Transplant of GABAergic Precursors Restores Hippocampal Inhibitory Function in a Mouse Model of Seizure Susceptibility

16 páginas, 8 figuras.-- Licencia Creative Commons Reconocimiento-No comercial.Defects in GABAergic function can cause epilepsy. In the last years, cell-based therapies have attempted to correct these defects with disparate success on animal models of epilepsy. Recently, we demonstrated that medial ganglionic eminence (MGE)-derived cells grafted into the neonatal normal brain migrate and differentiate into functional mature GABAergic interneurons. These cells are able to modulate the local level of GABA-mediated synaptic inhibition, which suggests their suitability for cell-based therapies. However, it is unclear whether they can integrate in the host circuitry and rescue the loss of inhibition in pathological conditions. Thus, as proof of principle, we grafted MGE-derived cells into a mouse model of seizure susceptibility caused by specific elimination of GABAergic interneuron subpopulations in the mouse hippocampus after injection of the neurotoxic saporin conjugated to substance P (SSP-Sap). This ablation was associated with significant decrease in inhibitory postsynaptic currents (IPSC) on CA1 pyramidal cells and increased seizure susceptibility induced by pentylenetetrazol (PTZ). Grafting of GFP+ MGE-derived cells in SSP-Sap-treated mice repopulates the hippocampal ablated zone with cells expressing molecular markers of mature interneurons. Interestingly, IPSC kinetics on CA1 pyramidal cells of ablated hippocampus significantly increased after transplantation, reaching levels similar to the normal mice. More importantly, this was associated with reduction in seizure severity and decrease in postseizure mortality induced by PTZ. Our data show that MGE-derived cells fulfill most of the requirements for an appropriate cell-based therapy, and indicate their suitability for neurological conditions where a modulation of synaptic inhibition is needed, such as epilepsy.This work was supported by grants from Spanish Ministry of Science and Innovation (SAF 07/61880 and FIS 07/0079), and the Regenerative Medicine Programme from CIPF. M.E.C. and I.Z. were recipients of Miguel Servet contract from Carlos III Institute (Spanish Ministry of Science and Innovation) and Ph.D. fellowship from Generalitat Valenciana, respectively.Peer reviewe

Transplant of GABAergic Precursors Restores Hippocampal Inhibitory Function in a Mouse Model of Seizure Susceptibility

Defects in GABAergic function can cause epilepsy. in the last years, cell-based therapies have attempted to correct these defects with disparate success on animal models of epilepsy. Recently, we demonstrated that medial ganglionic eminence (MGE)-derived cells grafted into the neonatal normal brain migrate and differentiate into functional mature GABAergic interneurons. These cells are able to modulate the local level of GABA-mediated synaptic inhibition, which suggests their suitability for cell-based therapies. However, it is unclear whether they can integrate in the host circuitry and rescue the loss of inhibition in pathological conditions. Thus, as proof of principle, we grafted MGE-derived cells into a mouse model of seizure susceptibility caused by specific elimination of GABAergic interneuron subpopulations in the mouse hippocampus after injection of the neurotoxic saporin conjugated to substance P (SSP-Sap). This ablation was associated with significant decrease in inhibitory postsynaptic currents (IPSC) on CA1 pyramidal cells and increased seizure susceptibility induced by pentylenetetrazol (PTZ). Grafting of GFP(+) MGE-derived cells in SSP-Sap-treated mice repopulates the hippocampal ablated zone with cells expressing molecular markers of mature interneurons. Interestingly, IPSC kinetics on CA1 pyramidal cells of ablated hippocampus significantly increased after transplantation, reaching levels similar to the normal mice. More importantly, this was associated with reduction in seizure severity and decrease in postseizure mortality induced by PTZ. Our data show that MGE-derived cells fulfill most of the requirements for an appropriate cell-based therapy, and indicate their suitability for neurological conditions where a modulation of synaptic inhibition is needed, such as epilepsy.Spanish Ministry of Science and InnovationCIPFCarlos III Institute (Spanish Ministry of Science and Innovation)Generalitat ValencianaAndalusian Ctr Mol Biol & Regenerat Med CABIMER, Dept Cell Therapy & Regenerat Med, Seville, SpainCIPF, Valencia, SpainUniversidade Federal de São Paulo, Dept Physiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, São Paulo, BrazilSpanish Ministry of Science and Innovation: SAF 07/61880Spanish Ministry of Science and Innovation: FIS 07/0079Web of Scienc

