Europäische Konferenz Statistische Informationssysteme zum Öko-Landbau

Am 26. und 27. April 2004 diskutierten 100 Experten aus ganz Europa in Berlin Ansätze zur Verbesserung der Datenverfügbarkeit im Bio-Landbau. Neben Experten aus Behörden und Organisationen der Bio-Branche waren auch zahlreiche Fachleute der Europäischen Kommission sowie der europäischen Statistikbehörde Eurostat vertreten. Ziel der ersten europäischen Konferenz über statistische Informationssysteme zum ökologischen Landbau war es,Vorschläge zusammenzutragen, wie die Erhebung zu Produktions- und Marktdaten im Bio-Landbau in Europa verbessert werden kann. Die Tagung des EU-finanzierten Projekts EISfOM (European Information Systems for Organic Markets) wurde von der ZMP und dem Fachgebiet Agrar- und Lebensmittelmarketing der Universität Kassel organisiert. Es zeigte sich, dass bei den zuständigen Behörden das Interesse an statistischen Daten zum ökologischen Landbau inzwischen sehr hoch ist, dass aber erheblicher Harmonisierungsbedarf sowohl auf einzelstaatlicher als auch auf EU-Ebene besteht. In Expertenworkshops wurden dazu Vorschläge zu statistischen Erhebungen im Bereich landwirtschaftliche Erzeugung, Buchführungsergebnisse (Farm Accountancy Data Network (FADN)), Handel,Verbraucher und Politikbewertung erörtert

European Information System for Organic Markets (EISFOM QLK5-2002-02400): WP 2: “Data collection and processing systems (DCPS) for the conventional markets” and WP 3: “Data collection and processing systems for organic markets” = Deliverable D2

European markets for organic products are developing fast. In Europe, as other parts of the world, more and more farm land is being converted to organic production. In order to adjust production and consumption levels, detailed market information is needed, especially where decisions with a long-term impact need to be taken, for example on converting specific land or livestock enterprises requiring high levels of investment in glasshouses, housing, processing facilities etc. Since public subsidies (regional / national / European) are heavily involved in these investments, valid, accurate and up-to-date information is essential not only for farmers and growers, but also for policy-makers, consultants, processing industry etc. EU-research projects such as OFCAP (FAIR3-CT96-1794) and OMIaRD (QLK5-2000-01124) have shown that regional or national data gathering takes place in many countries, but often only very basic data are reported, such as certified organic holdings, land areas and livestock numbers. Important market data, e.g. the amount of production, consumption, international trade or producer and consumer prices, do not exist in most European countries. In some European countries there are only rough estimates of the levels of production and consumption. There is no standardization and data are seldom comparable. Furthermore, detailed information on specific commodities is missing. Hence, investment decisions are taken under conditions of great uncertainty. Likewise, if politicians want to support organic agriculture, they do not know whether it would be better to support production or consumption or to address problems in the marketing channel. The EU concerted action EISfOM (QLK5-2002-02400) (European Information System for Organic Markets) is attempting to take the first steps in solving these problems. The aim of this concerted action is to build up a framework for reporting valid and reliable data for relevant production and market sectors of the European organic sector in order to meet the needs of policy-makers, farmers, processors, wholesalers and other actors involved in organic markets. In order to reach this aim, this action was split into several workpackages. This report describes the approach and results of workpackages 2 and 3. In this first chapter the objective and general approach of these work packages are described. Chapters 2 and 3 provide an overview of international statistics and data collection systems within the food supply chain at the public and the private level. Chapter 4 describes national statistics and data collection systems within the food supply chain. In Chapter 5, an analysis and appraisal is made of the results with regard to organic data collection and processing systems (DCPSs) and their integration into existing common DCPSs. Chapter 6 draws several general conclusions. Two substantial annexes complete the report, one with the country reports on the situation of data collection and processing in all investigated countries and the other with the first and the second stage questionnaires covering the different data collection levels

Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ suppression hybridization

In situ suppression hybridization with recombinant bacteriophage DNA libraries for chromosomes 8 and 21 was performed in two cases of acute nonlymphocytic leukemia, type FAB M2. In both cases, cytogenetic analysis by conventional G-banding revealed t(8;21)(q22;q22). In situ suppression hybridization was able to prove the reciprocal nature of the translocation in both cases by identifying the terminal end of chromosome 21 translocated to the derivative chromosome 8q−

Altered Cardiac Repolarization in Association with Air Pollution and Air Temperature among Myocardial Infarction Survivors

