INCEFA-PLUS Programme Overview and Update

INCEFA-PLUS is a five year project supported by the European Commission HORIZON2020 programme which commenced in mid 2015. 16 organisations from across Europe have combined forces to deliver new experimental data and a fatigue assessment procedure which will support the development of improved guidelines for assessment of environmental fatigue damage to ensure safe operation of nuclear power plants. Prior to the start of INCEFA-PLUS, an in-kind study was undertaken by several European organisations with the aim of developing the current state of the art for this technical area. This study identified three experimental variables which required further study in order to support improved assessment methodology for environmental fatigue, namely the effects of mean stress/strain, hold time and surface finish. Within INCEFA-PLUS, the effects of these three variables, plus strain amplitude, on fatigue endurance of austenitic stainless steels in light water reactor environments are therefore being studied experimentally. The data obtained will be collected and standardised in an online environmental fatigue database. In order to facilitate the exchange of fatigue data a standardized data format will be developed in the framework of a CEN workshop, to which international participants are welcome to participate. The outcome of the workshop will be a pre-normative document, a CEN Workshop Agreement (CWA) which will set a standard for enabling the exchange of fatigue data not only within the project but within the fatigue community. Based on the data generated and the resulting improvement in understanding, it is planned that INCEFAPLUS will develop and disseminate methods for including the new insights into assessment procedures for environmental fatigue degradation. This will take better account of the effects of mean strain, hold time and surface finish. This paper will provide more details on the background to this project and the way the project is organized to meet its objectives. Details will be provided as to how uncertainties due to variations in testing practice and specimen preparation have been minimized. Additionally, the choices associated with testing for the effects of surface finish, hold time and mean stress will be described along with the status of decisions so far within the project. The paper will also report current status of the project and when findings are likely to be disseminated

Protective role of nutraceuticals against myocarditis

Myocarditis is an inflammatory disease of the myocardium that mostly affects young adults. The disease is commonly caused by viral infection, medications, autoimmune disorders, and inflammatory conditions. Nearly 50% of the cases of myocarditis are due to post-viral immune response in a setting of an identifiable or non-identifiable infection. The clinical manifestation is nonspecific ranging from asymptomatic courses to sudden death in infants and young patients. This review describes the properties of phytochemicals as plant-derived active ingredients which can be used in the prevention and treatment of myocarditis and its associated risk factors. Meanwhile, it has illustrated epidemiological analyses, mechanism of action, and the metabolism of phytochemicals in animal and human clinical trials. We also mentioned the precise mechanism of action by which phytochemicals elicit their anti-viral, anti-inflammatory, antioxidant, and immunomodulatory effects and how they regulate signal transduction pathways. Nevertheless, comprehensive clinical trials are required to study the properties of phytochemicals in vivo, in vitro, and in silico for a proper management of myocarditis. Our findings indicate that phytochemicals function as potent adjunctive therapeutic drugs in myocarditis and its related complications

Application and validation of the notch master curve in medium and high strength structural steels

This paper applies and validates the Notch master curve in two ferritic steels with medium (steel S460M) and high (steel S690Q) strength. The Notch master curve is an engineering tool that allows the fracture resistance of notched ferritic steels operating within their corresponding ductile-to-brittle transition zone to be estimated. It combines the Master curve and the Theory of critical distances in order to take into account the temperature and the notch effect respectively, assuming that both effects are independent. The results, derived from 168 fracture tests on notched specimens, demonstrate the capability of the Notch master curve for the prediction of the fracture resistance of medium and high strength ferritic steels operating within their ductile-to-brittle transition zone and containing notches

Efficient mapping of CO adsorption on Cu1−xMx bimetallic alloys via machine learning

The electrochemical reduction of CO2 (CO2RR) has the potential to allay the greenhouse gas effect while also addressing global energy challenges by producing value-added fuels and chemicals (mostly C-2 molecules such as ethylene and ethanol). However, due to the complicated chemical pathways involved, achieving high selectivity and efficiency towards specific reduction products remains challenging. In fact, the design of more selective and efficient catalysts often relies on trial-and-error approaches, which are very time consuming and resource intensive. In response, driven by the inherent importance of CO adsorption energy in the conversion of CO2 into C2+ hydrocarbons and alcohols, we propose a two-step approach employing machine learning classification and regression algorithms to predict CO binding energies on CuM(111)/(100) (M = Al, Ti, V, Fe, Co, Ni, Zn, Nb, Mo, Ru, Pd, Ag, Cd, Sn, Sb, Hf, W, Ir, Pt, Au) bimetallic surfaces. Firstly, we assess the stability of each adsorption site by utilizing classification algorithms. Subsequently, focusing exclusively on the stable sites, we employ regression models to predict the adsorption energies of CO. Remarkably, by employing a Gradient Boosting Classifier for classification, together with a Gradient Boosting Regressor for regression, we predict CO binding energies with a high level of robustness and accuracy for Cu bimetallic alloys with up to 17% surface impurity concentrations. The accuracy of our models is demonstrated by F1 scores exceeding 96% and a mean square error below 0.05 eV(2) for the classification and regression parts, respectively. These remarkable results highlight the adaptability of our approach and its capability for efficiently screening Cu-based CO2RR electrocatalysts, enabling rapid evaluation of promising candidates for future in-depth explorations

