Repercusiones psicológicas y sociales de la prejubilación

En la actualidad, un gran número de investigadores han puesto su atención sobre el impacto psicosocial de la jubilación. El presente trabajo persigue principalmente dos objetivos: (1) elaborar un perfil de la prejubilación en el Principado de Asturias, atendiendo variables psicológicas, familiares y sociales; (2) tratar de determinar la posible existencia de un constructo específico en los prejubilados, denominado aquí «vida laboral interrumpida» y que a su vez englobaría la «autopercepción negativa» de otras investigaciones. Los resultados parecen mostrar la existencia de un posible constructo integrado por varios factores conductuales además de la tradicional autopercepción negativa

Epidemiologia del parasitismo intestinal infantil en el valle del Guadalquivir, España

BACKGROUND : Intestinal parasitisms represents a public health problem that should be periodically assessed in each region. In the present paper, a study about prevalence of intestinal parasites, has been carried out in children from the natural region of the Guadalquivir Valley. METHODS: During the period 1994-1996, 1.917 children without symptoms, aging between 6 and 10, were studied by means of coprologycal analysis and Graham method, all of them living in 20 villages in the Guadalquivir valley. RESULTS: The overall prevalence of intestinal parasitisms have been of 27,12%. The reported parasites and their prevalence are as follows: Enterobius vermicularis (20,44%), Giardia lamblia (5,05%), Entamoeba coli (2,45%), Endolimax nana (1,61%), Entamoeba histolytica (0,31%), Entamoeba hartmanni (0,05%), Iodamoeba bütschlii (0,05%). CONCLUSIONS: The overall prevalence of intestinal parasites is similar to that found in other spanish region, if only a little bit more favourable probably due to the long lasting drought and the improvements in health resourses, no geohelmints have been detected unlike other protozoosis, giardiasis mantains a relatively high prevalence.FUNDAMENTO: Las parasitosis intestinales en los niños constituyen un problema de salud pública que debe ser valorado periódicamente en cada región. En este trabajo se aborda, por primera vez en la región natural del Valle del Guadalquivir, un estudio amplio sobre la prevalencia del parasitismo intestinal en la población infantil de la zona. MÉTODOS: Durante el período 1994-1996, mediante análisis coprológico y método de Graham, se ha estudiado a 1.917 niños y niñas asintomáticos, con edades comprendidas entre seis y diez años, residentes en veinte localidades del Valle del Guadalquivir. RESULTADOS: El índice global de parasitación ha sido del 27,12 %. Las especies parásitas detectadas, así como sus prevalencias fueron: Enterobius vermicularis (20,44%), Giardia lamblia (5,05%), Entamoeba coli (2,45%), Endolimax nana (1,61%), Entamoeba histolytica (0,31%), Entamoeba hartmanni (0,05%), Iodamoeba bütschlii (0,05%). CONCLUSIONES: La prevalencia global encontrada es similar a la de otras regiones españolas, aunque quizás pueda considerarse algo más favorable. No se detectan geohelmintos, debido posiblemente a la mejora de la infraestructura higiénico-sanitaria y a los efectos de la prolongada sequía en la zona. La giardiasis, a diferencia de las restantes protozoosis, mantiene una prevalencia relativamente alta

Efecto del pastoreo de cerdos sobre las fracciones de nitrógeno, carbono y fósforo del suelo

The objective of this study was to evaluate the influence of grazing pigs on some soil chemical variables in a Mollisol in Maracay – Venezuela, under isohyperthermic conditions. Soil samples were taken from grazed (6 kg / m2) and non-grazed plots. Tat (0-5 or 5-10 cm depth), using a 2x2 factorial design. Total nitrogen, ammonia nitrogen, nitrate nitrogen and organic nitrogen were assessed. The extraction and fractionation of soil organic matter (SOM) and total oxidable organic carbon, total extractable carbon (CET), the carbon bonded to humic acids (CAH), fulvic acids (CAF), and non-humic substances (CSNH) were determinated. In addition, the phosphorous in the soil was fractionated by using the method of Hedley; extracting the fractions: resin exchangeable phosphorus (P-membrane), phosphorus extracted with sodium bicarbonate, NaOH extractable inorganic phosphorus, inorganic phosphorus and inorganic phosphorus extractable by HCl and inorganic phosphorus extractable in hot HCl. The treatments did not affect nitrogen, CAH and CAF, but the CET and CSNH were affected. . An increase on the fractions of phosphorus was observed, with higher increases in exchangeable phosphorus in grazed plotsEl objetivo del presente trabajo fue evaluar el efecto del pastoreo de cerdos, en algunas variables químicas en un Molisol en Maracay – Venezuela, bajo condiciones isohipertérmicas. Se tomaron muestras de suelos de dos lotes, uno sin cerdos y el otro con cerdos (6 kg de peso vivo por m2). Se consideraron dos profundidades de muestreo (0-5 y 5-10 cm) bajo un diseño factorial 2x2. Se determinó nitrógeno total, nitrógeno amoniacal, nitrógeno nítrico y nitrógeno orgánico. Se realizó la extracción y el fraccionamiento de la materia orgánica del suelo (MOS) y se determinó el carbono orgánico total oxidable, carbono extraíble total (CET), carbono unido a los ácidos húmicos (CAH), los ácidos fúlvicos (CAF) y sustancias no húmicas (CSNH). Además, se realizó el fraccionamiento del fósforo del suelo usando el método de Hedley, extrayéndose las fracciones de fósforo intercambiable en resina (P-membrana), fósforo extraído con bicarbonato de sodio, fósforo inorgánico extraíble en NaOH, fósforo inorgánico extraíble en HCl y fósforo inorgánico extraíble en HCl caliente. Los tratamientos aplicados no afectaron el nitrógeno, el CAH y el CAF, pero si el CET y CSNH en las parcelas con cerdos. Se observó incremento en las fracciones de fósforo evaluadas, especialmente el fósforo disponible, que fue mayor en el lote con cerdos

Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation

We report a case of a 13-year-old girl with soft tissue sarcoma of the hand, which showed muscle and neuroectodermal immunophenotypes. Molecular studies were performed on RNA collected from fine-needle aspiration (FNA) cytology and peripheral blood samples by nested reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis. This biphenotypic tumor showed simultaneous expression of EWS-FLI1 and PAX3-FKHR transcripts, specific of Ewing family tumors and alveolar rhabdomyosarcoma, respectively. Although childhood sarcomas with simultaneous muscle and neural differentiation have been described to have EWS-FLI1 transcripts, there are no reports of tumors with both transcripts. Cytological specimens are a good source of RNA for molecular studie

The res (restored cell structure by salinity) tomato mutant reveals the role of the DEAD-box RNA helicase SlDEAD39 in plant development and salt response

[EN] Increasing evidences highlight the importance of DEAD-box RNA helicases in plant development and stress responses. In a previous study, we characterized the tomato res mutant (restored cell structure by salinity), showing chlorosis and development alterations that reverted under salt-stress conditions. Map-based cloning demonstrates that RES gene encodes SlDEAD39, a chloroplast-targeted DEAD-box RNA helicase. Constitutive expression of SlDEAD39 complements the res mutation, while the silencing lines had a similar phenotype than res mutant, which is also reverted under salinity. Functional analysis of res mutant proved SlDEAD39 is involved in the in vivo processing of the chloroplast, 23S rRNA, at the hidden break-B site, a feature also supported by in vitro binding experiments of the protein. In addition, our results show that other genes coding for chloroplast-targeted DEAD-box proteins are induced by salt-stress, which might explain the rescue of the res mutant phenotype. Interestingly, salinity restored the phenotype of res adult plants by increasing their sugar content and fruit yield. Together, these results propose an unprecedented role of a DEAD-box RNA helicase in regulating plant development and stress response through the proper ribosome and chloroplast functioning, which, in turn, represents a potential target to improve salt tolerance in tomato cropsSecretaria de Estado de Investigacion, Desarrollo e Innovacion, Grant/Award Numbers: AGL2015-64991-C3-1-R, AGL2015-64991-C3-2-R, AGL2015-64991-C3-3-R, AGL2017-88702-C2-1-RCapel, C.; Albaladejo, I.; Egea, I.; Massaretto, IL.; Yuste-Lisbona, FJ.; Pineda Chaza, BJ.; García Sogo, B.... (2020). The res (restored cell structure by salinity) tomato mutant reveals the role of the DEAD-box RNA helicase SlDEAD39 in plant development and salt response. Plant Cell & Environment. 43(7):1722-1739. https://doi.org/10.1111/pce.13776S1722173943

Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer.

