Larval digeneans in Biomphalaria snails from the Salto Grande Dam area in the Uruguay River

Fil: Martorelli, Sergio Roberto. Centro de Estudios en Parasitología y Vectores (CEPAVE). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Marcotegui, Paula Soledad. Centro de Estudios en Parasitología y Vectores (CEPAVE). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: La Sala, Luciano Francisco. Departamento de Biología Bioquímica y Farmacia. Universidad Nacional del Sur. Bahía Blanca; ArgentinaFil: Montes, Martín M.. Centro de Estudios en Parasitología y Vectores (CEPAVE). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; Argentin

The Challenges for the Corporate Sustainability in Century XXI

Texto dispoñible en galego e españolNas últimas décadas presenciamos cambios económicos, políticos, sociais e ambientais que dunha maneira directa ou indirecta afectan ás empresas. Coa mundialización dos mercados, as economías atópanse máis dependentes unhas das outras e, á vez, máis susceptibles á crise, o que xera tamén un maior grao de incerteza. Ademais, cuestións como o desenvolvemento sostible ou a sostibilidade empresarial actualmente están en evidencia, o que fai aumentar a responsabilidade das empresas fronte aos seus grupos de interese. A necesidade de impulsar o desenvolvemento económico de forma sostible é un desafío para empresas e institucións gobernamentais, que nas últimas décadas buscaron solucións neste sentido a través de protocolos, convenios e acordos que foron pactados en varios cumios internacionais. Á vez, a creación de guías, normas e sistemas de certificación proporciónanlles ás empresas un amplo debate acerca das ferramentas de xestión que se utilizarán para velar pola planificación do desenvolvemento sostible. Neste contexto, o noso obxectivo céntrase en reflexionar sobre os desafíos para a sostibilidade no século XXI mediante todos estes instrumentos e políticas de xestión aplicados ao desenvolvemento sostible na empresaEn las últimas décadas presenciamos cambios económicos, políticos, sociales y ambientales que de manera directa o indirecta afectan a las empresas. Con la mundialización de los mercados, las economías se encuentran más dependientes unas de otras y, a la vez, más susceptibles a la crisis, lo que también genera un mayor grado de incertidumbre. Además, cuestiones como el desarrollo sostenible o la sostenibilidad empresarial actualmente están en evidencia, lo que hace aumentar la responsabilidad de las empresas frente a sus grupos de interés. La necesidad de impulsar el desarrollo económico de forma sostenible es un desafío para empresas e instituciones gubernamentales, que en las últimas décadas han buscado soluciones en este sentido a través de protocolos, convenios y acuerdos que han sido pactados en varias cumbres internacionales. A la vez, la creación de guías, normas y sistemas de certificación proporcionan a las empresas un amplio debate acerca de las herramientas de gestión que se utilizarán para velar por la planificación del desarrollo sostenible. En este contexto, nuestro objetivo se centra en reflexionar sobre los desafíos para la sostenibilidad en el siglo XXI mediante todos estos instrumentos y políticas de gestión aplicados al desarrollo sostenible en la empresaIn the last few decades have seen significant economic, political, social and environmental issues in a way that directly or indirectly affect business. With the globalization of markets, economies are more dependent on each other, and also more susceptible to the crisis, which also generates a higher degree of uncertainty. In addition, issues such as sustainable development and corporate sustainability are now in evidence which increases the responsibility of business to its stakeholders. The need to promote sustainable economic development is a challenge for businesses and government institutions, which in recent decades have sought solutions in this regard through protocols, conventions and agreements that were agreed upon in various summits. At the same time, creating guidelines, standards and certification systems provide companies with a broad debate about the management tools that are used to ensure sustainable development planning. In this context, our focus is to reflect on the challenges to sustainability in the twenty-first century with all these instruments and management policies applied to sustainable development in the companyS

Adverse Outcome of Early Recurrent Ischemic Stroke Secondary to Atrial Fibrillation after Repeated Systemic Thrombolysis

