Searching for solar-like oscillations in pre-main sequence stars using APOLLO

In recent years, our understanding of solar-like oscillations from main sequence to red giant stars has improved dramatically thanks to pristine data collected from space telescopes. One of the remaining open questions focuses around the observational identification of solar-like oscillations in pre-main sequence stars. We aim to develop an improved method to search for solar-like oscillations in pre-main sequence stars and apply it to data collected by the Kepler K2 mission. Our software APOLLO includes a novel way to detect low signal-to-noise ratio solar like oscillations in the presence of a high background level. By calibrating our method using known solar-like oscillators from the main Kepler mission, we apply it to T Tauri stars observed by Kepler K2 and identify several candidate pre-main sequence solar-like oscillators. We find that our method is robust even when applied to time-series of observational lengths as short as those obtained with the TESS satellite in one sector. We identify EPIC 205375290 as a possible candidate for solar-like oscillations in a pre-main sequence star with $\nu_\mathrm{max} \simeq 242\,\mu$Hz. We also derive EPIC 205375290's fundamental parameters to be $T_\mathrm{eff}$ = 3670$\pm$180 K, log $g$ = 3.85$\pm$0.3, $v$sin$i$ = 8 $\pm$ 1 km s$^{-1}$, and about solar metallicity from a high-resolution spectrum obtained from the Keck archive.Comment: 14 pages, 13 figure

Global distribution and bioclimatic characterization of alpine biomes

Although there is a general consensus on the distribution and ecological features of terrestrial biomes, the allocation of alpine ecosystems in the global biogeographic system is still unclear. Here, we delineate a global map of alpine areas above the treeline by modelling regional treeline elevation at 30 m resolution, using global forest cover data and quantile regression. We then used global datasets to 1) assess the climatic characteristics of alpine ecosystems using principal component analysis, 2) define bioclimatic groups by an optimized cluster analysis and 3) evaluate patterns of primary productivity based on the normalized difference vegetation index. As defined here, alpine biomes cover 3.56 Mkm(2) or 2.64% of land outside Antarctica. Despite temperature differences across latitude, these ecosystems converge below a sharp threshold of 5.9 degrees C and towards the colder end of the global climatic space. Below that temperature threshold, alpine ecosystems are influenced by a latitudinal gradient of mean annual temperature and they are climatically differentiated by seasonality and continentality. This gradient delineates a climatic envelope of global alpine biomes around temperate, boreal and tundra biomes as defined in Whittaker's scheme. Although alpine biomes are similarly dominated by poorly vegetated areas, world ecoregions show strong differences in the productivity of their alpine belt irrespectively of major climate zones. These results suggest that vegetation structure and function of alpine ecosystems are driven by regional and local contingencies in addition to macroclimatic factors

Which treatment for low back pain? A factorial randomised controlled trial comparing intravenous analgesics with oral analgesics in the emergency department and a centrally acting muscle relaxant with placebo over three days [ISRCTN09719705]

BACKGROUND: About two thirds of adults suffer from backpain at some time during their life. In the emergency room many patients with acute back pain are treated with intravenous non-steroidal analgesics. Whether this treatment is superior to oral administration of non-steroidal analgesics is unknown. Intravenous administration, however, requires considerable amounts of resources and accounts for high workload in busy clinics. In the further course centrally acting muscle relaxants are prescribed but the effectiveness remains unclear. The objective of this study is on the one hand to compare the effectiveness of intravenous with oral non-steroidal analgesics for acute treatment and on the other hand to compare the effectiveness of a centrally active muscle relaxant with placebo given for three days after presentation to the ED (emergency department). METHODS/DESIGN: This study is intended as a randomised controlled factorial trial mainly for two reasons: (1) the sequence of treatments resembles the actual proceedings in every-day clinical practice, which is important for the generalisability of the results and (2) this design allows to take interactions between the two sequential treatment strategies into account. There is a patient preference arm included because patients preference is an important issue providing valuable information: (1) it allows to assess the interaction between desired treatment and outcome, (2) results can be extrapolated to a wider group while (3) conserving the advantages of a fully randomised controlled trial. CONCLUSION: We hope to shed more light on the effectiveness of treatment modalities available for acute low back pain

Multilocal resistance assessment against common bunt of wheat (Triticum aestivum)

Bunt is one of the most devastating diseases of wheat, in Europe and Northern America mainly caused by Tilletia caries and T.controversa, in the warmer climates of the Near East by T.foetida. The generally obligate biotrophic pathogen is trans-mitted by contaminated seeds or can ersist in the soil. Infection occurs at the very first moments after germination of the grain. Once penetrated into the plant, the fungus grows endophytically, remaining undetected until early maturity stages when grains are replaced by spores. Besides yield losses, the malodorant spores contaminate the grains impairing their use as seeds or as food, thereby leading to serious economic losses. Usually the disease is controlled by the use of seed dressings and the use of certified seeds. For organic farming, however, re-sistance of wheat varieties to bunt s crucial as seed treatments with chemical pesticides are not allowed and several proposed alternatives, e.g. treatments with bacteria, hot water, vaccum-steam, steam-ultrasound or electrons, are expensive and lack efficiency. Major and some minor genes conferring resistance to Tilletia infections are described, however, the performance and stability and, therefore, usefulness of these resistances are under debate. Common bunt resistance is based on Flors’ gene for gene principle with an effector of the pathogen and a resistance gene in the host plants, able to detect the effector and to unleash the appropriate resistance mechanisms. To officiently use this type of resistance, it is important to characterize the effectors in the pathogen population as well as to monitor the presence and the efficacy of the resistance genes. While many of this information is available at local and regional level, only little is known at an interregional or even continental dimension. In order to obtain a better overview on the efficacy of resistance genes and the presence and distribution of pathogen races, the European Tilletia ringtest (ETR) was established including also the USA and Iraqi Kurdistan. The ringtest consists of a set of 65 wheat accessions including differentials to characterize the pathogen strains and 40 modern varieties and landraces with specific resistance features. The ringtest took place in 2015 and 2016. First results display a wide diversity of pathogen strains, allowing to recommend the deployment of the most appropriate resistance genes in the different cropping areas. Important differences in disease severity were observed among sites. Resistance was not always linked to the postulated resistance genes. Across all test sites no susceptible plant was observed in PI636170, a breeding line selected from a Turkish landrace. Low infection levels (≤25%) were observed in some breeding lines/genetic resources and also in released cultivars, e.g. Stava and SW Magnifik

Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data

The brain systems underlying placebo analgesia are insufficiently understood. Here we performed a systematic, participant-level meta-analysis of experimental functional neuroimaging studies of evoked pain under stimulus-intensity-matched placebo and control conditions, encompassing 603 healthy participants from 20 (out of 28 eligible) studies. We find that placebo vs. control treatments induce small, widespread reductions in pain-related activity, particularly in regions belonging to ventral attention (including mid-insula) and somatomotor networks (including posterior insula). Behavioral placebo analgesia correlates with reduced pain-related activity in these networks and the thalamus, habenula, mid-cingulate, and supplementary motor area. Placebo-associated activity increases occur mainly in frontoparietal regions, with high between-study heterogeneity. We conclude that placebo treatments affect pain-related activity in multiple brain areas, which may reflect changes in nociception and/or other affective and decision-making processes surrounding pain. Between-study heterogeneity suggests that placebo analgesia is a multi-faceted phenomenon involving multiple cerebral mechanisms that differ across studies

The Plastid Genome of Eutreptiella Provides a Window into the Process of Secondary Endosymbiosis of Plastid in Euglenids

