1,349 research outputs found
Effects On One-third Integer Resonant Extraction Due To sextupole Fields in The Lattice Bending Magnets
Novel genetic markers improve measures of atrial fibrillation risk prediction
Aims Atrial fibrillation (AF) is associated with adverse outcome. Whether recently discovered genetic risk markers improve AF risk prediction is unknown. Methods and results We derived and validated a novel AF risk prediction model from 32 possible predictors in the Women's Health Study (WHS), a cohort of 20 822 women without cardiovascular disease (CVD) at baseline followed prospectively for incident AF (median: 14.5 years). We then created a genetic risk score (GRS) comprised of 12 risk alleles in nine loci and assessed model performance in the validation cohort with and without the GRS. The newly derived WHS AF risk algorithm included terms for age, weight, height, systolic blood pressure, alcohol use, and smoking (current and past). In the validation cohort, this model was well calibrated with good discrimination [C-index (95% CI) = 0.718 (0.684-0.753)] and improved all reclassification indices when compared with age alone. The addition of the genetic score to the WHS AF risk algorithm model improved the C-index [0.741 (0.709-0.774); P = 0.001], the category-less net reclassification [0.490 (0.301-0.670); P < 0.0001], and the integrated discrimination improvement [0.00526 (0.0033-0.0076); P < 0.0001]. However, there was no improvement in net reclassification into 10-year risk categories of <1, 1-5, and 5+% [0.041 (−0.044-0.12); P = 0.33]. Conclusion Among women without CVD, a simple risk prediction model utilizing readily available risk markers identified women at higher risk for AF. The addition of genetic information resulted in modest improvements in predictive accuracy that did not translate into improved reclassification into discrete AF risk categorie
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Novel genetic markers improve measures of atrial fibrillation risk prediction
Aims Atrial fibrillation (AF) is associated with adverse outcome. Whether recently discovered genetic risk markers improve AF risk prediction is unknown. Methods and results We derived and validated a novel AF risk prediction model from 32 possible predictors in the Women's Health Study (WHS), a cohort of 20 822 women without cardiovascular disease (CVD) at baseline followed prospectively for incident AF (median: 14.5 years). We then created a genetic risk score (GRS) comprised of 12 risk alleles in nine loci and assessed model performance in the validation cohort with and without the GRS. The newly derived WHS AF risk algorithm included terms for age, weight, height, systolic blood pressure, alcohol use, and smoking (current and past). In the validation cohort, this model was well calibrated with good discrimination [C-index (95% CI) = 0.718 (0.684–0.753)] and improved all reclassification indices when compared with age alone. The addition of the genetic score to the WHS AF risk algorithm model improved the C-index [0.741 (0.709–0.774); P = 0.001], the category-less net reclassification [0.490 (0.301–0.670); P < 0.0001], and the integrated discrimination improvement [0.00526 (0.0033–0.0076); P < 0.0001]. However, there was no improvement in net reclassification into 10-year risk categories of <1, 1–5, and 5+% [0.041 (−0.044–0.12); P = 0.33]. Conclusion: Among women without CVD, a simple risk prediction model utilizing readily available risk markers identified women at higher risk for AF. The addition of genetic information resulted in modest improvements in predictive accuracy that did not translate into improved reclassification into discrete AF risk categories
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How close are hyperdeformed states to the scission point?
The HFB method with the Gogny force is used to study the effects of reflection asymmetry at I = 0{h_bar} on the barriers separating superdeformed and hyperdeformed minima from fission in the {sup 176}W and {sup 168}Yb nuclei. The fission barrier for the HD minimum is reduced by 5 MeV in {sup 176}W when reflection asymmetry is taken into account
Measurement of the response of heat-and-ionization germanium detectors to nuclear recoils
The heat quenching factor Q' (the ratio of the heat signals produced by
nuclear and electron recoils of equal energy) of the heat-and-ionization
germanium bolometers used by the EDELWEISS collaboration has been measured. It
is explained how this factor affects the energy scale and the effective
quenching factor observed in calibrations with neutron sources. This effective
quenching effect is found to be equal to Q/Q', where Q is the quenching factor
of the ionization yield. To measure Q', a precise EDELWEISS measurement of Q/Q'
is combined with values of Q obtained from a review of all available
measurements of this quantity in tagged neutron beam experiments. The
systematic uncertainties associated with this method to evaluate Q' are
discussed in detail. For recoil energies between 20 and 100 keV, the resulting
heat quenching factor is Q' = 0.91+-0.03+-0.04, where the two errors are the
contributions from the Q and Q/Q' measurements, respectively. The present
compilation of Q values and evaluation of Q' represent one of the most precise
determinations of the absolute energy scale for any detector used in direct
searches for dark matter.Comment: 28 pages, 7 figures. Submitted to Phys. Rev.
Parametrization of the octupole degrees of freedom
A simple parametrization for the octupole collective variables is proposed
and the symmetries of the wave functions are discussed in terms of the
solutions corresponding to the vibrational limit. [PACS: 21.60Ev, 21.60.Fw,
21.10.Re]Comment: 14 page
Tri-axial Octupole Deformations and Shell Structure
Manifestations of pronounced shell effects are discovered when adding
nonaxial octupole deformations to a harmonic oscillator model. The degeneracies
of the quantum spectra are in a good agreement with the corresponding main
periodic orbits and winding number ratios which are found by classical
analysis.Comment: 10 pages, Latex, 4 postscript figures, to appear in JETP Letter
Intrinsic vs. laboratory frame description of the deformed nucleus 48Cr
The collective yrast band of the nucleus Cr is studied using the
spherical shell model and the HFB method. Both approaches produce basically the
same axially symmetric intrinsic state up to the - accurately reproduced -
observed backbending. Agreement between both calculations extends to most
observables. The only significant discrepancy comes from the static moments of
inertia and can be attributed to the need of a more refined treatment of
pairing correlations in the HFB calculation.Comment: 4 pages, RevTeX 3.0 using psfig, 6 Postscript figures included using
uufile
Spectral analysis of the biharmonic operator subject to Neumann boundary conditions on dumbbell domains
We consider the biharmonic operator subject to homogeneous boundary
conditions of Neumann type on a planar dumbbell domain which consists of two
disjoint domains connected by a thin channel. We analyse the spectral behaviour
of the operator, characterizing the limit of the eigenvalues and of the
eigenprojections as the thickness of the channel goes to zero. In applications
to linear elasticity, the fourth order operator under consideration is related
to the deformation of a free elastic plate, a part of which shrinks to a
segment. In contrast to what happens with the classical second order case, it
turns out that the limiting equation is here distorted by a strange factor
depending on a parameter which plays the role of the Poisson coefficient of the
represented plate.Comment: To appear in "Integral Equations and Operator Theory
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