Chemical characterization and surface properties of a new bioemulsifier produced by Pedobacter sp. strain MCC-Z

A novel biopolymer was described in the form of an extracellular polysaccharide (EPS) by Pedobacter sp.strain MCC-Z, a member of a bacterial genus not previously described as an emulsifier producer. Thenew biomolecule was extracted, purified and characterized, and its surface and emulsifying propertieswere evaluated. The purified bioemulsifier, named Pdb-Z, showed high emulsifying activity (E24% = 64%)and reduced the surface tension of water up to 41 mN/m with a critical micelle concentration value of2.6 mg/mL. The chemical characterization of Pdb-Z was performed using1H NMR, FT-IR, HPLC/MS/MS andGC/MS. Pdb-Z was found to contain 67% of carbohydrates, consisting mainly of galactose and minor quan-tities of talose, 30% of lipids, being pentadecanoic acid the major lipidic constituent, and 3% of proteins. Thebioemulsifier was a glycolipids-protein complex with an estimated molecular mass of 106Da. Further-more, Pdb-Z emulsified pure aliphatic and aromatic hydrocarbons as well as diesel more efficiently thancommercial synthetic surfactants, used for comparison. Our results suggest Pdb-Z has interesting prop-erties for applications in remediation of hydrocarbon-contaminated environments and bioremediation processes

Statin therapy in chronic viral hepatitis: a systematic review and meta-analysis of nine studies with 195,602 participants

Background: Conflicting data suggest that statins could cause chronic liver disease in certain group of patients, while improving prognosis in those with chronic viral hepatitis (CVH). Purpose: To quantify the potential protective role of statins on some main liver-related health outcomes in clinical studies on CVH patients.Data Sources: The search strategy was explored by a medical librarian using bibliographic databases, from January 2015 to April 2020.Data synthesis: The results showed no significant difference in the risk of mortality between statin users and non-users in the overall analysis. However, the risk of mortality significantly reduced by 39% in statin users who were followed for more than three years. Moreover, the risk of HCC, fibrosis, and cirrhosis in those on statins decreased by 53%, 45% and 41%, respectively. Although ALT and AST reduced slightly following statin therapy, this reduction was not statistically significant. Limitations: A significant heterogeneity among studies was observed, resulting from differences in clinical characteristics between statin users and non-users, study designs, population samples, diseases stage, comorbidities, and confounding covariates. Conclusion: Not only long-term treatment with statins seems to be safe in patients affected by hepatitis, but also it significantly improves their prognosis

Efficacy and safety of Armolipid Plus®: an updated PRISMA compliant systematic review and meta-analysis of randomized controlled clinical trials.

Armolipid Plus® is a multi-constituent nutraceutical that claims to improve lipid profiles. The aim of this PRISMA compliant systematic review and meta-analysis was to globally evaluate the efficacy and safety of Armolipid Plus® on the basis of the available randomized, blinded, controlled clinical trials (RCTs). A systematic literature search in several databases was conducted in order to identify RCTs assessing the efficacy and safety of dietary supplementation with Armolipid Plus®. Two review authors independently identified 12 eligible studies (1050 included subjects overall) and extracted data on study characteristics, methods, and outcomes. Meta-analysis of the data suggested that dietary supplementation with Armolipid Plus® exerted a significant effect on body mass index (mean difference (MD) = -0.25 kg/m2, p = 0.008) and serum levels of total cholesterol (MD = -25.07 mg/dL, p < 0.001), triglycerides (MD = -11.47 mg/dL, p < 0.001), high-density lipoprotein cholesterol (MD = 1.84 mg/dL, p < 0.001), low-density lipoprotein cholesterol (MD = -26.67 mg/dL, p < 0.001), high sensitivity C reactive protein (hs-CRP, MD = -0.61 mg/L, p = 0.022), and fasting glucose (MD = -3.52 mg/dL, p < 0.001). Armolipid Plus® was well tolerated. This meta-analysis demonstrates that dietary supplementation with Armolipid Plus® is associated with clinically meaningful improvements in serum lipids, glucose, and hs-CRP. These changes are consistent with improved cardiometabolic health

