Mythological, Historical and Personal: the Story of Creation of Mary Renault’s Dilogy “Theseus”

The article is devoted to the mythological, historical and personal aspects of the creation of the Theseus dilogy (“The King Must Die”, 1958; “The Bull from the Sea”, 1962) by the English author Mary Renault (1905-1983). The relevance of the study is due to the need to comprehend these mythocentric works, which are the result of the synthesis of various types of artistic mythologism. The study is based on the principles of comparative historical, biographical and historical-genetic methods of analysis of a work of art. The traditions of mythologism in the English literature of the twentieth century are analyzed. The following features are distinguished: the mythological tradition of the twentieth century reflects the pressing issues of our time; modern mythologism implies a change or destruction of the canon. It is stated that the principle of historicity of M. Renault novels is implemented on the basis of archaeological and anthropological works of her contemporaries. It is proved that two types of artistic mythologism are simultaneously used in dilogy: demythologization and remythologization. The authors argue that this approach makes mythogenesis possible within the framework of a realistic narrative. In addition, the question about the implementation of the author’s creative intention to attract public attention to the problems of same-sex relationships is raised

Studies of resistance switching effects in metal/YBa2Cu3O7-x interface junctions

Current-voltage characteristics of planar junctions formed by an epitaxial c-axis oriented YBa2Cu3O7-x thin film micro-bridge and Ag counter-electrode were measured in the temperature range from 4.2 K to 300 K. A hysteretic behavior related to switching of the junction resistance from a high-resistive to a low-resistive state and vice-versa was observed and analyzed in terms of the maximal current bias and temperature dependence. The same effects were observed on a sub-micrometer scale YBa2Cu3O7-x thin film - PtIr point contact junctions using Scanning Tunneling Microscope. These phenomena are discussed within a diffusion model, describing an oxygen vacancy drift in YBa2Cu3O7-x films in the nano-scale vicinity of the junction interface under applied electrical fields.Comment: To be published in Applied Surface Science

Investigating the Methods of Management in Education with Taking the Case of a Teacher at the Stage of University

The paper reveals the problem of the professional formation of a future teacher, training a teacher with a high intellectual level of self-awareness, being capable of conceptual thinking, creativity and being ready to independently managing one’s own professional activity, which will allow interacting more effectively with the learning environment, being an active subject of professional and pedagogical activity

Evaluation of the influence of environmental factors on formation of oncologic morbidity of the Orenburg region

The aim of research is a studying of the cancer pathology in Orenburg and in some separate administrative areas. Areas with a high level of a morbidity of malignant neoplasms have been identified in children and adults. The risk’s evaluation of influence of certain carcinogens in ambient air and drinking water on health has been spent. Territories with a high level of risk have been established and priority pollutants have been identified that is causing high levels of risk.Целью исследования являлось изучение онкопатологии в Оренбуржье и в отдельных административных территориях. Выявлены территории с высоким уровнем заболеваемости злокачественными новообразованиями среди детей и взрослых. Проведена оценка риска влияния отдельных канцерогенов атмосферного воздуха и питьевой воды на состояние здоровья населения. Установлены территории с высоким уровнем риска, выявлены приоритетные поллютанты, обусловливающие высокие уровни риска

Nucleoporin98-96 Function Is Required for Transit Amplification Divisions in the Germ Line of Drosophila melanogaster

Production of specialized cells from precursors depends on a tightly regulated sequence of proliferation and differentiation steps. In the gonad of Drosophila melanogaster, the daughters of germ line stem cells (GSC) go through precisely four rounds of transit amplification divisions to produce clusters of 16 interconnected germ line cells before entering a stereotypic differentiation cascade. Here we show that animals harbouring a transposon insertion in the center of the complex nucleoporin98-96 (nup98-96) locus had severe defects in the early steps of this developmental program, ultimately leading to germ cell loss and sterility. A phenotypic analysis indicated that flies carrying the transposon insertion, designated nup98-962288, had dramatically reduced numbers of germ line cells. In contrast to controls, mutant testes contained many solitary germ line cells that had committed to differentiation as well as abnormally small clusters of two, four or eight differentiating germ line cells. This indicates that mutant GSCs rather differentiated than self-renewed, and that these GSCs and their daughters initiated the differentiation cascade after zero, or less than four rounds of amplification divisions. This phenotype remained unaffected by hyper-activation of signalling pathways that normally result in excessive proliferation of GSCs and their daughters. Expression of wildtype nup98-96 specifically in the germ line cells of mutant animals fully restored development of the GSC lineage, demonstrating that the effect of the mutation is cell-autonomous. Nucleoporins are the structural components of the nucleopore and have also been implicated in transcriptional regulation of specific target genes. The nuclear envelopes of germ cells and general nucleocytoplasmic transport in nup98-96 mutant animals appeared normal, leading us to propose that Drosophila nup98-96 mediates the transport or transcription of targets required for the developmental timing between amplification and differentiation

Differential Roles of HOW in Male and Female Drosophila Germline Differentiation

The adult gonads in both male and female Drosophila melanogaster produce gametes that originate from a regenerative pool of germline stem cells (GSCs). The differentiation programme that produces gametes must be co-ordinated with GSC maintenance and proliferation in order to regulate tissue regeneration. The HOW RNA-binding protein has been shown to maintain mitotic progression of male GSCs and their daughters by maintenance of Cyclin B expression as well as suppressing accumulation of the differentiation factor Bam. Loss of HOW function in the male germline results in loss of GSCs due to a delay in G2 and subsequent apoptosis. Here we show that female how mutant GSCs do not have any cell cycle defects although HOW continues to bind bam mRNA and suppress Bam expression. The role of HOW in suppressing germ cell Bam expression appears to be conserved between sexes, leading to different cellular outcomes in how mutants due to the different functions of Bam. In addition the role in maintaining Cyclin B expression has not been conserved so female how GSCs differentiate rather than arrest

Determination of the number of wounded nucleons in Pb+Pb collisions at 158 A GeV/c

The charged particle multiplicity distributions measured by two experiments, WA97 and NA57, in Pb+Pb collisions at 158 A GeV/c have been analyzed in the framework of the wounded nucleon model (WNM). We obtain a good description of the data within the centrality range of our samples. This allows us to make use of the measured multiplicities to estimate the number of wounded nucleons of the collision