Exact Boson Sampling using Gaussian continuous variable measurements

BosonSampling is a quantum mechanical task involving Fock basis state preparation and detection and evolution using only linear interactions. A classical algorithm for producing samples from this quantum task cannot be efficient unless the polynomial hierarchy of complexity classes collapses, a situation believe to be highly implausible. We present method for constructing a device which uses Fock state preparations, linear interactions and Gaussian continuous-variable measurements for which one can show exact sampling would be hard for a classical algorithm in the same way as Boson Sampling. The detection events used from this arrangement does not allow a similar conclusion for the classical hardness of approximate sampling to be drawn. We discuss the details of this result outlining some specific properties that approximate sampling hardness requires

Conditional Production of Superpositions of Coherent States with Inefficient Photon Detection

It is shown that a linear superposition of two macroscopically distinguishable optical coherent states can be generated using a single photon source and simple all-optical operations. Weak squeezing on a single photon, beam mixing with an auxiliary coherent state, and photon detecting with imperfect threshold detectors are enough to generate a coherent state superposition in a free propagating optical field with a large coherent amplitude ($\alpha>2$) and high fidelity ($F>0.99$). In contrast to all previous schemes to generate such a state, our scheme does not need photon number resolving measurements nor Kerr-type nonlinear interactions. Furthermore, it is robust to detection inefficiency and exhibits some resilience to photon production inefficiency.Comment: Some important new results added, to appear in Phys.Rev.A (Rapid Communication

Comparison of LOQC C-sign gates with ancilla inefficiency and an improvement to functionality under these conditions

We compare three proposals for non-deterministic C-sign gates implemented using linear optics and conditional measurements with non-ideal ancilla mode production and detection. The simplified KLM gate [Ralph et al, Phys.Rev.A {\bf 65}, 012314 (2001)] appears to be the most resilient under these conditions. We also find that the operation of this gate can be improved by adjusting the beamsplitter ratios to compensate to some extent for the effects of the imperfect ancilla.Comment: to appear in PR

Boson Sampling from Gaussian States

We pose a generalized Boson Sampling problem. Strong evidence exists that such a problem becomes intractable on a classical computer as a function of the number of Bosons. We describe a quantum optical processor that can solve this problem efficiently based on Gaussian input states, a linear optical network and non-adaptive photon counting measurements. All the elements required to build such a processor currently exist. The demonstration of such a device would provide the first empirical evidence that quantum computers can indeed outperform classical computers and could lead to applications

Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells.

Natural antibodies contribute to tissue homeostasis and protect against infections. They are secreted constitutively without external antigenic stimulation. The differentiation state and regulatory pathways that enable continuous natural antibody production by B-1 cells, the main cellular source in mice, remain incompletely understood. Here we demonstrate that natural IgM-secreting B-1 cells in the spleen and bone marrow are heterogeneous, consisting of (a) terminally differentiated B-1-derived plasma cells expressing the transcriptional regulator of differentiation, Blimp-1, (b) Blimp-1+, and (c) Blimp-1neg phenotypic B-1 cells. Blimp-1neg IgM-secreting B-1 cells are not simply intermediates of cellular differentiation. Instead, they secrete similar amounts of IgM in wild-type and Blimp-1-deficient (PRDM-1ΔEx1A) mice. Blimp-1neg B-1 cells are also a major source of IgG3. Consequently, deletion of Blimp-1 changes neither serum IgG3 levels nor the amount of IgG3 secreted per cell. Thus, the pool of natural antibody-secreting B-1 cells is heterogeneous and contains a distinct subset of cells that do not use Blimp-1 for initiation or maximal antibody secretion

Production of superpositions of coherent states in traveling optical fields with inefficient photon detection

We develop an all-optical scheme to generate superpositions of macroscopically distinguishable coherent states in traveling optical fields. It non-deterministically distills coherent state superpositions (CSSs) with large amplitudes out of CSSs with small amplitudes using inefficient photon detection. The small CSSs required to produce CSSs with larger amplitudes are extremely well approximated by squeezed single photons. We discuss some remarkable features of this scheme: it effectively purifies mixed initial states emitted from inefficient single photon sources and boosts negativity of Wigner functions of quantum states.Comment: 13 pages, 9 figures, to be published in Phys. Rev.

