Optimisation de la fiabilité des accélérateurs ADS dans le cadre du projet EUROTRANS

National audienceEUROTRANS est le projet européen réalisé dans le cadre du 6ème Plan Commun sur la R&D (PCRD), dont le but est développer les solutions technologiques pour la transmutation des déchets nucléaires dans un réacteur sous critique piloté par un accélérateur. L'acc élérateur délivre un faisceau continu de protons à haute intensité, sur une cible de spallation situé au coeur du réacteur. Pour limiter le nombre de chocs thermiques dans la cible de spallation et le coeur du réacteur, les accélérateurs utilisés dans les Accelerator Driven Systems (ADS), exigent une abilité accrue de moins de 5 arrêts faisceau de plus d'une seconde par an. Quelques aspects de l'étude sur la abilité des cryomodules accélérateur en cours à l'Institue de Physique Nucléaire d'Orsay seront illustrés dans ce papier. Le système de contrôle et commande bas niveau digital (low level radio frequency (LLRF)) d'alimentation des cavités supraconductrices (SC), garantissant la stabilit é nécessaire du faisceau sera présenté, ainsi que la conception du coupleur de puissance

Industrial Production and Delivery of 670 Fundamental Power Couplers for the XFEL Linac

WEPEC003International audienceWithin the XFEL project Laboratoire d'Accélérateur Linéaire (LAL) is engaged to deliver 800 fundamental power couplers operating at 1.3 GHz at nominal power of 120 kW for the superconducting linac. This paper presents the strategies chosen for industrial production along with that of conditioning so as to deliver couplers at the rate of 8 per week

Poremećaj pažnje sa hiperaktivnošću i mikronutritijenti

Attention Deficit Hyperactivity Disorder (ADHD) is a clinical behavioral disorder in children marked by an ongoing pattern of inattention and/or hyperactivity-impulsivity in all situations, which occurs early and persists through time. The aim of the paper is to review the previous scientific studies in which the issue of association between the attention deficit and hyperactivity and micronutrients (vitamins and minerals) was addressed, by examining the available literature. Numerous studies have correlated the diet, that is, nutritional deficits with the ADHD. Deficiency of fatty acids, as well as the lack of zinc and iron, were the most frequently observed. Some studies have reported a significant effect of precisely defined doses of vitamins D and B12, while others have determined the existence of a positive correlation between the severity of ADHD symptoms and the level of nutritional deficiency. Overall, the duction of appropriate nutritional and/ or supplementation regimens could be a good option for reducing the ADHD symptoms. As a practical contribution, all information on possible unwanted outcomes of micronutrient imbalance should be available to parents of children with ADHD and experts directly involved in working with these families. Larger studies are needed to determine the optimal multifactorial treatment that includes, in addition to medications and behavioral work, balanced nutrition with the necessary supplementation.Poremećaj pažnje sa hiperaktivnošću (eng. Attention Deficit Hyperactivity Disorder - ADHD) je klinički poremećaj ponašanja kod dece kod koga se javlja nedostatak pažnje i/ili hiperaktivnost u svim situacijama, a koji se javlјa rano i perzistira kroz vreme. Cilј rada je da se uvidom u dostupnu literaturu, napravi pregled dosadašnjih naučnih radova u kojima je obrađivana problematika povezanosti deficita pažnje i hiperaktivnosti i mikronutrijenata: vitamina i minerala. Brojne studije dovele su u vezu ishranu, odnosno, nutricione deficite sa nastankom ADHD. Najčešće su uočeni deficiti masnih kiselina, kao i nedostatak cinka i gvožđa. Neke studije su izvestile o značajnom učinku precizno određenih doza vitamin D i B12, dok su druge utvrdile postojanje pozitivne korelacije između jačine ADHD simptoma i nivoa nutritivnog deficita. Sveukupno, uvođenje odgovarajućih režima ishrane i/ili suplementacije bi mogla biti dobra opcija za smanjenje simptoma ADHD. Kao praktični doprinos, potrebno je da sve informacije o mogućim neželјenim ishodima disbalansa mikronutrijenata budu dostupne roditelјima dece sa ADHD i stručnjacima neposredno uklјučenim u rad sa ovim porodicama. Potrebne su veće studije za određivanje optimalnog multifaktorskog tretmana koji uklјučuje, pored lekova i bihevioralnog rada, izbalansiranu ishranu sa potrebnom suplementacijom

NORMALIZED WEIGHTED GEOMETRIC BONFERRONI MEAN OPERATOR OF INTERVAL ROUGH NUMBERS – APPLICATION IN INTERVAL ROUGH DEMATEL-COPRAS MODEL

