Analisis Vitamin-C Yang Terkandung Pada Buah Naga Menggunakan Metode Spektrofotometri Uv-Visible

Red dragon fruit atau lebih di kenal sebagai buah naga merupakan tanaman yang berasal dari familia Cactaceae. Kandungan gizi dalam buah naga sangatlah bermacam-macam salah satunya adalah vitamin C. Vitamin C adalah salah satu vitamin yang memiliki antioksida tinggi. Tujuan dari penelitian ini adalah untuk menganilis vitamin-C yang terkandung pada buah naga menggunakan metode spektrofotometri UV-Visible. Metode yang digunakan dalam penulisan ini adalah metode literature review article (LRA) yang merupakan sebuah metode yang sitematis, eksplisit dan reprodusibel dengan pengumpulan data dari berbagai jurnal ilmiah : Google Scholar, Researchgate, ScienceDirect, Pubmed, Publons.  Hasil yang didapatkan dari penelitian ini adalah tumbuhan buah naga merah yang memiliki kandungan  antioksidan dalam bentuk vitamin C yang cukup tinggi kadarnya dan bisa ditentukan menggunakan metode spektrofotometri UV-Visible

Operation of Circuit Breakers: Data and Analysis

[EN] An attempt has been made for the analysis on Circuit breakers (CBs) this paper. First, the types and arcing phenomenon of Oil and SF6 Circuit breakers were briefly discussed. However, various CBs were analyzed in terms of certain outage frequencies and reliability indices to ascertain the most reliable CB. This was possible using data collected from the 33kV Transmission Company of Nigeria (TCN) New Haven, Enugu. After the analysis, Emene Industrial CB had the highest value of availability of 0.9999 and the lowest tripping report while Ezillo had the highest failure rate of 0.1032.The authors are immensely grateful for the financial support from “African Centre of Excellence (ACE-SPED) University of Nigeria, Nsukka” to enable us to achieve the research (Muncho J. Mbunwe et al., 2019-2021).Madueme, VC.; Mbunwe, MJ.; Madueme, TC.; Ahmad, MA.; Anghel Drugarin, CV. (2021). Operation of Circuit Breakers: Data and Analysis. Multidisciplinary Journal for Education, Social and Technological Sciences. 8(2):60-73. https://doi.org/10.4995/muse.2021.12406OJS607382Anyaka, B.O. (2012). Reliability and Maintainability of Power System [Lecture Note]. http://engineering.unn.edu.ngCircuit globe, (n.d.). Circuit breaker, Retrieved June 10, 2017, from open source:- http://circuitglobe.com/circuit-breaker.htmlElectrical concepts, Circuit breaker and Arc Phenomenon, (n.d.). Retrieved June 10, 2017, from open source: http://electricalbaba.com/circuit-breaker-and-arc-phenomenon/Electrical Systems, (n.d.). Retrieved June 10, 2017, from open source: http://skm-eleksys.com/2012/02/sf6-circuit-breaker-working.htmlKezunovic, M. Ren, Z. Latisko, G. Sevcik, D.R. Lucey, J.S. Cook, W.E. and Koch, E.A. (2005). Automated Monitoring and Analysis of Circuit Breaker Operation, IEEE Transactions on Power Delivery, 20(3), p. 1910. https://doi.org/10.1109/TPWRD.2005.848466Pinnekamp, F. (2007). The circuit breaker: a showcase of industrial product development, Transmission group R&D and technology, ABB, Switzerland, p.31. https://new.abb.com/docs/default-source/technology/brosch%C3%BCre-chchrc2017final-einseitig-(002).pdf?sfvrsn=e3f37d14_2Saxena, S. Singh, A. Ali, M. Gandhi, K. (2012). Various Types of Circuit Breakers used in Power System for Smooth Working of the Transmission Line, MIT International Journal of Electrical and Instrumentation Engineering, 2(2), p. 106. https://www.semanticscholar.org/paper/06918326da2b2ac6fd80620d88961b68554b72edSuwanasri, T. Hlaing, M.T. and Suwanasri, C. (2014). Failure Rate Analysis of Power Circuit Breaker in High Voltage Substation, GMSARN International Journal, 8(1), 1-6. http://gmsarnjournal.com/home/journal-vol/journal-vol-8-no-1/Transmission Company of Nigeria. (2016). Tripping reports April - June 2016 [Unpublished Raw data]. New Haven, Enugu, Nigeria. https://www.tcn.org.ng/page_history.phpMuncho J. Mbunwe, M. Ayaz Ahmad, Syed Khalid Mustafa. (2020). An effective energy saving design strategy to maximize the use of electricity, J. Math. Comput. Sci., 10(5), 1808-1833, https://doi.org/10.28919/jmcs/4775Mbunwe Muncho J., Ezema Ejiofor E., Ngwu Anene A., C V Anghel Drugarin, M. Rehan Ajmal, M Ayaz Ahmad. (2021). Characterization of three phase solid state VAR compensation scheme in three phase pulse width modulation voltage source inverter, Journal of Physics: Conference Series, Vol. 1781, 012034, https://doi.org/10.1088/1742-6596/1781/1/012034M. Ayaz Ahmad, Irina Tvoroshenko, Jalal Hasan Baker, Vyacheslav Lyashenko. (2019). Modeling the Structure of Intellectual Means of Decision-Making Using a System Oriented NFO Approach, International Journal of Emerging Trends in Engineering Research , Vol. 7(11), 460-465. https://doi.org/10.30534/ijeter/2019/107112019Mykhailo Kopot, M. Ayaz Ahmad, Vyacheslav Lyashenko, Syed Khalid Mustafa. (2020). Prospects for Creating Sub-Millimeter Magnetrons, International Journal of Advanced Trends in Computer Science and Engineering, Vol. 9(4), 6184-6188. https://doi.org/10.30534/ijatcse/2020/294942020M. Ayaz Ahmad, Irina Tvoroshenko, Jalal Hasan Baker, Vyacheslav Lyashenko. (2019). Computational Complexity of the Accessory Function Setting Mechanism in Fuzzy Intellectual Systems, International Journal of Advanced Trends in Computer Science and Engineering, Vol. 8(5), 2370-2377. https://doi.org/10.30534/ijatcse/2019/77852019Muncho J. Mbunwe, Udochukwu B. Akuru, Hilary U. Ezea, Ogbonnaya I. Okoro, M. Ayaz Ahmad. (2020). Some Aspects of Future Energy Generation in Using of Solar Power Satellites, Int. J. Anal. Appl., 18 (1), 117-128. https://doi.org/10.28924/2291-8639-18-2020-11