Elastic forces that do no work and the dynamics of fast cracks

Elastic singularities such as crack tips, when in motion through a medium that is itself vibrating, are subject to forces orthogonal to the direction of motion and thus impossible to determine by energy considerations alone. This fact is used to propose a universal scenario, in which three dimensionality is essential, for the dynamic instability of fast cracks in thin brittle materials.Comment: 8 pages Latex, 1 Postscript figur

SUSApp: a mobile app for measuring and comparing questionnaire-based usability assessments

Usability questionnaires are one of the most used methods to measure usability in terms of the user’s subjective satisfaction. However, most of the usability questionnaires do not provide a complete environment to store measurements and compare different usability values of application categories and versions over the long term, which makes it difficult to study the usability of a software product or even the usability of different versions of such products over time, hindering the facility to obtain comparisons and thresholds in usability measurements for different product lines. In this paper we present SUSApp, a tool conceived for the analysis of usability through the SUS (System Usability Scale) questionnaire, which is one of the most popular ones. This tool was conceived for mobile platforms, and it is intended to easily analyze usability by storing and recovering past evaluations, and allowing to statistically compare usability measurements among different software products and applications categories. In addition, a user testing is presented. This has provided acceptable usability results concerning SUSApp in an experiment with real usersThis work has been partially supported by the funding projects «eMadrid-CM», granted by the Madrid Research Council (project code S2013/ICE-2715), and «Flexor» granted by the Spanish Government (project code TIN2014-52129-R

Cavity Quantum Electrodynamics with Anderson-localized Modes

A major challenge in quantum optics and quantum information technology is to enhance the interaction between single photons and single quantum emitters. Highly engineered optical cavities are generally implemented requiring nanoscale fabrication precision. We demonstrate a fundamentally different approach in which disorder is used as a resource rather than a nuisance. We generate strongly confined Anderson-localized cavity modes by deliberately adding disorder to photonic crystal waveguides. The emission rate of a semiconductor quantum dot embedded in the waveguide is enhanced by a factor of 15 on resonance with the Anderson-localized mode and 94 % of the emitted single-photons couple to the mode. Disordered photonic media thus provide an efficient platform for quantum electrodynamics offering an approach to inherently disorder-robust quantum information devices

Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus

In contrast to previously reported elevations in serum sclerostin levels in diabetic patients, the present study shows that the impaired bone microarchitecture and cellular turnover associated with type 2 diabetes mellitus (T2DM)-like conditions in ZDF rats are not correlated with changes in serum and bone sclerostin expression. INTRODUCTION: T2DM is associated with impaired skeletal structure and a higher prevalence of bone fractures. Sclerostin, a negative regulator of bone formation, is elevated in serum of diabetic patients. We aimed to relate changes in bone architecture and cellular activities to sclerostin production in the Zucker diabetic fatty (ZDF) rat. METHODS: Bone density and architecture were measured by micro-CT and bone remodelling by histomorphometry in tibiae and femurs of 14-week-old male ZDF rats and lean Zucker controls (n = 6/group). RESULTS: ZDF rats showed lower trabecular bone mineral density and bone mass compared to controls, due to decreases in bone volume and thickness, along with impaired bone connectivity and cortical bone geometry. Bone remodelling was impaired in diabetic rats, demonstrated by decreased bone formation rate and increased percentage of tartrate-resistant acid phosphatase-positive osteoclastic surfaces. Serum sclerostin levels (ELISA) were higher in ZDF compared to lean rats at 9 weeks (+40 %, p < 0.01), but this difference disappeared as their glucose control deteriorated and by week 14, ZDF rats had lower sclerostin levels than control rats (-44 %, p < 0.0001). Bone sclerostin mRNA (qPCR) and protein (immunohistochemistry) were similar in ZDF, and lean rats at 14 weeks and genotype did not affect the number of empty osteocytic lacunae in cortical and trabecular bone. CONCLUSION: T2DM results in impaired skeletal architecture through altered remodelling pathways, but despite altered serum levels, it does not appear that sclerostin contributes to the deleterious effect of T2DM in rat bone