Microscopic and biomolecular result of survey filarias diagnostic in the community of Angola in Chicala province of Bié

Bié is referred to as an endemic location for filariasis and has never been selected for mass administration of ivermectin. To understand the situation, we did a study in the locality of Chicala, in Kuito, and evaluated the co-endemicity of human filariasis, to obtain data via calibrated thick droplet microscopy and subcutaneous biopsy of samples collected in Chicala in Kuito, Bié and samples collected and preserved on Wathman filter paper for molecular diagnosis of filariae; Material and methods; The research was approved by the ethics committee of the Agostinho Neto University medical school. in deliberation number: 17/2021 and the samples collected after free and informed consent, the universe was 6015 people, data obtained from the local administration and was selected probabilistically from an approximate value of n0 400, the sample of 320 participants distributed in 12 conglomerates where we did research prolectively; The field work involved 2 microscopes, to read the slides, 2 interviewers, 1 guide and 1 driver; The Oncocerca volvulus worm was isolated from subcutaneous cellular tissue extracted from the iliac crest and/or calf muscles and crushed on a glass slide, hydrated in 1 drop of saline and analyzed using a binocular microscope (HC Olympus®), with a 100x objective., regarding the presence or absence of the filaria Oncocerca volvulus and one drop of fresh blood was collected by digital puncture and applied to the slide in a smear and on top of the slide and stained with giemsa and analyzed under the Binocular microscope (HC Olympus®) for the presence or absence of the filariae Wuchereria bancrofty and Loa Loa. All survey data were entered into Microsoft Excel 2010 and IBM SPSS version 21 statistical software was used for analysis. Results The average age of participants in the study was 39.8 years, the findings found in the calibrated thick drop were 0.3%, (+) positive for Wuchereria Bancrofty and subcutaneous biopsy 52.8% (+) positive for Oncocerca volvulus, 169/320 tests, 62.8% of participants were female, 0.3% of male participants had a positive calibrated thick drop (+) for Wuchereria Bancrofty, no observation of the characteristic eye worm was not registered Loa loa and 35% of women had a positive biopsy (+) and 17% of men had a biopsy (+) for Oncocerca volvulus at the age of 46-61 years, 0.3% had a positive (+) for Wuchereria Bancrofty and, 17.5% positive (+) for Oncocerca volvulus, and from 14 -29 years old, 17.2%, (+) and 30-45 years old, 14.1% for Oncocerca volvulus. The results in the conglomerates were: Ngombakasi, 0.3% positive (+) for Wuchereria Bancrofty and Chilomba 8.1%, Lumbachagi, 7.2%, Kalale, 6.9%, and João Kapa 6.6% positive (+), for Oncocerca volvulus, the results of samples preserved on filter paper from the residents of Chikala are missing. Conclusions. The Chicala in the municipality of Kuito, province of Bié, is hyperendemic for Oncocerca volvulus, a prevalence above 50%, and hypoendemic for Wuchereria Bancrofty, a prevalence lower than 10% with Loiasis outbreaks in the province to be determined; which allows the provincial authorities to invest in the mass administration of ivermectin because the risk of side effects is minimal or irrelevant.info:eu-repo/semantics/publishedVersio

