Multicomponent magnetic nanoparticle engineering: the role of structure-property relationship in advanced applications

Combining magnetic nanomaterials with materials of other classes can produce multicomponent nanoparticles with an entire ensemble of new structures and unique, enhanced, synergetic, and/or complementary functionalities. Here we discuss the most recent developments in the synthesis of multicomponent magnetic nanoparticles, describe the resulting structures and their novel properties, and explore their application in a variety of fields, including multimodal imaging, nanomedicine, sensing, surface-enhanced Raman scattering, and heterogeneous catalysis. The current synthetic methods (usu-ally bottom-up approaches) of multicomponent nanoparticles can produce a number of tailored mor-phologies (core@shell, yolk-shell, core-satellite, Janus, nanochains, anisotropic, etc.), making them invaluable for applications in biology, medicine, chemistry, physics, and engineering. But like any new technology, their synthesis methods need to be optimized to be simple, scalable, and as environmentally friendly as possible before they can be widely adopted. In particular, the use of life cycle assessment (LCA) to guide future works toward environmental sustainability is highlighted. Overall, this review not only presents a critical and timely summary of the state-of-the-art of this burgeoning field in both fundamental and applied nanotechnology, but also addresses the challenges associated with under-standing the particular structure-property relationships of multicomponent magnetic nanoparticles.The authors thank funding from the Spanish State Research Agency (AEI) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033 and from the Basque Government Industry and Education Department under the ELKARTEK, HAZITEK and PIBA (PIBA-2018-06) programs, respectively

Experiences on using Arduino for laboratory experiments of Automatic Control and Robotics

The free hardware platforms have become very important in engineering education in recent years. Among these platforms, Arduino highlights, characterized by its versatility, popularity and low price. This paper describes the implementation of four laboratory experiments for Automatic Control and Robotics courses at the University of Alicante, which have been developed based on Arduino and other existing equipment. Results were evaluated taking into account the views of students, concluding that the proposed experiments have been attractive to them, and they have acquired the knowledge about hardware configuration and programming that was intended

Metodología docente para la incorporación de laboratorios virtuales en el plan de estudios del master universitario en automática y robótica

En este artículo se describe la metodología empleada para el desarrollo y coordinación de las asignaturas obligatorias del Máster Universitario en Automática y Robótica de la Universidad de Alicante. Se ha trabajado en adecuar las guías docentes a la metodología mediante el trabajo colaborativo de los distintos profesores coordinadores de las asignaturas con el objetivo de garantizar que todos los conceptos necesarios sean cubiertos y complementados entre las asignaturas, apoyándose en mapas conceptuales. Otro aspecto en el que se ha hecho un especial énfasis en la metodología propuesta ha sido introducir como parte de las actividades teóricas y/o prácticas el uso de laboratorios virtuales remotos. Los laboratorios virtuales sirven de apoyo a la teoría para mostrar simulaciones y resultados prácticos mediante la interacción con equipamiento real. Además, muchas de estas herramientas admiten que el alumnado pueda trabajar a distancia desde sus casas, lo que redunda en la posibilidad de autoaprendizaje e incluso la realización de prácticas a distancia

An egg-shell bifunctional CeO2-modified NiPd/Al2O3 catalyst for petrochemical processes involving selective hydrogenation and hydroisomerization

The catalytic performance during the 1-butyne hydrogenation using two reduced Al2O3-supported Pd-based catalysts was carried out in a total recirculation system with an external fixed-bed reactor. The lab-prepared egg-shell NiPd/CeO2-Al2O3 catalyst (NiPdCe) with Pd loading = 0.5 wt%, Ni/Pd atomic ratio = 1 and CeO2 loading = 3 wt% was synthesized and characterized, and it was compared with an egg-shell Al2O3-supported Pd based commercial catalyst (PdCC). The reduced catalysts were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, and high-resolution transmission electron microscopy. The textural characteristics and ammonia temperature-programmed desorption profiles of the fresh (unreduced) catalysts were also obtained. Both catalysts show high 1-butyne conversion and selectivity to 1-butene, but the catalysts also present important differences between hydroisomerizing and hydrogenating capabilities. NiPdCe catalyst shows higher capability for hydroisomerization reactions, while the PdCC catalyst exhibits higher hydrogenating capability. The observed catalytic performances can be interesting for some industrial processes and can provide a guideline for the development of a Pd-based catalyst with specific catalytic properties.Fil: Méndez, Franklin J.. Universidad Nacional Autónoma de México; México. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Alves, Javier Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina. Universidad Nacional de La Plata. Facultad de Ingenierí­a. Departamento de Ingeniería Química; ArgentinaFil: Rojas Challa, Yahse Vitah Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; ArgentinaFil: Corona, Oscar. Universidad Nacional Autónoma de México; México. Instituto Tecnológico Venezolano Del Petróleo; VenezuelaFil: Villasana, Yanet. Instituto Venezolano de Investigaciones Científicas; Venezuela. Universidad Regional Amazonica Ikiam; EcuadorFil: Guerra, Julia. Universidad Simón Bolívar; VenezuelaFil: Garcia Colli, Germán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina. Universidad Nacional de La Plata. Facultad de Ingenierí­a. Departamento de Ingeniería Química; ArgentinaFil: Martinez, Osvaldo Miguel. Universidad Nacional de La Plata. Facultad de Ingenierí­a. Departamento de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; ArgentinaFil: Brito, Joaquín L.. Instituto Venezolano de Investigaciones Científicas; Venezuel