This paper presents a new approach to the treatment of uncertainty and imprecision in multi-criteria decision-making based on interval rough numbers (IRN). The IRN-based approach provides decision-making using only internal knowledge for the data and operational information of a decision-maker. A new normalized weighted geometric Bonferroni mean operator is developed on the basis of the IRN for the aggregation of the IRN (IRNWGBM). Testing of the IRNWGBM operator is performed through the application in a hybrid IR-DEMATEL-COPRAS multi-criteria model which is tested on real case of selection of optimal direction for the creation of a temporary military route. The first part of hybrid model is the IRN DEMATEL model, which provides objective expert evaluation of criteria under the conditions of uncertainty and imprecision. In the second part of the model, the evaluation is carried out using the new interval rough COPRAS technique

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver

BACKGROUND: Metabolic homeostasis in mammals critically depends on the regulation of fasting-induced genes by CREB in the liver. Previous genome-wide analysis has shown that only a small percentage of CREB target genes are induced in response to fasting-associated signaling pathways. The precise molecular mechanisms by which CREB specifically targets these genes in response to alternating hormonal cues remain to be elucidated. RESULTS: We performed chromatin immunoprecipitation coupled to high-throughput sequencing of CREB in livers from both fasted and re-fed mice. In order to quantitatively compare the extent of CREB-DNA interactions genome-wide between these two physiological conditions we developed a novel, robust analysis method, termed the ‘single sample independence’ (SSI) test that greatly reduced the number of false-positive peaks. We found that CREB remains constitutively bound to its target genes in the liver regardless of the metabolic state. Integration of the CREB cistrome with expression microarrays of fasted and re-fed mouse livers and ChIP-seq data for additional transcription factors revealed that the gene expression switches between the two metabolic states are associated with co-localization of additional transcription factors at CREB sites. CONCLUSIONS: Our results support a model in which CREB is constitutively bound to thousands of target genes, and combinatorial interactions between DNA-binding factors are necessary to achieve the specific transcriptional response of the liver to fasting. Furthermore, our genome-wide analysis identifies thousands of novel CREB target genes in liver, and suggests a previously unknown role for CREB in regulating ER stress genes in response to nutrient influx

Doping Dependence of the Redistribution of Optical Spectral Weight in Bi2_{2}Sr2_{2}CaCu2_{2}O8+δ_{8+\delta}

We present the ab-plane optical conductivity of four single crystals of Bi$_{2}$Sr$_{2}$CaCu$_{2}$O$_{8+\delta}$ (Bi2212) with different carrier doping levels from the strongly underdoped to the strongly overdoped range with $T_c$=66, 88, 77, and 67 K respectively. We focus on the redistribution of the low frequency optical spectral weight (SW) in the superconducting and normal states. The temperature dependence of the low-frequency spectral weight in the normal state is significantly stronger in the overdoped regime. In agreement with other studies, the superconducting order is marked by an increase of the low frequency SW for low doping, while the SW decreases for the highly overdoped sample. The effect crosses through zero at a doping concentration $\delta$=0.19 which is slightly to the right of the maximum of the superconducting dome. This sign change is not reproduced by the BCS model calculations, assuming the electron-momentum dispersion known from published ARPES data. Recent Cluster Dynamical Mean Field Theory (CDMFT) calculations based on the Hubbard and t-J models, agree in several relevant respects with the experimental data

A Data Streaming Architecture for Air Quality Monitoring in Smart Cities

This paper aims to present a modeling approach for the seamless data streaming process from smart IoT systems to Apache Kafka, leveraging the MQTT protocol. The paper begins by discussing the concept of real-time data streaming, emphasizing the need to transfer data from IoT/edge devices and sensors to Apache Kafka in a timely manner. The second part consists of a literature overview that shows the analysis and systematization of different types of architectures in the broad sense of crowdsensing, followed by specific architectures regarding edge and cloud computing. The methodology section will propose an infrastructure and data streaming architecture for smart environment services, such as air quality monitoring. Lastly, a discussion about results and future development will be shown in the last two sections. The proposed integration approach offers several advantages, including efficient and scalable data streaming, real-time analytics, and enhanced data processing capabilities

Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids.

The gut microbiota is essential for numerous aspects of human health. However, the underlying mechanisms of many host-microbiota interactions remain unclear. The aim of this study was to characterize effects of the microbiota on host epithelium using a novel ex vivo model based on mouse ileal organoids. We have explored the transcriptional response of organoids upon exposure to short-chain fatty acids (SCFAs) and products generated by two abundant microbiota constituents, Akkermansia muciniphila and Faecalibacterium prausnitzii. We observed that A. muciniphila metabolites affect various transcription factors and genes involved in cellular lipid metabolism and growth, supporting previous in vivo findings. Contrastingly, F. prausnitzii products exerted only weak effects on host transcription. Additionally, A. muciniphila and its metabolite propionate modulated expression of Fiaf, Gpr43, histone deacetylases (HDACs), and peroxisome proliferator-activated receptor gamma (Ppar¿), important regulators of transcription factor regulation, cell cycle control, lipolysis, and satiety. This work illustrates that specific bacteria and their metabolites differentially modulate epithelial transcription in mouse organoids. We demonstrate that intestinal organoids provide a novel and powerful ex vivo model for host-microbiome interaction studies