implication for assessing the risk of arbovirus outbreaks

Funding Information: This work was also supported by the U.S. Centers for Disease Control and Prevention through a cooperative agreement number 5NU14GH001237-03-00. The views expressed in this written publication do not necessarily reflect the official policies of the U.S. Department of Health and Human Services. European Foundation Initiative into Neglected Tropical Disease also supported this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank all community leaders, household heads staff from the provincial health directorates, staff from the Medical Entomology Laboratory from the National Institute of Health, staff from National Malaria Control Programme, and staff from the Laboratório de Transmissores de Hematozoários of the Oswaldo Cruz Institute for their support during field work, laboratory testing and identification of Aedes spp. We also thank José Feriano Américo who produced the maps of this work. Ours special thanks goes to Professor J. Dereck Charlwood who revised the English grammar and typos of the entire manuscript. Consent for publication Our manuscript does not present any individual person's data. Publisher Copyright: © 2018 Abílio et al. http://creativecommons.org/licenses/by/4.0/.Background: Aedes-borne arboviruses have emerged as an important public health problem worldwide and, in Mozambique, the number of cases and its geographical spread have been growing. However, information on the occurrence, distribution and ecology of Aedes aegypti and Ae. albopictus mosquitoes remain poorly known in the country. Methods: Between March and April 2016, a cross-sectional study was conducted in 32 districts in Mozambique to determine the distribution and breeding sites of Ae. aegypti and Ae. albopictus. Larvae and pupae were collected from a total of 2,807 water-holding containers using pipette, dipper, funnel and sweeping procedures, depending on the container type and location. Both outdoor and indoor water-holding containers were inspected. The immature forms were reared to adults and the identifications of the mosquito species was carried out with a stereomicroscope using a taxonomic key. Results: Aedes aegypti was found in every district sampled, while Ae. albopictus was only found in Moatize district, situated in Tete Province in the central part of the country. Six hundred and twenty-eight of 2,807 (22.4%) containers were positive for Ae. aegypti but only one (0.03%) was positive for Ae. albopictus. The Container Index (CI) of Aedes was highest in densely populated suburban areas of the central region (260/604; 43.0%), followed by suburban areas in northern areas (228/617; 36.9%) whilst the lowest proportion was found in urbanized southern areas (140/1586; 8.8%). The highest CI of Aedes was found in used tires (448/1268; 35.3%), cement tanks (20/62; 32.3%) and drums (21/95; 22.1%). Conclusion: Data from our study showed that Ae. aegypti is present nation-wide, since it occurred in every sampled district, whilst Ae. albopictus had a limited distribution. Therefore, the risk of transmission of dengue and chikungunya is likely to have been underestimated in Mozambique. This study highlights the need for the establishment of a national entomological surveillance program for Aedes spp. in Mozambique in order to gain a better understanding about vector bionomics and to support the development of informed effective vector control strategies.publishersversionpublishe

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

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Scientific Advances and New Frontiers in Mesothelioma Therapeutics

Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer that arises from the mesothelial surface of the pleural and peritoneal cavities, the pericardium, and rarely, the tunica vaginalis. The incidence of MPM is expected to increase worldwide in the next two decades. However, even with the use of multimodality treatment, MPM remains challenging to treat, with a 5-year survival rate of less than 5%. The International Association for the Study of Lung Cancer has gathered experts in different areas of mesothelioma research and management to summarize the most significant scientific advances and new frontiers related to mesothelioma therapeutics

Distribution and breeding sites of Aedes aegypti and Aedes albopictus in 32 urban/peri-urban districts of Mozambique: implication for assessing the risk of arbovirus outbreaks

Submitted by Sandra Infurna ([email protected]) on 2019-02-19T13:42:20Z No. of bitstreams: 1 gabrielagarcia_marianafdavid_etal_IOC_2018.pdf: 3042517 bytes, checksum: 816c1d8c25307b7acf7d49089e5ffbad (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2019-02-19T13:53:12Z (GMT) No. of bitstreams: 1 gabrielagarcia_marianafdavid_etal_IOC_2018.pdf: 3042517 bytes, checksum: 816c1d8c25307b7acf7d49089e5ffbad (MD5)Made available in DSpace on 2019-02-19T13:53:12Z (GMT). No. of bitstreams: 1 gabrielagarcia_marianafdavid_etal_IOC_2018.pdf: 3042517 bytes, checksum: 816c1d8c25307b7acf7d49089e5ffbad (MD5) Previous issue date: 2018Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Directorate of Public Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Ministry of Health. National Institute of Health. Maputo, Mozambique.Universidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. GHTM. Lisboa, Portugal.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários Rio de Janeiro, RJ. Brasil.Ministry of Health. National Institute of Health. Maputo, Mozambique.Aedes-borne arboviruses have emerged as an important public health problem worldwide and, in Mozambique, the number of cases and its geographical spread have been growing. However, information on the occurrence, distribution and ecology of Aedes aegypti and Ae. albopictus mosquitoes remain poorly known in the country