Background. Recurrent ischemic stroke is associated with adverse neurological outcome in patients with atrial fibrillation. There is very scarce information regarding the neurological outcome of atrial fibrillation patients undergoing repeated systemic thrombolysis after early recurrent ischemic stroke. Clinical Case and Discussion. We describe a case of a 76-year-old woman with known paroxysmal atrial fibrillation who was admitted because of an acute right middle cerebral artery ischemic stroke and who underwent repeated systemic thrombolysis within 110 hours. The patient underwent systemic thrombolysis after the first ischemic stroke with almost complete neurological recovery. On the fourth day after treatment, an acute left middle cerebral artery ischemic stroke was diagnosed and she was treated with full-dose intravenous recombinant tissue plasminogen activator. A hemorrhagic transformation of the left middle cerebral artery infarction was noted on follow-up cranial computed tomographic scans. The patient did not recover from the second cerebrovascular event and died 25 days after admission. Conclusion. To the best of our knowledge, this is the second case reporting the adverse neurological outcome of a patient with diagnosis of atrial fibrillation undergoing repeated systemic thrombolysis after early recurrent ischemic stroke. Our report represents a contribution to the scarce available evidence suggesting that repeated systemic thrombolysis for recurrent ischemic stroke should be avoided

On Applying the Lackadaisical Quantum Walk Algorithm to Search for Multiple Solutions on Grids

Quantum computing holds the promise of improving the information processing power to levels unreachable by classical computation. Quantum walks are heading the development of quantum algorithms for searching information on graphs more efficiently than their classical counterparts. A quantum-walk-based algorithm that is standing out in the literature is the lackadaisical quantum walk. The lackadaisical quantum walk is an algorithm developed to search two-dimensional grids whose vertices have a self-loop of weight $l$. In this paper, we address several issues related to the application of the lackadaisical quantum walk to successfully search for multiple solutions on grids. Firstly, we show that only one of the two stopping conditions found in the literature is suitable for simulations. We also demonstrate that the final success probability depends on the space density of solutions and the relative distance between solutions. Furthermore, this work generalizes the lackadaisical quantum walk to search for multiple solutions on grids of arbitrary dimensions. In addition, we propose an optimal adjustment of the self-loop weight $l$ for such scenarios of arbitrary dimensions. It turns out the other fits of $l$ found in the literature are particular cases. Finally, we observe a two-to-one relation between the steps of the lackadaisical quantum walk and the ones of Grover's algorithm, which requires modifications in the stopping condition. In conclusion, this work deals with practical issues one should consider when applying the lackadaisical quantum walk, besides expanding the technique to a wider range of search problems.Comment: Extended version of the conference paper available at https://doi.org/10.1007/978-3-030-61377-8_9 . 21 pages, 6 figure

Acidente botrópico fatal

The Snakebite caused by Bothrops gender cause local events secondary to acute inflammatory action of the poison. The occurrence of death (about 0.6% of all cases occurred each year in Brazil) is rare, but certainly traumatic. The report of this case aims to draw attention to possible local and systemic complications (sepsis and renal failure) in this type of poisoning and emphasize the therapeutic and supportive measures that should be carried out in a timely fashion.Os acidentes ofídicos causados pelo gênero Bothrops ocasionam manifestações locais secundárias à ação inflamatória aguda do veneno. A ocorrência de óbito (em torno de 0,6% do total de casos atendidos anualmente no Brasil) é rara, mas certamente, traumática. O relato deste caso visa chamar a atenção para possíveis complicações locais e sistêmicas (insuficiência renal e sepsis) neste tipo de envenenamento e enfatizar as medidas terapêuticas e de suporte que devem ser realizadas em tempo hábil

Solubility and solid phase studies of isomeric phenolic acids in pure solvents

The solubilities of gallic, protocatechuic, gentisic or α-resorcylic acids were measured in nine pure solvents (water, methanol, ethanol, 1-propanol, 2-propanol, 2-butanone, ethyl acetate, acetonitrile and dimethylformamide) at 298.15 K and 313.15 K, using the analytical isothermal shake-flask method. Additionally, solid phase studies of the selected phenolic acids were carried out using differential scanning calorimetry (DSC) and X-ray diffraction (XRD), giving access to important data on melting properties as well as on the structure of the solid phase before and after the dissolution. The NRTL-SAC model coupled to the reference solvent approach (RSA) were applied to correlate the solubility data in a set of seven solvents and, after used to predict the solubility in 1-propanol and dimethylformamide. Average relative deviations (ARD) between 28 and 40% for the correlation and between 16 and 59% for the predictions were obtained. These values are within the order of magnitude usually found for such type of semi-predictive models, using a limited set of data.This work is supported by: Project “AIProcMat@N2020 - Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020”, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); Project POCI-01-0145-FEDER-006984 – Associate Laboratory LSRE-LCM funded by ERDF through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI); Project POCI-01-0145-FEDER-030463 financed by COMPETE and Portugal2020 and national funds through FCT - Fundação para a Ciência e a Tecnologia . We also acknowledge the support of CICECO – Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (Ref. FCT UID/CTM/50011/2013 ). Appendix Ainfo:eu-repo/semantics/publishedVersio

