Carney triad. Report of one case

Indexación: Scopus.Carney described a disorder characterized by the presence of several uncommon tumors which were pulmonary chondromas, gastric sarcomas and extra-adrenal paragangliomas. We report a 14 year-old girl in whom multiple gastric tumors were discovered during a study of an iron deficiency anemia and was subjected to a partial gastrectomy. At 25 years of age, she developed several pulmonary chondromas and at 33 years, a mediastinal tumor with features of an extra-adrenal paraganglioma was found. At 35 years of age, a total gastrectomy was performed to remove a gastrointestinal stromal tumor with excision of peritoneal and lymph node metastasis. One year later, the patient died due to liver failure secondary to liver metastases.http://ref.scielo.org/4jhgg

Determinación de los índices de salud nutricional de la leche fresca de bovino mediante espectroscopía de infrarrojo cercano

Bovine milk is one of the most complete foods that exist. During the last decades, milk FA have shown to improve human health due to the reduction in risk of cardiovascular disease and related pathologies. The aim of this study was to evaluate the feasibility of near infrared spectroscopy (NIRS) reflectance analysis to predict the nutritional value, fatty acid (FA) composition, and health index of fresh milk from dairy cows of pastoral systems. The prediction of Atherogenicity and Thrombogenicity indexes, along with other FA ratios in fresh milk samples by NIRS were precise and accurate. In addition, the calibration model obtained by NIRS provides an opportunity for the routine quantification of milk’s healthy FA such as omega-3 and conjugated linoleic acid (CLA), with applications in the dairy industry for food labeling, and at the farm level for management of the dairy cow’s diet.La leche bovina es uno de los alimentos más completos que existe. Durante la última década, se ha demostrado que los ácidos grasos de la leche pueden mejorar la salud humana, a través de la reducción del riesgo de enfermedades cardiovasculares y patologías asociadas. El objetivo de este estudio fue evaluar la factibilidad del análisis de reflectancia NIRS para predecir valor nutricional, composición de ácidos grasos e índices de salud de leche fresca de vacas de sistemas lecheros pastoriles. La predicción por NIRS del índice aterogénico y trombogénico, de ácidos grasos en muestras de leche fresca, fueron precisos. Por tanto, el modelo de calibración obtenido por NIRS representa una oportunidad para la cuantificación rutinaria de los ácidos grasos saludables de la leche como omega-3 y CLA, con aplicaciones en la industria lechera para el etiquetado nutricional y a nivel de lechería para el manejo de la alimentación de las vacas

Genetic Dissection of Strain Dependent Paraquat-induced Neurodegeneration in the Substantia Nigra Pars Compacta

The etiology of the vast majority of Parkinson's disease (PD) cases is unknown. It is generally accepted that there is an interaction between exposures to environmental agents with underlying genetic sensitivity. Recent epidemiological studies have shown that people living in agricultural communities have an increased risk of PD. Within these communities, paraquat (PQ) is one of the most utilized herbicides. PQ acts as a direct redox cycling agent to induce formation of free radicals and when administered to mice induces the cardinal symptoms of parkinsonism, including loss of TH+-positive dopaminergic (DA) neurons in the ventral midbrain's substantia nigra pars compacta (SNpc). Here we show that PQ-induced SNpc neuron loss is highly dependent on genetic background: C57BL/6J mice rapidly lose ∼50% of their SNpc DA neurons, whereas inbred Swiss-Webster (SWR/J) mice do not show any significant loss. We intercrossed these two strains to map quantitative trait loci (QTLs) that underlie PQ-induced SNpc neuron loss. Using genome-wide linkage analysis we detected two significant QTLs. The first is located on chromosome 5 (Chr 5) centered near D5Mit338, whereas the second is on Chr 14 centered near D14Mit206. These two QTLs map to different loci than a previously identified QTL (Mptp1) that controls a significant portion of strain sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), suggesting that the mechanism of action of these two parkinsonian neurotoxins are different

Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03-1.07), HIV infection (HR 2.29, 95% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02-1.04), male sex (HR 2.21, 95% CI 1.24-3.91), oxygen requirement (HR 7.93, 95% CI 3.44-18.26) and invasive ventilation (HR 2.19, 95% CI 1.36-3.53). Conclusions: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes

Estudio florístico y vegetacional de una gradiente latitudinal en marismas del centro-sur de Chile

Las marismas son pantanos salobres que se forman en los estuarios de los ríos. Se estudió la flora y la vegetación de tres marismas ubicadas en Puerto Saavedra (Provincia de Cautín, 38º 46' S y 73º 24' W), Mehuín (Provincia de Valdivia, 39º 26' S y 73º 12' W), y Quillaipe (Provincia de Llanquihue, 41º 32' S y 72º 44' W), distribuidos en una gradiente latitudinal de alrededor de 400 km, en el centrosur de Chile. Por tratarse de formaciones vegetales azonales, que no dependen del macroclima, se esperaría altas similitudes florísticas y vegetacionales entre ellas. Se trabajó con metodología fitosociológica, muestreando 10 parcelas por marisma, a lo largo de un transepto de 100 m iniciado en el límite inferior de la vegetación. Se determinaron 18 especies halófitas, de las cuales sólo cuatro fueron alóctonas: Cotula coronopifolia, Spergularia rubra, Leontodon saxatilis y Lolium multiflorum. La primera especie se identificó en las tres marismas, pero dominó en Mehuín. Las otras tres especies sólo se detectaron en Mehuín. Esto sugiere que Mehuín ha sido el lugar más intervenido. La similitud florística demostró baja afinidad entre marismas, pero se encontró mayor similitud entre Mehuín y Quillaipe y menor entre Puerto Saavedra y Quillaipe. La mayor similitud florística entre Mehuín y Quillaipe se contrapone con la lejanía geográfica y climática entre esos lugares. Mehuín está más próximo a Puerto Saavedra. La vegetación de los extremos del gradiente latitudinal resultó más homogénea que aquella del lugar intermedio. Según los análisis estadísticos multivariados, los factores de anegamiento y salinidad aparecen como responsables de la distribución de las especies en la gradiente altitudinal en cada lugar. La diferencia florística entre los lugares sugiere la presencia de una gradiente latitudinal que no corresponde al carácter azonal de las marismas. La inclinación de la gradiente litoral y la naturaleza del sustrato en los diferentes lugares, podrían ser los factores responsables de las diferencias encontradas

Preselection of high and low ovulatory responders in sheep multiple ovulation and embryo transfer programs

The present study evaluated the feasibility of carrying out an easy-to-handle and cost-efficient test for the preselection of high– and low–ovulatory responder ewes under superovulatory protocols. The test was based on the assessment of the number of ovulations obtained in response to the administration of a single-shot eCG treatment. The predictive value of the test was determined by comparing the number of ovulations with yields obtained in response to a multiple-dose FSH treatment. In addition, the study determined possible effects of follicular status at first FSH dose and their relationship with subsequent ovarian response. A total of 31 Merino ewes received hormonal treatment comprising the administration of 800 IU of eCG at the end of progestative treatment. Twenty-three days later, multiple-dose FSH treatment (80-mg FSH, in six decreasing doses between Days 12 and 14 of a second progestative treatment) was applied to the same ewes. The study showed a significant relationship between the number of corpora lutea obtained in response to eCG treatment with respect to those obtained in response to FSH treatment (r = 0.791; P 0.05). Hence, there was a tendency for a higher mean of grades 1 and 2 embryos in high-responder in relation to low-responder ewes (6.1 ± 3.8 and 3.7 ± 4.0, respectively; P 0.05). However, a negative low relationship was found between the presence of large follicles and the ovulation rate in response to FSH treatment (r = −0.361; P < 0.05). In conclusion, the results show the feasibility of carrying out an easy-to-handle and cost-efficient procedure for the preselection of embryo donors. The procedure was based on high recurrence rate between hormonal treatments, which in turn accounts for a distinctive ewe ovulatory response.Fil: Bruno Gallaraga, M.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche; ArgentinaFil: Cueto, M.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche; ArgentinaFil: Gibbons, A.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche; ArgentinaFil: Pereyra Bonnet, Federico Alberto. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Subiabre, M.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche; ArgentinaFil: Gonzalez Bulnes, A.. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria; Españ