A ringed pole-on outflow from DO Tauri revealed by ALMA

We present new ALMA Band 6 observations including the CO (2-1) line and 1.3 mmcontinuum emission from the surroundings of the young stellar object DO Tauri. TheALMA CO molecular data show three different series of rings at different radial ve-locities. These rings have radii around 220 au and 800 au. We make individual fits tothe rings and note that their centers are aligned with DO Tauri and its optical high-velocity jet. In addition, we notice that the velocity of these structures increases withthe separation from the young star. We discuss the data under the hypothesis that therings represent velocity cuts through three outflowing shells that are possibly drivenby a wide-angle wind, dragging the environment material along a direction close to theline of sight (i= 19◦). We estimate the dynamical ages, the mass, the momentum andthe energy of each individual outflow shell and those of the whole outflow. The resultsare in agreement with those found in outflows from Class II sources. We make a roughestimate for the size of the jet/wind launching region, which needs to be of.15 au.We report the physical characteristics of DO Tauri?s disk continuum emission (almostface-on and with a projected major axis in the north-south direction) and its velocitygradient orientation (north-south), indicative of disk rotation for a 1-2 Mcentral star.Finally we show an HST [SII] image of the optical jet and report a measurement of itsorientation in the plane of the sky.Fil: Fernandez Lopez, Manuel. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Zapata Gonzalez, Luis Alberto. Universidad Nacional Autonoma de Mexico. Instituto de Astronomia; MéxicoFil: Rodríguez, Luis F.. Universidad Nacional Autonoma de Mexico. Instituto de Astronomia; MéxicoFil: Vazzano, María Mercedes. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Guzman, Andrés E.. National Astronomical Observatory Of Japan; JapónFil: López, Rosario. Universidad Autónoma de Barcelona. Facultad de Física. Departamento Astronomía y Meteorología; Españ

Preparation and characterization of a tumor-targeting dual-image system based on iron oxide nanoparticles functionalized with folic acid and rhodamine

Cancer is one of the diseases with most deaths worldwide, around 8.2 million annually. For this reason, several treatments and diagnostic tools have been investigated and developed over the past decades. Among them, a dual-image system has been developed to achieve and enhance the detection of cancer, which has not been done with systems currently available. The present study describes the preparation of a dual-image targeting system composed of magnetic iron oxide nanoparticles functionalized with folic acid and rhodamine; nanoparticles synthesis was achieved by a coprecipitation method; the functionalization was carried out by a carbodiimide with folic acid and/or the rhodamine isothiocyanate; conjugates were characterized by spectrometric techniques; toxicity was measured by cell proliferation assay on HeLa cells using progressive concentrations of functionalized nanoparticles. Cellular uptake assay was carried out by competitive assay on HeLa cells. Iron oxide magnetite nanoparticles, modified with folic acid and rhodamine, were successfully synthetized with a particle size lower than 20nm (TEM), EDS, HRTEM, and XDR showed highly crystalline Fe3O4 nanoparticles. Folic acid and rhodamine were conjugated with high efficiency. A significant selectivity and uptake, facilitated by surface modification of iron oxide nanoparticles with folic acid, were demonstrated.The multifunctional system showed suitable physicochemical and biological properties for cell targeting through folate receptors.This study was supported by the International Atomic Energy Agency (CRP-F22064, Contract no. 18358) and the Universidad Autónoma del Estado de México, through Project no. 3543/2013CHT

Interannual variability of the early summer circulation around the Balearic Islands: driving factors and potential effects on the marine ecosystem