Ocorrência de nematóides em culturas de cebola

Several nematode species were found in the State of São Paulo, Brazil, attacking roots of onion; namely, Meloidogyne incognita, M. javanica, M. thamesi, and Pratylenchus brachyurus. The last species seemed to be much more serious a detriment to onion production than the other ones. Symptoms exhibited by the attacked plants, particularily in seedlings, were: reduction of the aerial part and root system, chlorosis, magnesium and other element deficiencies, galls and necrosis on the roots and multilated roots. Control measures considered most economic are presented. They include: fumigation of the seed beds, crop rotation and repeated disturbance of the soil principally during hot-dry periods.Culturas de cebola (Allium cepa L.), conduzidas em duas localidades do Estado de São Paulo, sofreram infestação por nematóides parasitos das raízes, filiados aos gêneros Meloidogyne (M. incognita, M. javanica e M. thamesi) e pratylenchus (P. brachyurus). A última espécie pareceu ser bem mais nociva que as demais como parasita da planta em apreço. Os sintomas exibidos pelas plantas atacadas, principalmente pelos “seedlings", foram os seguintes: redução na parte aérea e no sistema radicular, clorose, sintomas de deficiência de magnésio e outros elementos, galhas e necroses nas raízes, raízes amputadas. As medidas de controle disponíveis, consideradas as mais econômicas, são apresentadas e incluem fumigação dos canteiros destinados às sementeiras, rotação de culturas e revolvimentos repetidos do solo, máxime em períodos quentes e secos

Assessment of Brand Type Influence in Purchase Decision.

Due to the proliferation of products on the shelves in the stores, many companies started to use brands to differentiate their offer from competitors. However, many managers create an improper positioning of their brands and, thus, reduce the value of their products, rather than expand it. In order to improve the understanding about the type of brand, this study aimed to analyze the consumer preference in relation to facial anti-aging cosmetics attributes that brands can influence, such as: brand type, price, perceived quality, minimum purchase quantity and status. To achieve this scope, a survey was carried, during the year of 2009, concerning the preferences of 100 women about anti-aging cosmetics. The data analysis was executed using conjoint analysis. It was discovered that, to the analyzed sample, the determinative attributes to choose an anti-aging facial cosmetic, arranged in ascending order, are: minimum purchase quantity, status, price, brand type and quality. And, despite a few exceptions, it was obtained that social brand is preferred by the respondents. Thus, since the quality is the most important attribute for the interviewees, social brands that focus on the quality of their products and on how they are made can be great sources of value for the companies.Com a proliferação de produtos nas gôndolas das lojas, muitas empresas passaram a utilizar as marcas com a finalidade de diferenciar sua oferta das dos concorrentes. Entretanto, muitos gestores posicionam indevidamente suas marcas e, dessa forma, reduzem o valor de seus produtos, ao invés de ampliá-lo. Com o objetivo de melhorar o entendimento do tipo de marca, este estudo se propôs a avaliar a preferência do consumidor em relação a atributos de cosméticos faciais anti-idade que as marcas influenciam, como: tipo de marca, preço, qualidade percebida, quantidade mínima de compra e status. Para isso, pesquisaram-se, durante o ano de 2009, as preferências de 100 mulheres em relação a cosméticos anti-idade. A análise dos dados foi feita por meio da conjoint analysis. Descobriu-se que, para a amostra estudada, os atributos determinativos da escolha de um creme facial anti-idade, dispostos em ordem crescente, perfazem a seguinte escala: quantidade mínima de compra, status, preço, tipo de marca e qualidade. E, não obstante algumas ressalvas, constatou-se que a marca social é a preferida pelas respondentes. Assim, como a qualidade é o item mais importante para as pessoas entrevistadas, marcas sociais que enfoquem a qualidade de seus produtos e o modo como são feitos podem ser grandes fontes de valor para as empresas.Con la proliferación de productos en las góndolas de las tiendas, muchas empresas pasaron a utilizar las marcas con la finalidad de diferenciar su oferta de las de los competidores. Sin embargo, muchos gestores posicionan indebidamente sus marcas y, de esta forma, reducen el valor de sus productos, en lugar de ampliarlo. Con el objetivo de mejorar la comprensión del tipo de marca, este estudio se propone evaluar la preferencia del consumidor en relación a atributos de cosméticos faciales anti-envejecimiento que las marcas determinan, como: tipo de marca, precio, calidad percibida, cantidad mínima de compra y status. Para eso, se investigaron, durante el año de 2009, las preferencias de 100 mujeres en relación a cosméticos anti-envejecimiento. El análisis de los datos fue hecho por medio de conjoint analysis. Se descubrió que, para la muestra estudiada, los atributos que determinan la elección de una crema facial anti-envejecimiento, dispuestos en orden creciente, construyen la siguiente escala: cantidad mínima de compra, status, precio, tipo de marca y calidad. Y, no obstante algunas reservas, se constató que la marca social es la preferida de los consultados. Así, como la calidad es el elemento más importante para las personas entrevistadas, marcas sociales que enfoquen la calidad de sus productos y el modo cómo son hechos pueden ser grandes fuentes de valor para las empresas

