than through contact with an intermediate host

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Prevalence, associated factors and predictors of anxiety: a community survey in Selangor, Malaysia

Background: Anxiety is the most common mental health disorders in the general population. This study aimed to determine the prevalence of anxiety, its associated factors and the predictors of anxiety among adults in the community of Selangor, Malaysia. Methods: A cross sectional study was carried out in three districts in Selangor, Malaysia. The inclusion criteria of this study were Malaysian citizens, adults aged 18 years and above, and living in the selected living quarters based on the list provided by the Department of Statistics Malaysia (DOS). Participants completed a set of questionnaires, including the validated Malay version of Generalized Anxiety Disorder 7 (GAD 7) to detect anxiety. Results: Of the 2512 participants who were approached, 1556 of them participated in the study (61.90 %). Based on the cut-off point of 8 and above in the GAD-7, the prevalence of anxiety was 8.2 %. Based on the initial multiple logistic regression analysis, the predictors of anxiety were depression, serious problems at work, domestic violence and high perceived stress. When reanalyzed again after removing depression, low self-esteem and high perceived stress, six predictors that were identified are cancer, serious problems at work, domestic violence, unhappy relationship with family, non-organizational religious activity and intrinsic religiosity. Conclusion: This study reports the prevalence of anxiety among adults in the community of Selangor, Malaysia and also the magnitude of the associations between various factors and anxiety