The Vlasov limit and its fluctuations for a system of particles which interact by means of a wave field

In two recent publications [Commun. PDE, vol.22, p.307--335 (1997), Commun. Math. Phys., vol.203, p.1--19 (1999)], A. Komech, M. Kunze and H. Spohn studied the joint dynamics of a classical point particle and a wave type generalization of the Newtonian gravity potential, coupled in a regularized way. In the present paper the many-body dynamics of this model is studied. The Vlasov continuum limit is obtained in form equivalent to a weak law of large numbers. We also establish a central limit theorem for the fluctuations around this limit.Comment: 68 pages. Smaller corrections: two inequalities in sections 3 and two inequalities in section 4, and definition of a Banach space in appendix A1. Presentation of LLN and CLT in section 4.3 improved. Notation improve

Cost-effectiveness Analysis of the Dental RECUR Pragmatic Randomized Controlled Trial: Evaluating a Goal-oriented Talking Intervention to Prevent Reoccurrence of Dental Caries in Children

BACKGROUND: The formation of dental caries is the most common chronic disease in children, and is preventable. The oral health-related quality of life has an immense impact on an individual’s daily functioning, well-being or overall quality of life. OBJECTIVES: This study aims to investigate the cost effectiveness of the Dental RECUR Brief Negotiated Interview for Oral Health (DR-BNI). This 30-minute therapeutic “talk” by a dental nurse with a parent/guardian was compared with a placebo-controlled intervention in preventing reoccurrence of dental caries in children who have had a primary tooth extracted. METHODS: An economic model was developed to simulate the clinical progression of dental caries among children who have previously had a primary tooth extracted. The analysis was conducted using the UK NHS perspective. The main outcome was the incremental cost-effectiveness ratio (ICER) based on the quality-adjusted life years (QALYs). Estimates of costs and probabilities were obtained from the DR-BNI multicentre randomised controlled trial (RCT), while QALY values were obtained from published literature. Univariate and probabilistic sensitivity analyses were conducted to assess the uncertainty of the result and robustness of the model. Affordability and risk-aversion of the intervention were investigated to help decision makers make the best possible choices. RESULTS: With an intervention cost of £6.47, the results from the RCT showed the healthcare cost for the DR-BNI intervention was £115.90 per child while the control had a healthcare cost of £119.46 per child. The QALYs gained for the prevention of reoccurrence of dental caries was higher in the DR-BNI intervention arm by 0.023 QALYs; thus, the DR-BNI was the dominant intervention. At willingness to pay threshold of £3500/QALY gained, a maximum probability of being cost effectiveness is achieved at 86%. The secondary analysis showed a cost-savings of £20.94 per participant for the prevention of at least one filling or extraction. Affordability results showed that the DR-BNI programme is affordable to the UK health system at a moderately low budget. CONCLUSIONS: This study shows the proactive talking intervention to have a very moderate cost and to be effective in providing better health related quality-of-life gains. The intervention is cost savings with a dominant ICER even with a 200% increase in the cost of intervention. The NHS will be providing better oral health for children at a better net monetary benefit-to-risk ratio by adopting the DR-BNI intervention in preventing the reoccurrence of dental fillings and extractions for each participant. Trial Registration: This trial was registered prospectively on 27th September 2013 with the trial registration number ISRCTN 24958829. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40258-022-00720-5

