Episodio de precipitaciones localmente intensas en La Palma durante el 7 de noviembre de 2017

Ponencia presentada en: VI Simposio Nacional de Predicción, celebrado en los servicios centrales de AEMET, en Madrid, del 17 al 19 de septiembre de 2018.El archipiélago canario se encuentra en una región de gran interés desde una perspectiva meteorológica. Situado en el Atlántico Norte suroriental, entre la zona templada y la región subtropical del planeta, Canarias ha sido afectada durante los últimos años por estructuras meteorológicas de variada naturaleza. Entre ellas cabe destacar las bajas atlánticas, depresiones aisladas de niveles altos, frentes activos, estructuras de naturaleza tropical, etc. Las islas son muy montañosas y cuentan con una compleja orografía, con una altitud media de 415 metros y elevados gradientes altitudinales en algunos casos, ya que se puede pasar del nivel del mar a los 3718 metros en el caso del Teide. Esta compleja orografía es un factor fundamental como mecanismo de disparo en situaciones de inestabilidad atmosférica. Además es una causa eficiente de realce de las precipitaciones. En este trabajo se analiza el episodio de precipitaciones intensas que afectó al municipio de Garafía (situado en el noroeste de la isla de La Palma) el pasado 7 de noviembre de 2017

Quantum invariants for the graph isomorphism problem

Graph Isomorphism is such an important problem in computer science, that it has been widely studied over the last decades. It is well known that it belongs to NP class, but is not NP-complete. It is thought to be of comparable difficulty to integer factorisation. The best known proved algorithm to solve this problem in general, was proposed by László Babai and Eugene Luks in 1983. Recently, there has been some research in the topic by using quantum computing, that also leads the present piece of research. In fact, we present a quantum computing algorithm that defines an invariant over Graph Isomorphism characterisation. This quantum algorithm is able to distinguish more non-isomorphic graphs than most of the known invariants so far. The proof of correctness and some hints illustrating the extent and reason of the improvement are also included in this paper

La ciudad como experiencia de conocimiento: Nuevas metodologías de aprendizaje, iniciación de la investigación y extensión universitaria a partir de la historia urbana

Depto. de GeografíaDepto. de Historia Moderna y ContemporáneaDepto. de Historia del ArteFac. de Geografía e HistoriaFALSEsubmitte

La ciudad como experiencia de conocimiento: nuevas metodologías de aprendizaje, iniciación a la investigación y extensión universitaria a partir de la historia urbana

Memoria que recoge las actividades desarolladas en el proyecto de Innovación docente 327 de 2020 con título La ciudad como experiencia de conocimiento: nuevas metodologías de aprendizaje, iniciación a la investigación y extensión universitaria a partir de la historia urbana y dirigido por Rubén Pallol Trigueros

La ciudad como experiencia de conocimiento: nuevas metodologías de aprendizaje, iniciación a la investigación y extensión universitaria a partir de la historia urbana

El proyecto de innovación docente "La ciudad como experiencia de conocimiento: nuevas metodologías de aprendizaje, iniciación a la investigación y extensión universitaria a partir de la historia urbana" es una iniciativa de varios profesores, investigadores y estudiantes de los grados de Historia e Historia del Arte, que pretende aprovechar todas las posibilidades que proporciona el estudio de la ciudad en el proceso de enseñanza y aprendizaje, la iniciación a la investigación, el fomento de la interdisciplinariedad y el desarrollo de actividades de extensión universitaria

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Episodio de precipitaciones localmente intensas en La Palma durante el 7 de noviembre de 2017 [Presentación]

Presentación realizada en el VI Simposio Nacional de Predicción "Memorial Antonio Mestre", celebrado en la sede central de AEMET en Madrid del 17 al 19 de septiembre de 2018

Hormone-control regions mediate steroid receptor-dependent genome organization

In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. Here we further describe that responsive TADs contain 20- to 100-kb-long clusters of intermingled estrogen receptor (ESR1) and progesterone receptor (PGR) binding sites, hereafter called hormone-control regions (HCRs). In T47D cells, we identified more than 200 HCRs, which are frequently bound by unliganded ESR1 and PGR. These HCRs establish steady long-distance inter-TAD interactions between them and organize characteristic looping structures with promoters in their TADs even in the absence of hormones in ESR1+-PGR+ cells. This organization is dependent on the expression of the receptors and is further dynamically modulated in response to steroid hormones. HCRs function as platforms that integrate different signals, resulting in some cases in opposite transcriptional responses to estrogens or progestins. Altogether, these results suggest that steroid hormone receptors act not only as hormone-regulated sequence-specific transcription factors but also as local and global genome organizers.We received funding from the European Research Council under the European Union's Seventh Framework Program (FP7/2007–2013)/ERC Synergy grant agreement 609989 (4DGenome). The content of this manuscript reflects only the author's views and the Union is not liable for any use that may be made of the information contained therein. We acknowledge support of the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013–2017’ and Plan Nacional (SAF2016-75006-P), as well as support of the CERCA Programme/Generalitat de Catalunya