Six summer surveys conducted from 2001 to 2005 and in 2012 by the Spanish Institute of Oceanography (IEO) reveal that the hydrographic early summer scenarios around the Balearic Islands are related to the winter atmospheric forcing in the northwestern Mediterranean Sea. The Balearic Islands (western Mediterranean Sea) lie at the transition between the southern, fresher, newly arrived Atlantic Waters (AW) and the northern, saltier, resident AW. The meridional position of the salinity driven oceanic density front separating the new from the resident AW is determined by the presence/absence of Western Intermediate Water (WIW) in the Mallorca and Ibiza channels. When WIW is present in the channels, the oceanic density front is found either at the south of the islands, or along the Emil Boudot escarpment. In contrast, when WIW is absent, new AW progresses northwards crossing the Ibiza channel and/or the Mallorca channel. In this later scenario, the oceanic density front is closer to the Balearic Islands. A good correspondence exists between standardized winter air temperature anomaly in the Gulf ofLions and the presence of WIW in the channels. We discuss the use of a regional climatic index based on these parameters to forecast in a first-order approach the position of the oceanic front, as it is expected to have high impact on the regional marine ecosystem.Post-print

Light-Activated Antibacterial Polymeric Surface Based on Porphycene

A photoactivatable antimicrobial polymeric surface based on a porphycene derivate was efficiently prepared and evaluated to kill pathogenic microorganisms. The development of this self-sterilizing material consisted in the electrochemical polymerization of a peripherally tetra-substituted porphycene bearing benzyl-carbazole groups (Pc-Cbz). The latter were used as electropolymerizable centers, while the porphycene core triggered the photodynamic action. The electrodeposited photodynamic films (P-Pc-Cbz) were obtained in a reproducible and controllable manner. Electrochemistry studies combined with spectroscopic measurements demonstrated that the porphycene core remains unaffected after the electrodeposition process. Moreover, it retains its spectroscopic and photodynamic properties within the polymeric matrix. The photoactive layers were photostable and able to produce reactive oxygen species (ROS) by both photodynamic mechanisms. Also, the antimicrobial efficiency of P-Pc-Cbz was evaluated against two antibiotic-resistant strains (methicillin-resistant Staphylococcus aureus and Escherichia coli), exhibiting an antimicrobial action higher than 99.998% over these Gram-positive and Gram-negative bacteria. This work represents the first electropolymerization of a porphycene derivative and the first porphycene-based photobiocidal surface. P-Pc-Cbz shows great potential as an efficient self-sterilizing coating activated by visible light.Fil: Gonzalez Lopez, Edwin Javier. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Renfige Rodriguez, Yone Melisa. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; ArgentinaFil: Santamarina, Sofia Carla. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Macor, Lorena Paola. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; ArgentinaFil: Otero, Luis Alberto. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; ArgentinaFil: Gervaldo, Miguel Andres. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; ArgentinaFil: Durantini, Andres Matías. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Durantini, Edgardo Néstor. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Durantini, Javier Esteban. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; ArgentinaFil: Heredia, Daniel Alejandro. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentin

Outcomes of abdominal wall reconstruction in patients with the combination of complex midline and lateral incisional hernias.

Background The best treatment for the combined defects of midline and lateral incisional hernia is not known. The aim of our multicenter study was to evaluate the operative and patient-reported outcomes using a modified posterior component separation in patients who present with the combination of midline and lateral incisional hernia. Methods We identified patients from a prospective, multicenter database who underwent operative repairs of a midline and lateral incisional hernia at 4 centers with minimum 2-year follow-up. Hernias were divided into a main hernia based on the larger size and associated abdominal wall hernias. Outcomes reported were short- and long-term complications, including recurrence, pain, and bulging. Quality of life was assessed with the European Registry for Abdominal Wall Hernias Quality of Life score. Results Fifty-eight patients were identified. Almost 70% of patients presented with a midline defect as the main incisional hernia. The operative technique was a transversus abdominis release in 26 patients (45%), a modification of transversus abdominis release 27 (47%), a reverse transversus abdominis release in 3 (5%), and a primary, lateral retromuscular preperitoneal approach in 2 (3%). Surgical site occurrences occurred in 22 patients (38%), with only 8 patients (14%) requiring procedural intervention. During a mean follow-up of 30.1 ± 14.4 months, 2 (3%) cases of recurrence were diagnosed and required reoperation. There were also 4 (7%) patients with asymptomatic but visible bulging. The European Registry for Abdominal Wall Hernias Quality of Life score showed a statistically significant decrease in the 3 domains (pain, restriction, and cosmetic) in the postoperative score compared with the preoperative score. Conclusion The different techniques of posterior component separation in the treatment of combined midline and lateral incisional hernia show acceptable results, despite the associated high complexity. Patient-reported outcomes after measurement of the European Registry for Abdominal Wall Hernias Quality of Life score demonstrated a clinically important improvement in quality of life and pain.post-print2.323 K

Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method.

Direct quantification of atherosclerotic plaque volume by three-dimensional vascular ultrasound (3DVUS) is more reproducible than 2DUS-based three-dimensional (2D/3D) techniques that generate pseudo-3D volumes from summed 2D plaque areas; however, its accuracy has not been reported. We aimed to determine 3DVUS accuracy for plaque volume measurement with special emphasis on small plaques (a hallmark of early atherosclerosis). The in vitro study consisted of nine phantoms of different volumes (small and medium-large) embedded at variable distances from the surface (superficial vs. >5 cm-depth) and comparison of 3DVUS data generated using a novel volumetric-linear array method with the real phantom volumes. The in vivo study was undertaken in a rabbit model of atherosclerosis in which 3DVUS and 2D/3D volume measurements were correlated against gold-standard histological measurements. In the in vitro setting, there was a strong correlation between 3DVUS measures and real phantom volume both for small (3.0-64.5 mm(3) size) and medium-large (91.1-965.5 mm(3) size) phantoms embedded superficially, with intraclass correlation coefficients (ICC) of 0.99 and 0.98, respectively; conversely, when phantoms were placed at >5 cm, the correlation was only moderate (ICC = 0.67). In the in vivo setting there was strong correlation between 3DVUS-measured plaque volumes and the histological gold-standard (ICC = 0.99 [4.02-92.5 mm(3) size]). Conversely, the correlation between 2D/3D values and the histological gold standard (sum of plaque areas) was weaker (ICC = 0.87 [49-520 mm(2) size]), with large dispersion of the differences between measurements in Bland-Altman plots (mean error, 79.2 mm(2)). 3DVUS using the volumetric-linear array method accurately measures plaque volumes, including those of small plaques. Measurements are more accurate for superficial arterial territories than for deep territories.S

Enfrentando los riesgos socionaturales

El objetivo del libro es comprender la magnitud de los Riesgos Socionaturales en México y Latinoamérica, para comprender el peligro que existe por algún tipo de desastre, ya sea inundaciones, sismos, remoción en masa, entre otros, además conocer qué medidas preventivas, correctivas y de contingencias existen para estar atentos ante alguna señal que la naturaleza esté enviando y así evitar alguna catástrofe. El libro se enfoca en los aspectos básicos de análisis de los peligros, escenarios de riesgo, vulnerabilidad y resiliencia, importantes para la gestión prospectiva o preventiva

Propuesta de mejora del Sistema Interno de Garantía de Calidad de la Facultad de Medicina

La garantía de calidad en el ámbito universitario puede considerarse como la atención sistemática, estructurada y continua a las titulaciones ofertadas. La garantía de calidad se compromete a poner en marcha los medios que aseguren y demuestren la calidad de los programas formativos que se desarrollan en cada una de las titulaciones ofrecidas por la Universidad y así cumplir con la obligación que tiene con la sociedad. El presente proyecto nace como fruto de la responsabilidad adquirida para el cumplimiento de las funciones encomendadas y, con el objetivo de seguir adoptando una estrategia de mejora continua de la calidad de la docencia y satisfacción de los colectivos implicados en el proceso de enseñanza-aprendizaje (Profesorado, Estudiantes y PAS)