Alterações eletrocardiográficas na intoxicação aguda por antidepressivo tricíclico e suas implicações clínicas

Introduction: The acute poisoning by tricyclic antidepressants is common in emergency rooms. Abnormalities in 12-lead electrocardiogram (ECG) are associated with this type of poisoning, with diagnostic and prognostic implications. The ECG may have incremental value especially in situations of altered consciousness, seizures or heart rhythm disturbances associated. Objective: To review the electrocardiographic changes described in tricyclic antidepressant poisoning and to establish their prognostic implications in the management of this condition. Methods: Bibliographic search in MEDLINE (PubMed) limited to articles published between 1980 and 2010 in English, using key words (tricyclic antidepressant overdose OR tricyclic antidepressant intoxication OR tricyclic antidepressant poisoning OR tricyclic antidepressant ingestion AND electrocardiography). Of the 133 articles identified, 44 were selected for review. Results: We identified prevalent as changes with diagnostic power in descending order the following findings: deviation of 40 ms terminal of QRS to the right of the frontal plane (from 61.0 to 83.0%), sinus tachycardia (40.7 to 57.7 %), QTc prolongation (8.2 to 53.0%), ratio R / S in aVR> 0.7 (28.8 to 32.9%), prolongation of QRS (8.2 to 21.3% ) and Brugada-pattern, the evidence is sparse, but suggestive of a greater chance of seizures and hypotension. Conclusion: The ECG is an instrument easily performed in the emergency room, providing diagnostic and prognostic information for poisoning by tricyclic and should be performed in all patients with suspicion of intoxicationIntrodução: A intoxicação aguda por antidepressivos tricíclicos é comum nas salas de emergência. Anormalidades no eletrocardiograma de 12 derivações (ECG) são associadas a este tipo de intoxicação, com implicações diagnósticas e prognósticas. O ECG pode ter valor incremental principalmente em situações de alteração de consciência, convulsões ou distúrbios do ritmo cardíaco associado. Objetivo: Revisar as principais alterações eletrocardiográficas descritas na intoxicação por antidepressivos tricíclicos e estabelecer suas implicações prognósticas no manejo desta condição clínica. Metodologia: Pesquisa bibliográfica no MEDLINE (PubMEd) limitada aos artigos publicados entre 1980 e 2010 em língua inglesa, utilizando-se unitermos (tricyclic antidepressant overdose OR tricyclic antidepressant intoxication OR tricyclic antidepressant poisoning OR tricyclic antidepressant ingestion AND electrocardiography). Dos 133 artigos identificados, foram selecionados 44 para a revisão.  Resultado: Foram identificados como alterações prevalentes com poder diagnóstico em ordem decrescente os seguintes achados: desvio dos 40 ms terminais do QRS para a direita do plano frontal (61,0-83,0%), taquicardia sinusal (40,7-57,7%), prolongamento do QTc (8,2-53,0%),relação R/S em aVR>0,7 (28,8-32,9%), prolongamento do QRS (8,2-21,3%) e padrão Brugada-like (2,3-15,3%).  Destes achados, somente o prolongamento do QRS foi prognóstico para morte, convulsão e arritmia e o prolongamento do QTc e a relação R/S em aVR>0,7 para arritmia ventricular. Para o padrão Brugada-like , as evidências são escassas, mas sugestivas de maior chance de convulsão e hipotensão. Conclusão: O ECG é um instrumento de fácil realização na sala de urgência, fornecendo informações diagnósticas e prognosticas para a intoxicação por tricíclicos, devendo ser realizado em todo paciente com suspeita desta intoxicação.