Euglenids are a group of protists that comprises species with diverse feeding modes. One distinct and diversified clade of euglenids is photoautotrophic, and its members bear green secondary plastids. In this paper we present the plastid genome of the euglenid Eutreptiella, which we assembled from 454 sequencing of Eutreptiella gDNA. Comparison of this genome and the only other available plastid genomes of photosynthetic euglenid, Euglena gracilis, revealed that they contain a virtually identical set of 57 protein coding genes, 24 genes fewer than the genome of Pyramimonas parkeae, the closest extant algal relative of the euglenid plastid. Searching within the transcriptomes of Euglena and Eutreptiella showed that 6 of the missing genes were transferred to the nucleus of the euglenid host while 18 have been probably lost completely. Euglena and Eutreptiella represent the deepest bifurcation in the photosynthetic clade, and therefore all these gene transfers and losses must have happened before the last common ancestor of all known photosynthetic euglenids. After the split of Euglena and Eutreptiella only one additional gene loss took place. The conservation of gene content in the two lineages of euglenids is in contrast to the variability of gene order and intron counts, which diversified dramatically. Our results show that the early secondary plastid of euglenids was much more susceptible to gene losses and endosymbiotic gene transfers than the established plastid, which is surprisingly resistant to changes in gene content

Dynamical locality and covariance: What makes a physical theory the same in all spacetimes?

The question of what it means for a theory to describe the same physics on all spacetimes (SPASs) is discussed. As there may be many answers to this question, we isolate a necessary condition, the SPASs property, that should be satisfied by any reasonable notion of SPASs. This requires that if two theories conform to a common notion of SPASs, with one a subtheory of the other, and are isomorphic in some particular spacetime, then they should be isomorphic in all globally hyperbolic spacetimes (of given dimension). The SPASs property is formulated in a functorial setting broad enough to describe general physical theories describing processes in spacetime, subject to very minimal assumptions. By explicit constructions, the full class of locally covariant theories is shown not to satisfy the SPASs property, establishing that there is no notion of SPASs encompassing all such theories. It is also shown that all locally covariant theories obeying the time-slice property possess two local substructures, one kinematical (obtained directly from the functorial structure) and the other dynamical (obtained from a natural form of dynamics, termed relative Cauchy evolution). The covariance properties of relative Cauchy evolution and the kinematic and dynamical substructures are analyzed in detail. Calling local covariant theories dynamically local if their kinematical and dynamical local substructures coincide, it is shown that the class of dynamically local theories fulfills the SPASs property. As an application in quantum field theory, we give a model independent proof of the impossibility of making a covariant choice of preferred state in all spacetimes, for theories obeying dynamical locality together with typical assumptions.Comment: 60 pages, LaTeX. Version to appear in Annales Henri Poincar

The Moon Zoo citizen science project: preliminary results for the Apollo 17 landing site

Moon Zoo is a citizen science project that utilises internet crowd-sourcing techniques. Moon Zoo users are asked to review high spatial resolution images from the Lunar Reconnaissance Orbiter Camera (LROC), onboard NASA’s LRO spacecraft, and perform characterisation such as measuring impact crater sizes and identify morphological ‘features of interest’. The tasks are designed to address issues in lunar science and to aid future exploration of the Moon. We have tested various methodologies and parameters therein to interrogate and reduce the Moon Zoo crater location and size dataset against a validated expert survey. We chose the Apollo 17 region as a test area since it offers a broad range of cratered terrains, including secondary-rich areas, older maria, and uplands. The assessment involved parallel testing in three key areas: (1) filtering of data to remove problematic mark-ups; (2) clustering methods of multiple notations per crater; and (3) derivation of alternative crater degradation indices, based on the statistical variability of multiple notations and the smoothness of local image structures. We compared different combinations of methods and parameters and assessed correlations between resulting crater summaries and the expert census. We derived the optimal data reduction steps and settings of the existing Moon Zoo crater data to agree with the expert census. Further, the regolith depth and crater degradation states derived from the data are also found to be in broad agreement with other estimates for the Apollo 17 region. Our study supports the validity of this citizen science project but also recommends improvements in key elements of the data acquisition planning and production