Effects of AgRP Inhibition on Energy Balance and Metabolism in Rodent Models

Activation of brain melanocortin-4 receptors (MC4-R) by α-melanocyte-stimulating hormone (MSH) or inhibition by agouti-related protein (AgRP) regulates food intake and energy expenditure and can modulate neuroendocrine responses to changes in energy balance. To examine the effects of AgRP inhibition on energy balance, a small molecule, non-peptide compound, TTP2515, developed by TransTech Pharma, Inc., was studied in vitro and in rodent models in vivo. TTP2515 prevented AgRP from antagonizing α-MSH-induced increases in cAMP in HEK 293 cells overexpressing the human MC4-R. When administered to rats by oral gavage TTP2515 blocked icv AgRP-induced increases in food intake, weight gain and adiposity and suppression of T4 levels. In both diet-induced obese (DIO) and leptin-deficient mice, TTP2515 decreased food intake, weight gain, adiposity and respiratory quotient. TTP2515 potently suppressed food intake and weight gain in lean mice immediately after initiation of a high fat diet (HFD) but had no effect on these parameters in lean chow-fed mice. However, when tested in AgRP KO mice, TTP2515 also suppressed food intake and weight gain during HFD feeding. In several studies TTP2515 increased T4 but not T3 levels, however this was also observed in AgRP KO mice. TTP2515 also attenuated refeeding and weight gain after fasting, an effect not evident in AgRP KO mice when administered at moderate doses. This study shows that TTP2515 exerts many effects consistent with AgRP inhibition however experiments in AgRP KO mice indicate some off-target effects of this drug. TTP2515 was particularly effective during fasting and in mice with leptin deficiency, conditions in which AgRP is elevated, as well as during acute and chronic HFD feeding. Thus the usefulness of this drug in treating obesity deserves further exploration, to define the AgRP dependent and independent mechanisms by which TTP2515 exerts its effects on energy balance

Regularities of morphological changes in the liver and kidneys of rats after acute immobilization stress

In everyday life every modern person is constantly confronted with stress factors. As a result of their actions in the human body there are complex stress reactions that can cause the emergence and development of various pathological changes

Ultrastructural characteristics of human oocytes vitrified before and after in vitro maturation

The development of an effective program that combines in vitro maturation (IVM) and cryopreservation for immature oocytes would represent a novel advance for in vitro fertilization (IVF), especially as a means to preserve the fertility of women in unique situations. The aim of this study was to analyze the ultrastructural characteristics of human oocytes, obtained after controlled ovarian stimulation, to determine whether IVM is best performed before or after vitrification. To this end, we analyzed the following features in a total of 22 MII oocytes: size, zona pellucida and perivitelline space, mitochondria number, M-SER (mitochondria-smooth endoplasmic reticulum) aggregates and M-V (mitochondria-vesicle) complexes, the number of cortical granules and microvilli, and the presence of vacuolization using transmission electron microscopy (TEM). Each oocyte presented a rounded shape, with an intact oolemma, and was surrounded by a continuous zona pellucida and perivitelline space. Statistical analysis comparing oocytes vitrified before or after IVM indicated that there were no significant differences between examined characteristics.This research was supported by the University of Alicante VIGROB-186 and UAUSTI14-04, and by the Chair of Human Fertility of the University of Alicante

Protocol for the Rare Dementia Support Impact Study: RDS Impact

OBJECTIVES: The Rare Dementia Support (RDS) Impact study will be the first major study of the value of multicomponent support groups for people living with or supporting someone with a rare form of dementia. The multicentre study aims to evaluate the impact of multicomponent support offered and delivered to people living with a rare form of dementia, comprising the following five Work Packages (WPs): (1) Longitudinal cohort interviews; (2) Theoretical development; (3) Developing measures; (4) Novel interventions; and (5) Economic analysis. METHODS: This is a mixed-methods design, including a longitudinal cohort study (quantitative and qualitative) and a feasibility randomised control trial (RCT). A cohort of >1000 individuals will be invited to participate. The primary and secondary outcomes will be in-part determined through a co-design Nominal Groups Technique pre-study involving caregivers to people living with a diagnosis of a rare dementia. Quantitative analyses of differences and predictors will be based on pre-specified hypotheses. A variety of quantitative (e.g. ANOVA and multiple linear regression techniques), qualitative (e.g. thematic analysis) and innovative analytical methods will also be developed and applied by involving the arts as a research method. RESULTS: The UCL Research Ethics Committee have approved this study. Data collection will begin in Q4 2019. CONCLUSIONS: The study will capture information through a combination of longitudinal interviews, questionnaires and scales, and novel creative data collection methods. The notion of 'impact' in the context of support for rare dementias will involve theoretical development, novel measures and methods of support interventions, and health economic analyses