The Collimated Jet Source in IRAS 16547-4247: Time Variation, Possible Precession, and Upper Limits to the Proper Motions Along the Jet Axis

The triple radio source detected in association with the luminous infrared source IRAS 16547-4247 has previously been studied with high angular resolution and high sensitivity with the Very Large Array (VLA) at 3.6-cm wavelength. In this paper, we present new 3.6 cm observations taken 2.68 years after the first epoch that allow a search for variability and proper motions, as well as the detection of additional faint sources in the region. We do not detect proper motions along the axis of the outflow in the outer lobes of this source at a 4-$\sigma$ upper limit of $\sim$160 km s$^{-1}$. This suggests that these lobes are probably working surfaces where the jet is interacting with a denser medium. However, the brightest components of the lobes show evidence of precession, at a rate of $0\rlap.^\circ08$ yr$^{-1}$ clockwise in the plane of the sky. It may be possible to understand the distribution of almost all the identified sources as the result of ejecta from a precessing jet. The core of the thermal jet shows significant variations in flux density and morphology. We compare this source with other jets in low and high mass young stars and suggest that the former can be understood as a scaled-up version of the latter.Comment: 26 pages, 9 figure

The Rotating Molecular Structures and the Ionized Outflow Associated with IRAS 16547-4247

We present VLA 1.3 cm radio continuum and water maser observations as well as SMA SO$_2$ (226.300 GHz) and 1.3 mm dust continuum observations toward the massive star formation region IRAS 16547-4247. We find evidence of multiple sources in the central part of the region. There is evidence of a rotating structure associated with the most massive of these sources, traced at small scales (~50 AU) by the water masers. At large scales (~1000 AU) we find a velocity gradient in the SO2 molecular emission with a barely resolved structure that can be modeled as a rotating ring or two separate objects. The velocity gradients of the masers and of the molecular emission have the same sense and may trace the same structure at different size scales. The position angles of the structures associated with the velocity gradients are roughly perpendicular to the outflow axis observed in radio continuum and several molecular tracers. We estimate the mass of the most massive central source to be around 30 solar masses from the velocity gradient in the water maser emission. The main source of error in this estimate is the radius of the rotating structure. We also find water masers that are associated with the large scale molecular outflow of the system, as well as water masers that are associated with other sources in the region. Our results suggest that the formation of this source, one of the most luminous protostars or protostellar clusters known, is taking place with the presence of ionized jets and disk-like structures.Comment: 26 pages, 7 figure

The Narrow Line Region of Ark 564

The continuum and emission-line spectrum of the narrow-line Seyfert 1 galaxy Ark 564 is used to investigate, for the first time, the physical conditions and structure of its narrow line region (NLR). For this purpose, composite models, accounting for the coupled effect of photoionization and shocks, are employed. The emission-line spectrum of Ark 564, which ranges from the ultraviolet to the near-infrared, shows a rich forbidden line spectrum. Strong emphasis is given to the study of the coronal line region. The diversity of physical conditions deduced from the observations requires multi-cloud models to reproduce the observed lines and continuum. We find that a combination of high velocity (Vs = 1500 km/s) shock-dominated clouds as well as low velocity (Vs = 150 km/s) radiation-dominated clouds explains the coronal lines, while the optical low-ionization lines are mainly explained by shock-dominated clouds. The results for Ark 564 are compared with those obtained for other Seyfert galaxies previously analyzed such as NGC 5252, Circinus, NGC 4051 and NGC 4151. The model results for the ultraviolet and optical permitted lines suggest that the broad line region may contribute up to 80%, depending on the emission-line, being of about 30% for Hbeta. The consistency of the multi-cloud model is checked by comparing the predicted and observed continuum, from radio to X-ray, and indicate that the dust-to-gas ratio in the clouds varies from 10^{-15} to 10^{-12}.Comment: 18 pages, 1 figure. Accepted in A&

Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen

<p>Abstract</p> <p>Background</p> <p>During pregnancy the immune system of the mother must protect any activation that may negatively affect the fetus. Changes in susceptibility to infection as well as resolution of some autoimmune disorders represent empirical evidence for pregnancy related alterations in immunity. Sex hormones reach extremely high levels during pregnancy and have been shown to have direct effects on many immune functions including the antiviral response of dendritic cells. Among the immunologically active proteins secreted by monocyte derived DCs (MDDC) are the alpha-defensins 1-3. This family of cationic antimicrobial peptides has a broad spectrum of microbicidal activity and has also been shown to link innate to adaptive immunity by attracting T cells and immature DCs, which are essential for initiating and polarizing the immune response.</p> <p>Methods</p> <p>We compare culture-generated monocyte derived DCs (MDDCs) with directly isolated myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) and measure their alpha-defensins 1-3 secretion by ELISA both, in basal situations and after hormone (E2 or PG) treatments. Moreover, using a cohort of pregnant women we isolated mDCs from blood and also measure the levels of these anti-microbial peptides along pregnancy.</p> <p>Results</p> <p>We show that mDCs and pDCs constitutively produce alpha-defensins 1-3 and at much higher levels than MDDCs. Alpha-defensins 1-3 production from mDCs and MDDCs but not pDCs is inhibited by E2. PG does not affect alpha-defensins 1-3 in any of the populations. Moreover, alpha-defensins 1-3 production by mDCs was reduced in the later stages of pregnancy in 40% of the patients.</p> <p>Conclusions</p> <p>Here, we demonstrate that mDCs and pDCs secrete alpha-defensins 1-3 and present a novel effect of E2 on the secretion of alpha-defensins 1-3 by dendritic cells.</p

Analysis of the mechanical properties of wood attacked by Xylotrechus arvicola (Coleoptera: Cerambycidae) larvae, and its influence on the structural properties of the plant

Xylotrechus arvicola is an invasive insect on Vitis vinifera in the main wine-producing regions of the Iberian Peninsula. X. arvicola larvae bore into the grapevine wood and make galleries, which cause structural damages to the plant. The aim of this study was to investigate how grapevine wood infested by larvae affects the mechanical properties of the plant in comparation with those of uninfested wood. Samples of grapevine wood uninfested and infested by larvae were collected from vineyards. Compression and flexural strengths as well as simulated structures of grapevine wood in field, in relation to harvest weight by variety, were used to quantify the wood mechanical properties. Infested wood endured a lower strength and normal tension, and exhibited a reduction in the structural capacities in the simulation of harvest weight of 'Cabernet-Sauvignon' variety (up to 62.0 %). 'Tempranillo' (despite its high mechanical slenderness values) and 'Cabernet-Sauvignon', were the varieties that showed a higher resistance on trunks and branches, respectively. A lower bending moment was observed on the infested branches of all varieties. Changes in the mechanical properties of infested wood suggest a decrease in mechanical resistance of wood attacked by larvae that could contribute to the rupture of the infested grapevine over time. Grapevine wood attacked by X. arvicola larvae could be more sensitive to mechanical external factors in vineyards such as strong winds, harvest weight and vibration exerted by harvesting machines

The Collimated Jet Source in IRAS 16547-4247: Time Variation, Possible Precession, and Upper Limits to the Proper Motions along the Jet Axis

The triple radio source detected in association with the luminous infrared source IRAS 16547-4247 has previously been studied with high angular resolution and high sensitivity with the Very Large Array at 3.6 cm wavelength. In this paper, we present new 3.6 cm observations taken 2.68 years after the first epoch that allow a search for variability and proper motions, as well as the detection of additional faint sources in the region. We do not detect proper motions along the axis of the outflow in the outer lobes of this source at a 4σ upper limit of ~160 $km s^{−1}$. This suggests that these lobes are probably working surfaces where the jet is interacting with a denser medium. However, the brightest components of the lobes show evidence of precession, at a rate of $0\mathring{.}08 yr^{−1}$ clockwise in the plane of the sky. It may be possible to understand the distribution of almost all the identified sources as the result of ejecta from a precessing jet. The core of the thermal jet shows significant variations in flux density and morphology. We compare this source with other jets in low- and high-mass young stars and suggest that the latter can be understood as a scaled-up version of the former.Astronom

Iodoarene-Catalyzed Cyclizations of Unsaturated Amides

The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route. Preliminary data from the use of chiral iodoarenes as precatalysts show that enantiocontrol is feasible