Peritoneal dissemination is the primary metastatic route of ovarian cancer (OvCa), and is often accompanied by the accumulation of ascitic fluid. The peritoneal cavity is lined by mesothelial cells (MCs), which can be converted into carcinoma-associated fibroblasts (CAFs) through mesothelial-to-mesenchymal transition (MMT). Here, we demonstrate that MCs isolated from ascitic fluid (AFMCs) of OvCa patients with peritoneal implants also undergo MMT and promote subcutaneous tumour growth in mice. RNA sequencing of AFMCs revealed that MMT-related pathways – including transforming growth factor (TGF)- signalling – are differentially regulated, and a gene signature was verified in peritoneal implants from OvCa patients. In a mouse model, pre-induction of MMT resulted in increased peritoneal tumour growth, whereas interfering with the TGF- receptor reduced metastasis. MC-derived CAFs showed activation of Smad-dependent TGF- signalling, which was disrupted in OvCa cells, despite their elevated TGF- production. Accordingly, targeting Smad-dependent signalling in the peritoneal pre-metastatic niche in mice reduced tumour colonization, suggesting that Smad-dependent MMT could be crucial in peritoneal carcinomatosis. Together, these results indicate that bidirectional communication between OvCa cells and MC-derived CAFs, via TGF--mediated MMT, seems to be crucial to form a suitable metastatic niche. We suggest MMT as a possible target for therapeutic intervention and a potential source of biomarkers for improving OvCa diagnosis and/or prognosis.post-print2310 K

First results on light readout from the 1-ton ArDM liquid argon detector for dark matter searches

ArDM-1t is the prototype for a next generation WIMP detector measuring both the scintillation light and the ionization charge from nuclear recoils in a 1-ton liquid argon target. The goal is to reach a minimum recoil energy of 30\,keVr to detect recoiling nuclei. In this paper we describe the experimental concept and present results on the light detection system, tested for the first time in ArDM on the surface at CERN. With a preliminary and incomplete set of PMTs, the light yield at zero electric field is found to be between 0.3-0.5 phe/keVee depending on the position within the detector volume, confirming our expectations based on smaller detector setups.Comment: 14 pages, 10 figures, v2 accepted for publication in JINS

Los Poyos del Molinillo (Frigiliana): new site of the Bronze Age in the East Axarquía (Málaga, Andalucía)

En este trabajo damos a conocer un nuevo yacimiento descubierto recientemente en el municipio de Frigiliana. La delimitación del área denominada Los Poyos del Molinillo permitió definir la existencia de un poblado y una covacha con restos de una inhumación. El estudio de los materiales arqueológicos, que incluye cerámica, piezas metálicas o elementos de molturación, o la datación AMS obtenida, permiten adscribir el yacimiento a la Edad del Bronce y ampliar el conocimiento de esta etapa en la Axarquía oriental (Málaga, Andalucía).In this work we present a new site recently discovered in the Frigiliana municipality (Málaga). The spatial delimitation of the so called Los Poyos del Molinillo area let us define a Bronze age settlement and an inhumation burial cave. The archaeological record includes ceramic, metallic items or grinding elements, all of them belonging to the Bronze Age, as well as an AMS Radiocarbon data. This site extends the knowledge about this period in the Eastern Axarquía (Málaga, Andalucía)

Slow relaxation dynamics of clogs in a vibrated granular silo

We experimentally explore the vibration-induced unclogging of arches halting the flow in a two-dimensional silo. The endurance of arches is determined by carrying out a survival analysis of their breaking times. By analyzing the dynamics of two morphological variables, we demonstrate that arches evolve toward less regular structures and it seems that there may exist a certain degree of irregularity that the arch reaches before collapsing. Moreover, we put forward that ¿ (the standard deviation of all angles between consecutive beads) describes faithfully the morphological evolution of the arch. Focusing on long-lasting arches, we study ¿ calculating its two-time autocorrelation function and its mean-squared displacement. In particular, the apparent logarithmic increase of the correlation and the decrease of the mean-squared displacement of ¿ when the waiting time is increased reveal a slowing down of the dynamics. This behavior is a clear hallmark of aging phenomena and confirms the lack of ergodicity in the unclogging dynamics. Our findings provide new insights on how an arch tends to destabilize and how the probability that it breaks with a long sustained vibration decreases with time