On-surface synthesis of heptacene on Ag(001) from brominated and non-brominated tetrahydroheptacene precursors

Achieving the Ag(001)-supported synthesis of heptacene from two related reactants reveals the effect of the presence of Br atoms on the reaction process. The properties of reactants, intermediates and end-products are further characterized by scanning tunneling microscopy and spectroscopy.Fil: Colazzo, Luciano. Donostia International Physics Center; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Mohammed, Mohammed S. G.. Donostia International Physics Center; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Dorel, Ruth. Barcelona Institute of Science and Technology; EspañaFil: Nita, Pawel. Donostia International Physics Center; España. Consejo Superior de Investigaciones Científicas; EspañaFil: García Fernández, Carlos. Donostia International Physics Center; EspañaFil: Abufager, Paula Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Lorente Palacios, Nicolas. Donostia International Physics Center; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Echavarren, Antonio M.. Barcelona Institute of Science and Technology; España. Universitat Rovira I Virgili; EspañaFil: De Oteyza, Dimas G.. Donostia International Physics Center; España. Consejo Superior de Investigaciones Científicas; España. Ikerbasque; Españ

Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome

INTRODUCTION: Apoptosis of neutrophils (polymorphonuclear neutrophils [PMNs]) may limit inflammatory injury in sepsis and acute respiratory distress syndrome (ARDS), but the relationship between the severity of sepsis and extent of PMN apoptosis and the effect of superimposed ARDS is unknown. The objective of this study was to correlate neutrophil apoptosis with the severity of sepsis and sepsis-induced ARDS. METHODS: A prospective cohort study was conducted in intensive care units of three tertiary hospitals in Porto Alegre, southern Brazil. Fifty-seven patients with sepsis (uncomplicated sepsis, septic shock, and sepsis-induced ARDS) and 64 controls were enrolled. Venous peripheral blood was collected from patients with sepsis within 24 hours of diagnosis. All surgical groups, including controls, had their blood drawn 24 hours after surgery. Control patients on mechanical ventilation had blood collected within 24 hours of initiation of mechanical ventilation. Healthy controls were blood donors. Neutrophils were isolated, and incubated ex vivo, and apoptosis was determined by light microscopy on cytospun preparations. The differences among groups were assessed by analysis of variance with Tukeys. RESULTS: In medical patients, the mean percentage of neutrophil apoptosis (± standard error of the mean [SEM]) was lower in sepsis-induced ARDS (28% ± 3.3%; n = 9) when compared with uncomplicated sepsis (57% ± 3.2%; n = 8; p < 0.001), mechanical ventilation without infection, sepsis, or ARDS (53% ± 3.0%; n = 11; p < 0.001) and healthy controls (69% ± 1.1%; n = 33; p < 0.001) but did not differ from septic shock (38% ± 3.7%; n = 12; p = 0.13). In surgical patients with sepsis, the percentage of neutrophil apoptosis was lower for all groups when compared with surgical controls (52% ± 3.6%; n = 11; p < 0.001). CONCLUSION: In medical patients with sepsis, neutrophil apoptosis is inversely proportional to the severity of sepsis and thus may be a marker of the severity of sepsis in this population

New segregates from the Neotropical genus Stryphnodendron (Leguminosae, Caesalpinioideae, mimosoid clade)

Non-monophyly is a prominent issue in mimosoid legumes, even in some of the less speciose genera such as the neotropical genus Stryphnodendron. This genus includes 35 species occurring from Nicaragua to Southern Brazil mostly in humid forests and savannas. Previous taxonomic studies of Stryphnodendron have highlighted morphologically distinct groups within the genus, recognized by differences on leaves (number of pinnae and size of leaflets), inflorescences (a simple or compound thyrse), and fruit types (legume, nucoid legume or follicle). Recent phylogenetic analyses have confirmed the non-monophyly of Stryphnodendron, supporting the recognition of three independent and morphologically well-delimited genera. Here we re-circumscribe Stryphnodendron and propose the two new genera Gwilymia and Naiadendron. In addition, we also provide an updated taxonomic account of the closely related genus Microlobius, including the proposal of a lectotype for the single species in the genus