Effects of an eccentric inner Jupiter on the dynamical evolution of icy body reservoirs in a planetary scattering scenario

Aims. We analyze the dynamics of small body reservoirs under the effects of an eccentric inner giant planet resulting from a planetary scattering event around a 0.5 M⊙ star. Methods. First, we used a semi-analytical model to define the properties of the protoplanetary disk that lead to the formation of three Jupiter-mass planets. Then, we carried out N-body simulations assuming that the planets are close to their stability limit together with an outer planetesimal disk. In particular, the present work focused on the analysis of N-body simulations in which a single Jupiter-mass planet survives after the dynamical instability event. Results. Our simulations produce outer small body reservoirs with particles on prograde and retrograde orbits, and other ones whose orbital plane flips from prograde to retrograde and back again along their evolution (“Type-F particles”). We find strong correlations between the inclination i and the ascending node longitude Ω of Type-F particles. First, Ω librates around 90° or/and 270°. This property represents a necessary and sufficient condition for the flipping of an orbit. Moreover, the libration periods of i and Ω are equal and they are out to phase by a quarter period. We also remark that the larger the libration amplitude of i, the larger the libration amplitude of Ω. We analyze the orbital parameters of Type-F particles immediately after the instability event (post IE orbital parameters), when a single Jupiter-mass planet survives in the system. Our results suggest that the orbit of a particle can flip for any value of its post IE eccentricity, although we find only two Type-F particles with post IE inclinations i ≲ 17°. Finally, our study indicates that the minimum value of the inclination of the Type-F particles in a given system decreases with an increase in the eccentricity of the giant planet.Fil: Zanardi, Macarena. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: de Elia, Gonzalo Carlos. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Di Sisto, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Naoz, S.. University of California at Los Angeles; Estados UnidosFil: Li, G.. Harvard-Smithsonian Center for Astrophysics; Estados UnidosFil: Guilera, O. M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Brunini, A.. Universidad Nacional de la Patagonia Austral; Argentin

Inhibition of HSP70 expression by calcium ionophore A23187 in human cells. An effect independent of the acquisition of DNA-binding activity by the heat shock transcription factor

Heat shock proteins (HSPs) are induced in mammalian cells in a variety of pathophysiological states and have an important role in cytoprotection in vitro and in vivo. In this study, we report that the calcium ionophore A23187, a glucose-regulated protein (GRP) inducer, dramatically inhibits HSP70 synthesis and HSP70 mRNA transcription after induction by heat shock, sodium arsenite, or prostaglandin A1 treatment in human K562 cells. A23187 does not suppress, and it actually prolongs, the DNA-binding activity of the human heat shock transcription factor (HSF), while it alters HSF1 phosphorylation in heat shock-treated cells. To inhibit HSP70 expression, A23187 needs to be present during heat shock, while treatment before or after heat shock does not affect HSP70 mRNA transcription. The GRP inducer thapsigargin, which specifically inhibits the endoplasmic reticulum Ca2+-ATPase, has no effect on heat-induced HSP70 synthesis, indicating that A23187 inhibitory activity is not due to depletion of intracellular calcium stores and is independent of the concomitant induction of GRP genes. Inhibition of HSP70 expression is correlated with alterations in HSF1 phosphorylation in heat-shocked cells, but not in sodium arsenite-treated cells, indicating that different mechanisms may be involved in mediating A23187 inhibitory activity

The Expander-Implant Breast Reconstruction in the COVID Era: Which is the “Unhappy” Tissue Expander Priority?

Breast surgeons seem to agree on the fact that a same-day surgery (mastectomy and breast reconstruction) protocol provides appropriate cancer treatment during times of unprecedented resource limitations, such as in the COVID era. In this scenario, pre-pectoral implant-based breast reconstruction can be definitively considered a sustainable technique. Nevertheless, the authors focus on the management of patients who had already undergone a same day procedure with two-stage breast reconstruction, implanting a breast tissue expander during the last two-year period and have been progressively delayed according to a surgical care based on priority. We coined the expression “unhappy tissue expander” to define all those symptomatic patients for which surgery should not be delayed even during an epidemic context. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266