Utilização de raios X na avaliação de danos causados por caruncho em sementes de feijão-caupi

In Brazil, the cowpea [Vigna unguiculata (L.) Walp], is important in the Northeast Region, where it is typically grown on family farms. The importance of the damage caused to the seed quality of this species by stored pests has been described in various studies. Using X-ray, it is possible to see the internal seed structures and identify possible changes and damage. The objective of this study was to identify the damage caused by the weevil [Callosobruchus maculatus (Fabr.)] by analyzing X-ray and evaluate its relationship to the physiological quality of the cowpea seed. Three cultivars were used (IPA-206, BRS-Pajeu and BRS-Potengi) and two lines (L 281.005 and L ESP 10). The samples were exposed to X-ray and germination test to determine the cause-effect relationship between weevil damage and seed germination. X-ray images were evaluated to determine damage severity and location in the seed. Seed damage classified as severe, located in the embryonic axis or in the cotyledons, resulted in abnormal seedlings or dead seeds. The X-ray test, therefore, is efficient for evaluating weevil damage in cowpea seeds and the damage caused to be associated with any resulting adverse germination effects.No Brasil, o feijão-caupi [Vigna unguiculata (L.) Walp], tem destaque na Região Nordeste, sendo uma cultura típica da agricultura familiar. A importância dos danos causados por pragas de armazenamento em sementes da referida espécie, em relação à sua qualidade, tem sido evidenciada em vários trabalhos. Através de imagens de raios X é possível visualizar as estruturas internas da semente, identificando possíveis alterações e danificações. Dessa forma, esse trabalho teve o objetivo de identificar os danos causados por caruncho (Callosobruchus maculatus) e sua relação com a qualidade fisiológica das sementes de feijão-caupi, por intermédio da análise de raios X. Foram utilizadas três cultivares (IPA-206, BRS-Pajeu e BRS-Potengi) e duas linhagens (L 281.005 e L ESP 10). As amostras foram submetidas ao teste de raios X e ao teste de germinação, a fim de determinar a relação de causa e efeito entre os danos provocados pelo caruncho e a germinação das sementes. Nas avaliações das imagens de raios X foi considerada a severidade e a localização dos danos na semente. Para os danos classificados como severos, localizados no eixo embrionário e, ou nos cotilédones, as sementes originaram plântulas anormais ou as sementes estavam mortas. Portanto, o teste de raios X é eficiente para a avaliação de danos causados por caruncho em sementes de feijão-caupi, permitindo relacionar os eventuais danos com os prejuízos causados à germinação.Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)CNP

Speciation in Western Scrub-Jays, Haldane’s rule, and genetic clines in secondary contact

Background Haldane’s Rule, the tendency for the heterogametic sex to show reduced fertility in hybrid crosses, can obscure the signal of gene flow in mtDNA between species where females are heterogametic. Therefore, it is important when studying speciation and species limits in female-heterogametic species like birds to assess the signature of gene flow in the nuclear genome as well. We studied introgression of microsatellites and mtDNA across a secondary contact zone between coastal and interior lineages of Western Scrub-Jays (Aphelocoma californica) to test for a signature of Haldane’s Rule: a narrower cline of introgression in mtDNA compared to nuclear markers. Results Our initial phylogeographic analysis revealed that there is only one major area of contact between coastal and interior lineages and identified five genetic clusters with strong spatial structuring: Pacific Slope, Interior US, Edwards Plateau (Texas), Northern Mexico, and Southern Mexico. Consistent with predictions from Haldane’s Rule, mtDNA showed a narrower cline than nuclear markers across a transect through the hybrid zone. This result is not being driven by female-biased dispersal because neutral diffusion analysis, which included estimates of sex-specific dispersal rates, also showed less diffusion of mtDNA. Lineage-specific plumage traits were associated with nuclear genetic profiles for individuals in the hybrid zone, indicating that these differences are under genetic control. Conclusions This study adds to a growing list of studies that support predictions of Haldane’s Rule using cline analysis of multiple loci of differing inheritance modes, although alternate hypotheses like selection on different mtDNA types cannot be ruled out. That Haldane’s Rule appears to be operating in this system suggests a measure of reproductive isolation between the Pacific Slope and interior lineages. Based on a variety of evidence from the phenotype, ecology, and genetics, we recommend elevating three lineages to species level: A. californica (Pacific Slope); A. woodhouseii (Interior US plus Edwards Plateau plus Northern Mexico); A. sumichrasti (Southern Mexico). The distinctive Edwards Plateau population in Texas, which was monophyletic in mtDNA except for one individual, should be studied in greater detail given habitat threat