Mortality, lifestyle and socio-economic status

This paper uses the British Health and Lifestyle Survey (1984-1985) data and the longitudinal follow-up of May 2003 to investigate the de- terminants of premature mortality risk in Great Britain. A behavioral model, which relates premature mortality to a set of observable and unobservable factors, is considered. We focus on unobservable indi- vidual heterogeneity and endogeneity a®ecting the mortality equation. A MSL approach for a multivariate probit (MVP) is used to estimate a recursive system of equations for deaths and lifestyles. This model is then compared with the univariate probit models that include or exclude lifestyles. In order to detect inequality in the distribution of health within the population and to calculate the contribution of socio- economic factors, we compare the range measure of health inequality to the Gini coe±cient for overall health inequality. A Gini decomposi- tion analysis for predicted premature mortality shows that endogenous lifestyles and unobservable heterogeneity strongly contribute to inequal- ity in mortality, reducing the role of socio-economic statu

Clinical characteristics, neuroimaging findings, and neuropsychological functioning in attention-deficit hyperactivity disorder: Sex differences

Recent clinical studies, in both children/adolescents and adults, have shown the extreme neuropsychological heterogeneity of attention-deficit hyperactivity disorder (ADHD): specific neuropsychological deficits have been found only in a minority of individuals, with no direct correlation between discrete cognitive performances and the trajectory of clinical symptoms. Deficits in specific neuropsychological functions may be common in ADHD, but nevertheless no cognitive or neuropsychological profile may fully explain the disorder. Sex differences in the ADHD presentation, both at a neuropsychological and clinical level, also contribute to this clinical and neuropsychological heterogeneity. At a neuropsychological level, females with ADHD may show greater working memory problems, poorer vocabulary skills and worse visual spatial reasoning. Structural and functional imaging study also show discrete differences across sex; however, the great majority of clinical studies mainly or exclusively include male participants with insufficient data to draw firm conclusions on sex differences within the disorder. Here, we report the recent literature data, discussing still open research questions about the clinical presentation, neuroimaging findings, and neuropsychological functioning in ADHD with a focus on the impact of sex differences—a deeper insight in these unresolved issues may have relevant clinical and therapeutic implications for tailored, effective, and long-lasting interventions

Three-dimensional hydrostratigraphical modelling supporting the evaluation of fluoride enrichment in groundwater: Lakes basin (Central Ethiopia)

Study region: The Lakes Basin is located in the Main Ethiopian Rift. It covers the northern part of the rift valley basin, the Upper Awash River basin, and some sub-basins from the Omo River basin. Due to the presence of high fluoride (F−) content, natural contamination of groundwater has long been recognized as a water-related health issue in the area. Study focus: A multidisciplinary research effort, including geological, hydrogeological, hydro-chemical, and geophysical investigations, was adopted to understand the 3D hydrogeological conceptual model and to evaluate F− enrichment in groundwater. New hydrological insights for the region: The 3D hydrogeological conceptual model shows a complex hydrogeological environment and a clear hydraulic interconnection between different aquifers. The geological setting has deeply influenced the geometry of the aquifers, recharge and discharge areas, and F− enrichment in groundwater. Two hydrogeological units, namely sedimentary and volcanic multi-aquifers, were identified. The analyses of groundwater circulation, flow paths, and distribution of F- concentrations in each aquifer were conducted. In groundwater, the concentration of fluoride varies from 0.1 to 68.9 mg L−1; in surface water, it ranges from 0.6 to 244.2 mg L−1. Fluoride concentration of 62 % of the water samples analyzed exceeded the 1.5 mg L−1 WHO threshold for fluoride concentration in drinking water. The proposed methodological approach has been demonstrated to be a powerful tool that could be applied in other similar areas

Geomagnetic survey of Italy. Repeat station network and magnetic maps: a short report

Starting in 1977, two geomagnetic project were undertaken in the frame of the >of the Consiglio Nazionale delle Ricerche(Project>of the National Research Council);1)a new national network of repeat stations for total field F, horizontal component H, vertical component Z, declination D.2)a 2nd order network of stations for F,Z,H to produce geomagnetic maps of Italy. The two projects were carried out by a > made up of Operating Units from Institutions to which the authors belong. The field work ended in 1981. The Istituto Nazionale di Geofisica coordinated the operations for both projects. This paper is intended to give a short report to the international scientific community on this work which has so far only appeared in the Italian literature.Published365-3681A. Geomagnetismo e PaleomagnetismoN/A or not JC

Огляд ефективних інформаційних методів забезпечення позааудиторної та самостійної роботи студентів

У праці представлено критичний аналіз існуючих методик навчання та оцінювання занять. Автори акцентували увагу на необхідності широкого запровадження інформаційних технологій, що дозволять привести освітні технології вищої медичної школи до сучасних вимог, та виховати конкуренток спроможного фахівця

A discrete latent factor model of smoking, cancer and mortality

This paper investigates the relationship between smoking and ill-health, with a focus on the onset of cancer. A discrete latent factor model for smoking and health outcomes, allowing for these to be commonly affected by unobserved factors, is jointly estimated, using the British Health and Lifestyle Survey (HALS) dataset. Post-estimation predictions suggest the reduction in time-to-cancer to be 5.7 years for those with an exposure of 30 pack-years, compared to never-smokers. Estimation of posterior probabilities for class membership shows that individuals in certain classes exhibit similar observables but highly divergent health outcomes, suggesting that unobserved factors influence outcomes. The use of a joint model changes the results substantially. The results show that failure to account for unobserved heterogeneity leads to differences in survival times between those with different smoking exposures to be overestimated by more than 50% (males, with 30 pack-years of exposure)

Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis

BACKGROUND: Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth.OBJECTIVES: To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (&gt; six months) MPH exposure with height, weight and timing of puberty.RESULTS: Eighteen studies (ADHD n = 4868) were included in the meta-analysis. MPH was associated with consistent statistically significant pre-post difference for both height (SMD = 0.27, 95% CI 0.16-0.38, p &lt; 0.0001) and weight (SMD = 0.33, 95% CI 0.22-0.44, p &lt; 0.0001) Z scores, with prominent impact on weight during the first 12 months and on height within the first 24-30 months. No significant effects of dose, formulation, age and drug-naïve condition as clinical moderators were found. Data on timing of puberty are currently limited.CONCLUSIONS: Long-term treatment with MPH can result in reduction in height and weight. However, effect sizes are small with possible minimal clinical impact. Long-term prospective studies may help to clarify the underlying biological drivers and specific mediators and moderators.</p

Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

How neuronal connections are established and organized into functional networks determines brain function. In the mammalian cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made toward parsing interneuron diversity, yet the molecular mechanisms by which interneuron-specific connectivity motifs emerge remain unclear. In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons

Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

How neuronal connections are established and organized into functional networks determines brain function. In the mammalian cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made toward parsing interneuron diversity, yet the molecular mechanisms by which interneuron-specific connectivity motifs emerge remain unclear. In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons