Contractile properties of fibroblasts derived from primary frozen shoulder and effects of TGF beta 1 stimulation

INTRODUCTION: Primary Frozen Shoulder (PFS) is a debilitating disease of unknown aetiology. There is fibrosis and contracture of the coracohumeral ligament, tissues of the rotator interval and the glenohumeral ligaments, leading to restrictive shoulder movements requiring surgical intervention [1]. Frozen shoulder has been postulated to be dupuytren’s disease of the shoulder with an association inferred since 1936. The purpose of the study was to test the hypothesis that cellular mechanisms of fibroblasts derived from primary frozen shoulder exhibited similar activity in terms of contraction and response to cytokine (transforming growth factor beta1) to fibroblasts derived from dupuytren’s disease. Understanding of cellular responses is critical to developing non surgical treatment strategies

Detection of SiO emission from a massive dense cold core

We report the detection of the SiO (J = 2 - 1) transition from the massive cold dense core G333.125-0.562. The core remains undetected at wavelengths shorter than 70 micron and has compact 1.2 mm dust continuum. The SiO emission is localised to the core. The observations are part of a continuing multi-molecular line survey of the giant molecular cloud G333. Other detected molecules in the core include 13CO, C18O, CS, HCO+, HCN, HNC, CH3OH, N2H+, SO, HC3N, NH3, and some of their isotopes. In addition, from NH3 (1,1) and (2,2) inversion lines, we obtain a temperature of 13 K. From fitting to the spectral energy distribution we obtain a colour temperature of 18 K and a gas mass of 2 x 10^3 solar mass. We have also detected a 22 GHz water maser in the core, together with methanol maser emission, suggesting the core will host massive star formation. We hypothesise that the SiO emission arises from shocks associated with an outflow in the cold core.Comment: 6 pages, 4 figures, 1 table, to be published in MNRA

Track and capture of the orbiter with the space station remote manipulator system

Results of the first study using the real-time, man-in-the-loop Systems Engineering Simulator (SES) for track and capture of the Space Shuttle Orbiter with the space station manipulator are presented. The objectives include evaluation of the operational coordination required between the orbiter pilot and the space station manipulator operator, evaluation of the locations and required number of closed-circuit television cameras, and evaluation of the orbiter grapple fixture clearance geometry. The SES is a premium quality real-time facility with full fidelity orbiter and space station crew workstations and cockpits

Citation Styles

 The practice of evidence based medicine and widespread clinical research have rendered literature search,a vital tool .It is practically impossible to write any article without inputs from previous literature,whether from a book,journal or a website. The backbone of any publication is the bibliography or references. This is a compilation of all the sources of data used for the research paper. A reference mentions all the details of the source,namely title,authors,journal name,year,volume and issue number and page numbers. In order to avoid plagiarism,all references should be quoted in proper context after giving due credit to the respective authors. If a manuscript needs to be revised with inclusion of additional references,the authors will have to also modify the list of references appropriately to accommodate the same.

Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection

Conventional and regulatory T cells develop in the thymus where they are exposed to samples of self-peptide MHC (pMHC) ligands. This probabilistic process selects for cells within a range of responsiveness that allows the detection of foreign antigen without excessive responses to self. Regulatory T cells are thought to lie at the higher end of the spectrum of acceptable self-reactivity and play a crucial role in the control of autoimmunity and tolerance to innocuous antigens. While many studies have elucidated key elements influencing lineage commitment, we still lack a full understanding of how thymocytes integrate signals obtained by sampling self-peptides to make fate decisions. To address this problem, we apply stochastic models of signal integration by T cells to data from a study quantifying the development of the two lineages using controllable levels of agonist peptide in the thymus. We find two models are able to explain the observations; one in which T cells continually re-assess fate decisions on the basis of multiple summed proximal signals from TCR-pMHC interactions; and another in which TCR sensitivity is modulated over time, such that contact with the same pMHC ligand may lead to divergent outcomes at different stages of development. Neither model requires that T and T are differentially susceptible to deletion or that the two lineages need qualitatively different signals for development, as have been proposed. We find additional support for the variable-sensitivity model, which is able to explain apparently paradoxical observations regarding the effect of partial and strong agonists on T and T development

User's manual for the Shuttle Electric Power System analysis computer program (SEPS), volume 2 of program documentation

The Shuttle Electric Power System Analysis SEPS computer program which performs detailed load analysis including predicting energy demands and consumables requirements of the shuttle electric power system along with parameteric and special case studies on the shuttle electric power system is described. The functional flow diagram of the SEPS program is presented along with data base requirements and formats, procedure and activity definitions, and mission timeline input formats. Distribution circuit input and fixed data requirements are included. Run procedures and deck setups are described

