The optical field angle distortion calibration feasibility study for the Hubble Space Telescope fine guidance sensors

The results of an analytical study to investigate the feasibility of calibrating the Hubble Space Telescope's (HST's) fine guidance sensors (FGSs) within HST mission accuracy limits are presented. The study has two purposes: (1) to determine the mathematical feasibility of the optical field angle distortion (OFAD) calibration algorithm and (2) to confirm that the OFAD, plate scale, and FGS-to-FGS alignment calibration algorithms produced a calibration of the FGSs that satisfied mission requirements. The study concluded that the mathematical specification of the OFAD algorithm is adequate and permits a determination of the FGS calibration parameters (accurate to better than 0.003 arc-second) sufficient to meet the mission requirements. The algorithms implemented, the characteristics of the simulated data and procedures for data analysis, and the study's results are discussed. In addition, several useful techniques for improving the stability and accuracy of the OFAD solution are outlined

Migrants\u27 Perceptions of Key Factors Contributing to Their Migration from Croatia and Decision to Remain Abroad

Hrvatska se kontinuirano suočava s padom broja stanovnika, ponajviše zbog niske stope nataliteta te migracije mladih i kvalificiranih radnika iz Hrvatske. Stoga je važno razumjeti glavne pokretače migracija, položaj hrvatskih migranata u inozemstvu te čimbenike koji mogu potaknuti njihov povratak. U ovom će se radu prikazati i analizirati dio empirijskih rezultata istraživanja Demografski potencijal hrvatskog iseljeništva koje provodi Institut za migracije i narodnosti u sklopu projekta »Mreža 2050 – Demografija, od izazova do odgovora«, a koji se odnosi na prva dva od spomenutih aspekata. U anketnom ispitivanju sudjelovalo je 497 ispitanika (Hrvata koji trenutačno žive u inozemstvu a većina ih je napustila Hrvatsku između 2016. i 2021.) koji su putem online upitnika dali svoje mišljenje o čimbenicima utjecaja na vlastitu odluku o iseljavanju. Upitnik je sadržavao uglavnom zatvorena pitanja s mogućnošću davanja i otvorenog odgovora. Predstavljeni su i raspravljeni glavni mikro i makročimbenici koji utječu na migraciju i aspiracije za migracijom prema percepciji sudionika te percepcije o aktualnim životnim okolnostima. Rezultati su pokazali da su čimbenici na makrorazini, koji se odnose na radne uvjete i stopu zaposlenosti, povezani s čimbenicima na mikrorazini, kao što je osobni socioekonomski status. Radne mogućnosti i radno okruženje smatrani su glavnim razlozima odlaska, a politička situacija donekle važnim čimbenikom koji utječe na osobnu kvalitetu života.Croatia has been facing a population decline, mainly due to a low birth rate and the emigration of young and qualified workers. Considering the historical and dynamic aspects of emigration (Draženović, Kunovac and Pripužić, 2018), leading to depopulation, it is necessary to investigate all contributing factors in Croatia and explore potential models and measures to mitigate these unfavourable processes. Apart from Germany, Croatian citizens have emigrated mostly to Ireland and Austria since the country acceded to the EU (Pokos, 2017). Research confirms that the number of Croatian citizens who immigrated to Germany, Ireland and Austria in 2016 was, on average, 62% higher than the official data reported by the Republic of Croatia (Jerić, 2019). The increasingly intensive emigration of the young and able-bodied population additionally contributes to a rapidly ageing population, exerting strong pressure on the sustainability of the pension system (Družić, Beg and Raguž Krištić, 2016) and underscores the importance of investigating the reasons for emigration and the factors essential for return. Migration is also an important area of interest for the European Union due to its exceptional impact on all aspects of society. Increased opportunities for mobility, advances in technology that provide access to information sources, and societal changes strongly suggest the need for policymakers to examine the micro, meso, and macro drivers that influence migration or potentially influence a person\u27s decision not to migrate or remigrate. Governments require migration analysis to create informed migration policies, including citizen participation in the policy development process. The perspectives of migrants and their behaviour should be taken into account when creating policies to better understand the key success factors needed for the desired outcomes of migrants (European Commission, 2020). According to Fargues (2017), migration is a complex process that is constantly changing as a result of various local, international, and global situations, highlighting the need for con¬tinual investigation and repeated surveying of the population. Within the current demographic climate, the World Youth Alliance Croatia (SSMH) launched the project “Network 2050 – Demography, From Challenges to Answers”, co-financed by the European Social Fund. The project is based on intersectoral cooperation, identified as necessary for improving collaborative efforts to address the effects of negative demographic trends on the social and economic development of Croatia and develop measures for demographic revitalisation. This paper will present the data and analysis of the empirical results of the research conducted by the Institute for Migration and Ethnic Studies. The study focuses on emigrants\u27 opinions and perspectives regarding the factors that influenced their decision to migrate. This includes their own perceptions of the situation in Croatia, as well as abroad in their host country, which played a role in their decision-making process and continues to potentially impact them. Additionally, the paper explores the emigrants’ perception of their current life