Study of Friction and Wear Effects in Aluminum Parts Manufactured via Single Point Incremental Forming Process Using Petroleum and Vegetable Oil-Based Lubricants

This paper focuses on studying how mineral oil, sunflower, soybean, and corn lubricants influence friction and wear effects during the manufacturing of aluminum parts via the single point incremental forming (SPIF) process. To identify how friction, surface roughness, and wear change during the SPIF of aluminum parts, Stribeck curves were plotted as a function of the SPIF process parameters such as vertical step size, wall angle, and tool tip semi-spherical diameter. Furthermore, lubricant effects on the surface of the formed parts are examined by energy dispersive spectroscopy (EDS) and scanning electron microscope (SEM) images, the Alicona optical 3D measurement system, and Fourier-transform infrared spectroscopy (FTIR). Results show that during the SPIF process of the metallic specimens, soybean and corn oils attained the highest friction, along forces, roughness, and wear values. Based on the surface roughness measurements, it can be observed that soybean oil produces the worst surface roughness finish in the direction perpendicular to the tool passes (Ra =1.45 μm) considering a vertical step size of 0.25 mm with a 5 mm tool tip diameter. These findings are confirmed through plotting SPIFed Stribeck curves for the soybean and corn oils that show small hydrodynamic span regime changes for an increasing sample step-size forming process. This article elucidates the effects caused by mineral and vegetable oils on the surface of aluminum parts produced as a function of Single Point Incremental Sheet Forming process parameters

SNe 2013K and 2013am: observed and physical properties of two slow, normal Type IIP events

We present one year of optical and near-infrared photometry and spectroscopy of the Type IIP SNe 2013K and 2013am. Both objects are affected by significant extinction, due to their location in dusty regions of their respective host galaxies, ESO 009-10 and NGC 3623 (M65). From the photospheric to nebular phases, these objects display spectra congruent with those of underluminous Type IIP SNe (i.e. the archetypal SNe 1997D or 2005cs), showing low photospheric velocities (~2 X 10**3 km/s at 50d) together with features arising from Ba II which are particularly prominent in faint SNe IIP. The peak V-band magnitudes of SN 2013K (-15.6 mag) and SN 2013am (-16.2 mag) are fainter than standard-luminosity Type IIP SNe. The ejected Nickel masses are 0.012+-0.010 and 0.015+-0.006 Msol for SN 2013K and SN 2013am, respectively. The physical properties of the progenitors at the time of explosion are derived through hydrodynamical modelling. Fitting the bolometric curves, the expansion velocity and the temperature evolution, we infer total ejected masses of 12 and 11.5 Msol, pre-SN radii of ~460 and ~360 Rsol, and explosion energies of 0.34 foe and 0.40 foe for SN 2013K and SN 2013am. Late time spectra are used to estimate the progenitor masses from the strength of nebular emission lines, which turn out to be consistent with red supergiant progenitors of ~15 Msol. For both SNe, a low-energy explosion of a moderate-mass red supergiant star is therefore the favoured scenario.Comment: accepted for publication MNRA

Generation of three dimensional retinal tissue with functional photoreceptors from human iPSCs

Many forms of blindness result from the dysfunction or loss of retinal photoreceptors. Induced pluripotent stem cells (iPSC) hold great potential for the modeling of these diseases or as potential therapeutic agents. However, to fulfill this promise, a remaining challenge is to induce human iPSC to recreate in vitro key structural and functional features of the native retina, in particular the presence of photoreceptors with outer-segment discs and light-sensitivity. Here we report that hiPSC can, in a highly autonomous manner, recapitulate spatiotemporally each of the main steps of retinal development observed in vivo and form 3-dimensional retinal cups that contain all major retinal cell types arranged in their proper layers. Moreover, the photoreceptors in our hiPSC-derived retinal tissue achieve advanced maturation, showing the beginning of outer-segment-disc formation and photosensitivity. This success brings us one step closer to the anticipated use of hiPSC for disease modeling and open possibilities for future therapies

SN 2017dio: A Type-Ic Supernova Exploding in a Hydrogen-rich Circumstellar Medium

SN 2017dio shows both spectral characteristics of a type-Ic supernova (SN) and signs of a hydrogen-rich circumstellar medium (CSM). Prominent, narrow emission lines of H and He are superposed on the continuum. Subsequent evolution revealed that the SN ejecta are interacting with the CSM. The initial SN Ic identification was confirmed by removing the CSM interaction component from the spectrum and comparing with known SNe Ic and, reversely, adding a CSM interaction component to the spectra of known SNe Ic and comparing them to SN 2017dio. Excellent agreement was obtained with both procedures, reinforcing the SN Ic classification. The light curve constrains the pre-interaction SN Ic peak absolute magnitude to be around ${M}_{g}=-17.6$ mag. No evidence of significant extinction is found, ruling out a brighter luminosity required by an SN Ia classification. These pieces of evidence support the view that SN 2017dio is an SN Ic, and therefore the first firm case of an SN Ic with signatures of hydrogen-rich CSM in the early spectrum. The CSM is unlikely to have been shaped by steady-state stellar winds. The mass loss of the progenitor star must have been intense, $\dot{M}\sim 0.02{({\epsilon }_{{\rm{H}}\alpha }/0.01)}^{-1}$ (${v}_{\mathrm{wind}}/500$ km s−1) $({v}_{\mathrm{shock}}/$10,000 km s−1)−3 M ⊙ yr−1, peaking at a few decades before the SN. Such a high mass-loss rate might have been experienced by the progenitor through eruptions or binary stripping

A Comprehensive DNA Barcode Library for the Looper Moths (Lepidoptera: Geometridae) of British Columbia, Canada

The construction of comprehensive reference libraries is essential to foster the development of DNA barcoding as a tool for monitoring biodiversity and detecting invasive species. The looper moths of British Columbia (BC), Canada present a challenging case for species discrimination via DNA barcoding due to their considerable diversity and limited taxonomic maturity.By analyzing specimens held in national and regional natural history collections, we assemble barcode records from representatives of 400 species from BC and surrounding provinces, territories and states. Sequence variation in the barcode region unambiguously discriminates over 93% of these 400 geometrid species. However, a final estimate of resolution success awaits detailed taxonomic analysis of 48 species where patterns of barcode variation suggest cases of cryptic species, unrecognized synonymy as well as young species.A catalog of these taxa meriting further taxonomic investigation is presented as well as the supplemental information needed to facilitate these investigations

NAC blocks Cystatin C amyloid complex aggregation in a cell system and in skin of HCCAA patients.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadHereditary cystatin C amyloid angiopathy is a dominantly inherited disease caused by a leucine to glutamine variant of human cystatin C (hCC). L68Q-hCC forms amyloid deposits in brain arteries associated with micro-infarcts, leading ultimately to paralysis, dementia and death in young adults. To evaluate the ability of molecules to interfere with aggregation of hCC while informing about cellular toxicity, we generated cells that produce and secrete WT and L68Q-hCC and have detected high-molecular weight complexes formed from the mutant protein. Incubations of either lysate or supernatant containing L68Q-hCC with reducing agents glutathione or N-acetyl-cysteine (NAC) breaks oligomers into monomers. Six L68Q-hCC carriers taking NAC had skin biopsies obtained to determine if hCC deposits were reduced following NAC treatment. Remarkably, ~50-90% reduction of L68Q-hCC staining was observed in five of the treated carriers suggesting that L68Q-hCC is a clinical target for reducing agents.Artic Therapeutics LLC Autonomous Community of Madrid (CAM). Spai

SN 2021foa, a transitional event between a Type IIn (SN 2009ip-like) and a Type Ibn supernova

We present photometric and spectroscopic data of the unusual interacting supernova (SN) 2021foa. It rose to an absolute magnitude peak of M-r & x2004;=& x2004;-18 mag in 20 days. The initial light curve decline shows some luminosity fluctuations before a long-lasting flattening. A faint source (M-r & x2004;similar to & x2004;-14 mag) was detected in the weeks preceding the main event, showing a slowly rising luminosity trend. The r-band absolute light curve is very similar to those of SN 2009ip-like events, with a faint and shorter duration brightening ('Event A') followed by a much brighter peak ('Event B'). The early spectra of SN 2021foa show a blue continuum with narrow (similar to 400 km s(-1)) H emission lines that, two weeks later, reveal a complex profile, with a narrow P Cygni on top of an intermediate-width (similar to 2700 km s(-1)) component. At +12 days, metal lines in emission appear and He I lines become very strong, with He I lambda 5876 reaching half of the H alpha luminosity, much higher than in previous SN 2009ip-like objects. We propose that SN 2021foa is a transitional event between the H-rich SN 2009ip-like SNe and the He-rich Type Ibn SNe