Observations and radiative transfer modelling of a massive dense cold core in G333

Cold massive cores are one of the earliest manifestations of high mass star formation. Following the detection of SiO emission from G333.125-0.562, a cold massive core, further investigations of the physics, chemistry and dynamics of this object has been carried out. Mopra and NANTEN2 molecular line profile observations, Australia Telescope Compact Array (ATCA) line and continuum emission maps, and Spitzer 24 and 70 \mum images were obtained. These new data further constrain the properties of this prime example of the very early stages of high mass star formation. A model for the source was constructed and compared directly with the molecular line data using a 3D molecular line transfer code - MOLLIE. The ATCA data reveal that G333.125-0.562 is composed of two sources. One of the sources is responsible for the previously detected molecular outflow and is detected in the Spitzer 24 and 70 \mum band data. Turbulent velocity widths are lower than other more active regions of G333 which reflects the younger evolutionary stage and/or lower mass of this core. The molecular line modelling requires abundances of the CO isotopes that strongly imply heavy depletion due to freeze-out of this species onto dust grains. The principal cloud is cold, moderately turbulent and possesses an outflow which indicates the presence of a central driving source. The secondary source could be an even less evolved object as no apparent associations with continuum emissions at (far-)infrared wavelengths.Comment: 10 pages, accepted to MNRA

Sub-au imaging of water vapour clouds around four Asymptotic Giant Branch stars

We present MERLIN maps of the 22-GHz H2O masers around four low-mass late-type stars (IK Tau U Ori, RT Vir and U Her), made with an angular resolution of ~ 15 milliarcsec and a velocity resolution of 0.1 km s-1. The H2O masers are found in thick expanding shells with inner radii ~ 6 to 16 au and outer radii four times larger. The expansion velocity increases radially through the H2O maser regions, with logarithmic velocity gradients of 0.5--0.9. IK Tau and RT Vir have well-filled H2O maser shells with a spatial offset between the near and far sides of the shell, which suggests that the masers are distributed in oblate spheroids inclined to the line of sight. U Ori and U Her have elongated poorly-filled shells with indications that the masers at the inner edge have been compressed by shocks; these stars also show OH maser flares. MERLIN resolves individual maser clouds, which have diameters of 2 -- 4 au and filling factors of only ~ 0.01 with respect to the whole H2O maser shells. The CSE velocity structure gives additional evidence the maser clouds are density bounded. Masing clouds can be identified over a similar timescale to their sound crossing time (~2 yr) but not longer. The sizes and observed lifetimes of these clouds are an order of magnitude smaller than those around red supergiants, similar to the ratio of low-mass:high-mass stellar masses and sizes. This suggests that cloud size is determined by stellar properties, not local physical phenomena in the wind.Comment: 21 pages, including 14 figures and 8 tables. Accepted for publication in MNRA

Polarization properties of OH masers in AGB and post-AGB stars

Context: Ground-state OH maser emission from late-type stars is usually polarized and remains a powerful probe of the magnetic field structure in the outer regions of circumstellar envelopes if observed with high angular and spectral resolutions. Observations in all four Stokes parameters are quite sparse and this is the most thorough, systematic study published to date. Aims: We aim to determine polarization properties of OH masers in an extensive sample of stars that show copious mass loss and search for candidate objects that are well-suited for high angular resolution studies. Methods: Full-polarization observations of the OH 1612 and 1667 MHz maser transitions were carried out for a sample of 117 AGB and post-AGB stars. Several targets were also observed in the 1665 MHz line. Results: Polarized features occur in more than 75% of the sources in the complete sample and there is no intrinsic difference in the occurrence of polarized emission between the three classes of objects of different infrared characteristics. The highest fractional polarization occurs for the post-AGB+PN and the Mira+SR classes at 1612 and 1667 MHz, respectively. Differences in the fractional polarization between the sources at different evolutionary stages appear to be related to depolarization caused by blending. The alignment of the polarization angles at the extreme sides of the shell implies a regular structure of the magnetic field of a strength of 0.3-2.3 mG. Conclusions: Polarized OH maser features are widespread in AGB and post-AGB stars. The relationship between the circular and linear fractional polarizations for a representative sample are consistent with the standard models of polarization for the Zeeman splitting higher than the Doppler line width, whereas the polarized features are the sigma components.Comment: Accepted for publication in Astronomy and Astrophysics. A version with appendices (Tab. A.1 and Fig. B.1) can be downloaded from http://paulo.astro.uni.torun.pl/~pw/arXiv_