Background: Epidemiological studies have shown that ambient particulate matter (PM) and changes in air temperature are associated with increased cardiopulmonary events. Objective: We hypothesized that patients with previous myocardial infarction (MI) experience changes in heart rate (HR) and repolarization parameters, such as Bazett-corrected QT interval (QTc), and T-wave amplitude (Tamp), in association with increases in air pollution and temperature changes. Methods: Between May 2003 and February 2004, 67 MI survivors from the Augsburg KORA-MI registry repeatedly sent 16 sec electrocardiograms (ECGs) with a personal transmitter (Viapac) via telephone to the Philips Monitoring Center, where ECG parameters were immediately analyzed. Meteorological data and air pollutants were acquired from fixed monitoring sites on an hourly basis. Additive mixed models were used for analysis. Effect modification by patient characteristics was investigated. Results: The analysis of the 1,745 ECGs revealed an increased HR associated with interquartile range (IQR) increases in PM levels among participants not using beta-adrenergic receptor blockers and among those with body mass index ≥ 30 kg/m2. We observed a 24- to 47-hr lagged QTc prolongation [0.5% change (95% confidence interval, 0.0–1.0%)] in association with IQR increases in levels of PM ≤ 2.5 µm in aerodynamic diameter, especially in patients with one [0.6% (0.1–1.0%)] or two [1.2% (0.4–2.1%)] minor alleles of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) single-nucleotide polymorphism rs2364725. Positive immediate (0–23 hr) and inverse delayed (48–71 hr up to 96–119 hr) associations were evident between PM and Tamp. We detected an inverse U-shaped association between temperature and Tamp, with a maximum Tamp at 5°C. Conclusions: Increased air pollution levels and temperature changes may lead to changes in HR and repolarization parameters that may be precursors of cardiac problems.The AIRGENE study was funded as part of the European Union’s 5th Framework Programme, key action 4: “Environment and Health,” contract QLRT-2002-02236. This research has been funded wholly or in part by the U.S. Environmental Protection Agency through Science to Achieve Results grants RD827354 and RD832415 to the University of Rocheste

Spinocerebellar ataxia type 14: refining clinicogenetic diagnosis in a rare adult‐onset disorder

Objectives: Genetic variant classification is a challenge in rare adult-onset disorders as in SCA-PRKCG (prior spinocerebellar ataxia type 14) with mostly private conventional mutations and nonspecific phenotype. We here propose a refined approach for clinicogenetic diagnosis by including protein modeling and provide for confirmed SCA-PRKCG a comprehensive phenotype description from a German multi-center cohort, including standardized 3D MR imaging. Methods: This cross-sectional study prospectively obtained neurological, neuropsychological, and brain imaging data in 33 PRKCG variant carriers. Protein modeling was added as a classification criterion in variants of uncertain significance (VUS). Results: Our sample included 25 cases confirmed as SCA-PRKCG (14 variants, thereof seven novel variants) and eight carriers of variants assigned as VUS (four variants) or benign/likely benign (two variants). Phenotype in SCA-PRKCG included slowly progressive ataxia (onset at 4-50 years), preceded in some by early-onset nonprogressive symptoms. Ataxia was often combined with action myoclonus, dystonia, or mild cognitive-affective disturbance. Inspection of brain MRI revealed nonprogressive cerebellar atrophy. As a novel finding, a previously not described T2 hyperintense dentate nucleus was seen in all SCA-PRKCG cases but in none of the controls. Interpretation: In this largest cohort to date, SCA-PRKCG was characterized as a slowly progressive cerebellar syndrome with some clinical and imaging features suggestive of a developmental disorder. The observed non-ataxia movement disorders and cognitive-affective disturbance may well be attributed to cerebellar pathology. Protein modeling emerged as a valuable diagnostic tool for variant classification and the newly described T2 hyperintense dentate sign could serve as a supportive diagnostic marker of SCA-PRKCG

The North Atlantic Waveguide and Downstream Impact Experiment

The North Atlantic Waveguide and Downstream Impact Experiment (NAWDEX) explored the impact of diabatic processes on disturbances of the jet stream and their influence on downstream high-impact weather through the deployment of four research aircraft, each with a sophisticated set of remote sensing and in situ instruments, and coordinated with a suite of ground-based measurements. A total of 49 research flights were performed, including, for the first time, coordinated flights of the four aircraft: the German High Altitude and Long Range Research Aircraft (HALO), the Deutsches Zentrum für Luft- und Raumfahrt (DLR) Dassault Falcon 20, the French Service des Avions Français Instrumentés pour la Recherche en Environnement (SAFIRE) Falcon 20, and the British Facility for Airborne Atmospheric Measurements (FAAM) BAe 146. The observation period from 17 September to 22 October 2016 with frequently occurring extratropical and tropical cyclones was ideal for investigating midlatitude weather over the North Atlantic. NAWDEX featured three sequences of upstream triggers of waveguide disturbances, as well as their dynamic interaction with the jet stream, subsequent development, and eventual downstream weather impact on Europe. Examples are presented to highlight the wealth of phenomena that were sampled, the comprehensive coverage, and the multifaceted nature of the measurements. This unique dataset forms the basis for future case studies and detailed evaluations of weather and climate predictions to improve our understanding of diabatic influences on Rossby waves and the downstream impacts of weather systems affecting Europe