Spitzer-IRAC survey of molecular jets in Vela-D

We present a survey of H2 jets from young protostars in the Vela-D molecular cloud (VMR-D), based on Spitzer -IRAC data between 3.6 and 8.0 micron. Our search has led to the identification of 15 jets and about 70 well aligned knots within 1.2 squared degree. We compare the IRAC maps with observations of the H2 1-0 S(1) line at 2.12 micron, with a Spitzer-MIPS map at 24 and 70 micron, and with a map of the dust continuum emission at 1.2 mm. We find a association between molecular jets and dust peaks. The jet candidate exciting sources have been searched for in the published catalog of the Young Stellar Objects of VMR-D. We selected all the sources of Class II or earlier which are located close to the jet center and aligned with it.The association between jet and exciting source was validated by estimating the differential extinction between the jet opposite lobes. We are able to find a best-candidate exciting source in all but two jets. Four exciting sources are not (or very barely) observed at wavelengths shorter than 24 micron, suggesting they are very young protostars. Three of them are also associated with the most compact jets. The exciting source Spectral Energy Distributions have been modeled by means of the photometric data between 1.2 micron and 1.2 mm. From SEDs fits we derive the main source parameters, which indicate that most of them are low-mass protostars. A significant correlation is found between the projected jet length and the [24] - [70] color, which is consistent with an evolutionary scenario according to which shorter jets are associated with younger sources. A rough correlation is found between IRAC line cooling and exciting source bolometric luminosity, in agreement with the previous literature. The emerging trend suggests that mass loss and mass accretion are tightly related phenomena and that both decrease with time.Comment: Accepted by The Astrophysical Journa

The Spitzer-IRAC Point Source Catalog of the Vela-D Cloud

This paper presents the observations of the Cloud D in the Vela Molecular Ridge, obtained with the IRAC camera onboard the Spitzer Space Telescope at the wavelengths \lambda = 3.6, 4.5, 5.8, 8.0 {\mu}m. A photometric catalog of point sources, covering a field of approximately 1.2 square degrees, has been extracted and complemented with additional available observational data in the millimeter region. Previous observations of the same region, obtained with the Spitzer MIPS camera in the photometric bands at 24 {\mu}m and 70 {\mu}m, have also been reconsidered to allow an estimate of the spectral slope of the sources in a wider spectral range. A total of 170,299 point sources, detected at the 5-sigma sensitivity level in at least one of the IRAC bands, have been reported in the catalog. There were 8796 sources for which good quality photometry was obtained in all four IRAC bands. For this sample, a preliminary characterization of the young stellar population based on the determination of spectral slope is discussed; combining this with diagnostics in the color-magnitude and color-color diagrams, the relative population of young stellar objects in the different evolutionary classes has been estimated and a total of 637 candidate YSOs have been selected. The main differences in their relative abundances have been highlighted and a brief account for their spatial distribution is given. The star formation rate has been also estimated and compared with the values derived for other star forming regions. Finally, an analysis of the spatial distribution of the sources by means of the two-point correlation function shows that the younger population, constituted by the Class I and flat-spectrum sources, is significantly more clustered than the Class II and III sources.Comment: Accepted by Ap

Pre-Main Sequence variables in the VMR-D : identification of T Tauri-like accreting protostars through Spitzer-IRAC variability

We present a study of the infrared variability of young stellar objects by means of two Spitzer-IRAC images of the Vela Molecular Cloud D (VMR-D) obtained in observations separated in time by about six months. By using the same space-born IR instrumentation, this study eliminates all the unwanted effects usually unavoidable when comparing catalogs obtained from different instruments. The VMR-D map covers about 1.5 square deg. of a site where star formation is actively ongoing. We are interested in accreting pre-main sequence variables whose luminosity variations are due to intermittent events of disk accretion (i.e. active T Tauri stars and EXor type objects). The variable objects have been selected from a catalog of more than 170,000 sources detected at a S/N ratio > 5. We searched the sample of variables for ones whose photometric properties are close to those of known EXor's. These latter are monitored in a more systematic way than T Tauri stars and the mechanisms that regulate the observed phenomenology are exactly the same. Hence the modalities of the EXor behavior is adopted as driving criterium for selecting variables in general. We selected 19 bona fide candidates that constitute a well-defined sample of new variable targets for further investigation. Out of these, 10 sources present a Spitzer MIPS 24 micron counterpart, and have been classified as 3 Class I, 5 flat spectrum and 2 Class II objects, while the other 9 sources have spectral energy distribution compatible with phases older than Class I. This is consistent with what is known about the small sample of known EXor's, and suggests that the accretion flaring or EXor stage might come as a Class I/II transition. We present also new prescriptions that can be useful in future searches for accretion variables in large IR databases.Comment: 35 pages, 12 figures To appear in Ap

