2,168 research outputs found
Cool for Cats
The iconic Schr\"odinger's cat state describes a system that may be in a
superposition of two macroscopically distinct states, for example two clearly
separated oscillator coherent states. Quite apart from their role in
understanding the quantum classical boundary, such states have been suggested
as offering a quantum advantage for quantum metrology, quantum communication
and quantum computation. As is well known these applications have to face the
difficulty that the irreversible interaction with an environment causes the
superposition to rapidly evolve to a mixture of the component states in the
case that the environment is not monitored. Here we show that by engineering
the interaction with the environment there exists a large class of systems that
can evolve irreversibly to a cat state. To be precise we show that it is
possible to engineer an irreversible process so that the steady state is close
to a pure Schr\"odinger's cat state by using double well systems and an
environment comprising two-photon (or phonon) absorbers. We also show that it
should be possible to prolong the lifetime of a Schr\"odinger's cat state
exposed to the destructive effects of a conventional single-photon decohering
environment. Our protocol should make it easier to prepare and maintain
Schr\"odinger cat states which would be useful in applications of quantum
metrology and information processing as well as being of interest to those
probing the quantum to classical transition.Comment: 10 pages, 7 figures. Significantly updated version with supplementary
informatio
The peritoneal tumour microenvironment of high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSC) disseminates early and extensively throughout the peritoneal space, causing multiple lesions that are a major clinical problem. The aim of this study was to investigate the cellular composition of peritoneal tumour deposits in patient biopsies and their evolution in mouse models using immunohistochemistry, intravital microscopy, confocal microscopy, and 3D modelling. Tumour deposits from the omentum of HGSC patients contained a prominent leukocyte infiltrate of CD3(+) T cells and CD68(+) macrophages, with occasional neutrophils. Alpha-smooth muscle actin(+) (α-SMA(+) ) pericytes and/or fibroblasts surrounded these well-vascularized tumour deposits. Using the murine bowel mesentery as an accessible mouse peritoneal tissue that could be easily imaged, and two different transplantable models, we found multiple microscopic tumour deposits after i.p. injection of malignant cells. Attachment to the peritoneal surface was rapid (6-48 h) with an extensive CD45(+) leukocyte infiltrate visible by 48 h. This infiltrate persisted until end point and in the syngeneic murine ID8 model, it primarily consisted of CD3(+) T lymphocytes and CD68(+) macrophages with α-SMA(+) cells also involved from the earliest stages. A majority of tumour deposits developed above existing mesenteric blood vessels, but in avascular spaces new blood vessels tracked towards the tumour deposits by 2-3 weeks in the IGROV-1 xenografts and 6 weeks in the ID8 syngeneic model; a vigorous convoluted blood supply was established by end point. Inhibition of tumour cell cytokine production by stable expression of shRNA to CXCR4 in IGROV-1 cells did not influence the attachment of cells to the mesentery but delayed neovascularization and reduced tumour deposit size. We conclude that the multiple peritoneal tumour deposits found in HGSC patients can be modelled in the mouse. The techniques described here may be useful for assessing treatments that target the disseminated stage of this disease
Examining Healthcare Institutions by Bringing Qualitative Data from Two Eras into Empirical Dialogue
In this paper, we argue that there is new insight to be gained by reexamining the classic text, Boys in White, in strategic ways. Specifically, we share excerpts from Boys in White with current medical students and ask for their reactions in qualitative interviews, examining the relevance (or lack thereof) of earlier meanings about professional training for current processes of professional training. We show how we have employed this technique in our current project revisiting Boys in White with current medical students, and discuss preliminary findings that reveal the potential of this technique for documenting evidence of macro-level forces in healthcare institutions using qualitative data on new doctors. We conclude with discussion of alternative approaches through which scholars could make use of this technique in future professional socialization scholarship that could shed light on dynamics of institutional persistence and change
Consensus-Based Agglomerative Hierarchical Clustering
Producción CientíficaIn this contribution, we consider that a set of agents assess a set of alternatives
through numbers in the unit interval. In this setting, we introduce a measure
that assigns a degree of consensus to each subset of agents with respect to every
subset of alternatives. This consensus measure is defined as 1 minus the outcome
generated by a symmetric aggregation function to the distances between
the corresponding individual assessments. We establish some properties of the
consensus measure, some of them depending on the used aggregation function.
