Diseño de un sistema de control financiero de proyectos para Puchi Constructora SPA

91 p.El siguiente proyecto de mejoramiento tiene como objetivo establecer un procedimiento y crear una herramienta que permita a la empresa constructora Puchi SpA controlar el flujo financiero de las obras que ejecuta y de esta manera conocer los costos generados a través del tiempo y compararlos con el presupuesto entregado.En un comienzo se realizó un estudio de la situación actual de la empresa, para conocer sus productos, procesos y la forma en que se estudian, conceptualizan y ejecutan los proyectos de construcción y habilitación.Luego se analizó con mayor profundidad la labor de la gerencia de finanzas quien es la encargada de estudiar el costo y beneficio monetario que genera cada proyecto, en donde se encontró la oportunidad de crear una herramienta que facilite esta tarea y entregue información que facilite la toma de decisiones. Posteriormente se establecieron los lineamientos generales, requisitos y consideraciones para la creación de un prototipo construido sobre el software MS Excel, en donde se ingresara la información referente a las compras, ventas y remuneraciones, las que se distribuirán según su clasificación. Además se definieron los procedimientos para el funcionamiento del sistema y el ingreso de la información necesaria, donde se detalla claramente los elementos y características esenciales

Fotobioreactor configurado con medio de giro para seguir la posición solar

1 documento en PDF de 18 páginasEsta invención se refiere a un fotobioreactor configurado con medios de giro electrónicos que sigue la posición solar. Particularmente, la presente invención reside en un arreglo de fotobioreactor con base en energía solar para el cultivo de microorganismos fotosintéticos, tal como la producción de Chlorella vulgaris, que incluye un serpentín translucido configurado para recibir la suspensión celular, montado sobre una plataforma con medios de giro electrónicos que sigue la posición solar; medios de iluminación alternativos; y, un soporte de banca que recibe dicho serpentín y dicha plataforma con medios de giro. Adicionalmente, los medios de giro electrónicos del fotobioreactor de la invención comprenden un módulo externo que analiza y regula el valor del periodo de la señal introducido por el usuario y la temporización y a su vez este módulo será también el conductor de potencia hacia los medios de iluminación, que permitirá la conmutación de estos y así obtener un valor de irradiación variable

Presentación

Prof. Dr. José Luis Pérez-Serrabona González, Dean of the Faculty of Law of the University of Granada, introduces the review De Lege Ferenda as a response to an illusion, an obligation and a commitment.El Prof. Dr. José Luis Pérez-Serrabona González, Decano de la Facultad de Derecho de la Universidad de Granada, presenta la revista De Lege Ferenda como la respuesta a una ilusión, a una obligación y a un compromiso

Parálisis periódica hipopotasémica tirotóxica: Reporte de un caso y revisión de la literatura

The hipopotasemic tiroxic periodic paralysis is an entity of low frequency, with incidence of 2 % in the western countries; in our means the incidence is smaller, and predominates between masculine young adults with hyperthyroidism antecedent; clinically one appears like episodes of acute muscular weakness; that they can put in risk the life of the patient; raising a diagnostic challenge occasions about which it does not exist previous antecedent of disease, taking the great majority of the times to think about diagnoses differential slike syndrome of Guillain- Barre-Landry, transverse myelitis, hysteria and acute medullary compression. The following is a patient with picture of acute muscular weakness exposes itself, that raised initially a probable picture of Guillain-Barre-Landry and in which later determined the presence of hyperthyroidism, like causal of hypokalemia and acute muscular weakness, diagnosing finally hipopotasemic tirotoxic periodic paralysis; in addition, a review of the literature is presented.La parálisis periódica hipopotasémica tirotóxica es una entidad de baja frecuencia, con incidencia del 2 % en los países occidentales; en nuestro medio la ocurrencia es menor, y, predomina entre adultos jóvenes masculinos con antecedente de hipertiroidismo; clínicamente se presenta con episodios de debilidad muscular aguda; que pueden poner en riesgo la vida del paciente; planteando un reto diagnóstico en ocasiones en que no existe ante- cedente previo de enfermedad, llevando la gran mayoría de las veces a pensar en diagnósticos diferenciales como síndrome de Guillain-Barre-Landry, mielitis transversa, histeria y compresión medular aguda. A continuación se expone un paciente con cuadro de debilidad muscular aguda, que planteó inicialmente un probable cuadro de Guillain-Barre-Landry (GBL) y en el que posteriormente se determinó la presencia de hipertiroidismo, como cau- sal de hipokalemia y debilidad muscular aguda, diagnosticándose finalmente parálisis hipopotasémica tirotóxica; además, se presenta una revisión de la literatura

Estimating the optimal sampling rate using wavelet transform: an application to optimal turbulence

