Automatic Road Survey by Using Vehicle Mounted Laser for Road Asset Management

In most countries local roads (i.e., urban and rural) form over 80% of the entire road network and constitute the country's largest asset value. In order for local roads to remain fit for purpose and maintain their value, they require periodic maintenance. To make the best use of scarce maintenance resources, road maintenance needs to be preventative which requires the condition of the road to be assessed periodically. Traditional road surveys suffer from the lack of repeatability and reproducibility, are high cost and time consuming. This work proposes a vehicle mounted point laser system for the automated, rapid and inexpensive measurement of a major mode of local road deterioration, namely fretting. Compared to other technologies such as Ground Penetrating Radar (GPR), visual sensors and the Mobile Laser Scanning (MLS) system, the point laser requires less computational power, is less sensitive to the surrounding environment and is of comparatively low cost. A robust approach is proposed which consists of a number of pre-processing algorithms to deal with noise and the effects of the vehicles dynamic motion, and a signal processing algorithm which analyses histograms of the distance from the road surface measured by the laser to account for changes in road texture. Road fretting measured by the proposed system on a variety of roads is compared with fretting determined using a standard visual assessment process. The results indicate that the proposed system can measure road fretting to the levels of detail which are suitable for planning, programming and preparations road management functions

Monochromatization of femtosecond XUV light pulses with the use of reflection zone plates

We report on a newly built laser based tabletop setup which enables generation of femtosecond light pulses in the XUV range via employing the process of high order harmonic generation HHG in a gas medium. The spatial, spectral, and temporal characteristics of the XUV beam are presented. Monochromatization of XUV light with minimum temporal pulse distortion is the central issue of this work. Off center reflection zone plates are shown to be superior to gratings when selection of a desired harmonic is carried out with the use of a single optical element. A cross correlation technique was applied to characterize the performance of zone plates in the time domain. By using laser pulses of 25 fs length to pump the HHG process, a pulse duration of 45 fs for monochromatized harmonics was achieved in the present setu

Unearthing Current Knowledge Gaps in Our Understanding of Tree Stability: Review and Bibliometric Analysis

Forest preservation and management are paramount for sustainable mitigation of climate change, timber production, and the economy. However, the potential of trees and forests to provide these benefits to the ecosystem is hampered by natural phenomena such as windthrow and anthropogenic activities. The aim of the current research was to undertake a critical thematic review (from 1983 to 2023) informed by a bibliometric analysis of existing literature on tree stability. The results revealed an increase in tree stability research between 2019 and 2022, with the USA, France, and Italy leading in research output, while Scotland and England notably demonstrated high research influence despite fewer publications. A keyword analysis showed that tree stability can be divided into four themes: tree species, architecture, anchorage, and environmental factors. Prominent studies on tree stability have focused on root anchorage. However, more recently, there has been a growing emphasis on urban forestry and disease-induced tree damage, underscoring a shift towards climate change and diversity research. It was concluded that considerable knowledge gaps still exist; that greater geographic diversification of research is needed and should include tropical and sub-tropical regions; that research relating to a wider range of soil types (and textures) should be conducted; and that a greater emphasis on large-scale physical modelling is required. Data and knowledge produced from these areas will improve our collective understanding of tree stability and therefore help decision makers and practitioners manage forestry resources in a more sustainable way into the future

Tunnel monitoring using multicore fibre displacement sensor

We describe the first application of multiplexed fibre Bragg grating strain sensors in a multicore fibre. Sets of gratings, acting as strain gauges, are co-located in the multicore fibre such that they enable the curvature to be measured. Multiple sets of these gratings allow the curvature to be measured at several points along the fibre. This sensor is configured to monitor displacement of concrete tunnel sections, and was demonstrated capable of displacement measurement with a resolution of ±0.1 mm over a range of several millimeters

ASSESSING THE CONDITION OF BURIED PIPE USING GROUND PENETRATING RADAR (GPR)

The invention of Ground Penetrating Radar (GPR) technology has facilitated the possibility of detecting buried utilities and has been used primarily in civil engineering for detecting structural defects, such as voids and cavities in road pavements, slabs and bridge decks, but has not been used to assess the condition of buried pipes. Pipe deterioration can be defined as pipes where, for example, cracking, differential deflection, missing bricks, collapses, holes, fractures and corrosion exists. Assessing the deterioration of underground pipes is important for service efficiency and asset management. This paper describes a research project that focused on the use of GPR for assessing the condition of buried pipes. The research involved the construction of a suitable GPR test facility in the laboratory to conduct controlled testing in a dry sand. Plastic pipes were chosen for the experiments. A series of laboratory experiments were conducted to determine the validity and effectiveness of standard commercially available GPR technology in assessing the condition of buried utilities with common types of damage. Several types of damage to the plastic pipe were investigated with respect to different GPR antenna frequencies. The GPR surveys were carried out in order to obtain signal signatures from damaged and undamaged pipes buried at 0.5 m depth. These surveys were organised on a grid pattern across the surface of the sand in the test facility. The results presented in this paper show that GPR can identify certain types of damage associated with a buried pipe under these controlled laboratory conditions

Time domain reflectometry (TDR) potential for soil condition monitoring of geotechnical assets

The performance of geotechnical assets is influenced by various external factors including time and changing loading and environmental conditions. These changes could reduce the asset’s ability to maintain its function, potentially resulting in failure, which could be extremely disruptive and expensive to remediate; thus, the ability to monitor the long-term condition of the ground is clearly desirable as this could function as an early-warning system, permitting intervention prior to failure. This study demonstrates, for the first time, the potential of using time domain reflectometry (TDR) for long-term monitoring of the relative health of an asset (via water content and dry density) in a field trial where a clayey sandy silt was exposed to leaking water from a pipe. TDR sensors were able to provide detailed information on the variation in the soil conditions and detect abrupt changes that would relay a prompt for asset inspections or interventions. It is proposed that TDR could be used alone or together with other shallow geophysical techniques for long-term condition monitoring of critical geotechnical assets. Early-warning systems could be based on thresholds defined from the values or the relative change of the measured parameter

Identification of gene mutations and fusion genes in patients with Sézary Syndrome

Sézary syndrome is a leukemic form of cutaneous T-cell lymphoma with an aggressive clinical course. The genetic etiology of the disease is poorly understood, with chromosomal abnormalities and mutations in some genes being involved in the disease. The goal of our study was to understand the genetic basis of the disease by looking for driver gene mutations and fusion genes in 15 erythrodermic patients with circulating Sézary cells, 14 of them fulfilling the diagnostic criteria of Sézary syndrome. We have discovered genes that could be involved in the pathogenesis of Sézary syndrome. Some of the genes that are affected by somatic point mutations include ITPR1, ITPR2, DSC1, RIPK2, IL6, and RAG2, with some of them mutated in more than one patient. We observed several somatic copy number variations shared between patients, including deletions and duplications of large segments of chromosome 17. Genes with potential function in the T-cell receptor signaling pathway and tumorigenesis were disrupted in Sézary syndrome patients, for example, CBLB, RASA2, BCL7C, RAMP3, TBRG4, and DAD1. Furthermore, we discovered several fusion events of interest involving RASA2, NFKB2, BCR, FASN, ZEB1, TYK2, and SGMS1. Our work has implications for the development of potential therapeutic approaches for this aggressive disease

Co-axial Printing of Convoluted Proximal Tubule for Kidney Disease Modeling

Despite the increasing incidence of kidney-related diseases, we are still far from understanding the underlying mechanisms of these diseases and their progression. This lack of understanding is partly because of a poor replication of the diseasesin vitro,limited to planar culture. Advancing towards three-dimensional models, hereby we propose coaxial printing to obtain microfibers containing a helical hollow microchannel. These recapitulate the architecture of the proximal tubule (PT), an important nephron segment often affected in kidney disorders. A stable gelatin/alginate-based ink was formulated to allow printability while maintaining structural properties. Fine-tuning of the composition, printing temperature and extrusion rate allowed for optimal ink viscosity that led to coiling of the microfiber's inner channel. The printed microfibers exhibited prolonged structural stability (42 days) and cytocompatibility in culture. Healthy conditionally immortalized PT epithelial cells and a knockout cell model for cystinosis (CTNS-/-) were seeded to mimic two genotypes of PT. Upon culturing for 14 days, engineered PT showed homogenous cytoskeleton organization as indicated by staining for filamentous actin, barrier-formation and polarization with apical markerα-tubulin and basolateral marker Na+/K+-ATPase. Cell viability was slightly decreased upon prolonged culturing for 14 days, which was more pronounced inCTNS-/-microfibers. Finally,CTNS-/-cells showed reduced apical transport activity in the microfibers compared to healthy PT epithelial cells when looking at breast cancer resistance protein and multidrug resistance-associated protein 4. Engineered PT incorporated in a custom-designed microfluidic chip allowed to assess leak-tightness of the epithelium, which appeared less tight inCTNS-/-PT compared to healthy PT, in agreement with itsin vivophenotype. While we are still on the verge of patient-oriented medicine, this system holds great promise for further research in establishing advancedin vitrodisease models