The double-peaked Type Ic supernova 2019cad: another SN 2005bf-like object

We present the photometric and spectroscopic evolution of supernova (SN) 2019cad during the first similar to 100 d from explosion. Based on the light-curve morphology, we find that SN 2019cad resembles the double-peaked Type Ib/c SN 2005bf and the Type Ic PTF11mnb. Unlike those two objects, SN 2019cad also shows the initial peak in the redder bands. Inspection of the g-band light curve indicates the initial peak is reached in similar to 8 d, while the r-band peak occurred similar to 15 d post-explosion. A second and more prominent peak is reached in all bands at similar to 45 d past explosion, followed by a fast decline from similar to 60 d. During the first 30 d, the spectra of SN 2019cad show the typical features of a Type Ic SN, however, after 40 d, a blue continuum with prominent lines of Si II lambda 6355 and C II lambda 6580 is observed again. Comparing the bolometric light curve to hydrodynamical models, we find that SN 2019cad is consistent with a pre-SN mass of 11 M-circle dot, and an explosion energy of 3.5 x 10(51) erg. The light-curve morphology can be reproduced either by a double-peaked Ni-56 distribution with an external component of 0.041 M-circle dot, and an internal component of 0.3 M-circle dot or a double-peaked Ni-56 distribution plus magnetar model (P similar to 11 ms and B similar to 26 x 10(14) G). If SN 2019cad were to suffer from significant host reddening (which cannot be ruled out), the Ni-56 model would require extreme values, while the magnetar model would still be feasible

Choice of the initial antiretroviral treatment for HIV-positive individuals in the era of integrase inhibitors

BACKGROUND: We aimed to describe the most frequently prescribed initial antiretroviral therapy (ART) regimens in recent years in HIV-positive persons in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) and to investigate factors associated with the choice of each regimen. METHODS: We analyzed initial ART regimens prescribed in adults participating in CoRIS from 2014 to 2017. Only regimens prescribed in >5% of patients were considered. We used multivariable multinomial regression to estimate Relative Risk Ratios (RRRs) for the association between sociodemographic and clinical characteristics and the choice of the initial regimen. RESULTS: Among 2874 participants, abacavir(ABC)/lamivudine(3TC)/dolutegavir(DTG) was the most frequently prescribed regimen (32.1%), followed by tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)/elvitegravir(EVG)/cobicistat(COBI) (14.9%), TDF/FTC/rilpivirine (RPV) (14.0%), tenofovir alafenamide (TAF)/FTC/EVG/COBI (13.7%), TDF/FTC+DTG (10.0%), TDF/FTC+darunavir/ritonavir or darunavir/cobicistat (bDRV) (9.8%) and TDF/FTC+raltegravir (RAL) (5.6%). Compared with ABC/3TC/DTG, starting TDF/FTC/RPV was less likely in patients with CD4100.000 copies/mL. TDF/FTC+DTG was more frequent in those with CD4100.000 copies/mL. TDF/FTC+RAL and TDF/FTC+bDRV were also more frequent among patients with CD4<200 cells//muL and with transmission categories other than men who have sex with men. Compared with ABC/3TC/DTG, the prescription of other initial ART regimens decreased from 2014-2015 to 2016-2017 with the exception of TDF/FTC+DTG. Differences in the choice of the initial ART regimen were observed by hospitals' location. CONCLUSIONS: The choice of initial ART regimens is consistent with Spanish guidelines' recommendations, but is also clearly influenced by physician's perception based on patient's clinical and sociodemographic variables and by the prescribing hospital location

SN 2016gsd: an unusually luminous and linear Type II supernova with high velocities

We present observations of the unusually luminous Type II supernova (SN) 2016gsd. With a peak absolute magnitude of V = -19.95 +/- 0.08, this object is one of the brightest Type II SNe, and lies in the gap of magnitudes between the majority of Type II SNe and the superluminous SNe. Its light curve shows little evidence of the expected drop from the optically thick phase to the radioactively powered tail. The velocities derived from the absorption in( )H alpha are also unusually high with the blue edge tracing the fastest moving gas initially at 20 000 km s(-1), and then declining approximately linearly to 15000 km s(-1) over similar to 100 d. The dwarf host galaxy of the SN indicates a low-metallicity progenitor which may also contribute to the weakness of the metal lines in its spectra. We examine SN 2016gsd with reference to similarly luminous, linear Type II SNe such as SNe 1979C and 1998S, and discuss the interpretation of its observational characteristics. We compare the observations with a model produced by the JEKYLL code and find that a massive star with a depleted and inflated hydrogen envelope struggles to reproduce the high luminosity and extreme linearity of SN 2016gsd. Instead, we suggest that the influence of interaction between the SN ejecta and circumstellar material can explain the majority of the observed properties of the SN. The high velocities and strong H alpha absorption present throughout the evolution of the SN may imply a circumstellar medium configured in an asymmetric geometry