Sampling rate and frequency content determination for optical quantities related to light propagation through turbulence are paramount experimental topics. Some papers about estimating properties of the optical turbulence seem to use ad hoc assumptions to set the sampling frequency used; this chosen sampling rate is assumed good enough to perform a proper measurement. On the other hand, other authors estimate the optimal sampling rate via fast Fourier transform of data series associated to the experiment. When possible, with the help of analytical models, cut-off frequencies, or frequency content, can be determined; yet, these approaches require prior knowledge of the optical turbulence. The aim of this paper is to propose an alternative, practical, experimental method to estimate a proper sampling rate. By means of the discrete wavelet transform, this approach can prevent any loss of information and, at the same time, avoid oversampling. Moreover, it is independent of the statistical model imposed on the turbulence.Fil: Funes, Gustavo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigaciones Opticas (i); ArgentinaFil: Fernández, Angel. Pontificia Universidad Catolica de Valparaiso; Chile. Universidad Tecnica Federico Santa María; ChileFil: Peréz, Darío G.. Pontificia Universidad Catolica de Valparaiso; ChileFil: Zunino, Luciano José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigaciones Opticas (i); ArgentinaFil: Serrano, Eduardo. Universidad Nacional de San Martín; Argentin

Bicycling-related accidents and factors contributing to injury

[EN] Objective: This study was conducted to find the epidemiological characteristics of bicycling-related maxillofacial fractures in a defined population, and identify factors contributing to injury. Methodology: A prospective study was carried out involving patients presenting with maxillofacial fractures sustained in bicycling-related accidents. Results: Between 908 of all cycling accidents attending for medical treatment, 122 patients (13% of all cycling accidents) were admitted with facial fractures between 2007 and 2014. Male and female ratio was 2.6:1, and the mean age was 29.4 years (standard deviation: 12.8, range: 12-79 years). Causes of injury included collisions (63%) and accidental falls (37%). The fracture patterns seen were mandibular (49%), zygomatic (32%), orbital (13%), nasal (7%), maxillary (2%), and frontal (2%). Condylar fractures were the most common of the mandibular fractures (63%). The most frequently observed concomitant lesions were orthopedic injuries. Conclusions: Bicycling-related maxillofacial injuries are common and therefore important to identify in order to design a sustainable transport system and for units that provide assistance to traffic accident victims. Missed diagnosis or delayed treatment can lead to facial deformities and functional problems. Wearing protective helmets and the improvement of the helmets design is one aspect that would be of interest for the prevention of injuries.González Peréz, LM.; Wideberg, J.; Gonzalez Perez-Somarriba, B. (2016). Bicycling-related accidents and factors contributing to injury. En XII Congreso de ingeniería del transporte. 7, 8 y 9 de Junio, Valencia (España). Editorial Universitat Politècnica de València. 1718-1726. https://doi.org/10.4995/CIT2016.2015.3718OCS1718172

Modeling of Deformation and Texture Development of Copper in a 120° ECAE Die

A flow line function is proposed to describe the material deformation in ECAE for a 120\degree die. This new analytical approach is incorporated into a viscoplastic self-consistent polycrystal code to simulate the texture evolution in Route A of copper and compared to experimental textures as well as to those corresponding to simple shear

El proceso enseñanza-aprendizaje basado en el aprendizaje colaborativo

Introduction: in the teaching-learning process the student is not an isolated person, his activity is developed through communication and exchange of information with his classmates, the teacher and the environment; conditions that favour collaborative learning.Objective: to describe the characteristics of the teaching-learning process based on collaborative learning.Methods: a search for information was carried out in the PubMed/MedLine, SciELO and Scopus databases, as well as in the ClinicalKeys services and the Google Scholar search engine. Original articles and systematic reviews written in the last five years, in Spanish or English, were selected.Development: the aspiration to comprehensively train the medical sciences student is inserted in the context of the transformations of the improvement of the educational system in Cuba, and the active teaching methods. The teaching-learning process of the subject of clinical pharmacology should be imbued with the active teaching method. The proposal made for the solution of the social problem identified, starts from considering the causes that generate it, as well as the social consequences of the same, an important role has the social responsibility of the researcher.Conclusions: pedagogical alternatives are needed to achieve a change in the conduction of the teaching-learning process. In collaborative learning, cognitive, affective, relational and motivational processes are put into action. This implies taking advantage of autonomous work, developing the cognitive independence and professional competences of teachers and creativity, with the aim of achieving improvement in the methods and forms of the process under analysis.Introducción: en el proceso enseñanza-aprendizaje el estudiante no es una persona aislada, su actividad se desarrolla a través de la comunicación e intercambio de información con sus compañeros, el profesor y el entorno; condiciones que favorecen el aprendizaje colaborativo. Objetivo: describir las características del proceso enseñanza aprendizaje basado en el aprendizaje colaborativo. Métodos: se realizó una búsqueda de información en las bases de dato PubMed/MedLine, SciELO y Scopus, así como en los servicios ClinicalKeys y el buscador Google Académico. Se seleccionaron los artículos originales y revisiones sistemáticas redactados en los últimos cinco años, en idioma español o inglés.Desarrollo: la aspiración de formar integralmente al estudiante de las ciencias médicas se inserta en el contexto de las transformaciones del perfeccionamiento del sistema educativo en Cuba, y los métodos activos de enseñanza. Al proceso de enseñanza- aprendizaje de la asignatura farmacología clínica debe imprimírsele el método activo de enseñanza. La propuesta que se realiza para la solución del problema social identificado, parte de considerar las causas que lo generan, así como las consecuencias sociales del mismo, un papel importante tiene la responsabilidad social del investigador.Conclusiones: se necesitan alternativas pedagógicas para lograr un cambio en la conducción del proceso de enseñanza-aprendizaje. En el aprendizaje colaborativo se ponen en acción procesos cognitivos, afectivos relacionales y motivacionales. Esto implica aprovechar el trabajo autónomo, desarrollar la independencia cognoscitiva y las competencias profesionales de los profesores y la creatividad, con el objetivo de alcanzar el mejoramiento en los métodos y formas del proceso objeto de análisis.

Co-designing implementation strategies to promote remote physical activity programs in frail older community-dwellers

Frailty; Integrated care; Older adultsFragilidad; Atención integrada; Personas mayoresFragilitat; Atenció integrada; AnciansBackground: The “AGIL Barcelona (AGILBcn)” community-based integrated care program is a multicomponent healthy aging intervention for frail older adults. In this context, the present study aimed to identify implementation strategies to optimize the accessibility, acceptability, and adaptability of mobile health (mhealth) interventions to enhance physical activity in frail older adults, and to prioritize action points according to their importance and feasibility, through a co-design process. Material and methods: A mixed methods approach was used. In the qualitative phase, a method adapted from the World Café was applied in 6 virtual groups to identify strategies to facilitate the virtual physical activity program. In the quantitative phase, prioritization and feasibility of the strategies was analyzed through surveys. Strategies were ranked based on priority vs. feasibility, revealing if strategies should either be: implemented first; if possible; taken into account for future consideration; or directly disregarded. The convenience sample included older adults (n = 7), community professionals (n = 9) and health professionals (n = 13). Qualitative data were analyzed by summative content analysis and quantitative data by nonparametric descriptive analyses. Results: A total of 27 strategies were identified and grouped into four categories: general strategies for reducing barriers; specific strategies for facilitating the use of a digital application; specific strategies for facilitating participation in virtual exercise groups; and specific strategies for facilitating external support. According to the ranking of strategies, the first ones to be implemented included: digital literacy, digital capability assessment, family technology support, weekly telephone follow-up by professionals, personalizing exercises, and virtual exercises in small groups. Conclusion: The active participation of all stakeholders enabled us to identify potential strategies for implementing person-oriented technology in physical activity programs and for engaging older adults.LV-G was funded by the Industrial Doctorates Program [reference 2020 DI 76], promoted by the Government of Catalonia, Spain. This study received funding by the Barcelona Science Plan of the Cultural Institute of Barcelona-Barcelona City Council and by la Caixa Foundation [19S01576-006]

CryoEM structures of the SARS-CoV-2 spike bound to antivirals

(Póster 63) Background: Single-particle cryoelectron microscopy (cryoEM) has played a key role in the fight against COVID-19. The molecular mechanisms for the action of some of the currently approved drugs targeting the SARS-CoV-2 RNA-dependent RNA polymerase, the fast developments of the current available vaccines and antibody therapies are examples of the impact of the knowledge gained from the cryoEM structures of SARS-CoV-2 proteins in complex with proteins (ACE2 or antibodies/nanobodies) or small compounds. Our aim is to use this technology to understand structurally how certain antiviral compounds and proteins targeting the spike may inhibit viral entry. Methods: 1) Production of wild-type and mutated spike and ACE2 proteins using baculovirus/insect cells. 2) Spike binding kinetics: protein-protein and protein-small compound interactions measured by BLI Biolayer interferometry (BLI) and/or microscale Thermophoresis (MST). 3) Buffer optimization for cryoEM grid preparation of spike variants by thermal shift assays and negative-staining electron microscopy (NSEM). These techniques are also used to adjust the molar ratio of spike:ACE2 and spike:small-compound complexes. 4) Structural characterization by cryoEM. Results: At IBV-CSIC we have created a pipeline for the production and characterization of several spike variants and ACE2 decoys. While this pipeline is described in detail in other oral/poster communications, this communication is centered around one of the pillars within this pipeline; the structural characterization of possible drug candidates bound to the SARS-CoV-2 spike by cryoEM. In this way, we have successfully solved structures of the spike bound to: A) protein inhibitors as ACE2 decoys; B) a small inhibitory compound; C) mixtures of proteins and small-compound (nanobody-heparan derivative) working cooperatively as inhibitors. These protein/drug candidates were previously selected based on the results obtained in our interactomics platform, whereas their concentration and the buffer conditions for cryoEM grids preparation were established based on thermal shift assays and NSEM. Conclusion: CryoEM is a powerful tool to directly visualize the effect caused by a potential drug on a protein target. In a short period of time we have developed this technique in our institute to be applied to the SARS-CoV-2 spike protein, not only to obtain high-resolution structures of SARS- CoV-2 spike variants of concern (see WP4) but also to obtain the structures of complexes of the spike with various inhibitory compounds of very different nature