Near- and Far-Infrared Counterparts of Millimeter Dust Cores in the Vela Molecular Ridge Cloud D

The aim of this paper is to identify the young protostellar counterparts associated to dust millimeter cores of the Vela Molecular Ridge Cloud D through new IR observations (H_2 narrow-band at 2.12 micron and N broad band at 10.4 micron) along with an investigation performed on the existing IR catalogues. The association of mm continuum emission with infrared sources from catalogues (IRAS, MSX, 2MASS), JHK data from the literature and new observations, has been established according to spatial coincidence, infrared colours and spectral energy distributions. Only 7 out of 29 resolved mm cores (and 16 out of the 26 unresolved ones) do not exhibit signposts of star formation activity. The other ones are clearly associated with: far-IR sources, H_2 jets or near-IR objects showing a high intrinsic colour excess. The distribution of the spectral indices pertaining to the associated sources is peaked at values typical of Class I objects, while three objects are signalled as candidates Class 0 sources. We remark the high detection rate (30%) of H_2 jets driven by sources located inside the mm-cores. They appear not driven by the most luminous objects in the field, but rather by less luminous objects in young clusters, testifying the co-existence of both low- and intermediate-mass star formation. The presented results reliably describe the young population of VMR-D. However, the statistical evaluation of activity vs inactivity of the investigated cores, even in good agreement with results found for other star forming regions, seems to reflect the limiting sensitivity of the available facilities rather than any property intrinsic to the mm-condensations.Comment: 38 pages. To be published to Astronomy & Astrophysic

Spitzer-MIPS survey of the young stellar content in the Vela Molecular Cloud-D

A new, unbiased Spitzer-MIPS imaging survey (~1.8 square degs) of the young stellar content of the Vela Molecular Cloud-D is presented. The survey is complete down to 5mJy and 250mJy at 24micron (mu) and 70mu, respectively. 849 sources are detected at 24mu and 52 of them also have a 70mu counterpart. The VMR-D region is one that we have already partially mapped in dust and gas millimeter emission, and we discuss the correlation between the Spitzer compact sources and the mm contours. About half of the 24mu sources are located inside the region delimited by the 12CO(1-0) contours (corresponding to only one third of the full area mapped with MIPS) with a consequent density increase of about 100% of the 24mu sources [four times for 70mu ones] moving from outside to inside the CO contours. About 400 sources have a 2MASS counterpart. So we have constructed a Ks vs. Ks-[24] diagram and identified the protostellar population. We find an excess of Class I sources in VMR-D in comparison with other star forming regions. This result is reasonably biased by the sensitivity limits, or, alternatively, may reflect a very short lifetime (<=10^6yr) of the protostellar content in this cloud. The MIPS images have identified embedded cool objects in most of the previously identified starless cores; in addition, there are 6 very young, possibly Class 0 objects identified. Finally we report finding of the driving sources for a set of five out of six very compact protostellar jets previously discovered in near-infrared images.Comment: 29 pages, 14 figures. To appear in Ap.

Datasets for the validation of the "in vivo" siRNA-silencing of CD40 and for the detection of new markers of atherosclerosis progression in ApoE-deficient mice

AbstractData presented in this Data in Brief article correspond to the article "in vivo" silencing of CD40 reduces progression of experimental atherogenesis through a NFκB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis" (M. Hueso, L. De Ramon, E. Navarro, E. Ripoll, J.M. Cruzado, J.M. Grinyo, J. Torras, 2016) [1]. Here, we describe the validation of the silencing of CD40 expression with a specific siRNA in ApoE−/− mouse aortas, and its systemic effects on splenic lymphocytic subpopulations as well as on the infiltration of aortic intima by F4/80+, galectin-3+ macrophages or by NF-κB+ cells. We also show the output of a Gene Ontology and TLDA analysis which allowed the detection of potential mediators of atherosclerosis progression. We provide the scientific community with a set of genes whose expression is increased during atherosclerosis progression but downregulated upon CD40 silencing