Articulation between Pre-school and 1st Cycle of Basic Education

La articulación entre las diversas etapas del proceso educativo implica una secuencialidad progresiva, otorgando a cada etapa la función de completar, profundizar y extender la etapa anterior, en una perspectiva de continuidad y unidad global de educación y/o enseñanza. Corresponde a los educadores infantiles y a los maestros del 1er Ciclo de Educación Básica tener una actitud activa en la búsqueda de continuidad/secuencialidad, al tiempo que afirmar y destacar la especificidad de cada etapa, y también para crear condiciones para una articulación social en la escucha a los padres, otros profesionales (que ocasionalmente pueden estar con los niños), los niños mismos y sus perspectivas.The articulation between the various stages of the educational path implies a progressive sequentiality, granting each stage the function of completing, deepening and extending the previous stage, in a perspective of continuity and global unity of education and/or teaching. It is incumbent upon the Childhood Educators and the Teachers of the 1st Cycle of Basic Education to have an active attitude in the search for continuity/sequentiality, while asserting and highlighting the specificity of each stage, and also to create conditions for a social articulation by listening to the parents, other professionals (who may occasionally be with the children), the children themselves and their perspectives.A articulação entre as várias etapas do percurso educativo implica uma sequencialidade progressiva, concedendo a cada etapa a função de completar, aprofundar e alargar a etapa anterior, numa perspetiva de continuidade e unidade global de educação e/ou ensino. Aos Educadores de Infância e aos Professores do 1º Ciclo do Ensino Básico compete ter uma atitude ativa na procura desta continuidade/sequencialidade, não deixando de afirmar e realçar a especificidade de cada etapa, e devem ainda criar condições para uma articulação social escutando os pais, os outros profissionais (que ocasionalmente possam estar com as crianças), as próprias crianças e as suas perspetivas.peerReviewe

Training proposals for Early Childhood Educators and Teachers of the 1st Cycle of Basic Education

El artículo que se presenta a continuación es una propuesta para que la formación de educadores y docentes del primer ciclo de educación básica en Portugal se extienda, en este caso en particular, a las nuevas tecnologías. Nos referimos a la importancia de la informática en la formación inicial de los docentes y maestros de primer ciclo para que sea más fácil para los educadores y maestros abordar las necesidades de los niños de hoy, así como para guiarlos en este nuevo proceso de aprendizaje, y puedan ayudar para trabajar la información que adquieren fuera del entorno escolar, teniendo en cuenta que la información no es conocimiento y que el estudiante debe seguir siendo guiado por alguien que ya ha trabajado o puede trabajar en esa información, agregando así otra función a las funciones de educador y profesor, el de gestores de información. Uno de los desafíos en la educación de maestros y educadores está relacionado con la necesidad de adaptarse a una sociedad cambiante donde la tecnología y el análisis espacial se han vuelto esenciales. El papel del maestro está cambiando pero no disminuye en importancia. Ahora tiene la función de transformar la información en conocimiento. En este contexto, las nuevas tecnologías son una herramienta importante. Hemos construido este artículo basado en las opiniones de varios autores, autores que también han sido la base de una tesis que contiene la parte empírica aludiendo al tema aquí descrito.The article presented below is a proposal for the training of Educators and Teachers of 1st Cycle of Basic Education in Portugal to be extended, in this case in particular, to new technologies. We refer to the importance of computer science in the initial training of 1st cycle Teachers and Teachers to make it easier for Educators and Teachers to deal with the needs of today’s children, as well as to guide them in this new learning process, and can help to work the information they acquire outside the school environment, taking into account that information is not knowledge and the student continues to need to be guided by someone who has already worked or is able to work on that information, thus adding another function to the functions of Educator and Professor, that of information managers. One of the challenges in educating teachers and educators is related to the need to adapt to a changing society where technology and spatial analysis have become essential. The role of the teacher is changing but it does not diminish in importance. It now has the function of transforming information into knowledge. In this context, new technologies are an important tool. We have constructed this article based on the opinions of several authors, authors that have also been the basis of a thesis that contains the empirical part alluding to the theme described here.O artigo em seguida apresentado é uma proposta para que a formação, de Educadores e Professores de 1º Ciclo do Ensino Básico em Portugal, seja ampliada, neste caso em particular, às novas tecnologias. Fazemos referência à importância da informática na formação inicial de Educadores e Professores do 1º Ciclo para que seja mais fácil aos Educadores e Professores lidarem com as necessidades das crianças de hoje, bem como para que as consigam orientar neste novo processo de aprendizagem, e as possam ajudar a trabalhar a informação que adquirem fora do ambiente escolar, tendo em atenção que informação não é conhecimento e o aluno continua a necessitar de ser orientado por alguém que já trabalhou ou tem condições para trabalhar essa informação, acrescendo assim mais uma função às funções de Educador e Professor, a de gestores de informação. Um dos desafios na formação de Educadores e Professores está relacionado com a necessidade de adaptação a uma sociedade em mudança, onde a tecnologia e a capacidade de análise espacial se tornaram essenciais. O papel do professor está a alterar-se mas este não diminui de importância. Este tem agora a função de transformar a informação em conhecimento. Neste contexto, as novas tecnologias, são uma importante ferramenta. Construímos este artigo com base em opiniões de diversos autores, autores estes que estiveram também na base de uma tese que contém a parte empírica alusiva ao tema aqui descrito.peerReviewe

Características deseables para un SGSI orientado a PYMES

La sociedad de la información cada vez depende más de los Sistemas de Gestión de la Seguridad de la Información (SGSI), y poder disponer de estos sistemas ha llegado a ser vital para la evolución de las PYMES. Sin embargo, este tipo de compañías requiere de SGSIs adaptados a sus especiales características, y que estén optimizados desde el punto de vista de los recursos necesarios para implantarlos y mantenerlos. En este artículo se presenta un análisis de las diferentes propuestas que están surgiendo orientadas a implantar los SGSIs en las PYMES, con el objetivo de determinar las características que debería tener una metodología de gestión de seguridad orientada a las PYMES.Sociedad Argentina de Informática e Investigación Operativ

Cultural Heritage Restoration of a Hemispherical Vault by 3D Modelling and Projection of Video Images with Unknown Parameters and from Unknown Locations

[EN] Reverse engineering applied to architectural restoration for the reconstruction of structural surfaces depends on metric precision. Sometimes there are elements on these surfaces whose value is even higher than the building itself. This is the case for many churches whose ceilings have pictorial works of art. Reconstruction requires the existence of some identifiable remainder and/or a surface geometry that enables mathematical development. In our case, the vault has an irregular hemispherical geometry (without possible mathematical development), and there are no significant remains of the painting (which was destroyed by a fire). Through the 3D modelling of the irregular vault and two historic frames with a camera of unknown geometry, an inverse methodology is designed to project the original painting without metric deformations. For this, a new methodology to locate the camera positions is developed. After, a 3D virtual mathematical model of the complete image on the vault is calculated, and from it, partial 3D virtual images are automatically calculated depending on the variable unknown positions of the video cannons (distributed along the upper corridor of the apse) that will project them (visually forming a perfect complete 3D image)Herráez Boquera, J.; Denia Rios, JL.; Priego De Los Santos, E.; Navarro Esteve, PJ.; Martín Sánchez, MT.; Rodríguez Pereña, J. (2021). Cultural Heritage Restoration of a Hemispherical Vault by 3D Modelling and Projection of Video Images with Unknown Parameters and from Unknown Locations. Applied Sciences. 11(12):1-12. https://doi.org/10.3390/app11125323112111

Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

L-Asparaginase (ASNase) is used in the treatment of acute lymphoblastic leukemia, being produced and commercialized only from bacterial sources. Alternative Saccharomyces cerevisiae ASNase II coded by the ASP3 gene was biosynthesized by recombinant Pichia pastoris MUTs under the control of the AOX1 promoter, using different cultivation strategies. In particular, we applied multistage fed-batch cultivation divided in four distinct phases to produce ASNase II and determine the fermentation parameters, namely specific growth rate, biomass yield, and enzyme activity. Cultivation of recombinant P. pastoris under favorable conditions in a modified defined medium ensured a dry biomass concentration of 31 gdcw.L−1 during glycerol batch phase, corresponding to a biomass yield of 0.77 gdcw.gglycerol-1 and a specific growth rate of 0.21 h−1. After 12 h of glycerol feeding under limiting conditions, cell concentration achieved 65 gdcw.L−1 while ethanol concentration was very low. During the phase of methanol induction, biomass concentration achieved 91 gdcw.L−1, periplasmic specific enzyme activity 37.1 U.gdcw-1, volumetric enzyme activity 3,315 U.L−1, overall enzyme volumetric productivity 31 U.L−1.h−1, while the specific growth rate fell to 0.039 h−1. Our results showed that the best strategy employed for the ASNase II production was using glycerol fed-batch phase with pseudo exponential feeding plus induction with continuous methanol feeding