circumstances. The target group comprised Croats currently living as expatriates in European countries. A total of 497 respondents, Croats currently living abroad, most of whom left Croatia between 2016 and 2021, took part in the survey. Three main research questions guided the investigation: 1) What are the key drivers of migration at the micro, meso, and macro levels that influence the decision to emigrate or stay, according to the perception of emigrants from Croatia?; 2) What factors influence the decision of Croats to stay abroad?; and, 3) What are the key factors that influence the decision to return to Croatia? For the purposes of this paper, the general results related to research questions 1 and 2 will be presented. The instrument used for data collection was an online questionnaire that respondents filled out independently. The questionnaire consisted of 62 questions, mostly closed-ended, with only a few open-ended questions to accommodate additional information if participants chose to elaborate on their perceptions. Including this option also allowed for the possibility of results that were not expected by the research team. The questions were divided into five thematic chapters: sociodemographic data, migration status, socioeconomic status, returnee motivational status, and identity and value system. The questionnaire was administered with special attention to the time of completion, clarity, and appropriateness of the questions. The data collection process included advertising the research project and posting calls for participation on various social media networks across platforms managed by members of various Croatian dias¬pora groups. Additionally, advertising was conducted through social groups and institutions, as well as using the snowball method. Data was collected during the period from July to October 2021. At the beginning, the purpose of the questionnaire was explained, and respondents were informed that their participation was voluntary with the possibility to withdraw at any time. Consistency in the questionnaire administration was achieved by exclusively offering it online. A total of 500 responses were received, of which 497 were valid, while three questionnaires were partially filled. Only key socio-demographic information was collected and, together with the respondents\u27 personal perceptions, it was examined in relation to the key drivers of emigration. Their perception is the key feedback that can help state authorities and policymakers in designing measures aimed at retaining the population and attract¬ing potential returnees. Their perception was viewed as potentially showing indica¬tors of migration drivers, push and pull factors, as well as demonstrating public perception around key issues and policies, and the type of information (including its accuracy) used to inform migration. Respecting the perception of the general public when creating policies is in line with the concepts promoted by the EU Parliament (2020), which encourages the participation of citizens in decision-making. According to the obtained sociodemographic data, 208 respondents (41.9%) were female, and 289 respondents (58.1%) were male. The most represented age category (39%) was 30–39 years old. Additionally, 24% of respondents were between 40 and 49 years old, 22% were between 18 and 29 years old 9.5 % were between 50 and 59 years old, 3.2% were 60–69 years old and 2% were between 70 and 81 years old. This indicates that the majority of respondents who leave are younger than 40, i.e. in the reproductive age group. The results obtained support the relevance of the research by Družić, Beg and Raguž Krištić (2016), who warn about the loss of the young population in Croatia, which results in population ageing. The majority (78.3%) were born in Croatia, and the next significant group (13.1%) was born in Bosnia and Herzego¬vina. The largest group of respondents, at the time of the questionnaire, lived in Germany, followed by the numerically significant groups in Great Britain, Ireland and Sweden. The trend shown by the majority of respondents coming from Germany is in line with the large wave of migration to Germany since 2013 when Croatia entered the EU, and since July 2015 when the labour market in Germany was opened to Croatia. Jurić (2022) and Pokos (2017) describe Germany as still the most desirable country for Croatian emigration. The results showed that macro-level factors related to working conditions and employment rates influence micro-level factors, such as socioeconomic status. Work opportunities and the working environment were perceived as somewhat important because respondents believe that these aspects affect their personal quality of life. An interesting result is that the number of respondents who stated that they were married or in a partnership doubled after moving. It is worth mentioning that Jang, Cast¬erline and Snyder (2014) warn that the longer the time spent abroad, the stronger the ties made, potentially leading to the establishment of family life connected to the host country. This could negatively affect the potential decision to return. The influence of this factor at the micro level requires further research to show the possible impact of marriages abroad on the mobility of new families and their possible return to Croatia, especially if Croatia\u27s goal is to encourage the return of its emigrants. The results of this study, as well as the recommendations of researchers such as Kis, Ozdemir and Ward (2015) on the importance of improving working conditions and wages as a means of improving living conditions, are useful for formulating strategies for population retention. Additionally, certain political restrictions can negatively affect the achievement of the country\u27s migration goals (Boswell, 2002), which, in the case of Croatia, involves return migration and population retention

Heat and moisture exchangers (HMEs) and heated humidifiers (HHs) in adult critically ill patients: a systematic review, meta-analysis and meta-regression of randomized controlled trials

The aims of this systematic review and meta-analysis of randomized controlled trials are to evaluate the effects of active heated humidifiers (HHs) and moisture exchangers (HMEs) in preventing artificial airway occlusion and pneumonia, and on mortality in adult critically ill patients. In addition, we planned to perform a meta-regression analysis to evaluate the relationship between the incidence of artificial airway occlusion, pneumonia and mortality and clinical features of adult critically ill patients

Pacific island regional preparedness for El Niño

The El Niño Southern Oscillation (ENSO) cycle is often blamed for disasters in Pacific island communities. From a disaster risk reduction (DRR) perspective, the challenges with the El Niño part of the ENSO cycle, in particular, are more related to inadequate vulnerability reduction within development than to ENSO-induced hazard influences. This paper analyses this situation, filling in a conceptual and geographic gap in El Niño-related research, by reviewing El Niño-related preparedness (the conceptual gap) for Pacific islands (the geographic gap). Through exploring El Niño impacts on Pacific island communities alongside their vulnerabilities, resiliences, and preparedness with respect to El Niño, El Niño is seen as a constructed discourse rather than as a damaging phenomenon, leading to suggestions for El Niño preparedness as DRR as part of development. Yet the attention which El Niño garners might bring resources to the Pacific region and its development needs, albeit in the short term while El Niño lasts. Conversely, the attention given to El Niño could shift blame from underlying causes of vulnerability to a hazard-centric viewpoint. Instead of focusing on one hazard-influencing phenomenon, opportunities should be created for the Pacific region to tackle wider DRR and development concerns

Carpal tunnel syndrome and the use of computer mouse and keyboard: A systematic review

<p>Abstract</p> <p>Background</p> <p>This review examines evidence for an association between computer work and carpal tunnel syndrome (CTS).</p> <p>Methods</p> <p>A systematic review of studies of computer work and CTS was performed. Supplementary, longitudinal studies of low force, repetitive work and CTS, and studies of possible pathophysiological mechanisms were evaluated.</p> <p>Results</p> <p>Eight epidemiological studies of the association between computer work and CTS were identified. All eight studies had one or more limitation including imprecise exposure and outcome assessment, low statistical power or potentially serious biases. In three of the studies an exposure-response association was observed but because of possible misclassification no firm conclusions could be drawn. Three of the studies found risks below 1. Also longitudinal studies of repetitive low-force non-computer work (n = 3) were reviewed but these studies did not add evidence to an association. Measurements of carpal tunnel pressure (CTP) under conditions typically observed among computer users showed pressure values below levels considered harmful. However, during actual mouse use one study showed an increase of CTP to potentially harmful levels. The long term effects of prolonged or repeatedly increased pressures at these levels are not known, however.</p> <p>Conclusion</p> <p>There is insufficient epidemiological evidence that computer work causes CTS.</p

Cryptic species in a well-known habitat: applying taxonomics to the amphipod genus Epimeria (Crustacea, Peracarida)

Taxonomy plays a central role in biological sciences. It provides a communication system for scientists as it aims to enable correct identification of the studied organisms. As a consequence, species descriptions should seek to include as much available information as possible at species level to follow an integrative concept of ‘taxonomics’. Here, we describe the cryptic species Epimeria frankei sp. nov. from the North Sea, and also redescribe its sister species, Epimeria cornigera. The morphological information obtained is substantiated by DNA barcodes and complete nuclear 18S rRNA gene sequences. In addition, we provide, for the first time, full mitochondrial genome data as part of a metazoan species description for a holotype, as well as the neotype. This study represents the first successful implementation of the recently proposed concept of taxonomics, using data from highthroughput technologies for integrative taxonomic studies, allowing the highest level of confidence for both biodiversity and ecological research

Prenatal Hyperandrogenization Induces Metabolic and Endocrine Alterations Which Depend on the Levels of Testosterone Exposure

Prenatal hyperandrogenism is able to induce polycystic ovary syndrome (PCOS) in rats. The aim of the present study was to establish if the levels of prenatal testosterone may determine the extent of metabolic and endocrine alterations during the adult life. Pregnant Sprague Dawley rats were prenatally injected with either 2 or 5 mg free testosterone (groups T2 and T5 respectively) from day 16 to day 19 day of gestation. Female offspring from T2 and T5 displayed different phenotype of PCOS during adult life. Offspring from T2 showed hyperandrogenism, ovarian cysts and ovulatory cycles whereas those from T5 displayed hyperandrogenism, ovarian cysts and anovulatory cycles. Both group showed increased circulating glucose levels after the intraperitoneal glucose tolerance test (IPGTT; an evaluation of insulin resistance). IPGTT was higher in T5 rats and directly correlated with body weight at prepubertal age. However, the decrease in the body weight at prepubertal age was compensated during adult life. Although both groups showed enhanced ovarian steroidogenesis, it appears that the molecular mechanisms involved were different. The higher dose of testosterone enhanced the expression of both the protein that regulates cholesterol availability (the steroidogenic acute regulatory protein (StAR)) and the protein expression of the transcriptional factor: peroxisome proliferator-activated receptor gamma (PPAR gamma). Prenatal hyperandrogenization induced an anti-oxidant response that prevented a possible pro-oxidant status. The higher dose of testosterone induced a pro-inflammatory state in ovarian tissue mediated by increased levels of prostaglandin E (PG) and the protein expression of cyclooxygenase 2 (COX2, the limiting enzyme of PGs synthesis). In summary, our data show that the levels of testosterone prenatally injected modulate the uterine environment and that this, in turn, would be responsible for the endocrine and metabolic abnormalities and the phenotype of PCOS during the adult life

Human Neural Stem Cells Differentiate and Promote Locomotor Recovery in an Early Chronic Spinal coRd Injury NOD-scid Mouse Model

Traumatic spinal cord injury (SCI) results in partial or complete paralysis and is characterized by a loss of neurons and oligodendrocytes, axonal injury, and demyelination/dysmyelination of spared axons. Approximately 1,250,000 individuals have chronic SCI in the U.S.; therefore treatment in the chronic stages is highly clinically relevant. Human neural stem cells (hCNS-SCns) were prospectively isolated based on fluorescence-activated cell sorting for a CD133(+) and CD24(-/lo) population from fetal brain, grown as neurospheres, and lineage restricted to generate neurons, oligodendrocytes and astrocytes. hCNS-SCns have recently been transplanted sub-acutely following spinal cord injury and found to promote improved locomotor recovery. We tested the ability of hCNS-SCns transplanted 30 days post SCI to survive, differentiate, migrate, and promote improved locomotor recovery.hCNS-SCns were transplanted into immunodeficient NOD-scid mice 30 days post spinal cord contusion injury. hCNS-SCns transplanted mice demonstrated significantly improved locomotor recovery compared to vehicle controls using open field locomotor testing and CatWalk gait analysis. Transplanted hCNS-SCns exhibited long-term engraftment, migration, limited proliferation, and differentiation predominantly to oligodendrocytes and neurons. Astrocytic differentiation was rare and mice did not exhibit mechanical allodynia. Furthermore, differentiated hCNS-SCns integrated with the host as demonstrated by co-localization of human cytoplasm with discrete staining for the paranodal marker contactin-associated protein.The results suggest that hCNS-SCns are capable of surviving, differentiating, and promoting improved locomotor recovery when transplanted into an early chronic injury microenvironment. These data suggest that hCNS-SCns transplantation has efficacy in an early chronic SCI setting and thus expands the "window of opportunity" for intervention

Phenotype and genotype of 87 patients with Mowat-Wilson syndrome and recommendations for care

Mowat-Wilson syndrome (MWS) is a rare intellectual disability/multiple congenital anomalies syndrome caused by heterozygous mutation of the ZEB2 gene. It is generally underestimated because its rarity and phenotypic variability sometimes make it difficult to recognize. Here, we aimed to better delineate the phenotype, natural history, and genotype-phenotype correlations of MWS.MethodsIn a collaborative study, we analyzed clinical data for 87 patients with molecularly confirmed diagnosis. We described the prevalence of all clinical aspects, including attainment of neurodevelopmental milestones, and compared the data with the various types of underlying ZEB2 pathogenic variations.ResultsAll anthropometric, somatic, and behavioral features reported here outline a variable but highly consistent phenotype. By presenting the most comprehensive evaluation of MWS to date, we define its clinical evolution occurring with age and derive suggestions for patient management. Furthermore, we observe that its severity correlates with the kind of ZEB2 variation involved, ranging from ZEB2 locus deletions, associated with severe phenotypes, to rare nonmissense intragenic mutations predicted to preserve some ZEB2 protein functionality, accompanying milder clinical presentations.ConclusionKnowledge of the phenotypic spectrum of MWS and its correlation with the genotype will improve its detection rate and the prediction of its features, thus improving patient care.GENETICS in MEDICINE advance online publication, 4 January 2018; doi:10.1038/gim.2017.221