A novel epigenetic signature for early diagnosis in lung cancer

Purpose: lung cancer remains as the leading cause of cancer-related death worldwide, mainly due to late diagnosis. Cytology is the gold-standard method for lung cancer diagnosis in minimally invasive respiratory samples, despite its low sensitivity. We aimed to identify epigenetic biomarkers with clinical utility for cancer diagnosis in minimally/noninvasive specimens to improve accuracy of current technologies. Experimental design: the identification of novel epigenetic biomarkers in stage I lung tumors was accomplished using an integrative genome-wide restrictive analysis of two different large public databases. DNA methylation levels for the selected biomarkers were validated by pyrosequencing in paraffin-embedded tissues and minimally invasive and noninvasive respiratory samples in independent cohorts. Results: we identified nine cancer-specific hypermethylated genes in early-stage lung primary tumors. Four of these genes presented consistent CpG island hypermethylation compared with nonmalignant lung and were associated with transcriptional silencing. A diagnostic signature was built using multivariate logistic regression model based on the combination of four genes: BCAT1, CDO1, TRIM58, and ZNF177. Clinical diagnostic value was also validated in multiple independent cohorts and yielded a remarkable diagnostic accuracy in all cohorts tested. Calibrated and cross-validated epigenetic model predicts with high accuracy the probability to detect cancer in minimally and noninvasive samples. We demonstrated that this epigenetic signature achieved higher diagnostic efficacy in bronchial fluids as compared with conventional cytology for lung cancer diagnosis. Conclusions: minimally invasive epigenetic biomarkers have emerged as promising tools for cancer diagnosis. The herein obtained epigenetic model in combination with current diagnostic protocols may improve early diagnosis and outcome of lung cancer patients

X-Ray Nanothermometry of Nanoparticles in Tumor-Mimicking Tissues under Photothermia

Temperature plays a critical role in regulating body mechanisms and indicating inflammatory processes. Local temperature increments above 42 °C are shown to kill cancer cells in tumorous tissue, leading to the development of nanoparticle-mediated thermo-therapeutic strategies for fighting oncological diseases. Remarkably, these therapeutic effects can occur without macroscopic temperature rise, suggesting localized nanoparticle heating, and minimizing side effects on healthy tissues. Nanothermometry has received considerable attention as a means of developing nanothermosensing approaches to monitor the temperature at the core of nanoparticle atoms inside cells. In this study, a label-free, direct, and universal nanoscale thermometry is proposed to monitor the thermal processes of nanoparticles under photoexcitation in the tumor environment. Gold-iron oxide nanohybrids are utilized as multifunctional photothermal agents internalized in a 3D tumor model of glioblastoma that mimics the in vivo scenario. The local temperature under near-infrared photo-excitation is monitored by X-ray absorption spectroscopy (XAS) at the Au L3-edge (11 919 eV) to obtain their temperature in cells, deepening the knowledge of nanothermal tumor treatments. This nanothermometric approach demonstrates its potential in detecting high nanothermal changes in tumor-mimicking tissues. It offers a notable advantage by enabling thermal sensing of any element, effectively transforming any material into a nanothermometer within biological environmentsThis work was supported by the Comunidad de Madrid (2018-T1/IND-1005 (A.E.), 2018-T1/IND-10360, 2022–5A/IND-24234 (A.M-N.), ASAP-CM S2022/BMD-7434 (A.E.) and NanoMagCOST CMS2018/NMT-4321 (J.C.) projects), MICINN (FPI PRE2020-96246 grant (R.L-M.), PID2021-127033OB-C21 (A.E.), RYC2020-029282-I (A.E.), PID2021-126323OA-I00 (A.M-N), PID2019-106099RB-C43 AEI/10.13039/501100011033 (J.R.) projects and CSIC (PIE-20226AT024 (A.E.)). IMDEA Nanociencia acknowledges the “Severo Ochoa” program for Centres of Excellence in R&D (SEV-2016-0686, CEX2020-001039-S). The authors thank Milagros Guerra for TEM preparation at the electron microscopy service at the Centro de Biología Molecular Severo Ochoa (CBMSO, CSIC-UAM Spain), the ICMM-CSIC technical personnel for ICP-OES measurements, and the Histology Facility at CNB-CSIC (Spain) for the histological preparation of biological samples. The authors thank the SAMBA beamline (SOLEIL synchrotron, France) staff for their support during the experiment

Outcomes of abdominal wall reconstruction in patients with the combination of complex midline and lateral incisional hernias.

Background The best treatment for the combined defects of midline and lateral incisional hernia is not known. The aim of our multicenter study was to evaluate the operative and patient-reported outcomes using a modified posterior component separation in patients who present with the combination of midline and lateral incisional hernia. Methods We identified patients from a prospective, multicenter database who underwent operative repairs of a midline and lateral incisional hernia at 4 centers with minimum 2-year follow-up. Hernias were divided into a main hernia based on the larger size and associated abdominal wall hernias. Outcomes reported were short- and long-term complications, including recurrence, pain, and bulging. Quality of life was assessed with the European Registry for Abdominal Wall Hernias Quality of Life score. Results Fifty-eight patients were identified. Almost 70% of patients presented with a midline defect as the main incisional hernia. The operative technique was a transversus abdominis release in 26 patients (45%), a modification of transversus abdominis release 27 (47%), a reverse transversus abdominis release in 3 (5%), and a primary, lateral retromuscular preperitoneal approach in 2 (3%). Surgical site occurrences occurred in 22 patients (38%), with only 8 patients (14%) requiring procedural intervention. During a mean follow-up of 30.1 ± 14.4 months, 2 (3%) cases of recurrence were diagnosed and required reoperation. There were also 4 (7%) patients with asymptomatic but visible bulging. The European Registry for Abdominal Wall Hernias Quality of Life score showed a statistically significant decrease in the 3 domains (pain, restriction, and cosmetic) in the postoperative score compared with the preoperative score. Conclusion The different techniques of posterior component separation in the treatment of combined midline and lateral incisional hernia show acceptable results, despite the associated high complexity. Patient-reported outcomes after measurement of the European Registry for Abdominal Wall Hernias Quality of Life score demonstrated a clinically important improvement in quality of life and pain.post-print2.323 K

Metodología de análisis de gestión de calidad en el Máster Universitario en Automática y Robótica

En el presente artículo se describe la investigación docente desarrollada con el objetivo de llevar a cabo el seguimiento y aplicación, del sistema interno de garantía de calidad de la Escuela Politécnica Superior de la Universidad de Alicante, al Máster Universitario en Automática y Robótica. Esta investigación es fruto de una red docente en la que han participado todos los profesores con docencia en el Máster, y en la que han trabajado coordinadamente con el objetivo de recoger los principales indicadores de calidad del Máster atendiendo a distintos criterios. Estos indicadores han servido, por un lado, para comprobar la existencia o no de deficiencias en la implantación e impartición del Título. Por otro lado, estos indicadores han servido como base para la elaboración de la documentación requerida para la reacreditación del Máster ante la ANECA. En este artículo se describe la coordinación llevada a cabo, las principales consideraciones a tener en cuenta para la implantación del sistema de garantía de calidad, así como las conclusiones extraídas de la red

Coordinación, seguimiento y gestión de calidad del Máster Universitario en Automática y Robótica

En la presente memoria se describe la red docente creada con el objetivo de llevar a cabo el seguimiento y aplicación del sistema interno de garantía de calidad de la Escuela Politécnica Superior de la Universidad de Alicante al Máster Universitario en Automática y Robótica. En esta red han participado todos los profesores con docencia en el Máster y han trabajado coordinadamente con el objetivo de recoger los principales indicadores de calidad del Máster atendiendo a distintos criterios. Estos indicadores han servido, por un lado, para comprobar la existencia o no de deficiencias en la implantación e impartición del Título. Por otro lado, estos indicadores han servido como base para la elaboración de la documentación requerida para la reacreditación del Máster ante la ANECA. En la presente memoria se describe la coordinación llevada a cabo así como las principales conclusiones extraídas de la red así como del propio informe de reacreditación