A disk of dust and molecular gas around a high-mass protostar

The processes leading to the birth of low-mass stars such as our Sun have been well studied, but the formation of high-mass (> 8 x Sun's mass) stars has heretofore remained poorly understood. Recent observational studies suggest that high-mass stars may form in essentially the same way as low-mass stars, namely via an accretion process, instead of via merging of several low-mass (< 8 Msun) stars. However, there is as yet no conclusive evidence. Here, we report the discovery of a flattened disk-like structure observed at submillimeter wavelengths, centered on a massive 15 Msun protostar in the Cepheus-A region. The disk, with a radius of about 330 astronomical units (AU) and a mass of 1 to 8 Msun, is detected in dust continuum as well as in molecular line emission. Its perpendicular orientation to, and spatial coincidence with the central embedded powerful bipolar radio jet, provides the best evidence yet that massive stars form via disk accretion in direct analogy to the formation of low-mass stars

The rotating molecular structures and the ionized outflow associated with IRAS 16547-4247

We present Very Large Array 1.3 cm radio continuum and water maser observations as well as Submillimeter Array SO 2 (226.300 GHz) and 1.3 mm dust continuum observations toward the massive star formation region IRAS 16547−4247. We find evidence of multiple sources in the central part of the region. There is evidence of a rotating structure associated with the most massive of these sources, traced at small scales (∼50 AU) by the water masers. At large scales (∼1000 AU), we find a velocity gradient in the SO 2 molecular emission with a barely resolved structure that can be modeled as a rotating ring or two separate objects. The velocity gradients of the masers and of the molecular emission have the same sense and may trace the same structure at different size scales. The position angles of the structures associated with the velocity gradients are roughly perpendicular to the outflow axis observed in radio continuum and several molecular tracers. We estimate the mass of the most massive central source to be around 30 solar masses from the velocity gradient in the water maser emission. The main source of error in this estimate is the radius of the rotating structure. We also find water masers that are associated with the large-scale molecular outflow of the system, as well as water masers that are associated with other sources in the region. Our results suggest that the formation of this source, one of the most luminous protostars or protostellar clusters known, is taking place with the presence of ionized jets and disk-like structures.Astronom

Distinct Associations of BMI and Fatty Acids With DNA Methylation in Fasting and Postprandial States in Men

We have previously shown that blood global DNA methylation (DNAm) differs between postprandial state (PS) and fasting state (FS) and is associated with BMI and polyunsaturated fatty acid (PUFA) (negatively and positively, respectively) in 12 metabolically healthy adult Mexican men (AMM cohort) equally distributed among conventional BMI classes. Here, we detailed those associations at CpG dinucleotide level by exploiting the Infinium methylation EPIC array (Illumina). We sought differentially methylated CpG (dmCpG) that were (1) associated with BMI (BMI-dmCpG) and/or fatty acids (FA) (FA-dmCpG) in FS or PS and (2) different across FS and PS within a BMI class. BMI-dmCpG and FA-dmCpG were more numerous in FS compared to PS and largely prandial state-specific. For saturated and monounsaturated FA, dmCpG overlap was higher across than within the respective saturation group. Several BMI- and FA-dmCpG mapped to genes involved in metabolic disease and in some cases matched published experimental data sets. Notably, SETDB1 and MTHFS promoter dmCpG could explain the previously observed associations between global DNAm, PUFA content, and BMI in FS. Surprisingly, overlap between BMI-dmCpG and FA-dmCpG was limited and the respective dmCpG were differentially distributed across functional genomic elements. BMI-dmCpG showed the highest overlap with dmCpG of the saturated FA palmitate, monounsaturated C20:1 and PUFA C20:2. Of these, selected promoter BMI-dmCpG showed opposite associations with palmitate compared to C20:1 and C20:2. As for the comparison between FS and PS within BMI classes, dmCpG were strikingly more abundant and variably methylated in overweight relative to normoweight or obese subjects (∼70-139-fold, respectively). Overweight-associated dmCpG-hosting genes were significantly enriched in targets for E47, SREBP1, and RREB1 transcription factors, which are known players in obesity and lipid homeostasis, but none overlapped with BMI-dmCpG. We show for the first time that the association of BMI and FA with methylation of disease-related genes is distinct in FS and PS and that limited overlap exists between BMI- and FA-dmCpG within and across prandial states. Our study also identifies a transcriptional regulation circuitry in overweight that might contribute to adaptation to that condition or to transition to obesity. Further work is necessary to define the pathophysiological implications of these findings