1,615 research outputs found
RECONSTRUCTION CHALLENGES TO THE SOCIAL SERVICE PROFESSIONS
The mass media has been ever-vigilant in keeping the public informed of the extent of crime in our society. In addition to the rates at which crimes are committed, it is the nature of the crimes that is particularly horrifying. Gross abuse of children, incest, callous murder of innocent people, community traumatisation by gangs and the like have become so common-place that we pay scant attention to the destabilising impact of these events on people and communities. These are, however, symptoms of the disintegrating social fabric and moral fibre in our society
AN EXPLORATORY STUDY ON DAY LABOURERS IN ELARDUS PARK PRETORIA
On Barnard Street, Elardus Park in Pretoria men are standing, raising a finger or miming a skill to attract the attention of potential employers. It is also common to see men swarm arounda car, pointing to themselves in an effort to get noticed and thus hired. This study deals with these people, who are day labourers leading a difficult life as they manage to survive in anentrepreneurial way. Their main need is to access work more easily. Skills training would make this possible. Social work could make a contribution in this respect
The effect of varying levels of vehicle automation on driversā lane changing behaviour
Much of the Human Factors research into vehicle automation has focused on driver responses to critical scenarios where a crash might occur. However, there is less knowledge about the effects of vehicle automation on driversā behaviour during non-critical take-over situations, such as driver-initiated lane-changing or overtaking. The current driving simulator study, conducted as part of the EC-funded AdaptIVe project, addresses this issue. It uses a within-subjects design to compare driversā lane-changing behaviour in conventional manual driving, partially automated driving (PAD) and conditionally automated driving (CAD). In PAD, drivers were required to re-take control from an automated driving system in order to overtake a slow moving vehicle, while in CAD, the driver used the indicator lever to initiate a system-performed overtaking manoeuvre. Results showed that while driversā acceptance of both the PAD and CAD systems was high, they generally preferred CAD. A comparison of overtaking positions showed that drivers initiated overtaking manoeuvres slightly later in PAD than in manual driving or CAD. In addition, when compared to conventional driving, drivers had higher deviations in lane positioning and speed, along with higher lateral accelerations during lane changes following PAD. These results indicate that even in situations which are not time-critical, driversā vehicle control after automation is degraded compared to conventional driving
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Full-Depth Recycling Study: Test Track Construction and First Level Analysis of Phase 1 HVS and Laboratory Testing
This first-level report describes the first phase of a study comparing the performance of four different full-depth pavement reclamation strategies, namely pulverization with no stabilization (FDR-NS), stabilization with foamed asphalt and portland cement (FDR-FA), stabilization with portland cement only (FDR-PC), and stabilization with engineered asphalt emulsion (FDR-EE). A literature review, the test track layout and design, stabilization and asphalt concrete mix designs, and test track construction are discussed, as well as results of Heavy Vehicle Simulator (HVS) and laboratory testing. A number of problems were experienced during construction of the FDR-PC and FDR-EE lanes on the test track and consequently only the FDR-NS and FDR-FA lanes and one section of the FDR-PC lane (5 percent measured cement content) were considered satisfactorily uniform for the purposes of accelerated pavement testing. The FDR-FA and FDR-PC sections performed very well and testing on both was terminated long before the terminal rut of 0.5 in. (12.5 mm) or average crack density of 0.8 ft/ft2 (2.5 m/m2 ) were reached (no cracks were observed on either section). The two FDR-NS sections performed acceptably, with the section with the thicker asphalt surfacing (120 mm) outperforming the section with the thinner asphalt surfacing (60 mm), as expected. Terminal rut was reached on both sections, but no cracking was observed. The FDR-EE sections performed poorly, with terminal rut and terminal cracking both reached after a limited number of load repetitions. This poor performance was attributed to problems associated with construction, and consequently no conclusions can be drawn from the test results regarding this stabilization strategy. The advantages of using foamed asphalt with cement and cement only recycling strategies over recycling strategies with no stabilization are clearly evident from the results. A second phase of accelerated pavement testing, full-scale field testing, and additional laboratory testing are planned to collect sufficient data for the development of mechanistic-empirical design criteria (and revised gravel factors) for full-depth reclaimed pavements. However, there is sufficient evidence to show that pavements that are rehabilitated using full-depth reclamation strategies will satisfactorily withstand design traffic levels common in California. Rehabilitation using this approach is quick, has minimal disruption to traffic, reuses all materials, does not require removal of material from the site, and effectively replaces weak base layers, thus preventing reflective cracking that is common in more traditional overlay projects. Based on these conclusions, it is recommended that full-depth reclamation be promoted as an appropriate rehabilitation strategy in California. Future research on partial- and full-depth reclamation should be coordinated to facilitate consistent design and specification documentation, and to facilitate the preparation of a comprehensive guide covering all forms of pavement recycling
Were they in the loop during automated driving? Links between visual attention and crash potential
Background: A proposed advantage of vehicle automation is that it relieves drivers from the moment-to-moment demands of driving, to engage in other, non-driving related, tasks. However, it is important to gain an understanding of driversā capacity to resume manual control, should such a need arise. As automation removes vehicle control-based measures as a performance indicator, other metrics must be explored. Methods: This driving simulator study, conducted under the European Commission (EC) funded AdaptIVe project, assessed driversā gaze fixations during partially-automated (SAE Level 2) driving, on approach to critical and non-critical events. Using a between-participant design, 75 drivers experienced automation with one of five out-of-the-loop (OOTL) manipulations, which used different levels of screen visibility and secondary tasks to induce varying levels of engagement with the driving task: 1) no manipulation, 2) manipulation by light fog, 3) manipulation by heavy fog, 4) manipulation by heavy fog plus a visual task, 5) no manipulation plus an n-back task. Results: The OOTL manipulations influenced driversā first point of gaze fixation after they were asked to attend to an evolving event. Differences resolved within one second and visual attention allocation adapted with repeated events, yet crash outcome was not different between OOTL manipulation groups. Drivers who crashed in the first critical event showed an erratic pattern of eye fixations towards the road centre on approach to the event, while those who did not demonstrated a more stable pattern. Conclusions: Automated driving systems should be able to direct driversā attention to hazards no less than 6 seconds in advance of an adverse outcome
Control of nuclear-cytoplasmic shuttling of Ankrd54 by PKCĪ“
AIM
To identify and characterize the effect of phosphorylation on the subcellular localization of Ankrd54.
METHODS
HEK293T cells were treated with calyculin A, staurosporin or phorbol 12-myristate 13-acetate (PMA). Cells were transfected with eGFP-tagged Ankrd54 with or without Lyn tyrosine kinase (wild-type, Y397F mutant, or Y508F mutant). The subcellular localization was assessed by immunofluorescence imaging of cells, immunoblotting of subcellular fractionations. The phosphorylation of Ankrd54 was monitored using Phos-tagTM gel retardation. Phosphorylated peptides were analysed by multiple-reaction-monitoring (MRM) proteomic analysis.
RESULTS
Activation of PKC kinases using PMA promoted nuclear export of Ankrd54 and correlated with increased Ankrd54 phosphorylation, assayed using Phos-tagTM gel retardation. Co-expression of an active form of the PKCĪ“ isoform specifically promoted both phosphorylation and cytoplasmic localization of Ankrd54, while PKCĪ“, Akt and PKA did not. Alanine mutation of several serine residues in the amino-terminal region of Ankrd54 (Ser14, Ser17, Ser18, Ser19) reduced both PMA induced cytoplasmic localization and phosphorylation of Ankrd54. Using MRM proteomic analysis, phosphorylation of the Ser18 residue of Ankrd54 was readily detectable in response to PMA stimulation. PMA stimulation of cells co-expressing Ankrd54 and Lyn tyrosine kinase displayed increased co-immunoprecipitation and enhanced co-localization in the cytoplasm.
CONCLUSION
We identify phosphorylation by PKCĪ“ as a major regulator of nuclear-cytoplasmic shuttling of Ankrd54, and its interaction with the tyrosine kinase Lyn
Establishing the Learned Effect of Repeated Wingate Anaerobic Tests
The Wingate anaerobic test (WAnT) is a recognized and well established tool used to measure power output, muscular endurance and fatigue. Changes within the aforementioned variables attributable to a learning effect could reduce the reliability of these measures. The purpose of this study was to establish the number of WAnT trials needed to produce a learned effect and reliability of that effect. Ten apparently healthy college-aged males participated in five trials of 30-second cycle ergometer sprints separated by a minimum of 72 hours. Resistance for trials was calculated at 7.5% of each respective subjectsā weight. This study tracked the changes in Peak Power (PP), Mean Power (MP) over time. Paired samples t-test using 2 tails revealed PP increased on all trials (2-5) when compared to trial 1 (+57W, +69W, +68W, +48W) (p=0.02, p=0.03, p=0.04, p=0.14) respectively, and indicated peak wattage at trial 3. MP also increased on all trials (2-5) when compared to trial 1 (+32W, +49W, +39W, +32W) (p=0.01, p=0.01, p=0.02, p=0.05) respectively, demonstrating mean peak wattage at trial 3. These results suggest that a learning effect is present within PP and MP until the third trial of the WAnT. All but 30% subjects elicited peak PP and MP during trial 3. Thereby, suggesting that when performing WAnT, utilizing less than 3 practice trials might elicit significant power increase due to this learned effect. Further research should be conducted in order to support the findings from the present investigation
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