Os fatores de alavacagem da qualidade dos internetbankings

Banks are interested on netbaking channel in order to address the client desires and needs and get a competitive differential. This research was carried out to identify the opinion of internetbanking clients about the performance of this service in the quality dimensions of E-BANKING model, observing the importance given to each dimension. To achieve this objective, it was surveyed, in a random way, the perception of 150 inhabitants of São Paulo city and internetbanking users of Abn Amro Real, Banco do Brasil, Bradesco, Itaú, ou Unibanco. To analyze the data, it was employed the factor analysis to verify whether dimensions of E-BANKING model represent adequately the measurement variables. Moreover, it was developed a importance-performance matrix to identify the quality dimensions that have big impact on the users value perception and that could be improved. It was found that virtual banks performance is correctly measured by the variables set that forms each dimension of the model. Evaluating the internetbankings performance in the dimensions, taking in account the dimensions importance to the respondents, it was observed that banks focus should be improve the performance of aspects that influence the tangibility, empathy and reliability of this virtual service channel.Os bancos estão interessados no netbanking, a fim de atender aos desejos e às necessidades do mercado e obter um diferencial competitivo. Esta pesquisa foi realizada para se identificar a opinião dos clientes de internetbanking em relação ao desempenho desse serviço nas dimensões de qualidade do modelo E-BANKING, observando-se a importância atribuída a cada uma delas. Para isso, levantou-se, aleatoriamente, a percepção de 150 residentes na cidade de São Paulo e usuários do internetbanking do Abn Amro Real, Banco do Brasil, Bradesco, Itaú, ou Unibanco. Na análise dos dados, empregou-se análise fatorial, para verificar se as dimensões do modelo E-BANKING representavam adequadamente as variáveis de mensuração. Ademais, elaborou-se a matriz importância-desempenho para identificar as dimensões de qualidade que têm grande impacto na percepção de valor dos usuários e que poderiam ser melhoradas. Constatou-se que o desempenho dos bancos virtuais nas cinco dimensões do modelo E-BANKING é adequadamente mensurado pelo conjunto de variáveis que compõem cada dimensão. Ao avaliar o desempenho dos internetbankings nas dimensões, levando-se em conta a importância de cada uma delas para os respondentes, obteve-se que o foco dos bancos deve ser melhorar o desempenho nos aspectos que influenciam a tangibilidade, empatia e confiabilidade desse canal de serviço virtual

Do Airports green cities? : Von der Airport City zur nachhaltigen Region ; Flughafenstrategien und Regionalentwicklung

Multivariate pattern recognition approaches have become a prominent tool in neuroimaging data analysis. These methods enable the classification of groups of participants (e.g. controls and patients) on the basis of subtly different patterns across the whole brain. This study demonstrates that these methods can be used, in combination with automated morphometric analysis of structural MRI, to determine with great accuracy whether a single subject has been engaged in regular mental training or not. The proposed approach allowed us to identify with 94.87% accuracy (p<0.001) if a given participant is a regular meditator (from a sample of 19 regular meditators and 20 non-meditators). Neuroimaging has been a relevant tool for diagnosing neurological and psychiatric impairments. This study may suggest a novel step forward: the emergence of a new field in brain imaging applications, in which participants could be identified based on their mental experience

Redes de políticas no agronegócio no estado de São Paulo: Formas de orquestração de interesses produtivos nos complexos agroindustriais citrícola e sucroalcooleiro

Agribusiness is organized into policy networks. The orchestrations of interests associations are important to reveal the field of agroindustrial political governance which grew with the agricultural policies at the corporatist level, under the state regulation of Brazilian agriculture in the years 1960s and 1970s, and which have become more plural governances or in networks coordinated and oriented by business, agricultural product or agroindustrial sector. This article presents, through the citrical and sugar- alcohol agroindustrial case study in the State of São Paulo in the period 1964-2010, and the most important transformations in the two most important networks of agribusiness in São Paulo from the theoretical field of political neoinstitutionalism.El agronegocio se organiza en redes de políticas. Las orquestaciones de asociaciones de interés son importantes para revelar el campo de la gobernanza política agroindustrial que creció con las políticas agrícolas a nivel corporativo en Brasil, es decir, bajo la regulación estatal de la agricultura brasileña en los años sesenta y setenta, y que se convirtió en una gobernanza más pluralista o en redes coordinadas y orientadas a los negocios, productos agrícolas o sector agroindustrial. El presente artículo muestra los casos agroindustriales de cítricos y sucroalcoholero en el estado de São Paulo en el período 1964/2010 y presenta las transformaciones más importantes en las dos redes de políticas más importantes del agronegocio paulista, a partir del campo teórico del neoinstitucionalismo político.O agronegócio se organiza em redes de políticas. Orquestrações das associações de interesses são importantes para revelar o campo da governança política agroindustrial que cresceu com as políticas agrícolas em nível corporativista no Brasil, isto é, sob a regulação estatal da agricultura brasileira nos anos 1960 e 1970, e que se transformaram em governanças mais plurais ou em redes coordenadas e orientadas por negócio, por produto agrícola ou setor agroindustrial. O presente artigo mostra, por meio dos estudos dos casos agroindustriais citrícola e sucroalcooleiro no estado de São Paulo no período 1964/2010, as transformações mais importantes nas duas redes de políticas mais importantes do agronegócio paulista, a partir do campo teórico do neoinstitucionalismo político

Factores asociados con el acceso anterior a la gestación a los servicios de salud por adolescentes gestantes

OBJECTIVE: To assess determinants of access to primary care services prior to pregnancy by pregnant adolescents. METHODS: Theory-based cross-sectional study conducted to examine access to heath services at five dimensions: geographic, economic, administrative, psychosocial and information. There were included in the study 200 first-time pregnant adolescents (aged 10 to 19 years) who attended a primary care unit in the municipality of Indaiatuba, Southeastern Brazil, in 2003. Data was collected using a semi-structured questionnaire applied in face-to-face interviews conducted just before their first pre-natal care visit. Data analyses were performed through Person's chi-square or Fisher's exact test, and by a multivariate logistic regression model including all five dimensions of access. RESULTS: More than half (63.7%) of the adolescents utilized some gynecological care service. Information (43.8%) or psychosocial feelings of embarrassment or fear (37.0%) barriers were the most frequent reasons given for not having sought care before. The main barrier to health service access was related to the psychosocial dimension, reported by 77.0% of the adolescents studied. CONCLUSIONS: Among all barriers to health service access, the most important were those related to the psychosocial dimension. There is a need for new strategies to facilitate access to health services by adolescents, including actions to reduce gender-based barriers taking into consideration sociodemographic characteristics of this population and the relationship they have with their partners.OBJETIVO: Analizar los factores determinantes del acceso de adolescentes gestantes a los servicios de atención primaria a la salud, anterior a la ocurrencia de la gestación. MÉTODOS: Se efectuó estudio transversal basado en referencial teórico. El acceso a servicios fue analizado en cinco dimensiones: geográfico, económico, administrativo, psicosocial y de información. Participaron 200 adolescentes primigestas (10 a 19 años) atendidas en una unidad básica de salud del municipio de Indaiatuba (Sureste de Brasil), en 2003. Se aplicó a las participantes en el momento de su primera consulta pre-natal un cuestionario con preguntas abiertas y cerradas referentes al acceso al último servicio de salud utilizado, anterior a la gestación. Los datos fueron analizados por medio de la prueba de Chi cuadrado de Pearson o exacto de Fischer y por regresión logística múltiple, considerando las cinco dimensiones del acceso. RESULTADOS: Más de la mitad (63,7%) de las adolescentes utilizó algún servicio de salud para consulta ginecológica. Entre las que nunca consultaron un ginecólogo, las justificativas dadas fueron falta de información (43,8%) o sentimiento de miedo o vergüenza (37,0%). La principal dificultad de acceso al servicio estuvo relacionada con barreras psicosociales, identificadas por 77,0% de las adolescentes. CONCLUSIONES: Entre las barreras de acceso al servicio de salud, fueron significativas solo las psicosociales. Son necesarias nuevas estrategias para facilitar el acceso al servicio de salud a las adolescentes, incluyendo acciones que disminuyan las barreras de género y que se consideren sus características sociodemográficas y el vínculo con sus parejas.OBJETIVO: Analisar os fatores determinantes do acesso de adolescentes gestantes a serviços de atenção primária à saúde, anterior à ocorrência da gestação. MÉTODOS: Estudo transversal baseado em referencial teórico. O acesso a serviços foi analisado em cinco dimensões: geográfico, econômico, administrativo, psicossocial e de informação. Participaram 200 adolescentes primigestas (10 a 19 anos) atendidas em uma unidade básica de saúde do município de Indaiatuba (SP), em 2003. Um questionário com perguntas abertas e fechadas referentes ao acesso ao último serviço de saúde utilizado, anterior à gestação, foi aplicado às participantes no momento de sua primeira consulta de pré-natal. Os dados foram analisados por meio do teste de qui-quadrado de Pearson ou exato de Fisher e por regressão logística múltipla, considerando as cinco dimensões de acesso. RESULTADOS: Mais da metade (63,7%) das adolescentes utilizou algum serviço de saúde para consulta ginecológica. Entre as que nunca consultaram um ginecologista, as justificativas dadas foram falta de informação (43,8%) ou sentimento de medo ou vergonha (37,0%). A principal dificuldade de acesso ao serviço esteve relacionada a barreiras psicossociais, identificadas por 77,0% das adolescentes. CONCLUSÕES: Entre as barreiras de acesso ao serviço de saúde, foram significativas apenas as psicossociais. São necessárias novas estratégias para facilitar o acesso ao serviço de saúde às adolescentes, incluindo ações que diminuam as barreiras de gênero e que se considerem suas características sociodemográficas e o vínculo com seus parceiros

Ultrasound-assisted drying of orange peel in atmospheric freeze-dryer and convective dryer operated at moderate temperature

This is an Author's Accepted Manuscript of an article published in Ronaldo E. Mello, Alessia Fontana, Antonio Mulet, Jefferson Luiz, G. Correa & Juan A. Cárcel (2020) Ultrasound-assisted drying of orange peel in atmospheric freeze-dryer and convective dryer operated at moderate temperature, Drying Technology, 38:1-2, 259-267, DOI: 10.1080/07373937.2019.1645685 [copyright Taylor & Francis], available online at: http://www.tandfonline.com/10.1080/07373937.2019.1645685[EN] Atmospheric freeze-drying (AFD) at -10 degrees C and moderate temperature convective drying (MTD) at 50 degrees C without and with ultrasound application (20.5 kW/m(3)) were carried out. Alcohol insoluble residue (AIR) and its swelling capacity (SC), water retention capacity (WRC) and fat retention capacity (FRC) were measured in the dried product. Ultrasound significantly shortened the drying time in both processes, the intensification effect being more significant in atmospheric freeze-drying (57% and 27% reduction in atmospheric freeze-drying and convective drying, respectively). As regards AIR and WRC, no effect was observed of either the drying temperature or ultrasound application. On the contrary, SC was significantly lower in AFD samples. The FRC of MTD samples was similar to that of the fresh ones and higher than the values obtained for atmospheric freeze-dried samples. Therefore, convective drying at moderate temperature preserved the AIR properties better than atmospheric freeze-drying.The authors acknowledge the financial support of INIA-ERDF through project RTA2015-00060-C04-02. We are also grateful for the economic support of the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (Capes)- Finance Code 001, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG).Mello, RE.; Fontana, A.; Mulet Pons, A.; Correa, J.; Carcel, JA. (2020). Ultrasound-assisted drying of orange peel in atmospheric freeze-dryer and convective dryer operated at moderate temperature. Drying Technology. 38(1-2):259-267. https://doi.org/10.1080/07373937.2019.1645685S259267381-2Freire, F. B., Atxutegi, A., Freire, F. B., Freire, J. T., Aguado, R., & Olazar, M. (2016). An adaptive lumped parameter cascade model for orange juice solid waste drying in spouted bed. Drying Technology, 35(5), 577-584. doi:10.1080/07373937.2016.1190937Tasirin, S. M., Puspasari, I., Sahalan, A. Z., Mokhtar, M., Ghani, M. K. A., & Yaakob, Z. (2014). Drying ofCitrus sinensisPeels in an Inert Fluidized Bed: Kinetics, Microbiological Activity, Vitamin C, and Limonene Determination. Drying Technology, 32(5), 497-508. doi:10.1080/07373937.2013.838782Zielinska, M., Sadowski, P., & Błaszczak, W. (2015). Combined hot air convective drying and microwave-vacuum drying of blueberries (Vaccinium corymbosumL.): Drying kinetics and quality characteristics. Drying Technology, 34(6), 665-684. doi:10.1080/07373937.2015.1070358Moreno, C., Brines, C., Mulet, A., Rosselló, C., & Cárcel, J. A. (2017). Antioxidant potential of atmospheric freeze-dried apples as affected by ultrasound application and sample surface. Drying Technology, 35(8), 957-968. doi:10.1080/07373937.2016.1256890Garcia-Perez, J. V., Ortuño, C., Puig, A., Carcel, J. A., & Perez-Munuera, I. (2011). Enhancement of Water Transport and Microstructural Changes Induced by High-Intensity Ultrasound Application on Orange Peel Drying. Food and