We also introduce an agglomerative hierarchical clustering procedure that is generated
by similarity functions based on the previous consensus measuresMinisterio de Economía, Industria y Competitividad (ECO2012-32178)Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA066U13
Signatures of chaotic and non-chaotic-like behaviour in a non-linear quantum oscillator through photon detection
The driven non-linear duffing osillator is a very good, and standard, example
of a quantum mechanical system from which classical-like orbits can be
recovered from unravellings of the master equation. In order to generated such
trajectories in the phase space of this oscillator in this paper we use a the
quantum jumps unravelling together with a suitable application of the
correspondence principle. We analyse the measured readout by considering the
power spectra of photon counts produced by the quantum jumps. Here we show that
localisation of the wave packet from the measurement of the oscillator by the
photon detector produces a concomitant structure in the power spectra of the
measured output. Furthermore, we demonstrate that this spectral analysis can be
used to distinguish between different modes of the underlying dynamics of the
oscillator.Comment: 7 pages, 6 figure
Recommended from our members
Keeping Everyone In: rough sleepers and the Coronavirus emergency in Nottingham
Mixed couples in France. Statistical facts, definitions, and social reality
Mixed couples are usually defined as combining national, cultural, racial or religious differences, but these definitions are generally elaborated only empirically. More recently, researchers have proposed the concept of "mixedness" which goes beyond those descriptive factors of difference. The French national Migration, Tradition and Citizenship Act also helps to show why it is not easy to reach a single definition.A detailed look at statistical realities illustrates how complex it is to count mixed couples. The figures differ if we consider mixed marriages as flows (new marriages each year) or as stock (how many people live in a mixed family). They also vary depending on what differences —cultural belonging or nationality— are taken into account. Many French-foreign marriages bring together people who have the same cultural identities. From the sociological point of view, mixed marriage should be defined as combining perceived differences and existing social order and norms. Studies on mixedness look at how socially constructed differences in contact, e.g. in private life, influence social relations and modify social realities. Mixed couples experience specific social constraints due to the migration situation of at least one of the partners, and therefore these couples need time to learn to manage the cultural and social differences in their relationship. Differences between the partners due to their cultural and social affiliations or gender roles are not equal and also influence the transcultural hybridisation process, sometimes even hindering it considerably.Una pareja mixta se define generalmente como la combinación de las diferencias nacionales, culturales, raciales o religiosas. Pero estas definiciones generalmente se elaboran sólo empíricamente. Más recientemente, los investigadores han propuesto el concepto de «mestizaje», que va más allá de los factores descriptivos de la diferencia. La tradición de migración nacional francesa y la Ley de ciudadanía también ayudan a entender por qué no es fácil llegar a una definición única. Una mirada pormenorizada a la realidad estadística ilustra lo complejo que es contar el número de parejas mixtas. Las cifras difieren si se considera el matrimonio mixto como un flujo (los matrimonios nuevos cada año) o como población (número de personas que viven en una familia mixta). También varían en función de qué diferencias se tienen en cuenta —la pertenencia cultural o la nacionalidad. Muchos matrimonios entre franceses y extranjeros unen a personas que tienen la misma identidad cultural. Desde el punto de vista sociológico, el matrimonio mixto debería definirse como la combinación de las diferencias percibidas y el orden social existente y las normas. Los estudios sobre el mestizaje tratan de cómo las diferencias sociales en contacto -por ejemplo en la vida privada- influyen en las relaciones sociales y modifican la realidad social. Las parejas mixtas están involucradas en determinadas limitaciones sociales debido a la situación de migrante de por lo menos uno de los cónyuges. Por lo tanto, estas parejas necesitan tiempo para aprender a gestionar las diferencias culturales y sociales en su relación. Las diferencias entre los cónyuges, debidas a sus filiaciones sociales y culturales y a los roles de género, no están en pie de igualdad y también influyen en el proceso de hibridación transcultural, a veces incluso obstaculizándolo considerablemente
The Zero-Removing Property and Lagrange-Type Interpolation Series
The classical Kramer sampling theorem, which provides a method for obtaining orthogonal sampling formulas, can be formulated in a more general nonorthogonal setting. In this setting, a challenging problem is to characterize the situations when the obtained nonorthogonal sampling formulas can be expressed as Lagrange-type interpolation series. In this article a necessary and sufficient condition is given in terms of the zero removing property. Roughly speaking, this property concerns the stability of the sampled functions on removing a finite number of their zeros
Observation of a Modulational Instability in Bose-Einstein condensates
We observe the breakup dynamics of an elongated cloud of condensed Rb
atoms placed in an optical waveguide. The number of localized spatial
components observed in the breakup is compared with the number of solitons
predicted by a plane-wave stability analysis of the nonpolynomial nonlinear
Schr\"odinger equation, an effective one-dimensional approximation of the
Gross-Pitaevskii equation for cigar-shaped condensates. It is shown that the
numbers predicted from the fastest growing sidebands are consistent with the
experimental data, suggesting that modulational instability is the key
underlying physical mechanism driving the breakup.Comment: 6 pages, 5 figure
Recommended from our members
Seeing energy differently: exploring the impact of a green ICT initiative at De Montfort University: Greenview project report
- …