A Temperate and Wholesome Beverage: the Defense of the American Beer Industry, 1880-1920

For decades prior to National Prohibition, the liquor question received attention from various temperance, prohibition, and liquor interest groups. Between 1880 and 1920, these groups gained public interest in their own way. The liquor interests defended their industries against politicians, religious leaders, and social reformers, but ultimately failed. While current historical scholarship links the different liquor industries together, the beer industry constantly worked to distinguish itself from other alcoholic beverages. To counter threats from anti-alcohol groups, beer industry advocates presented their drink as a wholesome, pure, socially and culturally rich, and economically significant beverage that stood apart from other alcoholic beverages, especially distilled spirits. Alongside these responses, breweries industrialized, reflecting scientific and technological innovations that allowed for modern production, storage, and distribution methods. Despite popularity and economic successes, the beer industry could not survive the anti-saloon campaigns, the changing nature of the American economy and taxation, political ambitions of the anti-liquor interests, and the influence of the First World War, which brought with it anti-German sentiments. This thesis will uncover the story of the American beer industry\u27s attempt to adjust to several threats facing it and how beer was ultimately condemned to the same fate as wine and spirits when National Prohibition went into effect

Where is the chromospheric response to conductive energy input from a hot pre-flare coronal loop?

Before the onset of a flare is observed in hard X-rays there is often a pro- longed pre-flare or pre-heating phase with no detectable hard X-ray emission but pronounced soft X-ray emission suggesting that energy is being released and deposited into the corona and chromosphere already at this stage. This work analyses the temporal evolution of coronal source heating and the chromospheric response during this pre-heating phase to investigate the origin and nature of early energy release and transport during a solar flare. Simultaneous X-ray, EUV, and microwave observations of a well observed flare with a prolonged pre-heating phase are analysed to study the time evolution of the thermal emission and to determine the onset of particle acceleration. During the 20 minutes duration of the pre-heating phase we find no hint of accelerated electrons, neither in hard X-rays nor in microwave emission. However, the total energy budget during the pre-heating phase suggests that energy must be supplied to the flaring loop to sustain the observed temperature and emission measure. Under the assumption of this energy being transported toward the chromosphere via thermal conduc- tion, significant energy deposition at the chromosphere is expected. However, no detectable increase of the emission in the AIA wavelength channels sensitive to chromospheric temperatures is observed. The observations suggest energy release and deposition in the flaring loop before the onset of particle acceleration, yet a model in which energy is conducted to the chromosphere and subsequent heating of the chromosphere is not supported by the observations

Master Grazer: Improving Grazing Management in Kentucky

The Master Grazer Educational Program is the result of funding provided by the Kentucky Agricultural Development Board to educate producers on better utilization of grazing lands to improve livestock production and the profitability of the State. County agriculture and natural resource agents, extension specialists, industry contacts and producers work together to make this program a success. The Master Grazer Educational Program began in 2006 as evening lecture sessions taking place in local extension offices. In 2008, the program grew with the addition of a field session that showcased a farm with successful grazing practices, a farm with underdeveloped grazing practices, and a final session for participants to develop their own grazing system. In 2010, the program was modified into the Applied Master Grazer Program. This program placed more emphasis on the importance of the county agriculture. The agents decided which topics would be covered and administered many areas of the program. The program now consists of a minimum of two evening field sessions in which a farm is showcased for a particular topic, as well as one impact session in which participants can interact and contribute to a producer forum. For the purpose of this article, reporting will be focused on the last two years of the Master Grazer Program. The past few years, events such as Grazing Schools, the Advanced Grazing Schools, and Pasture Walks have been held to discuss timely topics of forage and livestock management. Also, the Master Grazer Program has a newsletter, website, and DVD series

Effectiveness and cost-effectiveness of basic versus biofeedback-mediated intensive pelvic floor muscle training for female stress or mixed urinary incontinence: protocol for the OPAL randomised trial

This is the final version. Available on open access from BMJ Publishing Group via the DOI in this recordIntroduction Accidental urine leakage is a distressing problem that affects around one in three women. The main types of urinary incontinence (UI) are stress, urgency and mixed, with stress being most common. Current UK guidelines recommend that women with UI are offered at least 3 months of pelvic floor muscle training (PFMT). There is evidence that PFMT is effective in treating UI, however it is not clear how intensively women have to exercise to give the maximum sustained improvement in symptoms, and how we enable women to achieve this. Biofeedback is an adjunct to PFMT that may help women exercise more intensively for longer, and thus may improve continence outcomes when compared with PFMT alone. A Cochrane review was inconclusive about the benefit of biofeedback, indicating the need for further evidence. Methods and analysis This multicentre randomised controlled trial will compare the effectiveness and cost-effectiveness of PFMT versus biofeedback-mediated PFMT for women with stress UI or mixed UI. The primary outcome is UI severity at 24 months after randomisation. The primary economic outcome measure is incremental cost per quality-adjusted life-year at 24 months. Six hundred women from UK community, outpatient and primary care settings will be randomised and followed up via questionnaires, diaries and pelvic floor assessment. All participants are offered six PFMT appointments over 16 weeks. The use of clinic and home biofeedback is added to PFMT for participants in the biofeedback group. Group allocation could not be masked from participants and healthcare staff. An intention-to-treat analysis of the primary outcome will estimate the mean difference between the trial groups at 24 months using a general linear mixed model adjusting for minimisation covariates and other important prognostic covariates, including the baseline score. Ethics and dissemination Approval granted by the West of Scotland Research Ethics Committee 4 (16/LO/0990). Written informed consent will be obtained from participants by the local research team. Serious adverse events will be reported to the data monitoring and ethics committee, the ethics committee and trial centres as required. A Standard Protocol Items: Recommendations for Interventional Trials checklist and figure are available for this protocol. The results will be published in international journals and included in the relevant Cochrane review. Trial registration number ISRCTN57746448; Pre-results.National Institute for Health Research (NIHR

Environmental DNA Based Surveillance for the Highly Invasive Carpet Sea Squirt Didemnum vexillum : A Targeted Single-Species Approach

Funding Information: The authors would like to thank the site operators, owners and Solway Firth Partnership for allowing access and sample collection at studied sites visited during this study. Thanks also to Frank Armstrong, Katy Beaton, Maria Campbell, Pablo Dias, James Dooley, Judith Horrill, Nial McLeod, Warren Murray, Andrea Taylor, Joe Triscott, and Bill Turrell for contributing to field work and sample collection. The authors thank National Museums Scotland and particularly Fiona Ware for the loan of reference material (specimen register number NMS.Z.2015.82.8, 9 and 14 and NMS.Z.2018.2.2) which was used in the present study. KS thank the Japan Society for the Promotion of Science for post-doctoral fellowship funding.Peer reviewedPublisher PD

Mapping yield and yield-related traits using diverse common bean germplasm

Common bean (bean) is one of the most important legume crops, and mapping genes for yield and yield-related traits is essential for its improvement. However, yield is a complex trait that is typically controlled by many loci in crop genomes. The objective of this research was to identify regions in the bean genome associated with yield and a number of yield-related traits using a collection of 121 diverse bean genotypes with different yields. The beans were evaluated in replicated trials at two locations, over two years. Significant variation among genotypes was identified for all traits analyzed in the four environments. The collection was genotyped with the BARCBean6K_3 chip (5,398 SNPs), two yield/antiyield gene-based markers, and seven markers previously associated with resistance to common bacterial blight (CBB), including a Niemann–Pick polymorphism (NPP) gene-based marker. Over 90% of the single-nucleotide polymorphisms (SNPs) were polymorphic and separated the panel into two main groups of small-seeded and large-seeded beans, reflecting their Mesoamerican and Andean origins. Thirty-nine significant marker-trait associations (MTAs) were identified between 31 SNPs and 15 analyzed traits on all 11 bean chromosomes. Some of these MTAs confirmed genome regions previously associated with the yield and yield-related traits in bean, but a number of associations were not reported previously, especially those with derived traits. Over 600 candidate genes with different functional annotations were identified for the analyzed traits in the 200-Kb region centered on significant SNPs. Fourteen SNPs were identified within the gene model sequences, and five additional SNPs significantly associated with five different traits were located at less than 0.6 Kb from the candidate genes. The work confirmed associations between two yield/antiyield gene-based markers (AYD1m and AYD2m) on chromosome Pv09 with yield and identified their association with a number of yield-related traits, including seed weight. The results also confirmed the usefulness of the NPP marker in screening for CBB resistance. Since disease resistance and yield measurements are environmentally dependent and labor-intensive, the three gene-based markers (CBB- and two yield-related) and quantitative trait loci (QTL) that were validated in this work may be useful tools for simplifying and accelerating the selection of high-yielding and CBB-resistant bean cultivars

Airborne electromagnetic imaging of discontinuous permafrost

The evolution of permafrost in cold regions is inextricably connected to hydrogeologic processes, climate, and ecosystems. Permafrost thawing has been linked to changes in wetland and lake areas, alteration of the groundwater contribution to stream flow, carbon release, and increased fire frequency. But detailed knowledge about the dynamic state of permafrost in relation to surface and groundwater systems remains an enigma. Here, we present the results of a pioneering ~1,800 line-kilometer airborne electromagnetic survey that shows sediments deposited over the past ~4 million years and the configuration of permafrost to depths of ~100 meters in the Yukon Flats area near Fort Yukon, Alaska. The Yukon Flats is near the boundary between continuous permafrost to the north and discontinuous permafrost to the south, making it an important location for examining permafrost dynamics. Our results not only provide a detailed snapshot of the present-day configuration of permafrost, but they also expose previously unseen details about potential surface – groundwater connections and the thermal legacy of surface water features that has been recorded in the permafrost over the past 1,000 years. This work will be a critical baseline for future permafrost studies aimed at exploring the connections between hydrogeologic, climatic, and ecological processes, and has significant implications for the stewardship of Arctic environments