Bioprocess Technology, 5(6), 2256-2265. doi:10.1007/s11947-011-0645-0Do Nascimento, E. M. G. C., Mulet, A., Ascheri, J. L. R., de Carvalho, C. W. P., & Cárcel, J. A. (2016). Effects of high-intensity ultrasound on drying kinetics and antioxidant properties of passion fruit peel. Journal of Food Engineering, 170, 108-118. doi:10.1016/j.jfoodeng.2015.09.015Martins, M. P., Cortés, E. J., Eim, V., Mulet, A., & Cárcel, J. A. (2018). Stabilization of apple peel by drying. Influence of temperature and ultrasound application on drying kinetics and product quality. Drying Technology, 37(5), 559-568. doi:10.1080/07373937.2018.1474476García-Pérez, J. V., Cárcel, J. A., Riera, E., & Mulet, A. (2009). Influence of the Applied Acoustic Energy on the Drying of Carrots and Lemon Peel. Drying Technology, 27(2), 281-287. doi:10.1080/07373930802606428Blasco, M., García-Pérez, J. V., Bon, J., Carreres, J. E., & Mulet, A. (2006). Effect of Blanching and Air Flow Rate on Turmeric Drying. Food Science and Technology International, 12(4), 315-323. doi:10.1177/1082013206067352Garau, M. C., Simal, S., Femenia, A., & Rosselló, C. (2006). Drying of orange skin: drying kinetics modelling and functional properties. Journal of Food Engineering, 75(2), 288-295. doi:10.1016/j.jfoodeng.2005.04.017Garau, M. C., Simal, S., Rosselló, C., & Femenia, A. (2007). Effect of air-drying temperature on physico-chemical properties of dietary fibre and antioxidant capacity of orange (Citrus aurantium v. Canoneta) by-products. Food Chemistry, 104(3), 1014-1024. doi:10.1016/j.foodchem.2007.01.009Beigi, M. (2015). Hot air drying of apple slices: dehydration characteristics and quality assessment. Heat and Mass Transfer, 52(8), 1435-1442. doi:10.1007/s00231-015-1646-8Santos, P. H. S., & Silva, M. A. (2008). Retention of Vitamin C in Drying Processes of Fruits and Vegetables—A Review. Drying Technology, 26(12), 1421-1437. doi:10.1080/07373930802458911Gallego-Juárez, J. A., Riera, E., de la Fuente Blanco, S., Rodríguez-Corral, G., Acosta-Aparicio, V. M., & Blanco, A. (2007). Application of High-Power Ultrasound for Dehydration of Vegetables: Processes and Devices. Drying Technology, 25(11), 1893-1901. doi:10.1080/07373930701677371Santacatalina, J. V., Ahmad-Qasem, M. H., Barrajón-Catalán, E., Micol, V., García-Pérez, J. V., & Cárcel, J. A. (2014). Use of Novel Drying Technologies to Improve the Retention of Infused Olive Leaf Polyphenols. Drying Technology, 33(9), 1051-1060. doi:10.1080/07373937.2014.982251Silva, V. M., & Viotto, L. A. (2010). Drying of sicilian lemon residue: influence of process variables on the evaluation of the dietary fiber produced. Ciência e Tecnologia de Alimentos, 30(2), 421-428. doi:10.1590/s0101-20612010000200020Garcia-Amezquita, L. E., Tejada-Ortigoza, V., Campanella, O. H., & Welti-Chanes, J. (2018). Influence of Drying Method on the Composition, Physicochemical Properties, and Prebiotic Potential of Dietary Fibre Concentrates from Fruit Peels. Journal of Food Quality, 2018, 1-11. doi:10.1155/2018/9105237Abou-Arab, E. A., Mahmoud, M. H., & Abu-Salem, F. M. (2017). Functional Properties of Citrus Peel as Affected by Drying Methods. American Journal of Food Technology, 12(3), 193-200. doi:10.3923/ajft.2017.193.200Ghanem Romdhane, N., Bonazzi, C., Kechaou, N., & Mihoubi, N. B. (2015). Effect of Air-Drying Temperature on Kinetics of Quality Attributes of Lemon (Citrus limoncv. lunari) Peels. Drying Technology, 33(13), 1581-1589. doi:10.1080/07373937.2015.101226