A deletion at Adamts9-magi1 Locus is associated with psoriatic arthritis risk

Objective: Copy number variants (CNVs) have been associated with the risk to develop multiple autoimmune diseases. Our objective was to identify CNVs associated with the risk to develop psoriatic arthritis (PsA) using a genome-wide analysis approach. Methods: A total of 835 patients with PsA and 1498 healthy controls were genotyped for CNVs using the Illumina HumanHap610 BeadChip genotyping platform. Genomic CNVs were characterised using CNstream analysis software and analysed for association using the χ2 test. The most significant genomic CNV associations with PsA risk were independently tested in a validation sample of 1133 patients with PsA and 1831 healthy controls. In order to test for the specificity of the variants with PsA aetiology, we also analysed the association to a cohort of 822 patients with purely cutaneous psoriasis (PsC). Results: A total of 165 common CNVs were identified in the genome-wide analysis. We found a highly significant association of an intergenic deletion between ADAMTS9 and MAGI1 genes on chromosome 3p14.1 (p=0.00014). Using the independent patient and control cohort, we validated the association between ADAMTS9-MAGI1 deletion and PsA risk (p=0.032). Using next-generation sequencing, we characterised the 26 kb associated deletion. Finally, analysing the PsC cohort we found a lower frequency of the deletion compared with the PsA cohort (p=0.0088) and a similar frequency to that of healthy controls (p>0.3). Conclusions: The present genome-wide scan for CNVs associated with PsA risk has identified a new deletion associated with disease risk and which is also differential from PsC risk

Caso de Rabia canina importada de Marruecos a España. Junio de 2013.

El 5 de junio de 2013, el servicio de epidemiología de Castilla-La Mancha notificó al Centro de Coordinación de Alertas y Emergencias Sanitarias (CCAES) un caso confirmado de rabia en un perro abatido por la policía en la ciudad de Toledo el 1 de junio. El animal había mordido a cuatro niños y un adulto. Uno de los niños requirió hospitalización e ingresó en la Unidad de Cuidados Intensivos. El Laboratorio Nacional de Referencia para lyssavirus realizó el diagnóstico por inmunofluorescencia, PCR y cultivo celular, así como la secuenciación genómica de la cepa del virus y su comparación con las cepas circulantes en países endémicos. Inmediatamente tras conocerse los resultados, los cuatro niños y el adulto recibieron profilaxis post-exposición con vacuna e inmunoglobulina1 . Las investigaciones preliminares revelaron que el perro había viajado con sus dueños el 22 de mayo desde Cataluña a una pequeña localidad a 10 km de Toledo. Según los dueños, el perro había escapado unos días antes de ser localizado en Toledo. En ese momento existía la sospecha, aún sin confirmar, de que el perro hubiera estado unos meses antes en Marruecos. España (territorio peninsular, Islas Baleares y Canarias) ha estado libre de rabia terrestre desde 1978. Tras recibir la notificación y según lo establecido en el Plan de Contingencia para el control de la rabia en España2 , se constituyó una comisión técnica formada por representantes de la Dirección General de Salud Pública, Calidad e Innovación del Ministerio de Sanidad, Servicios Sociales e Igualdad (DGSPCI), la Dirección General de Sanidad de la Producción Agrícola y Ganadera del Ministerio de Agricultura, Alimentación y Medio Ambiente (DGSPA), las Comunidades Autónomas afectadas, el Laboratorio Nacional de Referencia de rabia y el Centro Nacional de Epidemiología (CNE). Los objetivos de esta comisión eran coordinar la investigación del suceso, evaluar el riesgo para la salud humana y animal, proponer la activación de los correspondientes niveles de alerta y coordinar la aplicación de las medidas de control apropiadas.N

Guía de práctica clínica para el tratamiento del cáncer de próstata metastásico hormonosensible en el Seguro Social del Perú (EsSalud)

Introduction: This article summarizes the clinical practice guideline (CPG) for the treatment of metastatic hormone-sensitive prostate cancer in the Social Security of Peru (EsSalud). Objective: To provide evidence-based clinical recommendations for the treatment of adults with hormone-sensitive metastatic adenocarcinoma of the prostate with de novo or recurrent presentation and high or low metastatic volume in EsSalud. Methods: A guideline development group (GDG) was formed, which included specialist physicians and methodologists, who formulated clinical questions. Systematic searches were conducted for systematic reviews and - when deemed relevant - primary studies in PubMed during 2022. Evidence was selected to answer each of the clinical questions posed. The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic working meetings, the GEG used the GRADE methodology to review the evidence and formulate recommendations. The CPG was reviewed by external experts before its approval. Results: The CPG addressed 6 clinical questions, divided into 2 main topics: considerations on androgen deprivation therapy (ADT) and ADT combined with other therapies. Based on these questions, 10 recommendations were formulated (4 strong and 6 conditional), and 6 points of good clinical practice. Conclusion: Evidence-based recommendations were issued for the management of patients with this pathology.Introducción: Este artículo resume la guía de práctica clínica (GPC) para el tratamiento del cáncer de próstata metastásico hormonosensible en el Seguro Social del Perú (EsSalud). Objetivo: Proveer recomendaciones clínicas basadas en evidencia para el tratamiento de adultos con adenocarcinoma de próstata metastásico hormonosensible con presentación de novo o recurrente y de alto o bajo volumen metastásico en EsSalud. Métodos: Se conformó un grupo elaborador de la guía (GEG) que incluyó médicos especialistas y metodólogos, el cual formuló preguntas clínicas. Se realizaron búsquedas sistemáticas de revisiones sistemáticas y –cuando fue considerado pertinente– estudios primarios en PubMed durante el 2022. Se seleccionó la evidencia para responder cada una de las preguntas clínicas planteadas. Se evaluó la certeza de evidencia usando la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). En reuniones de trabajo periódicas, el GEG usó la metodología GRADE para revisar la evidencia y formular las recomendaciones. La GPC fue revisada por expertos externos antes de su aprobación. Resultados: La GPC abordó 6 preguntas clínicas, divididas en 2 temas principales: consideraciones sobre la terapia de deprivación androgénica (TDA) y TDA combinada con otras terapias. En base a dichas preguntas se formularon 10 recomendaciones (4 fuertes y 6 condicionales) y 6 puntos de buena práctica clínica. Conclusión: Se emitieron recomendaciones basadas en evidencia para el manejo de pacientes con esta patología

Dairy product consumption and changes in cognitive performance: two-year analysis of the PREDIMED-Plus Cohort

Scope: Dairy consumption has been suggested to impact cognition; however, evidence is limited and inconsistent. This study aims to longitudinally assess the association between dairy consumption with cognitive changes in an older Spanish population at high cardiovascular disease risk. Methods and results: Four thousand six hundred sixty eight participants aged 55–75 years, completed a validated food frequency questionnaire at baseline and a neuropsychological battery of tests at baseline and 2-year follow-up. Multivariable linear regression models are used, scaled by 100 (i.e., the units of β correspond to 1 SD/100), to assess associations between baseline tertile daily consumption and 2-year changes in cognitive performance. Participants in the highest tertile of total milk and whole-fat milk consumption have a greater decline in global cognitive function (β: –4.71, 95% CI: –8.74 to –0.69, p-trend = 0.020 and β: –6.64, 95% CI: –10.81 to –2.47, p-trend = 0.002, respectively) compared to those in the lowest tertile. No associations are observed between low fat milk, yogurt, cheese or fermented dairy consumption, and changes in cognitive performance. Conclusion:Results suggest there are no clear prospective associations between consumption of most commonly consumed dairy products and cognition, although there may be an association with a greater rate of cognitive decline over a 2-year period in older adults at high cardiovascular disease risk for whole-fat milk

Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

[Purpose]: We explored the cross-sectional association between the adherence to three different provegetarian (PVG) food patterns defined as general (gPVG), healthful (hPVG) and unhealthful (uPVG), and the cardiometabolic risk in adults with metabolic syndrome (MetS) of the PREDIMED-Plus randomized intervention study. [Methods]: We performed a cross-sectional analysis of baseline data from 6439 participants of the PREDIMED-Plus randomized intervention study. The gPVG food pattern was built by positively scoring plant foods (vegetables/fruits/legumes/grains/potatoes/nuts/olive oil) and negatively scoring, animal foods (meat and meat products/animal fats/eggs/fish and seafood/dairy products). The hPVG and uPVG were generated from the gPVG by adding four new food groups (tea and coffee/fruit juices/sugar-sweetened beverages/sweets and desserts), splitting grains and potatoes and scoring them differently. Multivariable-adjusted robust linear regression using MM-type estimator was used to assess the association between PVG food patterns and the standardized Metabolic Syndrome score (MetS z-score), a composed index that has been previously used to ascertain the cardiometabolic risk, adjusting for potential confounders. [Results]: A higher adherence to the gPVG and hPVG was associated with lower cardiometabolic risk in multivariable models. The regression coefficients for 5th vs. 1st quintile were − 0.16 (95% CI: − 0.33 to 0.01) for gPVG (p trend: 0.015), and − 0.23 (95% CI: − 0.41 to − 0.05) for hPVG (p trend: 0.016). In contrast, a higher adherence to the uPVG was associated with higher cardiometabolic risk, 0.21 (95% CI: 0.04 to 0.38) (p trend: 0.019). [Conclusion]: Higher adherence to gPVG and hPVG food patterns was generally associated with lower cardiovascular risk, whereas higher adherence to uPVG was associated to higher cardiovascular risk.This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated FIS projects leaded by JS-S and JVi, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to JS-S; the European Research Council (Advanced Research Grant 2014–2019; agreement #340918) granted to MÁM-G.; the Recercaixa (number 2013ACUP00194) grant to JS-S; grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 grant from the Generalitat Valenciana; the SEMERGEN grant; None of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication