Estilo de vida sedentário entre adolescentes na cidade de Ribeirão Preto (SP)

Introduction: Physical inactivity has been pointed out as one of the major public health problems of the 21st century and the benefits of the regular practice of physical activity during adolescence are important for the biological process of growth and development. Objective: To analyze the prevalence of physical inactivity among adolescents enrolled in schools in the city of Ribeirão Preto (SP). Methods: From September 1 to November 30, 2013, a cross-sectional, observational and descriptive study was conducted  with adolescents enrolled in 14 state schools in the city of Ribeirão Preto (SP) using the International Physical Activity Questionnaire, short version. Results: A total of 535 adolescents participated, 35% of them boys and 65% girls; 65% were 10 to 14 years old and 35% were 15 to 19 years old; 52.3% studied in the evening period and 10.3% worked part time on a daily basis. Regarding the level of physical activity, 15.5% of the boys and 24.1% of the girls were classified as sedentary (p>0.05). 60.4% of the boys performed physical activity of vigorous intensity, while 56.3% of the girls showed preference for physical activity of low or moderate intensity (p=0.03). The girls aged 15 to 19 years spent more time sitting during the week, while the girls aged 10 to 14 years were less active during the weekend. 24.2% of the girls aged 10 to 14 years who studied during the morning period and 13.7% of the boys and 18% of the girls who studied during the evening period were classified as sedentary. Conclusion: High rates of sedentary lifestyle were observed among adolescents enrolled in state (or public?) schools in Ribeirão Preto (Brazil). Girls presented higher rates of sedentary lifestyle than boys. Boys performed physical activity of vigorous intensity more frequently than girls. The older girls had higher rates of physical inactivity (hours spent in the sitting position) during the week days compared to the younger ones, while the latter spent more time in physical inactivity during the weekend.  Introdução: Adolescência é o período de transição entre a infância e a vida adulta, caracterizado por modificações no desenvolvimento físico, emocional, sexual e social e pelos esforços em alcançar os objetivos relacionados às expectativas culturais da sociedade em que vive. Objetivo: Avaliar a prevalência de inatividade física entre adolescentes matriculados em escolas da cidade de Ribeirão Preto (SP). Métodos: Estudo transversal, observacional e descritivo realizado entre 01/09/2013 e 30/11/2013, com adolescentes matriculados em 14 escolas estaduais da cidade de Ribeirão Preto (SP), utilizando-se o International Physical Activity Questionnarie, versão curta. Resultados: Participaram 535 adolescentes sendo 35 % masculino e 65 % feminino; 65% tinham entre 10 e 14 anos e 35% entre 15 e 19 anos; 52,3% estudavam no período vespertino e 10,3% trabalhavam meio período ao dia. Quanto ao nível de atividade física encontrou-se 15,5% dos meninos e 24,1% das meninas classificados como sedentários (p>0,05). As moças com idades entre 10 e 14 anos referiram nível de atividade física menor que as da faixa etária dos 15 aos 19 anos (p= 0,507). 60,4% dos rapazes realizam atividade física de intensidade vigorosa enquanto 56,3% das moças mostraram preferência por atividades físicas de intensidade baixa ou moderada (p=0,03). As moças na faixa etária dos 15 aos 19 anos passam mais tempo sentadas durante a semana, enquanto que nos finais de semana são menos ativas aquelas com idades entre 10 e 14 anos. Classificou-se como sedentários 24,2% das moças com idades entre 10 e 14 anos que estudam no período da manhã e, no período vespertino, 13,7% dos rapazes e 18% das moças na faixa etária dos 15 aos 19 anos. Conclusões: A prevalência de sedentarismo foi de 21% sendo maior para o sexo feminino na faixa etária dos 10 aos 14 anos, que são menos ativas nos finais de semana e que estudam no período da manhã

Personalized early detection and prevention of breast cancer: ENVISION consensus statement

Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early detection and prevention of breast cancer. In a consensus conference held in 2019, the members of this network identified research areas requiring development to enable evidence-based personalized interventions that might improve the benefits and reduce the harms of existing breast cancer screening and prevention programmes. The priority areas identified were: 1) breast cancer subtype-specific risk assessment tools applicable to women of all ancestries; 2) intermediate surrogate markers of response to preventive measures; 3) novel non-surgical preventive measures to reduce the incidence of breast cancer of poor prognosis; and 4) hybrid effectiveness–implementation research combined with modelling studies to evaluate the long-term population outcomes of risk-based early detection strategies. The implementation of such programmes would require health-care systems to be open to learning and adapting, the engagement of a diverse range of stakeholders and tailoring to societal norms and values, while also addressing the ethical and legal issues. In this Consensus Statement, we discuss the current state of breast cancer risk prediction, risk-stratified prevention and early detection strategies, and their implementation. Throughout, we highlight priorities for advancing each of these areas

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified